公开(公告)号：US20110016967A1

公开(公告)日：2011-01-27

申请号：US12935446

申请日：2009-03-26

申请人： Osamu Tonomura ,  Satoshi Nagahara ,  Manabu Kano ,  Shinji Hasebe

发明人： Osamu Tonomura ,  Satoshi Nagahara ,  Manabu Kano ,  Shinji Hasebe

IPC分类号： G01F7/00 ,  F15D1/00 ,  F17D3/00 ,  G06G7/50

CPC分类号： B01J19/0093 ,  B01F13/0059 ,  B01F15/0264 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00959 ,  B01L3/502746 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2300/0864 ,  G05D7/0186 ,  G05D7/0694 ,  Y10T137/8175 ,  Y10T137/8593

摘要： The present invention provides a fluid distribution device for uniformly distributing and outputting a fluid, which is supplied to an input flow channel, into at least three output flow channels, comprising a plurality of branch flow channels, at least three fluid bifurcation portions, and at least one fluid converging portion, wherein the fluid distribution device is configured to correspond to a pressure drop compartment connection model composed of a fluid balance equation and a pressure balance equation. Furthermore, the present invention provides a micro plant using the fluid distribution device, a method of designing the fluid distribution device and a method of detecting blockage of flow channels of the fluid distribution device.

摘要翻译： 本发明提供了一种流体分配装置，用于均匀地分配和输出被提供给输入流动通道的流体至少三个输出流动通道，其包括多个分支流动通道，至少三个流体分叉部分，以及在 至少一个流体会聚部分，其中所述流体分配装置被配置为对应于由流体平衡方程和压力平衡方程组成的压降室连接模型。 此外，本发明提供一种使用流体分配装置的微型装置，流体分配装置的设计方法以及检测流体分配装置的流路阻塞的方法。

公开(公告)号：US20060223166A1

公开(公告)日：2006-10-05

申请号：US11304119

申请日：2005-12-15

申请人： Peter Wilding ,  Larry Kricka ,  Jay Zemel

发明人： Peter Wilding ,  Larry Kricka ,  Jay Zemel

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34

CPC分类号： B01L3/5027 ,  B01F5/0601 ,  B01F15/0264 ,  B01J19/0093 ,  B01J2219/0059 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L7/525 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/146 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0406 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/086 ,  C12Q1/686 ,  C12Q2565/629 ,  C40B40/06 ,  Y10S366/03 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S977/923 ,  Y10S977/953

摘要： Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.

公开(公告)号：US06981522B2

公开(公告)日：2006-01-03

申请号：US10160393

申请日：2002-05-30

申请人： Stephen D. O'Connor ,  Christoph D. Karp ,  Eugene Dantsker

发明人： Stephen D. O'Connor ,  Christoph D. Karp ,  Eugene Dantsker

IPC分类号： F15C1/06 ,  F16K37/00

CPC分类号： B01F5/064 ,  B01F13/0059 ,  B01F15/0264 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00833 ,  B01J2219/00869 ,  B01J2219/00891 ,  B01J2219/00997 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  B29C65/02 ,  B29C66/02 ,  B29C66/026 ,  B29C66/71 ,  B29K2023/00 ,  B29K2023/12 ,  B29L2031/756 ,  B81B2201/058 ,  B81C3/008 ,  G01N30/6095 ,  G01N2030/565 ,  Y10T137/206 ,  Y10T137/212 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/8359 ,  B29C2035/0827 ,  B29K2067/00

摘要： Microfluidic devices having a plurality of functional features for performing one or more fluidic operations in parallel are provided. Reagents, samples or other fluids common to multiple functional features (“common fluids”) may be input into a microfluidic device or system through one or more distributing inputs that divide and distribute the common fluids as desired. The use of a multi-layer fabrication technique allows multiple distributing inputs to distribute to multiple functional features in a microfluidic device without undesirable fluid channel intersections.

