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公开(公告)号：US11065033B2
公开(公告)日：2021-07-20
申请号：US16917166
申请日：2020-06-30
Applicant: Medical University of South Carolina
Inventor： Stephen Kalhorn , Ryan Kellogg , Joe Ruscito
Abstract: The present invention provides minimally invasive subdural evacuating systems and methods of use thereof. The subdural evacuating systems include a cutting component and a rod component, wherein the rod component provides an external physical indicator that the surface of the dura mater has been reached, permitting the cutting component to accurately pierce the dura mater with minimal to no risk of damaging any adjacent anatomy.
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2.发明申请Compositions and Methods for Tissue Engineering, Tissue Regeneration and Wound Healing 有权组织工程，组织再生和伤口愈合的组成和方法公开(公告)号：US20130236431A1
公开(公告)日：2013-09-12
申请号：US13854480
申请日：2013-04-01
Inventor： Robert G. Gourdie , Jay D. Potts
CPC classification number: A61K35/28 , A61K38/17 , A61K38/1709 , A61K38/177 , A61K38/1841 , A61L27/227 , A61L27/3834 , A61L27/52 , C12N5/0068 , C12N5/0662 , C12N5/0663 , C12N2533/54 , A61K2300/00
Abstract: In accordance with certain embodiments of the present disclosure, a kit is described. The kit includes primed living cells joined to and at least partially within a three-dimensional hydrogel structure and an isolated polypeptide having the carboxy-terminal amino acid sequence of an alpha Connexin, or a conservative variant thereof, wherein the polypeptide does not include the full length alpha Connexin protein.
Abstract translation: 根据本公开的某些实施方案，描述了试剂盒。 该试剂盒包括与三维水凝胶结构连接并且至少部分地连接在三维水凝胶结构内的引发活细胞和具有α连接蛋白或其保守变体的羧基末端氨基酸序列的分离多肽，其中多肽不包括全部 长度的α连接蛋白。
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3.发明申请Tissue specific and target RNA-specific ribozymes as antimicrobial therapeutics against microbial pathogens 审中-公开组织特异性和靶RNA特异性核酶作为抗微生物病原体的抗微生物治疗剂公开(公告)号：US20030125280A1
公开(公告)日：2003-07-03
申请号：US10127025
申请日：2002-04-19
Applicant: Medical University of South Carolina , The Penn State Research Foundation, a Pennsylvania corporation
Inventor： James S. Norris , Michael G. Schmidt , Joseph W. Dolan , Steven D. London , Harold D. May , Gary A. Clawson
IPC: A61K048/00 , A61K009/127 , C12N015/86 , C12N015/88 , C12N007/00
CPC classification number: C12N15/88 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/127
Abstract: The invention provides compositions comprising the tissue specific and target RNA-specific ribozyme(s) in either a viral delivery system or a biologic liposome preparation, wherein the viral delivery system or a biologic liposome comprises a pathogen-specific promotor upstream from a sequence encoding a triple ribozyme comprising a) a 5null autocatalytically cleaving ribozyme sequence, b) a catalytic ribozyme comprising a target RNA-specific binding site and c) a 3null autocatalytically cleaving ribozyme sequence. The invention also provides methods of treating and/or preventing bacterial infections by administering the compositions of the invention.
Abstract translation: 本发明提供了包含病毒递送系统或生物脂质体制剂中的组织特异性和靶RNA特异性核酶的组合物，其中所述病毒递送系统或生物脂质体包含来自编码 三核酶包含a）5'自催化切割核酶序列，b）包含靶RNA特异性结合位点的催化核酶，和c）3'自动催化裂解核酶序列。 本发明还提供了通过施用本发明的组合物治疗和/或预防细菌感染的方法。
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公开(公告)号：USD722698S1
公开(公告)日：2015-02-17
申请号：US29477363
申请日：2013-12-20
Applicant: The Medical University of South Carolina
Designer： Bruce M. Frankel , Mark Evald Semler
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公开(公告)号：US20040072138A1
公开(公告)日：2004-04-15
申请号：US10429231
申请日：2003-05-02
Applicant: Medical University of South Carolina
Inventor： Inderjit Singh
IPC: A01N001/00 , A01N001/02 , A61K031/7056 , A61K031/198
CPC classification number: A61K31/197 , A61K31/00 , A61K31/137 , A61K31/145 , A61K31/175 , A61K31/192 , A61K31/198 , A61K31/20 , A61K31/275 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/366 , A61K31/40 , A61K31/4015 , A61K31/4196 , A61K31/472 , A61K31/522 , A61K31/661 , A61K31/7052 , A61K31/7056 , A61K31/7076 , C12N9/99 , A61K2300/00
Abstract: This current invention includes compositions and methods of nitric oxide synthase inhibitors to treat or reduce ischemia/reperfusion injury in a patient. More specifically, the invention relates to a combinational therapy of 5-Aminoimidazole-4-carboxamide-1-B-D-ribonucleoside (AICAR) and N-acetyl cysteine (NAC) to attenuate ischemia/reperfusion injury to a transplanted organ.
