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1.发明授权
公开(公告)号：US5629305A
公开(公告)日：1997-05-13
申请号：US441766
申请日：1995-05-16
申请人： Arne T. Eek , Sven Erik Sj ostrand
发明人： Arne T. Eek , Sven Erik Sj ostrand
IPC分类号： A61K45/06 , A61B17/04 , A61B17/06 , A61B17/34 , A61F2/00 , A61K31/00 , A61K31/335 , A61K31/43 , A61K31/44 , A61K31/70 , A61P1/00 , A61P1/04 , C07D401/00 , C07D403/00
CPC分类号： A61K31/70 , A61B17/0469 , A61B17/06066 , A61K31/00 , A61K31/44 , A61K45/06 , A61B17/34 , A61F2002/30095 , A61F2002/30103 , A61F2210/0023 , A61F2210/0047
摘要： A synergistic pharmaceutical combination and composition are disclosed for the treatment of gastritis and peptic ulcer containing a therapeutic amount of a proton pump inhibitor such as e.g., omeprazole or lansoprazole, which increases intragastric pH, and a therapeutic amount of an acid degradable antibacterial compound such as a penicillin or a macrolide. In particular, the combination is directed to the treatment of infections caused by Helicobacter pylori by raising the bioavailability of acid degradable antibacterial compounds.
摘要翻译： 公开了用于治疗胃炎和消化性溃疡的协同药物组合和组合物，其含有治疗量的质子泵抑制剂例如奥美拉唑或兰索拉唑，其增加胃内pH，以及治疗量的酸可降解抗菌化合物，例如 青霉素或大环内酯类。 特别地，该组合旨在通过提高酸可降解抗菌化合物的生物利用度来治疗由幽门螺杆菌引起的感染。
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公开(公告)号：US5219358A
公开(公告)日：1993-06-15
申请号：US751903
申请日：1991-08-29
CPC分类号： A61B17/06066 , A61B17/0469 , A61B17/062 , A61B17/34 , A61B2017/00867 , A61F2002/30095 , A61F2002/30103 , A61F2210/0023 , A61F2210/0047
摘要： Surgical needles are fabricated from a shape memory alloy. The alloy has a low temperature state, in which the needle is formable into an elongated shape to pass through an elongated tube, and a high temperature state, in which the needle forms an arc. The needle is particularly adapted for use in endoscopic surgery. A needle that has a remembered curved shape is straightened and passed to a surgical site through a cannula. It is then returned to its curved shape by heating it at the surgical site. After use, it is withdrawn through the cannula.
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3.发明申请公开(公告)号：US20120232529A1
公开(公告)日：2012-09-13
申请号：US13460596
申请日：2012-04-30
IPC分类号： A61L29/14
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/221 , A61B2017/00398 , A61B2017/00867 , A61B2017/00871 , A61B2017/00876 , A61B2017/1205 , A61B2090/3954 , A61F2/01 , A61F2002/30098 , A61F2002/30103 , A61F2002/30105 , A61F2210/0033 , A61F2210/0047 , A61F2210/0052
摘要： A shape memory material with integrated actuation using embedded particles. One embodiment provides a shape memory material apparatus comprising a shape memory material body and magnetic pieces in the shape memory material body. Another embodiment provides a method of actuating a device to perform an activity on a subject comprising the steps of positioning a shape memory material body in a desired position with regard to the subject, the shape memory material body capable of being formed in a specific primary shape, reformed into a secondary stable shape, and controllably actuated to recover the specific primary shape; including pieces in the shape memory material body; and actuating the shape memory material body using the pieces causing the shape memory material body to be controllably actuated to recover the specific primary shape and perform the activity on the subject.
