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1.发明授权Coatings for medical articles including natural biodegradable polysaccharides 失效包括天然可生物降解多糖在内的医疗用品涂料公开(公告)号：US08241655B2
公开(公告)日：2012-08-14
申请号：US11127351
申请日：2005-05-12
IPC分类号： A61K39/395 , A61F2/02
CPC分类号： A61L31/16 , A61F2210/0004 , A61F2310/00389 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/406 , A61L2300/416 , A61L2300/418 , A61L2300/622 , C08L5/00
摘要： Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
摘要翻译： 描述了包括天然可生物降解多糖的可生物降解涂层。 涂层由具有侧联偶合基团的多种天然可生物降解多糖形成。
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公开(公告)号：US20120010707A1
公开(公告)日：2012-01-12
申请号：US13242457
申请日：2011-09-23
CPC分类号： A61L27/34 , A61L33/0029 , C08L33/06
摘要： Polymeric coatings that include coupled biomolecules are formed on the surface of articles, such as medical devices. A coated layer that includes a synthetic polymer including a reactive group is formed on a surface and then a biomolecule is attached to the reactive group. The synthetic polymer can be an acrylate polymer or an amine-containing polymer having pendent photoreactive groups.
摘要翻译： 包括偶联的生物分子的聚合物涂层形成在诸如医疗装置的制品的表面上。 在表面上形成包括含有反应性基团的合成聚合物的涂层，然后将生物分子连接到反应性基团上。 合成聚合物可以是具有侧基光反应性基团的丙烯酸酯聚合物或含胺聚合物。
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公开(公告)号：US07550443B2
公开(公告)日：2009-06-23
申请号：US11090517
申请日：2005-03-25
申请人： Sean M. Stucke , Ralph A. Chappa , Joseph A. Chinn
发明人： Sean M. Stucke , Ralph A. Chappa , Joseph A. Chinn
IPC分类号： A61K31/727 , A61K9/14 , A61K9/50
CPC分类号： A61K31/4745 , A61K31/727 , A61L31/10 , A61L31/16 , A61L33/0029 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608
摘要： The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity that are able to release a bioactive agent, wherein the coatings are formed using biostable or biodegradable polymeric material and photoreactive groups.
摘要翻译： 本发明提供了用于向医疗制品提供生物相容性表面的方法和组合物。 特别地，本发明提供具有能够释放生物活性剂的肝素活性的生物相容性涂层，其中使用生物稳定或可生物降解的聚合物材料和光反应性基团形成涂层。
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公开(公告)号：US20080243243A1
公开(公告)日：2008-10-02
申请号：US11824908
申请日：2007-07-03
IPC分类号： A61F2/06
CPC分类号： A61L29/085 , A61F2/91 , A61L27/34 , A61L31/10 , A61L33/0029 , A61L33/122 , A61L33/128 , A61L2420/08 , C08L89/00 , C08L89/06
摘要： Coatings including adhesion factors for the surfaces of implantable medical articles are disclosed. The coatings are used to improve the function of the device by promoting a pro-healing response following implantation. The coatings can modulate endothelialization of the article surface to reduce the risk of adverse tissue responses that may reduce the functionality of the device.
摘要翻译： 公开了包括可植入医疗制品表面的粘附因子的涂层。 涂层用于通过促进植入后的预愈合反应来改善装置的功能。 涂层可以调节制品表面的内皮化，以减少可能降低装置功能的不利组织反应的风险。
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5.发明授权公开(公告)号：US08512736B2
公开(公告)日：2013-08-20
申请号：US11271213
申请日：2005-11-11
CPC分类号： A61L27/20 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61K47/34 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L29/16 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/604 , A61L2300/606 , A61L2420/02 , B05D1/36 , B05D7/52 , C08B31/006 , C08B31/04 , C08B33/02 , C08B33/04 , C08L3/02 , C08L3/12 , C09D103/02 , C09D103/18
摘要： Biodegradable coatings and articles that include natural biodegradable polysaccharides are described. The coatings and articles are formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
摘要翻译： 描述了包括天然可生物降解多糖的可生物降解的涂层和制品。 涂层和制品由具有悬挂偶联基团的多种天然可生物降解多糖形成。
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公开(公告)号：US20100226960A1
公开(公告)日：2010-09-09
申请号：US11524926
申请日：2006-09-21
IPC分类号： A61F2/00 , A61K38/02 , A61K31/7088 , A61K31/715 , A61K35/12 , A61P43/00
CPC分类号： A61L27/20 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61K47/34 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L29/16 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/604 , A61L2300/606 , A61L2420/02 , B05D1/36 , B05D7/52 , C08B31/006 , C08B31/04 , C08B33/02 , C08B33/04 , C08L3/02 , C08L3/12 , C09D103/02 , C09D103/18
摘要： Matrices formed from a natural biodegradable material and that exhibit surface degradation in the presence of an enzyme are described. Matrices including a bioactive agent can be implanted or formed in a subject for release of the bioactive agent upon degradation of the matrix. The matrix can be provided in various forms, including coatings for implantable devices, implants, and in-situ formed matrices. The matrix can also be in the form of a medical device having a structure that is used to treat a medical condition.