Abstract translation: 本发明包括用于治疗或减少患者的缺血/再灌注损伤的一氧化氮合酶抑制剂的组合物和方法。 更具体地，本发明涉及5-氨基咪唑-4-甲酰胺-1-B-D-核糖核苷（AICAR）和N-乙酰半胱氨酸（NAC）的组合疗法，以减少移植器官的缺血/再灌注损伤。
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Patent Agency Ranking
公开(公告)号：US20170107190A1
公开(公告)日：2017-04-20
申请号：US15293107
申请日：2016-10-13
Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education , Medical University of South Carolina
Inventor： Peter Wipf , Carol A. Feghali-Bostwick
IPC: C07D305/08 , C07D305/06
CPC classification number: C07D305/08 , C07D305/06
Abstract: A compound, or a pharmaceutically acceptable salt thereof, having a structure of wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl; X is —S—, —S(O)—, or S(O)2—; R20 and R21 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, or halogenated alkyl; one of R22, R23, and R24 is —O— and the others of R22, R23 and R24 are independently —CH2—, or —C(R13)— wherein R13 is alkyl, alkenyl, alkynyl, trialkylsilyl group, or —(CH2)mOR15, wherein R15 is alkyl or an aryl and m is an integer in the range of 1 to 10; and R25 is H, alkyl, substituted alkyl, halogen, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C1-C3 alkoxy, aryloxy, or —(CH2)qOR17, wherein R17 is alkyl an aryl and q is an integer in the range of 1 to 10.
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公开(公告)号：US20130236504A1
公开(公告)日：2013-09-12
申请号：US13784930
申请日：2013-03-05
Applicant: CLEMSON UNIVERSITY , MEDICAL UNIVERSITY OF SOUTH CAROLINA
Inventor： Frank Alexis , Bruce Frankel
IPC: A61K31/52 , A61K31/4188
CPC classification number: A61K31/52 , A61K9/5107 , A61K31/495 , A61K45/06 , A61K47/6929 , A61K2300/00
Abstract: Disclosed are delivery systems that can be used for treating cancer. The delivery systems include a delivery vehicle in conjunction with a chemo-adjuvant. The chemo-adjuvant can enhance the efficacy of a therapeutic agent that can be delivered in conjunction with the delivery vehicle or can be delivered independently of the delivery vehicle.
Abstract translation: 公开了可用于治疗癌症的递送系统。 递送系统包括与化学辅助剂结合的递送载体。 化学佐剂可以增强可以与递送载体一起递送的治疗剂的功效，或者可以独立于递送载体递送。
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公开(公告)号：US20030092651A1
公开(公告)日：2003-05-15
申请号：US10082973
申请日：2002-02-26
Inventor： James S. Norris , Gary A. Clawson , Michael G. Schmidt , Brian Hoel , Wei-Hua Pan , Joseph W. Dolan , David Schofield , Caroline Westwater , Cancan Huang
IPC: A61K048/00 , C07H021/02
CPC classification number: C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/127 , C12N2799/021
Abstract: The present invention relates to multi-ribozymes and their use to target RNA in a tissue-specific, target RNA-specific, or pathogen-specific manner for the treatment of cancers, proliferative disease, and bacterial, parasitic and viral infections. More specifically, the present invention relates to the use of virions and viral vectors to package and deliver DNA encoding the multi-ribozymes to a host. The present invention relates to the use of liposomes and lipid-DNA complexes to deliver DNA encoding ribozymes to a host. Most specifically, the invention relates to the use of target specific virions to package and deliver DNA comprising a target specific promoter and encoding a ribozyme(s) directed to the target organism nucleic acids. The present invention further relates to a novel vectors encoding a multi-ribozyme structure with enhanced 5null and/or 3null autocatalytically cleaving ribozymes. The invention further relates to nucleotides encoding a multi-ribozyme comprising one or more ribozyme cassettes which contain one or more trans-acting ribozymes and one or more autocatalytically cleaving ribozyme sequences.
Abstract translation: 本发明涉及多核酶及其用于以组织特异性，靶RNA特异性或病原体特异性方式靶向用于治疗癌症，增殖性疾病和细菌，寄生虫和病毒感染的RNA的用途。 更具体地，本发明涉及病毒粒子和病毒载体用于将编码多核酶的DNA包装并递送至宿主的用途。 本发明涉及脂质体和脂质DNA复合物将编码核酶的DNA递送至宿主的用途。 最具体地，本发明涉及靶特异性病毒体用于包装和递送包含靶特异性启动子并编码针对靶生物核酸的核酶的DNA的用途。 本发明还涉及编码具有增强的5'和/或3'自动催化裂解核酶的多核酶结构的新载体。 本发明还涉及编码多核酶的核苷酸，其包含一个或多个含有一个或多个反式作用核酶和一个或多个自动催化裂解核酶序列的核酶盒。
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公开(公告)号：US20230143233A1
公开(公告)日：2023-05-11
申请号：US18054447
申请日：2022-11-10
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , MEDICAL UNIVERSITY OF SOUTH CAROLINA
Inventor： Paul Sajda , Truman R. Brown , Mark S. George , Robin Goldman , Josef Faller , Jaycee Doose , James McIntosh , Joshua B. Teves , Yida Lin , Golbarg T. Saber , Aidan Blankenship , Spiro P. Pantazatos , Xiaoxiao Sun
CPC classification number: A61B5/055 , A61N2/006 , A61N2/02 , A61B5/4064
Abstract: The present subject matter relates to techniques for systems and methods for determining alpha phase in brain of subjects undergoing depressive disorder. The disclosed system for a closed-loop operation in simultaneous functional magnetic resonance imaging (fMRI)-electroencephalogram (EEG)-transcranial magnetic stimulation (TMS), can include a processor that be configured to receive and process a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and/or transcranial magnetic stimulation (TMS) pulse simultaneously.
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公开(公告)号：US20210000502A1
公开(公告)日：2021-01-07
申请号：US16917166
申请日：2020-06-30
Applicant: Medical University of South Carolina
Inventor： Stephen Kalhorn , Ryan Kellogg , Joe Ruscito
Abstract: The present invention provides minimally invasive subdural evacuating systems and methods of use thereof. The subdural evacuating systems include a cutting component and a rod component, wherein the rod component provides an external physical indicator that the surface of the dura mater has been reached, permitting the cutting component to accurately pierce the dura mater with minimal to no risk of damaging any adjacent anatomy.
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