摘要翻译： 一种形状记忆材料，具有使用嵌入式颗粒的集成驱动。 一个实施例提供一种形状记忆材料装置，其包括形状记忆材料体和形状记忆材料体中的磁性片。 另一个实施例提供了一种致动装置以对被摄体执行活动的方法，包括以下步骤：将形状记忆材料体相对于被摄体定位在期望的位置，形状记忆材料体能够形成为特定的主要形状 重新形成二次稳定的形状，并可控地致动以恢复特定的主要形状; 包括形状记忆材料体中的碎片; 并且使用导致形状记忆材料体被可控地致动的片致动形状记忆材料体，以恢复特定的主形状并且对被检体进行活动。
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4.发明授权公开(公告)号：US07591834B2
公开(公告)日：2009-09-22
申请号：US10810422
申请日：2004-03-26
IPC分类号： A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/221 , A61B2017/00398 , A61B2017/00867 , A61B2017/00871 , A61B2017/00876 , A61B2017/1205 , A61B2090/3954 , A61F2/01 , A61F2002/30098 , A61F2002/30103 , A61F2002/30105 , A61F2210/0033 , A61F2210/0047 , A61F2210/0052
摘要： A shape memory material with integrated actuation using embedded particles. One embodiment provides a shape memory material apparatus comprising a shape memory material body and magnetic pieces in the shape memory material body. Another embodiment provides a method of actuating a device to perform an activity on a subject comprising the steps of positioning a shape memory material body in a desired position with regard to the subject, the shape memory material body capable of being formed in a specific primary shape, reformed into a secondary stable shape, and controllably actuated to recover the specific primary shape; including pieces in the shape memory material body; and actuating the shape memory material body using the pieces causing the shape memory material body to be controllably actuated to recover the specific primary shape and perform the activity on the subject.
摘要翻译： 一种形状记忆材料，具有使用嵌入式颗粒的集成驱动。 一个实施例提供一种形状记忆材料装置，其包括形状记忆材料体和形状记忆材料体中的磁性片。 另一个实施例提供了一种致动装置以对被摄体执行活动的方法，包括以下步骤：将形状记忆材料体相对于被摄体定位在期望的位置，形状记忆材料体能够形成为特定的主要形状 重新形成二次稳定的形状，并可控地致动以恢复特定的主要形状; 包括形状记忆材料体中的碎片; 并且使用导致形状记忆材料体被可控地致动的片致动形状记忆材料体，以恢复特定的主形状并且对被检体进行活动。
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5.发明申请公开(公告)号：US20110046740A1
公开(公告)日：2011-02-24
申请号：US12546191
申请日：2009-08-24
申请人： Chao C. Chen , Hung-Wen Wei
发明人： Chao C. Chen , Hung-Wen Wei
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/4611 , A61F2002/2835 , A61F2002/30092 , A61F2002/30098 , A61F2002/301 , A61F2002/30102 , A61F2002/30103 , A61F2002/30387 , A61F2002/30433 , A61F2002/30517 , A61F2002/30565 , A61F2002/30579 , A61F2002/30604 , A61F2002/30668 , A61F2002/30797 , A61F2002/30823 , A61F2002/4415 , A61F2002/4485 , A61F2210/0014 , A61F2210/0033 , A61F2210/0038 , A61F2210/0042 , A61F2210/0047 , A61F2220/0025 , A61F2220/0041 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00071
摘要： The present invention provides a spinal implant for stabilizing adjacent vertebrae of a patient, comprising (i) two or more cages; and (ii) a support which is returnable from a constrained linear shape to an expanded shape and affixed to each of the two or more cages, said implant having a first configuration to arrange the cages in order when the support is in the constrained linear shape, and a second configuration that gives a transformed arrangement of the cages to define a plane by the cages and the support when the support is in the expanded shape. Also provided are a surgical instrument set and a method for implanting a spinal implant to a disc space of a patient.
摘要翻译： 本发明提供了一种用于稳定患者的相邻椎骨的脊柱植入物，包括（i）两个或更多个笼子; 和（ii）支撑件，该支撑件可从受约束的线性形状返回到扩展形状并且固定到两个或多个笼中的每个上，所述植入物具有第一构型，以在支撑件处于约束线形时依次排列笼子 以及第二构造，当支撑件处于展开形状时，其给出笼的转换布置以由笼和支撑件限定平面。 还提供了一种手术器械组和将脊柱植入物植入患者的椎间盘空间的方法。
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6.发明申请公开(公告)号：US20050212630A1
公开(公告)日：2005-09-29
申请号：US10810422
申请日：2004-03-26
申请人： Patrick Buckley , Duncan Maitland
发明人： Patrick Buckley , Duncan Maitland
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/221 , A61B2017/00398 , A61B2017/00867 , A61B2017/00871 , A61B2017/00876 , A61B2017/1205 , A61B2090/3954 , A61F2/01 , A61F2002/30098 , A61F2002/30103 , A61F2002/30105 , A61F2210/0033 , A61F2210/0047 , A61F2210/0052
摘要： A shape memory material with integrated actuation using embedded particles. One embodiment provides a shape memory material apparatus comprising a shape memory material body and magnetic pieces in the shape memory material body. Another embodiment provides a method of actuating a device to perform an activity on a subject comprising the steps of positioning a shape memory material body in a desired position with regard to the subject, the shape memory material body capable of being formed in a specific primary shape, reformed into a secondary stable shape, and controllably actuated to recover the specific primary shape; including pieces in the shape memory material body; and actuating the shape memory material body using the pieces causing the shape memory material body to be controllably actuated to recover the specific primary shape and perform the activity on the subject.
