-
公开(公告)号:US3197481A
公开(公告)日:1965-07-27
申请号:US22513662
申请日:1962-09-20
申请人: AMERICAN CYANAMID CO
发明人: WILLIAMS ADDOR ROGER
IPC分类号: C07D339/06 , C07D339/08 , C07F9/165 , C07F9/24 , C07F9/655 , C07F9/6553 , C08K5/45 , C22B3/38
CPC分类号: C22B3/0077 , C07D339/06 , C07D339/08 , C07F9/1651 , C07F9/2458 , C07F9/65515 , C07F9/6552 , C07F9/6553 , C07F9/655345 , C07F9/655363 , C08K5/45 , C22B3/007 , Y02P10/234
-
公开(公告)号:US3725512A
公开(公告)日:1973-04-03
申请号:US3725512D
申请日:1970-09-28
申请人: STAUFFER CHEMICAL CO
发明人: WALSH E
IPC分类号: A01N57/18 , C07F9/655 , C07F9/6553 , C07F9/16
CPC分类号: A01N57/18 , C07F9/65515 , C07F9/6553 , C07F9/655345
摘要: Phosphonated mercaptals and mercaptoles corresponding to the formula
WHEREIN ''''ALKYLENE'''' MEANS A DIVALENT SATURATED ALIPHATIC RADICAL HAVING FROM ONE TO THREE CARBON ATOMS; R is selected from the group consisting of lower alkyl and phenyl and R'' is lower alkyl; X is selected from the group consisting of sulfur and oxygen; R2 is lower alkyl of from one to three carbon atoms.摘要翻译: 磷酸化的巯基和对应于式的巯基“亚烷基”是指具有一个到三个碳原子的一个饱和的饱和二氧化硅; R选自低级烷基和苯基,R'是低级烷基; X选自硫和氧; R2是1-3个碳原子的低级烷基。
-
公开(公告)号:US3470207A
公开(公告)日:1969-09-30
申请号:US3470207D
申请日:1967-04-21
申请人: AMERICAN CYANAMID CO
发明人: ADDOR ROGER WILLIAMS
IPC分类号: C07F9/44 , C07F9/6553 , C07D69/00 , C07F9/16 , C07F9/28
CPC分类号: C07F9/6553 , C07F9/44
-
公开(公告)号:US5578601A
公开(公告)日:1996-11-26
申请号:US450062
申请日:1995-05-25
申请人: Peter R. Seoane , Joseph M. Salvino , Brent D. Douty , Mohamed M. A. Awad , Roland E. Dolle , David G. Sawutz , David M. Faunce , Wayne T. Houck
发明人: Peter R. Seoane , Joseph M. Salvino , Brent D. Douty , Mohamed M. A. Awad , Roland E. Dolle , David G. Sawutz , David M. Faunce , Wayne T. Houck
IPC分类号: C07C279/16 , C07D213/75 , C07D217/02 , C07D235/14 , C07D453/02 , C07F9/54 , C07F9/572 , C07F9/6553 , A01N43/42
CPC分类号: C07D213/75 , C07C279/16 , C07D217/02 , C07D235/14 , C07D453/02 , C07F9/5456 , C07F9/5728 , C07F9/6553 , C07F9/655345 , C07C2101/14
摘要: Disclosed are nonpeptides having bradykinin antagonist activity of the formulae (I) and (II) ##STR1## or a pharmaceutically acceptable salt thereof therefor.
