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    Flea ecdysone nucleic acid molecules and uses thereof
    1.
    发明授权
    Flea ecdysone nucleic acid molecules and uses thereof 失效
    跳蚤蜕皮激素核酸分子及其用途

    公开(公告)号：US06767721B2

    公开(公告)日：2004-07-27

    申请号：US10065200

    申请日：2002-09-25

    申请人： Nancy Wisnewski ,  Anna M. Becher ,  Eric Jarvis

    发明人： Nancy Wisnewski ,  Anna M. Becher ,  Eric Jarvis

    IPC分类号： C12P2106

    CPC分类号： C07K14/4359 ,  C07K14/721 ,  Y10S530/858

    摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.

    摘要翻译： 本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

    Flea ecdysone and ultraspiracle nucleic acid molecules, proteins and uses thereof
    3.
    发明授权
    Flea ecdysone and ultraspiracle nucleic acid molecules, proteins and uses thereof 有权
    跳蚤蜕皮激素和超尖锐核酸分子，蛋白质及其用途

    公开(公告)号：US06489140B1

    公开(公告)日：2002-12-03

    申请号：US09435019

    申请日：1999-11-05

    申请人： Nancy Wisnewski ,  Anna M. Becher ,  Eric Jarvis

    发明人： Nancy Wisnewski ,  Anna M. Becher ,  Eric Jarvis

    IPC分类号： C12P2106

    CPC分类号： C07K14/4359 ,  C07K14/721 ,  Y10S530/858

    摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.

    摘要翻译： 本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

    Flea ultraspiracle nucleic acid molecules
    4.
    发明授权
    Flea ultraspiracle nucleic acid molecules 失效
    跳蚤超尖锐核酸分子

    公开(公告)号：US07667019B2

    公开(公告)日：2010-02-23

    申请号：US11697551

    申请日：2007-04-06

    申请人： Nancy Wisnewski ,  Anna M. Becher ,  Eric Jarvis

    发明人： Nancy Wisnewski ,  Anna M. Becher ,  Eric Jarvis

    IPC分类号： C07H21/04 ,  A61K38/00

    CPC分类号： C07K14/4359 ,  C07K14/721 ,  Y10S530/858

    摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.

    摘要翻译： 本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

    FLEA ULTRASPIRACLE NUCLEIC ACID MOLECULES
    5.
    发明申请
    FLEA ULTRASPIRACLE NUCLEIC ACID MOLECULES 失效
    FLEA ULTRASPIRACLE核酸分子

    公开(公告)号：US20070231894A1

    公开(公告)日：2007-10-04

    申请号：US11697551

    申请日：2007-04-06

    申请人： Nancy Wisnewski ,  Anna Becher ,  Eric Jarvis

    发明人： Nancy Wisnewski ,  Anna Becher ,  Eric Jarvis

    IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N5/06

    CPC分类号： C07K14/4359 ,  C07K14/721 ,  Y10S530/858

    摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.

    摘要翻译： 本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

    Regulation of angiogenesis with zinc finger proteins
    6.
    发明授权
    Regulation of angiogenesis with zinc finger proteins 失效
    用锌指蛋白调节血管生成

    公开(公告)号：US07560440B2

    公开(公告)日：2009-07-14

    申请号：US11486994

    申请日：2006-07-14

    申请人： Edward Rebar ,  Andrew Jamieson ,  Qiang Liu ,  Pei-Qi Liu ,  Alan Wolffe ,  Stephen P. Eisenberg ,  Eric Jarvis

    发明人： Edward Rebar ,  Andrew Jamieson ,  Qiang Liu ,  Pei-Qi Liu ,  Alan Wolffe ,  Stephen P. Eisenberg ,  Eric Jarvis

    IPC分类号： A61K48/00

    CPC分类号： A61K48/005 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/52 ,  C07K2319/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2740/13043 ,  C12N2799/021 ,  C12N2810/85 ,  C12N2830/008

    摘要： Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.

    摘要翻译： 本文提供了用于调节血管生成的各种方法和组合物，所述方法和组合物可用于血管形成调节是有用的多种应用，包括但不限于缺血和伤口愈合的治疗。 某些方法和组合物通过使用结合一个或多个VEGF基因中的特定靶位点的各种锌指蛋白来实现。 还公开了编码锌指蛋白的核酸。 还公开了用锌指蛋白和核酸调节一种或多种VEGF基因的表达的方法。 这些方法也可用于涉及内皮细胞生长调节的各种治疗应用中。 还提供了包括锌指蛋白或编码它们的核酸的药物组合物。

    Regulation of angiogenesis with zinc finger proteins
    7.
    发明授权
    Regulation of angiogenesis with zinc finger proteins 失效
    用锌指蛋白调节血管生成

    公开(公告)号：US08071564B2

    公开(公告)日：2011-12-06

    申请号：US12553826

    申请日：2009-09-03

    申请人： Edward Rebar ,  Andrew Jamieson ,  Qiang Liu ,  Pei-Qi Liu ,  Alan Wolffe ,  Stephen P. Eisenberg ,  Eric Jarvis

    发明人： Edward Rebar ,  Andrew Jamieson ,  Qiang Liu ,  Pei-Qi Liu ,  Alan Wolffe ,  Stephen P. Eisenberg ,  Eric Jarvis

    IPC分类号： A61K48/00 ,  C07H21/02

    CPC分类号： A61K48/005 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/52 ,  C07K2319/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2740/13043 ,  C12N2799/021 ,  C12N2810/85 ,  C12N2830/008

    摘要： Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.

    摘要翻译： 本文提供了用于调节血管生成的各种方法和组合物，所述方法和组合物可用于血管形成调节是有用的多种应用，包括但不限于缺血和伤口愈合的治疗。 某些方法和组合物通过使用结合一个或多个VEGF基因中的特定靶位点的各种锌指蛋白来实现。 还公开了编码锌指蛋白的核酸。 还公开了用锌指蛋白和核酸调节一种或多种VEGF基因的表达的方法。 这些方法也可用于涉及内皮细胞生长调节的各种治疗应用中。 还提供了包括锌指蛋白或编码它们的核酸的药物组合物。

    L-arabinose fermenting yeast
    10.
    发明授权
    L-arabinose fermenting yeast 有权
    L-阿拉伯糖发酵酵母

    公开(公告)号：US08372626B2

    公开(公告)日：2013-02-12

    申请号：US12909523

    申请日：2010-10-21

    申请人： Min Zhang ,  Arjun Singh ,  Pirkko Suominen ,  Eric Knoshaug ,  Mary Ann Franden ,  Eric Jarvis

    发明人： Min Zhang ,  Arjun Singh ,  Pirkko Suominen ,  Eric Knoshaug ,  Mary Ann Franden ,  Eric Jarvis

    IPC分类号： C12N1/14

    CPC分类号： C12N15/81 ,  C12P7/06 ,  C12P7/08

    摘要： An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. A yeast strain engineered to metabolize arabinose through a novel pathway is also disclosed. Methods of producing ethanol include utilizing these modified yeast strains.

    摘要翻译： 提供利用酵母菌株的L-阿拉伯糖，用于通过引入和表达细菌araA，araB和araD基因来生产乙醇。 还将L-阿拉伯糖转运蛋白引入酵母中以增强阿拉伯糖的摄取。 酵母携带额外的基因组突变，使其能够消耗L-阿拉伯糖，甚至作为唯一的碳源，并产生乙醇。 还公开了通过新途径工程化代谢阿拉伯糖的酵母菌株。 生产乙醇的方法包括利用这些改良的酵母菌株。