摘要翻译： 描述了由天然可生物降解材料形成的并且在酶存在下显示表面降解的基质。 包括生物活性剂的基质可以在受试者中植入或形成，以在基质降解时释放生物活性剂。 基质可以以各种形式提供，包括用于可植入装置的涂层，植入物和原位形成的基质。 该基质还可以是具有用于治疗医疗状况的结构的医疗装置的形式。
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公开(公告)号：US06528107B2
公开(公告)日：2003-03-04
申请号：US09359235
申请日：1999-07-22
申请人： Joseph A. Chinn , Richard E. Phillips, Jr. , Joseph A. Sauter , R. Michael Casanova , Chandrashekhar P. Pathak , Mark A. Moore , L. Diane Bruce
发明人： Joseph A. Chinn , Richard E. Phillips, Jr. , Joseph A. Sauter , R. Michael Casanova , Chandrashekhar P. Pathak , Mark A. Moore , L. Diane Bruce
IPC分类号： A61L1500
CPC分类号： A61L31/16 , A61F2/2409 , A61L27/16 , A61L27/54 , A61L2300/404 , A61L2300/42
摘要： A method is provided for producing antimicrobial, antithrombogenic medical devices. The method employs an antimicrobial treatment process wherein an antimicrobial agent is dissolved in an appropriate solvent and the resulting solution is contacted with a portion of a medical device of interest. The antimicrobial treatment process is advantageously performed without the need for additional compounds to facilitate antimicrobial agent uptake into the device. The method further comprises an antithrombogenic treatment process wherein antithrombogenic agents or materials are applied or otherwise associated with at least some portion of the medical device.
摘要翻译： 提供了用于生产抗微生物，抗血栓形成的医疗装置的方法。 该方法采用抗微生物处理方法，其中将抗微生物剂溶解在合适的溶剂中，并将所得溶液与感兴趣的医疗装置的一部分接触。 抗微生物处理方法有利地进行，而不需要额外的化合物以促进抗微生物剂吸收到装置中。 该方法还包括抗血栓形成治疗方法，其中抗血栓形成剂或材料被施用或以其它方式与医疗装置的至少一部分相关联。
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公开(公告)号：US06416549B1
公开(公告)日：2002-07-09
申请号：US09357666
申请日：1999-07-20
IPC分类号： A61F224
CPC分类号： A61F2/2445 , A61F2210/0004 , A61F2250/0067
摘要： This invention provides an antithrombogenic annuloplasty rings, and methods for making the same, wherein the annuloplasty rings have a desired degree of initial rigidity to facilitate ease of handling during implantation but which becomes flexible some time after implantation. The annuloplasty ring contains a relatively rigid insert enclosed by a fabric sheath, the insert being at least partly comprised of a biodegradable material. Following surgical implantation of the annuloplasty ring, the rigid insert component of the ring, upon exposure to blood and/or other physiological fluids, undergoes a controlled biodegradation which decreases its rigidity, thereby increasing the flexibility of the implanted annuloplasty ring. Furthermore, at least some portion of the annuloplasty ring has incorporated into or onto its structure one or more antithrombogenic agents or materials in a manner which reduces the likelihood of thrombosis following implantation.
摘要翻译： 本发明提供一种抗血栓形成瓣环成形术环及其制造方法，其中瓣环成形术环具有期望程度的初始刚性，以便于在植入期间容易处理，但在植入后一段时间变得柔性。 瓣膜成形术环包含由织物护套包围的相对刚性的插入物，插入件至少部分地由可生物降解的材料构成。 在环形成形术环的手术植入之后，环的刚性插入部件在暴露于血液和/或其它生理液体时经受受控的生物降解，其降低其刚性，从而增加植入的瓣膜成形术环的柔性。 此外，瓣膜成形术环的至少一部分已经以降低植入后血栓形成的可能性的方式并入其结构中或其结构上，一种或多种抗血栓形成剂或材料。
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公开(公告)号：US06416548B2
公开(公告)日：2002-07-09
申请号：US09357584
申请日：1999-07-20
IPC分类号： A61F224
CPC分类号： A61F2/2445 , A61F2250/0067 , Y10S623/901
摘要： This invention provides an antimicrobial annuloplasty rings, and methods for making the same, wherein the annuloplasty rings have a desired degree of initial rigidity to facilitate ease of handling during implantation but which becomes flexible some time after implantation. The annuloplasty ring contains a relatively rigid insert enclosed by a fabric sheath, the insert being at least partly comprised of a biodegradable material. Following surgical implantation of the annuloplasty ring, the rigid insert component of the ring, upon exposure to blood and/or other physiological fluids, undergoes a controlled biodegradation which decreases its rigidity, thereby increasing the flexibility of the implanted annuloplasty ring. Furthermore, at least some portion of the annuloplasty ring of the invention has incorporated therein one or more antimicrobial agents in a manner which reduces the likelihood of device infection following implantation.
摘要翻译： 本发明提供一种抗微生物瓣环成形术环及其制造方法，其中瓣环成形术环具有期望的初始刚性程度，以便于在植入期间易于处理，但在植入后一段时间变得柔性。 瓣膜成形术环包含由织物护套包围的相对刚性的插入物，插入件至少部分地由可生物降解的材料构成。 在环形成形术环的手术植入之后，环的刚性插入部件在暴露于血液和/或其它生理液体时经受受控的生物降解，其降低其刚性，从而增加植入的瓣膜成形术环的柔性。 此外，本发明的瓣环成形术环的至少一部分以其降低植入后装置感染的可能性的方式并入其中的一种或多种抗微生物剂。
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公开(公告)号：US07550444B2
公开(公告)日：2009-06-23
申请号：US11090655
申请日：2005-03-25
IPC分类号： A61K31/727 , A61K47/00 , A61F2/00
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L33/0011 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608 , C08L33/10 , C08L29/04 , C08L39/06
摘要： The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
摘要翻译： 本发明提供了用于向医疗制品提供生物相容性表面的方法和组合物。 特别地，本发明提供具有肝素活性的生物相容性涂层。 在一些方面，本发明的生物相容性涂层能够释放生物活性剂。 可以使用生物稳定或可生物降解的聚合物材料和光反应性基团形成涂层。 本发明还提供了通过进行生物相容性涂料组合物的预辐射来提高含生物活性剂的涂层的质量的方法。
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