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公开(公告)号：US20240285793A1
公开(公告)日：2024-08-29
申请号：US18657338
申请日：2024-05-07
发明人： Nicole F. Steinmetz
CPC分类号： A61K47/6901 , A61K9/0019 , A61K9/5184 , A61K31/555 , A61K39/12 , A61P35/00 , A61K2039/585 , C12N2750/12022 , C12N2750/12023 , C12N2770/00034 , C12N2770/00042 , C12N2770/32022 , C12N2770/32023
摘要： A method of treating cancer in a subject that includes administering to the cancer a therapeutically effective amount of an anti-cancer virus particle, the virus particle including a rod-shaped plant virus or virus-like particle and mitoxantrone (MTO) or analogs thereof, wherein the MTO is loaded into the interior channel of the rod-shaped plant virus particle.
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公开(公告)号：US20240024452A1
公开(公告)日：2024-01-25
申请号：US18236676
申请日：2023-08-22
IPC分类号： A61K39/12 , C12N7/00 , A61P35/04 , A61P35/00 , A61K31/704
CPC分类号： A61K39/12 , C12N7/00 , A61P35/04 , A61P35/00 , A61K31/704 , A61K2039/5258
摘要： A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
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3.发明授权公开(公告)号：US11739301B2
公开(公告)日：2023-08-29
申请号：US16759652
申请日：2018-10-29
发明人： Nicole F. Steinmetz , Hema Masarapu , He Hu
IPC分类号： C12N7/00 , A61K47/54 , A61K47/55 , A61P35/00 , A61K31/136 , A61K31/704 , A61K41/00
CPC分类号： C12N7/00 , A61K47/546 , A61K47/55 , A61P35/00 , A61K31/136 , A61K31/704 , A61K41/0071
摘要： A method of targeting cancer tissue in a subject includes administering to the subject a plurality of functionalized Tymovirus virus or virus-like particles loaded with or conjugated to an imaging agent, a therapeutic agent or a targeting agent.
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公开(公告)号：US11730833B2
公开(公告)日：2023-08-22
申请号：US17522182
申请日：2021-11-09
CPC分类号： A61K49/1896 , A61K49/085 , A61K49/108
摘要： An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.
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公开(公告)号：US11590183B2
公开(公告)日：2023-02-28
申请号：US16492884
申请日：2018-03-12
发明人： Nicole F. Steinmetz , Karin L. Lee
摘要： A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
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公开(公告)号：US20230024508A1
公开(公告)日：2023-01-26
申请号：US17680813
申请日：2022-02-25
IPC分类号： A61K39/12 , C12N7/00 , A61P35/04 , A61P35/00 , A61K31/704
摘要： A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
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公开(公告)号：US11433123B2
公开(公告)日：2022-09-06
申请号：US16319765
申请日：2017-07-21
摘要： A method of treating cancer in a subject in need thereof includes administering in situ to cancer cells of the subject a nanoparticle construct that includes a plurality of cowpea mosaic virus or virus-like particles electrostatically coupled to a plurality of G4 dendrimers having a different surface charge than the cowpea mosaic virus or virus-like particles. The nanoparticle construct upon delivery to a subject can provide a sustained release of the cowpea mosaic virus or virus-like particles and/or G4 dendrimers to a cell or tissue of the subject. The cancer selected from the group consisting of melanoma, breast cancer, colon cancer, lung cancer, and ovarian cancer.
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公开(公告)号：US20210361728A1
公开(公告)日：2021-11-25
申请号：US17369405
申请日：2021-07-07
发明人： Nicole F. Steinmetz , Chao Wang
IPC分类号： A61K35/768 , C12N7/00 , C07K16/28 , A61P35/00
摘要： A method of treating cancer in a subject that includes administering in situ to the cancer of the subject a therapeutically effective amount of a plant virus or plant virus-like particle in combination with administration of an immune checkpoint therapy to the subject.
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公开(公告)号：US20200246482A1
公开(公告)日：2020-08-06
申请号：US16854444
申请日：2020-04-21
摘要： Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment.
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公开(公告)号：US20190030148A1
公开(公告)日：2019-01-31
申请号：US16161596
申请日：2018-10-16
IPC分类号： A61K39/00 , C07K14/005 , C12N7/00
摘要： A vaccine composition including a plant virus particle linked to an HER2 antigen is described. The vaccine composition can be used for methods of treating or preventing an HER2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the vaccine composition.
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