公开(公告)号：US06890093B2

公开(公告)日：2005-05-10

申请号：US10046071

申请日：2002-01-11

申请人： Christoph D. Karp ,  Joseph F. Covington

发明人： Christoph D. Karp ,  Joseph F. Covington

IPC分类号： B01D17/00 ,  B01F5/04 ,  B01F5/06 ,  B01F13/00 ,  B01F15/02 ,  B01L3/00 ,  B81B1/00 ,  G01N35/00 ,  B81B7/00

CPC分类号： B01D17/00 ,  B01D17/0208 ,  B01D17/08 ,  B01F5/0471 ,  B01F5/0604 ,  B01F5/064 ,  B01F13/0059 ,  B01F15/0205 ,  B01F15/0264 ,  B01L3/5027 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N2035/00237 ,  G01N2035/00544 ,  Y10T137/2224

摘要： Robust microfluidic mixing devices mix multiple fluid streams passively, without the use of moving parts. In one embodiment, these devices contain microfluidic channels that are formed in various layers of a three-dimensional structure. Mixing may be accomplished with various manipulations of fluid flow paths and/or contacts between fluid streams. In various embodiments, structures such as channel overlaps, slits, converging/diverging regions, turns, and/or apertures may be designed into a mixing device. Mixing devices may be rapidly constructed and prototyped using a stencil construction method in which channels are cut through the entire thickness of a material layer, although other construction methods including surface micromachining techniques may be used.

摘要翻译： 强大的微流体混合装置将被动地混合多个流体流，而不使用运动部件。 在一个实施例中，这些装置包含在三维结构的各个层中形成的微流体通道。 混合可以通过流体流动路径和/或流体流之间的接触的各种操作来实现。 在各种实施例中，可以将诸如通道重叠，狭缝，会聚/发散区域，匝和/或孔的结构设计成混合装置。 混合装置可以使用模板施工方法进行快速构造和原型制备，其中通道切割材料层的整个厚度，尽管可以使用包括表面微加工技术的其他构造方法。

公开(公告)号：US20050095602A1

公开(公告)日：2005-05-05

申请号：US10701097

申请日：2003-11-04

申请人： Jason West ,  Timothy Shepodd ,  Stewart Griffiths ,  Ronald Renzi ,  Boyd Wiedenman

发明人： Jason West ,  Timothy Shepodd ,  Stewart Griffiths ,  Ronald Renzi ,  Boyd Wiedenman

IPC分类号： B01F5/06 ,  B01F13/00 ,  B01L3/00 ,  C12M1/34 ,  C12Q1/68

CPC分类号： B01L3/5027 ,  B01F5/061 ,  B01F13/0059 ,  B01F15/0264 ,  B01F2005/0631 ,  B01J2219/00286 ,  B01J2219/00432 ,  B01J2219/00511 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00664 ,  B01J2219/00691 ,  B01J2219/00722 ,  B01J2219/00729 ,  B01L3/5023 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/086

摘要： Disclosed are microflulidic chips that include a plurality of vias; a functionalized porous polymer monolith capable of being in fluid communication with a via; a microarray capable of being in fluid communication with the functionalized porous polymer monolith; and an observation port through which at least one target disposed within the microarray is capable of being detected. The disclosed microfluidic chips contain microarrays that can be effectively coupled to functionalized porous polymer monoliths for capturing and concentrating sample nucleic acids. Also disclosed are microfluidic chips containing microarray probes having observation ports that enable the preparation of microarrays and the detection of targets. These microfluidic chips are capable of capturing and concentrating genetic material for the analysis and identification of biological organisms, such as so-called “threat genes” from chimeric bioweapons.

摘要翻译： 公开了包括多个通孔的微氟代片; 能够与通孔流体连通的功能化的多孔聚合物整料; 能够与官能化的多孔聚合物整料流体连通的微阵列; 以及能够检测设置在微阵列内的至少一个靶的观察端口。 所公开的微流控芯片包含可以有效耦合到功能化的多孔聚合物整料上的微阵列，用于捕获和浓缩样品核酸。 还公开了包含具有能够制备微阵列和检测靶的观察端口的微阵列探针的微流体芯片。 这些微流体芯片能够捕获和浓缩用于分析和鉴定生物生物体的遗传物质，例如嵌合生物武器中所谓的“威胁基因”。

公开(公告)号：US06827095B2

公开(公告)日：2004-12-07

申请号：US10134119

申请日：2002-04-25

申请人： Stephen D. O'Connor ,  Christoph D. Karp ,  Eugene Dantsker ,  Marci Pezzuto

发明人： Stephen D. O'Connor ,  Christoph D. Karp ,  Eugene Dantsker ,  Marci Pezzuto

IPC分类号： F15C112

CPC分类号： B01F5/064 ,  B01F13/0059 ,  B01F15/0205 ,  B01F15/0264 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0689 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0688 ,  G01N35/10 ,  G01N2035/00326 ,  Y10T137/0402 ,  Y10T137/2147 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/5109 ,  Y10T137/5283

摘要： A modular microfluidic system includes a plurality of discrete microfluidic modules each capable of performing at least one operation and at least one microfluidic coupling device for fluidically coupling the modules to perform a sequence of operations. The microfluidic modules and coupling devices may be constructed according to various techniques. In one embodiment, coupling devices are fabricated from multiple layers and each include a fluidic inlet port, a fluidic outlet port, and at least one sandwiched stencil layer having a microfluidic channel formed therein. Also described are integrated microfluidic systems and methods capable of performing various sequences of operations.