摘要翻译： 一种形状记忆材料，具有使用嵌入式颗粒的集成驱动。 一个实施例提供一种形状记忆材料装置，其包括形状记忆材料体和形状记忆材料体中的磁性片。 另一个实施例提供了一种致动装置以对被摄体执行活动的方法，包括以下步骤：将形状记忆材料体相对于被摄体定位在期望的位置，形状记忆材料体能够形成为特定的主要形状 重新形成二次稳定的形状，并可控地致动以恢复特定的主要形状; 包括形状记忆材料体中的碎片; 并且使用导致形状记忆材料体被可控地致动的片致动形状记忆材料体，以恢复特定的主形状并且对被检体进行活动。
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7.发明授权
公开(公告)号：US5633244A
公开(公告)日：1997-05-27
申请号：US442382
申请日：1995-05-16
申请人： Arne T. Eek , Sven E. Sjostrand
发明人： Arne T. Eek , Sven E. Sjostrand
IPC分类号： A61K45/06 , A61B17/04 , A61B17/06 , A61B17/34 , A61F2/00 , A61K31/00 , A61K31/335 , A61K31/43 , A61K31/44 , A61K31/70 , A61P1/00 , A61P1/04 , C07D401/00 , C07D403/00 , A61K31/415 , A61K31/34
CPC分类号： A61K31/70 , A61B17/0469 , A61B17/06066 , A61K31/00 , A61K31/44 , A61K45/06 , A61B17/34 , A61F2002/30095 , A61F2002/30103 , A61F2210/0023 , A61F2210/0047
摘要： A synergistic pharmaceutical combination or composition is disclosed for the treatment of gastritis and peptic ulcer containing a therapeutic amount of a histamine H.sub.2 receptor blocking agent, which increases intragastric pH, and an acid degradable antibacterial compound. In particular, the combination is directed to the treatment of infections by Helicobacter pylori by raising the bioavailability of acid degradable antibacterial compounds.
摘要翻译： 公开了用于治疗胃炎和消化性溃疡的协同药物组合或组合物，其含有治疗量的组胺H2受体阻断剂，其增加胃内pH，以及酸降解抗菌化合物。 特别地，该组合旨在通过提高酸可降解抗菌化合物的生物利用度来治疗幽门螺杆菌的感染。
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公开(公告)号：US07828845B2
公开(公告)日：2010-11-09
申请号：US10650494
申请日：2003-08-28
CPC分类号： A61F2/4455 , A61F2/4465 , A61F2002/2817 , A61F2002/2835 , A61F2002/30014 , A61F2002/30032 , A61F2002/30062 , A61F2002/30095 , A61F2002/30102 , A61F2002/30103 , A61F2002/30131 , A61F2002/30133 , A61F2002/30176 , A61F2002/30177 , A61F2002/30235 , A61F2002/30579 , A61F2002/30971 , A61F2002/4475 , A61F2002/448 , A61F2002/4635 , A61F2210/0004 , A61F2210/0023 , A61F2210/0042 , A61F2210/0047 , A61F2230/0013 , A61F2230/0015 , A61F2230/0054 , A61F2230/0056 , A61F2230/0069 , A61F2250/0018 , A61F2250/003
摘要： Intervertebral spacers are provided for use in orthopedic treatment of spinals defects. The intervertebral spacer is formed of a shape memory polymer. The spacer can be fabricated into a desired configuration and then deformed into an alternative or deformed configuration. Cooling the deformed spacer effectively freezes the spacer into its deformed conformation. The deformed configuration can be selected to facilitate implantation of the spacer into a prepared disc space between adjacent vertebrae. During operation, the surgeon can heat the spacer to allow it to revert to its original configuration. The spacer in its original conformation is sized to restore and/or maintain the adjacent vertebrae in a desired conformation and disc space height.