摘要翻译: 公开了具有式(I)和(II)的缓激肽拮抗剂活性的非肽或其药学上可接受的盐。
-
公开(公告)号:US3519709A
公开(公告)日:1970-07-07
申请号:US3519709D
申请日:1967-03-28
申请人: AMERICAN CYANAMID CO
发明人: ADDOR ROGER WILLIAMS
IPC分类号: C07F9/22 , C07F9/44 , C07F9/6553 , A01N9/36 , C07C155/08 , C07F9/24
CPC分类号: C07F9/44 , C07F9/22 , C07F9/6553
-
公开(公告)号:US3197365A
公开(公告)日:1965-07-27
申请号:US31319963
申请日:1963-10-02
申请人: AMERICAN CYANAMID CO
发明人: BYRON LOVELL JAMES
IPC分类号: C07D339/06 , C07D339/08 , C07F9/24 , C07F9/655 , C07F9/6553
CPC分类号: C07F9/655363 , C07D339/06 , C07D339/08 , C07F9/2458 , C07F9/65515 , C07F9/6553 , C07F9/655345
-
公开(公告)号:US20100279983A1
公开(公告)日:2010-11-04
申请号:US12301797
申请日:2007-05-21
申请人: Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Helen Chen , Stephane Raeppel , Michael Mannion , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou , Nancy Z. Zhou
发明人: Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Helen Chen , Stephane Raeppel , Michael Mannion , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou , Nancy Z. Zhou
IPC分类号: A61K31/675 , A61K31/67 , A61K31/665 , C07D409/12 , C07D277/80 , C07D277/36 , C07D333/72 , C07D307/83 , A61P31/04
CPC分类号: C07F9/655354 , C07F9/65395 , C07F9/6541 , C07F9/6553 , C07F9/6558 , C07F9/6561
摘要: This invention provides novel β-lactamase inhibitors of the aryl- and heteroarylsulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammonium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazidime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases. Formula (I) or pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供具有氮基阳离子或季铵基团的芳基 - 和杂芳基磺酰氨基甲基膦酸酯单酯类的新颖的β-内酰胺酶抑制剂。 这些化合物抑制三种类型的β-内酰胺酶,并且与通常对β-内酰胺抗生素具有抗性的那些微生物相互作用可促进β-内酰胺类抗生素(如亚胺培南和头孢他啶)对抗生素的抗菌作用。 &bgr;内酰胺酶。 式(I)或其药学上可接受的盐。
-
公开(公告)号:US4814325A
公开(公告)日:1989-03-21
申请号:US908493
申请日:1986-09-17
IPC分类号: A01N57/16 , C07F9/6553 , A01N43/32 , A01N43/24 , C07D339/00 , C07D339/08
CPC分类号: A01N57/16 , C07F9/6553
摘要: Dithiacycloalkenyl phosphoric esters of the following formula are effective for the control of soil and foliar insects, acarids and nematodes: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is lower alkoxy or lower alkylthio;R.sub.3 is hydrogen, lower alkyl or phenyl;R.sub.4, R.sub.5 and R.sub.6 are independently hydrogen or lower alkyl;Z is oxygen or sulfur;x is 0 or 1;y is 0, 1 or 2; andn is 0, 1 or 2.
摘要翻译: 下式的二硫代环烯基磷酸酯对于控制土壤和叶面昆虫,螨虫和线虫是有效的:其中R1是低级烷基; R2是低级烷氧基或低级烷硫基; R3是氢,低级烷基或苯基; R4,R5和R6独立地是氢或低级烷基; Z是氧或硫; x为0或1; y为0,1或2; n为0,1或2。
-
公开(公告)号:US3564013A
公开(公告)日:1971-02-16
申请号:US3564013D
申请日:1964-07-09
申请人: STAUFFER CHEMICAL CO
发明人: WALSH EDWARD NELSON
IPC分类号: C07F9/655 , C07F9/6553 , C07D89/06
CPC分类号: C07F9/655345 , C07F9/65515 , C07F9/6553
摘要: PHOSPHONATED CYCLIC MERCAPTALS AND MERCAPTOLES CORRESPONDING TO THE FORMULA
R1-O-P(=X)(-R)-S-ALKYLENE-C(-R2)
IN WHICH ALKYLENE IS A DIVALENT SATURATED ALIPHATIC RADICAL HAVING FROM 1 TO 3 CARBON ATOMS; R AND R1 ARE LOWER ALKYL AND PHENYL; THE GROUPS REPRESENTED BY X ARE INDEPENDENTLY SULFUR OR OXYGEN; R2 IS AN ALKYL FROM 1 TO 3 CARBONS OR HYDROGEN AND N IS AN INTEGER FROM 1 TO 2, INCLUSIVE. THE ABOVE COMPOUNDS ARE EFFECTIE INSECTICIDES AND MITICIDES. REPRESENTATIVE COMPOUNDS ARE 2-METHYL-2(O-ETHYL ETHYLPHOSPHORODITHIOMETHYLENE)-1,3-OXATHIOLANE, DITHIOLANE, 2-METHYL-2-(O-ETHYL METHYLPHOSPHORODITHIOMETHYLENE)-1,3-DITHIOLANE, AND 2-METHYL-2-(O-ETHYLPHENYLPHOSPHONODITHIOMETHYLENE)-1,3-DITHIOLANE.-
公开(公告)号:US2769013A
公开(公告)日:1956-10-30
申请号:US30301152
申请日:1952-08-06
IPC分类号: C07F9/08 , C07F9/201 , C07F9/6553 , C10M137/10
CPC分类号: C10M137/105 , C07F9/08 , C07F9/201 , C07F9/6553 , C07F9/655345 , C10M2223/04 , C10M2223/042 , C10M2223/047 , C10N2240/14
-
-
-
-
-
-
-
-
-