摘要翻译： 模块化微流体系统包括多个离散微流体模块，每个离散的微流体模块能够执行至少一个操作和至少一个微流体耦合装置，用于流体耦合模块以执行一系列操作。 微流体模块和耦合装置可以根据各种技术构造。 在一个实施例中，耦合装置由多个层制成，并且每个包括流体入口端口，流体出口端口和至少一个夹在其中形成有微流体通道的夹层模板层。 还描述了能够执行各种操作序列的集成微流体系统和方法。

公开(公告)号：US06616327B1

公开(公告)日：2003-09-09

申请号：US09668913

申请日：2000-09-25

申请人： Michael M. Kearney ,  Kenneth R. Peterson ,  Michael W. Mumm

发明人： Michael M. Kearney ,  Kenneth R. Peterson ,  Michael W. Mumm

IPC分类号： B01F506

CPC分类号： B01F5/06 ,  B01F5/0601 ,  B01F15/0264 ,  B01L3/5027 ,  G01N30/6017

摘要： Fluid transporting fractal devices, which can be employed whenever a controlled distribution and/or collection of fluids is desired, are constructed to position fractal stages of either progressively smaller or progressively larger scales along the direction of flow (Plates #1-#8). A preferred construction assigns generations of recursive fractal pattern to plates arranged in a stack.

摘要翻译： 在需要流体的受控分布和/或收集时可以使用的流体输送分形装置被构造成沿着流动方向（板＃1-＃8）定位逐渐变小或逐渐变大的分级阶段。 优选的结构将递归分形图案分派给布置在堆叠中的板。

公开(公告)号：US20030150792A1

公开(公告)日：2003-08-14

申请号：US10256505

申请日：2002-09-27

申请人： Nanostream, Inc.

发明人： Jeffrey A. Koehler ,  Paren P. Patel

IPC分类号： B01D063/08

CPC分类号： B01D61/18 ,  B01D61/20 ,  B01D63/081 ,  B01D63/087 ,  B01D63/088 ,  B01D65/003 ,  B01F13/0059 ,  B01F15/0264 ,  B01J19/0093 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2400/0406 ,  B01L2400/0688 ,  B29C59/14 ,  B29C59/16 ,  B29C65/18 ,  B29C66/02 ,  B29C66/026 ,  B29C66/1122 ,  B29C66/45 ,  B29C66/71 ,  B29C66/727 ,  B29C66/73161 ,  B29C66/81812 ,  B29C66/92441 ,  B29C66/929 ,  B29C2035/0827 ,  B29K2023/00 ,  B29K2023/06 ,  B29K2023/12 ,  B29K2071/00 ,  B29L2031/756 ,  B32B38/0008 ,  B32B38/10 ,  B32B2037/0092 ,  B32B2309/02 ,  B32B2309/12 ,  B81B2201/058 ,  B81C3/008 ,  G01N27/44791 ,  G01N30/6095 ,  G01N2030/565

摘要： A frit for use in multi-layer microfluidic separation devices is provided. The frit comprises a polymeric membrane that may be securely bonded within the device and minimizes lateral wicking. A secure bond is ensured by treating the polymer to match its surface energy to that of the materials to which it is bound. Treatments include plasma treatment, irradiation and the application of acids.