摘要翻译： 提供椎间隔垫用于矫形治疗脊髓缺陷。 椎间隔垫由形状记忆聚合物形成。 间隔件可以制造成所需的构造，然后变形为替代或变形构造。 冷却变形的间隔物有效地将间隔件冻结成其变形构型。 可以选择变形的构造以便于将间隔件植入到相邻椎骨之间的制备的椎间盘空间中。 在手术过程中，外科医生可以加热间隔器以使其恢复到其原始配置。 其原始构造中的间隔物的尺寸被设计成恢复和/或维持相邻椎骨具有期望的构象和椎间盘空间高度。
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公开(公告)号：US20050080489A1
公开(公告)日：2005-04-14
申请号：US10650494
申请日：2003-08-28
申请人： Bradley Estes , Andrew Dickson
发明人： Bradley Estes , Andrew Dickson
CPC分类号： A61F2/4455 , A61F2/4465 , A61F2002/2817 , A61F2002/2835 , A61F2002/30014 , A61F2002/30032 , A61F2002/30062 , A61F2002/30095 , A61F2002/30102 , A61F2002/30103 , A61F2002/30131 , A61F2002/30133 , A61F2002/30176 , A61F2002/30177 , A61F2002/30235 , A61F2002/30579 , A61F2002/30971 , A61F2002/4475 , A61F2002/448 , A61F2002/4635 , A61F2210/0004 , A61F2210/0023 , A61F2210/0042 , A61F2210/0047 , A61F2230/0013 , A61F2230/0015 , A61F2230/0054 , A61F2230/0056 , A61F2230/0069 , A61F2250/0018 , A61F2250/003
摘要： This invention relates to intervertebral spacers for use in orthopedic treatment of spinal defects. The intervertebral space is formed of a shape memory polymer. The spacer can be fabricated into a desired configuration and then deformed into an alternative or deformed configuration. Cooling the deformed spacer effectively freezes the spacer into its deformed conformation. The deformed configuration can be selected to facilitate implantation of the spacer into a prepared disc space between adjacent vertebrae. During operation, the surgeon can heat the spacer to allow it to revert to its original configuration. The spacer in its original conformation is sized to restore and/or maintain the adjacent vertebrae in a desired conformation and disc space height.
摘要翻译： 本发明涉及用于脊柱缺损矫形治疗的椎间隔垫。 椎间隙由形状记忆聚合物形成。 间隔件可以制造成所需的构造，然后变形为替代或变形构造。 冷却变形的间隔物有效地将间隔件冻结成其变形构型。 可以选择变形的构造以便于将间隔件植入到相邻椎骨之间的制备的椎间盘空间中。 在手术过程中，外科医生可以加热间隔器以使其恢复到其原始配置。 其原始构造中的间隔物的尺寸被设计成恢复和/或维持相邻椎骨具有期望的构象和椎间盘空间高度。
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10.发明授权
公开(公告)号：US5599794A
公开(公告)日：1997-02-04
申请号：US51722
申请日：1993-04-22
申请人： Arne T. Eek , Sven Erik Sj ostrand
发明人： Arne T. Eek , Sven Erik Sj ostrand
IPC分类号： A61K45/06 , A61B17/04 , A61B17/06 , A61B17/34 , A61F2/00 , A61K31/00 , A61K31/335 , A61K31/43 , A61K31/44 , A61K31/70 , A61P1/00 , A61P1/04 , C07D401/00 , C07D403/00 , A61K31/445
CPC分类号： A61K31/70 , A61B17/0469 , A61B17/06066 , A61K31/00 , A61K31/44 , A61K45/06 , A61B17/34 , A61F2002/30095 , A61F2002/30103 , A61F2210/0023 , A61F2210/0047
摘要： The invention consists of a combination of a substance that increases the intragastric pH and an acid degradable antibacterial compound. By this combined product regimen it will be possible to obtain maximal local antibacterial effect of acid degradable antibiotics as well as enhanced bioavailability of the active antibiotic, thus resulting in higher amounts of the active compound in the gastric mucosa due to secretion of weak bases. Both pharmacological effects contribute to drastically increased antimicrobial capacity of acid degradable antibiotics to be used against local infections in the gastrointestinal tract causing gastritis and/or peptic ulcer. The invention also selects to the use of said combination and a process for the preparation thereof.
摘要翻译： 本发明由增加胃内pH的物质与酸降解抗菌化合物的组合组成。 通过该组合产品方案，可以获得酸降解抗生素的最大局部抗菌作用以及提高活性抗生素的生物利用度，从而由于弱碱分泌导致胃粘膜中活性化合物的量增加。 两种药理作用都有助于大幅提高酸降解抗生素的抗菌能力，以抵抗胃肠道局部感染引起胃炎和/或消化性溃疡。 本发明还选择了所述组合的用途及其制备方法。
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