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公开(公告)号：US08377461B2
公开(公告)日：2013-02-19
申请号：US11295836
申请日：2005-12-06
IPC分类号： A61F2/00 , A61F13/00 , A61K9/14 , A61K31/727
CPC分类号： A61L29/085 , A61L27/34 , A61L31/10 , A61L33/0011
摘要： The invention provides medical articles that include more than one biocompatibility-promoting function. In one aspect, the invention provides a medical articles that include a polymeric matrix including more than one biocompatible agent, wherein each biocompatible agent is provided at a distinct portion of the medical article surface. Methods of making medical articles, as well as methods of using the same, are also described.
摘要翻译： 本发明提供包括多于一种生物相容性促进功能的医疗制品。 在一个方面，本发明提供了包括包含多于一种生物相容剂的聚合物基质的医疗制品，其中每个生物相容性试剂提供在医疗用品表面的不同部分。 还描述了制造医疗用品的方法及其使用方法。
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公开(公告)号：US08535700B2
公开(公告)日：2013-09-17
申请号：US11261954
申请日：2005-10-28
CPC分类号： A61L31/10 , A61L27/34 , A61L33/0029 , A61L33/122 , C08L89/06
摘要： Pro-fibrotic coatings for medical articles are described that include a pro-fibrotic polymer such as collagen. The pro-fibrotic coatings can also include a thromboresistant polymer. The coatings can be formed by activation of photoreactive groups pendent or independent of the coating materials.
摘要翻译： 描述了用于医疗制品的原纤维化涂层，其包括前纤维化聚合物如胶原蛋白。 前纤维化涂层还可以包括抗血栓性聚合物。 可以通过活化侧基或独立于涂层材料的光反应性基团来形成涂层。
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公开(公告)号：US08039524B2
公开(公告)日：2011-10-18
申请号：US12783907
申请日：2010-05-20
申请人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Pam Read, legal representative , Dale G. Swan , Peter H. Duquette
发明人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
IPC分类号： C08F2/50
CPC分类号： B82Y30/00 , A61L27/34 , C09D4/00 , Y10S522/904 , Y10T428/249991 , Y10T428/249992 , C08F220/56 , C08F220/54
摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。
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公开(公告)号：US07087658B2
公开(公告)日：2006-08-08
申请号：US10745080
申请日：2003-12-23
申请人： Dale G. Swan , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Ralph A. Chappa , Sean M. Stucke , Peter H. Duquette
发明人： Dale G. Swan , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Ralph A. Chappa , Sean M. Stucke , Peter H. Duquette
CPC分类号： C08J7/18 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/10 , A61L33/06 , A61L33/12 , B05D1/00 , B05D3/06 , B05D3/061 , B05D3/067 , B05D7/52 , G01N33/54353 , G01N33/54393 , Y10T428/31855
摘要： A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.
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公开(公告)号：US07348055B2
公开(公告)日：2008-03-25
申请号：US10028518
申请日：2001-12-21
申请人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
发明人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
IPC分类号： B32B27/00
CPC分类号： B82Y30/00 , A61L27/34 , C09D4/00 , Y10S522/904 , Y10T428/249991 , Y10T428/249992 , C08F220/56 , C08F220/54
摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。
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公开(公告)号：US20100240789A1
公开(公告)日：2010-09-23
申请号：US12783907
申请日：2010-05-20
申请人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
发明人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
IPC分类号： C08F2/46
CPC分类号： B82Y30/00 , A61L27/34 , C09D4/00 , Y10S522/904 , Y10T428/249991 , Y10T428/249992 , C08F220/56 , C08F220/54
摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。
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公开(公告)号：US06669994B2
公开(公告)日：2003-12-30
申请号：US09840406
申请日：2001-04-23
申请人： Dale G. Swan , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Ralph A. Chappa , Sean M. Stucke , Peter H. Duquette
发明人： Dale G. Swan , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Ralph A. Chappa , Sean M. Stucke , Peter H. Duquette
IPC分类号： C08F248
CPC分类号： C08J7/18 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/10 , A61L33/06 , A61L33/12 , B05D1/00 , B05D3/06 , B05D3/061 , B05D3/067 , B05D7/52 , G01N33/54353 , G01N33/54393 , Y10T428/31855
摘要： A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.
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公开(公告)号：US20120004339A1
公开(公告)日：2012-01-05
申请号：US13234270
申请日：2011-09-16
申请人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
发明人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
IPC分类号： C08F8/00
CPC分类号： B82Y30/00 , A61L27/34 , C09D4/00 , Y10S522/904 , Y10T428/249991 , Y10T428/249992 , C08F220/56 , C08F220/54
摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。
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公开(公告)号：US07736689B2
公开(公告)日：2010-06-15
申请号：US11846955
申请日：2007-08-29
申请人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
发明人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
IPC分类号： A61L33/00
CPC分类号： B82Y30/00 , A61L27/34 , C09D4/00 , Y10S522/904 , Y10T428/249991 , Y10T428/249992 , C08F220/56 , C08F220/54
摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。
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10.发明授权Coatings for medical articles including natural biodegradable polysaccharides 失效包括天然可生物降解多糖在内的医疗用品涂料公开(公告)号：US08241655B2
公开(公告)日：2012-08-14
申请号：US11127351
申请日：2005-05-12
IPC分类号： A61K39/395 , A61F2/02
CPC分类号： A61L31/16 , A61F2210/0004 , A61F2310/00389 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/406 , A61L2300/416 , A61L2300/418 , A61L2300/622 , C08L5/00
摘要： Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
摘要翻译： 描述了包括天然可生物降解多糖的可生物降解涂层。 涂层由具有侧联偶合基团的多种天然可生物降解多糖形成。
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