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公开(公告)号：US20160058733A1
公开(公告)日：2016-03-03
申请号：US14936472
申请日：2015-11-09
Inventor： Mark G. Frattini , Hakim Djaballah , Thomas J. Kelly
IPC: A61K31/365 , A61N5/10 , A61K31/352 , C07D493/18 , C07D493/08
CPC classification number: A61K31/365 , A61K9/0019 , A61K31/122 , A61K31/352 , A61N5/10 , C07D493/08 , C07D493/18 , C09B13/02 , C09B61/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.
Abstract translation: 本发明提供了用于治疗增殖性疾病如癌症的化合物，方法，药物组合物和试剂盒。 在一个方面，所述方法包括抑制蛋白激酶如细胞分裂周期（Cdc）激酶活性的化合物。 另一方面，所述方法包括抑制Cdc7和/或Dbf4活性的化合物。 另一方面，该方法包括表现出抗增殖性质的化合物，其可用于治疗诸如癌症的疾病。 可用于任何方法的化合物包括式（A）或（B）的化合物或其药学上可接受的盐。 式（A）或（B）的示例性化合物包括：颗粒状颗粒A，颗粒状蛋白B，二氢大戟素A，二氢巨球蛋白B，医药霉素和放线菌素。
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2.发明授权Reducible compounds which provide leuco dyes for analytical compositions, elements and methods of using same 失效分解组合物，元素和使用方法的低分子化合物的可降解化合物
公开(公告)号：US5108903A
公开(公告)日：1992-04-28
申请号：US215140
申请日：1988-07-05
Applicant: Jared B. Mooberry
Inventor： Jared B. Mooberry
IPC: G01N31/22 , C07D279/22 , C09B13/02 , C09B19/00 , C09B21/00 , C09B29/00 , C09B53/00 , C09B55/00 , C09B62/78 , C09B62/825 , C12Q1/04 , C12Q1/26 , G01N33/52
CPC classification number: C09B13/02 , C12Q1/04 , G01N33/52 , C12Q2304/20
Abstract: Certain reducible compounds are useful in analytical compositions, elements and methods, for example for the detection of bacterial cells. These compounds comprise a moiety which provides a leuco dye upon reduction. This lecuo dye can then be oxidized with additional molecules of reducible compound in order to provide a detectable dye. Thus, these reducible compounds are considered bioamplifiers from which a multiplicity of dye molecules can be provided from a single reducible compound molecule. Structurally, the reducible compounds are quinones having suitable substituents which promote varying amounts of leuco dye release at physiological pH.
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3.发明授权Liquid crystal dielectrics, new dyestuffs useful therein, processes for their preparation, and electrooptical display elements based thereon 失效液晶电介质，其中可用的新染料，其制备方法和基于其的电光显示元件
公开(公告)号：US4499004A
公开(公告)日：1985-02-12
申请号：US462153
申请日：1983-01-28
Applicant: Gunther Haas , Georg Weber
Inventor： Gunther Haas , Georg Weber
Abstract: A new liquid crystal dielectric contains at least one dyestuff of formula I ##STR1## wherein R.sup.1 and R.sup.2 are identical or different and each is alkyl or alkoxy each of 3 to 8 C atoms or a group Z--Y--, or one of R.sup.1 and R.sup.2 can also be hydrogen, methyl, ethyl, methoxy or ethoxy; Z is R--Ph--, R--Ph--Ph--, R--Cy--, R--Cy--Cy--, R--Cy--Ph-- or R--Ph--Cy--; Ph is 1,4-phenylene; Cy is 1,4-cyclohexylene; Y is --CH.sub.2 --, --O--, --S--, --NH--, --CH.sub.2 CH.sub.2 --, --CH.sub.2 --O--, --CH.sub.2 --S--, --CH.sub.2 --NH--, or a direct bond; and R is hydrogen or alkyl or alkoxy, each of 1-8 C atoms.