摘要翻译： 提供了用于多层微流体分离装置的玻璃料。 玻璃料包括聚合物膜，其可以牢固地结合在装置内并使侧向芯吸最小化。 通过处理聚合物使其表面能与其所结合的材料的表面能相匹配来确保牢固的粘合。 处理包括等离子体处理，照射和酸的应用。

公开(公告)号：US20030039169A1

公开(公告)日：2003-02-27

申请号：US10149994

申请日：2002-08-27

发明人： Wolfgang Ehrfeld ,  Volker Hessel

IPC分类号： B01F005/00

CPC分类号： B01F13/0064 ,  B01F5/0601 ,  B01F5/0604 ,  B01F13/0094 ,  B01F15/0264 ,  B01J19/0093 ,  B01J2219/00835 ,  B01J2219/00858 ,  B01J2219/00889 ,  B01J2219/00995

摘要： Micromixers constitute a main component of microreactors that have three-dimensional microstructures in a fixed matrix, in which chemical reactions take place. In said micromixer, fluids from their respective supply chambers are divided into spatially separated fluid streams using a network of microchannels allocated to the respective streams. Said streams then emerge as jets with identical volumetric flows for each fluid into a mixing chamber. The invention aims to ensure that identical volumetric flows are achieved for each fluid at the respective microchannel outflow and to produce a micromixer with a simple, compact construction. Wedge-shaped plates can be used as the supply elements (2a-d). Said plates can be assembled to form at least one ring sector which surrounds the mixing chamber (5) in the form of a curve. Alternatively, planar plates can be used which comprise a cavity in their central region, into which the microchannels (31-34) provided for each fluid form one or more symmetrical bifurcation cascades (3) comprising at least two stages. The micromixer can be used in microreactors, for example in the field of combined chemistry, for creating emulsion and gaseous/liquid dispersions and for gas-phase catalysis.

摘要翻译： 微混合器构成在其中发生化学反应的固定基质中具有三维微结构的微反应器的主要成分。 在所述微型混合器中，使用分配给相应流的微通道网络将来自它们各自供应室的流体分成空间分离的流体流。 然后，所述流出现为具有相同体积流量的射流，每个流体进入混合室。 本发明旨在确保在相应的微通道流出处为每个流体获得相同的体积流量，并产生具有简单紧凑结构的微混合器。 楔形板可用作供应元件（2a-d）。 所述板可以组装成形成以曲线形式围绕混合室（5）的至少一个环形部分。 或者，可以使用平面板，其包括在其中心区域中的腔，其中为每个流体设置的微通道（31-34）形成包括至少两个级的一个或多个对称分叉级联（3）。 微混合器可用于微反应器，例如在组合化学领域，用于产生乳液和气/液分散体以及用于气相催化。

公开(公告)号：US06224762B1

公开(公告)日：2001-05-01

申请号：US09389073

申请日：1999-09-02

申请人： Gilles Ferschneider ,  Jean-Christophe Viguie ,  Olivier Callebert ,  Frédéric Hoffmann

发明人： Gilles Ferschneider ,  Jean-Christophe Viguie ,  Olivier Callebert ,  Frédéric Hoffmann

IPC分类号： B01D1508

CPC分类号： B01J8/0492 ,  B01D15/1842 ,  B01D53/0423 ,  B01D53/0446 ,  B01D2215/023 ,  B01D2257/7027 ,  B01D2259/402 ,  B01F5/0601 ,  B01F15/0264 ,  B01J8/0453 ,  C07C7/12 ,  C07C15/08

摘要： Device (DME) or panel for collecting, distributing, mixing or drawing off several fluids, at least one main fluid and at least two secondary fluids, that comprises at least: means for collecting a main fluid (3, 9), at least two injection and/or draw-off rails (6, 7) that allow the passage of secondary fluids, at least two mixing chambers (11a, 11b) that communicate with injection and/or draw-off rails (6, 7) with orifices or passages (6i, 7i), means (12, 4) for redistributing the fluid that is obtained from said mixing chambers, means (5a, 5b) for separating collecting and redistributing means and draw-off rails (6, 7) are arranged one above the other, and mixing chambers (11a, 11b) are arranged on both sides of the rails and symmetrically relative to the orifices that have an injection function.

摘要翻译： 用于收集，分配，混合或抽出多种流体的装置（DME）或面板，至少一个主流体和至少两个次级流体，至少包括：用于收集主流体（3,9）的装置，至少两个 允许次流体通过的至少两个混合室（11a，11b）的喷射和/或牵引轨道（6,7），所述至少两个混合室（11a，11b）与喷嘴和/或排出轨道（6,7） 通道（6i，7i），用于重新分配从所述混合室获得的流体的装置（12,4），用于分离收集和重新分配装置和抽出轨道（6,7）的装置（5a，5b） 并且混合室（11a，11b）相对于具有注射功能的孔对称地布置在轨道的两侧。