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公开(公告)号：US06991929B1
公开(公告)日：2006-01-31
申请号：US09807659
申请日：1999-10-08
申请人： Erik D′Hondt
发明人： Erik D′Hondt
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , C12N2770/32451 , C12N2770/32463 , C12N2770/32471
摘要： A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a) culturing Hepatitis A virus and harvesting a Hepatitis A preparation; b) treating said Hepatitis A preparation with a protease; and thereafter c) separating intact virus from protease digested material; d) inactivating said virus. Also described are vaccines comprising the inactivated Hepatitis A virus, preferably in combination with strong adjuvants.
摘要翻译： 描述了生产基本上不含宿主细胞污染的灭活的甲型肝炎病毒的方法，该方法包括：a）培养甲型肝炎病毒并收获甲型肝炎制剂; b）用蛋白酶处理所述甲型肝炎制剂; 然后c）将完整的病毒与蛋白酶消化的材料分离; d）使所述病毒失活。 还描述了包含灭活的甲型肝炎病毒的疫苗，优选与强佐剂组合。
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公开(公告)号：US20160185826A1
公开(公告)日：2016-06-30
申请号：US15015249
申请日：2016-02-04
发明人： Young-Sun LIN , Jinyi CHENG , Ya-Lin CHIANG , Ming-Cheng CHEN , Kuei-Tai A. LAI , Chih Ya YANG
IPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K39/125 , A61K39/15 , C12N7/00 , A61K39/145
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55572 , A61K2039/627 , A61K2039/645 , A61K2039/70 , C07K2319/40 , C12N7/00 , C12N2720/12322 , C12N2720/12323 , C12N2720/12334 , C12N2720/12371 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2730/10171 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16171 , C12N2770/16022 , C12N2770/16023 , C12N2770/16034 , C12N2770/16071 , C12N2770/28122 , C12N2770/28123 , C12N2770/28134 , C12N2770/28171 , C12N2770/32322 , C12N2770/32323 , C12N2770/32334 , C12N2770/32371 , C12N2770/32422 , C12N2770/32423 , C12N2770/32434 , C12N2770/32471 , Y02A50/467
摘要： The invention is directed to dimeric fusion proteins and virus-like particles comprising such dimeric fusion proteins. These dimeric fusion proteins comprise an antigen or antigenic fragment carried between two viral structural proteins or fragments thereof, with or without linkers, in a manner that, relative to traditional monomeric platforms, minimizes steric hindrance among the antigen or antigenic fragment and the viral structural proteins or fragments thereof. This novel design provides for multivalent vaccines and enhanced immunogenicity. The invention also relates to nucleic acids encoding such dimeric fusion proteins and host cells comprising such nucleic acids. The invention further relates to pharmaceutical compositions comprising the dimeric fusion proteins and/or virus-like particles of the invention, and methods of prevention or treatment using such compositions.
摘要翻译： 本发明涉及包含这种二聚融合蛋白的二聚融合蛋白和病毒样颗粒。 这些二聚融合蛋白包含携带在两个病毒结构蛋白或其片段之间的抗原或抗原性片段，其具有或不具有接头，相对于传统的单体平台，使抗原或抗原片段和病毒结构蛋白之间的空间位阻最小化 或其片段。 这种新颖的设计提供了多价疫苗和增强的免疫原性。 本发明还涉及编码这种二聚融合蛋白的核酸和包含这种核酸的宿主细胞。 本发明还涉及包含本发明的二聚融合蛋白和/或病毒样颗粒的药物组合物，以及使用这种组合物的预防或治疗方法。
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公开(公告)号：US20050112144A1
公开(公告)日：2005-05-26
申请号：US10878094
申请日：2004-06-28
申请人： Erik D'Hondt
发明人： Erik D'Hondt
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , C12N2770/32451 , C12N2770/32463 , C12N2770/32471
摘要： A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a)culturing Hepatitis A virus and harvesting a Hepatitis A preparation; b) treating said Hepatitis A preparation with a protease; and thereafter c) separating intact virus from protease-digested material; d) inactivating said virus. Also described are vaccines comprising the inactivated Hepatitis A virus, preferably in combination with strong adjuvants.
摘要翻译： 描述了生产基本上不含宿主细胞污染的灭活的甲型肝炎病毒的方法，该方法包括：a）培养甲型肝炎病毒并收获甲型肝炎制剂; b）用蛋白酶处理所述甲型肝炎制剂; 然后c）将完整病毒与蛋白酶消化的材料分离; d）使所述病毒失活。 还描述了包含灭活的甲型肝炎病毒的疫苗，优选与强佐剂组合。
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