Abstract translation: 一种新的液晶电介质包含至少一种式I的染料，其中R 1和R 2相同或不同，并且各自为3至8个C原子的烷基或烷氧基或ZY-基团，或者R 1和R 2中的一个 也可以是氢，甲基，乙基，甲氧基或乙氧基; Z是R-Ph + 13，R-Ph-Ph-，R-Cy-，R-Cy-Cy-，R- Cy-Ph-或R-Ph-Cy-; Ph为1,4-亚苯基; Cy是1,4-亚环己基; Y是-CH 2 - ， - O - ， - S - ， - NH - ， - CH 2 CH 2 - ， - CH 2 -O-，-CH 2 -S-，-CH 2 -NH-或直接键; 且R为氢或烷基或烷氧基，各为1-8个C原子。
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公开(公告)号：US2275741A
公开(公告)日：1942-03-10
申请号：US30845739
申请日：1939-12-09
Applicant: EASTMAN KODAK CO
Inventor： DICKEY JOSEPH B , MCNALLY JAMES G
IPC: C09B13/02
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公开(公告)号：US2183870A
公开(公告)日：1939-12-19
申请号：US19328838
申请日：1938-03-01
Applicant: GEN ANILINE WORKS INC
Inventor： RUDOLF ROBL
IPC: C09B13/02
CPC classification number: C09B13/02
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Patent Agency Ranking
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公开(公告)号：US12109189B2
公开(公告)日：2024-10-08
申请号：US18138351
申请日：2023-04-24
Inventor： Mark G. Frattini , Hakim Djaballah , Thomas J. Kelly
IPC: A61K31/365 , A61K9/00 , A61K31/122 , A61K31/352 , A61N5/10 , C07D493/08 , C07D493/18 , C09B13/02 , C09B61/00 , C12Q1/6886
CPC classification number: A61K31/365 , A61K9/0019 , A61K31/122 , A61K31/352 , A61N5/10 , C07D493/08 , C07D493/18 , C09B13/02 , C09B61/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B):
or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.-
公开(公告)号：US20140211293A1
公开(公告)日：2014-07-31
申请号：US14228776
申请日：2014-03-28
Applicant: Liquavista B.V.
Inventor： Robin Leguijt , Romaric Mathieu Massard , Jurriën Mans , Muhammad Arief Adityaputra
CPC classification number: G02B26/005 , C09B1/005 , C09B13/02 , C09B23/105 , C09B29/0003 , C09B33/12 , C09B33/16 , C09B33/18 , C09B33/24 , C09B43/32 , C09B55/005 , C09B55/006 , C09B57/007 , C09B57/02
Abstract: Electrowetting apparatus including a compound comprising a plurality of colorant moieties and a linker. The plurality of colorant moieties includes a first colorant moiety having a first net dipole and a second colorant moiety having a second net dipole, wherein the plurality of colorant moieties are linked by and disposed around the linker so that the first net dipole and the second net dipole at least partially cancel each other.
Abstract translation: 包括包含多个着色剂部分和接头的化合物的电泳设备。 多个着色剂部分包括具有第一净偶极子的第一着色剂部分和具有第二净偶极子的第二着色剂部分，其中多个着色剂部分由连接体连接并设置在连接体周围，使得第一网络偶极子和第二网络 偶极子至少部分地相互抵消。
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公开(公告)号：US5846682A
公开(公告)日：1998-12-08
申请号：US799212
申请日：1997-02-13
Applicant: Katsumi Murofushi , Yoshikazu Hosada
Inventor： Katsumi Murofushi , Yoshikazu Hosada
CPC classification number: C09D11/50 , C09B1/325 , C09B11/12 , C09B11/24 , C09B11/28 , C09B13/02 , C09B15/00 , C09B19/00 , C09B21/00 , C09B23/005 , C09B23/0058 , C09B23/04 , C09B23/06 , C09B23/102 , C09B23/105 , C09B23/107 , C09B23/145 , C09B5/002 , C09B57/008 , G03G9/0926 , G03G9/0975 , G03G9/09775
Abstract: A light decolorizable recording material comprising a colored dye having absorptions in the visible light region and a boron compound represented by the general formula (1), ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each independently represents an alkyl, aryl, allyl, aralkyl, alkenyl, alkynyl, silyl, heterocyclic, substituted alkyl, substituted aryl, substituted allyl, substituted aralkyl, substituted alkenyl, substituted alkynyl or substituted silyl group, and Z.sup.+ represents a quaternary ammonium, quaternary pyridinium, quaternary quinolinium or phosphonium cation.
Abstract translation: 一种光可脱色记录材料，其包含在可见光区域具有吸收的着色染料和由通式（1）表示的硼化合物，其中R 1，R 2，R 3和R 4各自独立地表示烷基，芳基 烯丙基，芳烷基，烯基，炔基，甲硅烷基，杂环，取代的烷基，取代的芳基，取代的烯丙基，取代的芳烷基，取代的烯基，取代的炔基或取代的甲硅烷基，Z +代表季铵，季吡啶鎓，季喹啉或鏻阳离子 。
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公开(公告)号：US2982596A
公开(公告)日：1961-05-02
申请号：US77215758
申请日：1958-11-06
Applicant: SANDOZ LTD
Inventor： ERNST MERIAN
IPC: C09B13/02
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