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    THERAPEUTIC COMPOSITIONS
    3.
    发明申请
    THERAPEUTIC COMPOSITIONS 审中-公开
    治疗组合物

    公开(公告)号：US20140329893A1

    公开(公告)日：2014-11-06

    申请号：US14095121

    申请日：2013-12-03

    申请人： BTG International Limited

    发明人： Richard L. Veech

    IPC分类号： C07C69/72 ,  C07C67/465 ,  C07C67/14 ,  C07C69/675 ,  C07C67/46

    CPC分类号： C07C69/72 ,  A23L27/66 ,  A23L33/10 ,  A23L33/105 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/19 ,  A61K31/22 ,  A61K31/365 ,  A61K31/765 ,  C07B2200/07 ,  C07C67/14 ,  C07C67/46 ,  C07C67/465 ,  C07C69/675 ,  C07D323/00 ,  A23V2250/30

    摘要： Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i) increasing cardiac efficiency, particularly efficiency in use of glucose, (ii) for providing energy source, particularly in diabetes and insulin resistant states and (iii) treating disorders caused by damage to brain cells, particularly by retarding or preventing brain damage in memory associated brain areas such as found in Alzheimer's and similar conditions.These compositions may be taken as nutritional aids, for example for athletes, or for the treatment of medical conditions, particularly those associated with poor cardiac efficiency, insulin resistance and neuronal damage. The invention further provides methods of treatment and novel esters and polymers for inclusion in the compositions of the invention.

    摘要翻译： 提供了包含酮体和/或其代谢前体的组合物，其适用于给予人和动物，并且其特性包括（i）提高心脏效率，特别是使用葡萄糖的效率，（ii）提供 能源，特别是在糖尿病和胰岛素抵抗状态下，以及（iii）治疗由脑细胞损伤引起的疾病，特别是通过延迟或预防记忆相关脑区域的脑损伤，例如在阿尔茨海默病和类似病症中发现的。 这些组合物可以作为营养辅助剂，例如用于运动员，或用于治疗医疗状况，特别是与心脏功能降低，胰岛素抵抗和神经元损伤相关的那些。 本发明还提供了用于包含在本发明的组合物中的治疗方法和新的酯和聚合物。

    THERAPEUTIC COMPOSITIONS
    6.
    发明申请
    THERAPEUTIC COMPOSITIONS 审中-公开

    公开(公告)号：US20130079406A1

    公开(公告)日：2013-03-28

    申请号：US13652988

    申请日：2012-10-16

    申请人： BTG International Limited

    发明人： Richard L. Veech

    IPC分类号： A61K31/225 ,  A61P9/00

    CPC分类号： C07C69/72 ,  A23L27/66 ,  A23L33/10 ,  A23L33/105 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/19 ,  A61K31/22 ,  A61K31/365 ,  A61K31/765 ,  C07B2200/07 ,  C07C67/14 ,  C07C67/46 ,  C07C67/465 ,  C07C69/675 ,  C07D323/00 ,  A23V2250/30

    摘要： Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i) increasing cardiac efficiency, particularly efficiency in use of glucose, (ii) for providing energy source, particularly in diabetes and insulin resistant states and (iii) treating disorders caused by damage to brain cells, particularly by retarding or preventing brain damage in memory associated brain areas such as found in Alzheimer's and similar conditions.These compositions may be taken as nutritional aids, for example for athletes, or for the treatment of medical conditions, particularly those associated with poor cardiac efficiency, insulin resistance and neuronal damage. The invention further provides methods of treatment and novel esters and polymers for inclusion in the compositions of the invention.

    Therapeutic compositions
    7.
    发明申请
    Therapeutic compositions 审中-公开
    治疗组合物

    公开(公告)号：US20010041736A1

    公开(公告)日：2001-11-15

    申请号：US09843694

    申请日：2001-04-30

    申请人： BTG International Limited

    发明人： Richard L. Veech

    IPC分类号： A61K031/365 ,  A61K031/215 ,  C07C069/66

    CPC分类号： C07C69/72 ,  A23L27/66 ,  A23L33/10 ,  A23L33/105 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/19 ,  A61K31/22 ,  A61K31/365 ,  A61K31/765 ,  C07B2200/07 ,  C07C67/14 ,  C07C67/46 ,  C07C67/465 ,  C07C69/675 ,  C07D323/00 ,  A23V2250/30

    摘要： Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i) increasing cardiac efficiency, particularly efficiency in use of glucose, (ii) for providing energy source, particularly in diabetes and insulin resistant states and (iii) treating disorders caused by damage to brain cells, particularly by retarding or preventing brain damage in memory associated brain areas such as found in Alzheimer's and similar conditions. These compositions may be taken as nutritional aids, for example for athletes, or for the treatment of medical conditions, particularly those associated with poor cardiac efficiency, insulin resistance and neuronal damage. The invention further provides methods of treatment and novel esters and polymers for inclusion in the compositions of the invention.

    摘要翻译： 提供了包含酮体和/或其代谢前体的组合物，其适用于给予人和动物，并且其特性包括（i）提高心脏效率，特别是使用葡萄糖的效率，（ii）提供 能源，特别是在糖尿病和胰岛素抵抗状态下，以及（iii）治疗由脑细胞损伤引起的疾病，特别是通过延迟或预防记忆相关脑区域的脑损伤，例如在阿尔茨海默病和类似病症中发现的。 这些组合物可以作为营养辅助剂，例如用于运动员，或用于治疗医疗状况，特别是与心脏功能降低，胰岛素抵抗和神经元损伤相关的那些。 本发明还提供了用于包含在本发明的组合物中的治疗方法和新的酯和聚合物。

    Process for the production of polybasic acid esters with recovery of boron trifluoride
    9.
    发明授权
    Process for the production of polybasic acid esters with recovery of boron trifluoride 失效
    通过回收三氟化硼生产多元酸酯的方法

    公开(公告)号：US4973743A

    公开(公告)日：1990-11-27

    申请号：US428093

    申请日：1989-10-27

    申请人： Stephen W. Turner ,  Charles W. Blewett

    发明人： Stephen W. Turner ,  Charles W. Blewett

    IPC分类号： B01J27/12 ,  C07B61/00 ,  C07C67/465 ,  C11C3/00

    CPC分类号： C07C67/465

    摘要： This invention provides a process for preparing an oligomer of at least one polyunsaturated aliphatic C.sub.12-22 monocarboxylic acid ester in the presence of boron trifluoride resulting in a high yield or predominantly trimeric product which, upon hydrolysis, affords a high yield of polybasic, predominantly trimeric, acids. This invention further provides such a process with excellent recovery of the boron trifluoride.

    摘要翻译： 本发明提供一种在三氟化硼存在下制备至少一种多不饱和脂肪族C 12-22单羧酸酯的低聚物的方法，其产生高收率或主要是三聚产物，其在水解时提供高产率的多元，主要是三聚体 ，酸。 本发明还提供了具有优异的三氟化硼回收率的方法。