公开(公告)号：US20230321859A1

公开(公告)日：2023-10-12

申请号：US18022801

申请日：2020-09-10

Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBH

Inventor： Jue CHEN ,  Zheguang FAN ,  Hongjian TAO

IPC: B26D7/26 ,  G01N1/06

CPC classification number: B26D7/2614 ,  G01N1/06 ,  G01N2001/061

Abstract: A knife holder is provided. The knife holder includes: a base; a pressure plate pivotally arranged to the base and configured to releasably clamp a blade in a sectioning position together with the base; and a blade changing apparatus embedded in the base and configured to output an unused blade out of the base to change a used blade.

公开(公告)号：US20230236091A1

公开(公告)日：2023-07-27

申请号：US17773286

申请日：2019-10-31

Applicant: Leica Biosystems Nussloch GmbH

Inventor： Zheguang FAN ,  Song JIN

IPC: G01N1/06

CPC classification number: G01N1/06 ,  G01N2001/061

Abstract: A blade clamping device for a microtome is provided. The blade clamping device includes: a base part; a pressure plate rotatably connected to the base part via a rotation shaft; a clamping pin received in the base part, and configured to extend out of the base part and push the pressure plate to rotate, so as to clamp a blade between the base part and the pressure plate; and a drive unit received in the base part, connected to the clamping pin and configured to drive the clamping pin to extend out of the base part.

公开(公告)号：US20190195743A1

公开(公告)日：2019-06-27

申请号：US16292081

申请日：2019-03-04

Applicant: Aquaro Histology, Inc.

Inventor： Collin Rich ,  Nolan Orfield ,  Vincent Alessi

IPC: G01N1/00 ,  G01N1/31 ,  G01N1/06 ,  G01N1/28 ,  G01N1/36

CPC classification number: G01N1/00 ,  G01N1/06 ,  G01N1/2813 ,  G01N1/312 ,  G01N1/36 ,  G01N1/44 ,  G01N2001/061 ,  H05K999/99

Abstract: A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby recirculating fluid flow between the fluid channel inlet and the fluid channel outlet to carry sections between the sample sectioning module and the section mounting region.

公开(公告)号：US20170363519A1

公开(公告)日：2017-12-21

申请号：US15691698

申请日：2017-08-30

Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Hui GONG ,  Jing YUAN ,  Tao JIANG ,  Lei DENG ,  Qingming LUO

IPC: G01N1/06

CPC classification number: G01N1/06 ,  G01N1/14 ,  G01N1/18 ,  G01N35/1081 ,  G01N2001/061 ,  G01N2001/185 ,  Y10S83/9155

Abstract: An automatic slicing and collecting device, the device including: a first tank, a vibrating microtome, a first pipeline, and a second pipeline. The first tank is filled with a buffer solution. The vibrating microtome is disposed in the first tank. One end of the first pipeline is connected to the vibrating microtome to collect sections, and the other end of the first pipeline is connected to a pump. The pump includes a reversible motor. The first pipeline is provided with a first valve, and a filter is disposed between the pump and the first pipeline. One end of the second pipeline is disposed between the first valve of the first pipeline and the pump, and the second pipeline is provided with a second valve.

公开(公告)号：US09719889B2

公开(公告)日：2017-08-01

申请号：US15208940

申请日：2016-07-13

Applicant: Focus e-Beam Technology (Beijing) Co., Ltd.

Inventor： Zhongwei Chen

IPC: G01N1/06 ,  B26D7/18 ,  G01N1/28

CPC classification number: G01N1/06 ,  B26D7/1845 ,  G01N1/286 ,  G01N2001/061 ,  G01N2001/063 ,  G01N2001/066 ,  G01N2001/2873 ,  Y10T83/0448 ,  Y10T83/0453 ,  Y10T83/2066 ,  Y10T83/2096

Abstract: Provided is a process of using a microtomic system for the preparation of sections for microscope examination. A cutting edge in the system can cut through a sample block and produce a section one end of which remains attached to the cutting edge. A voltage generator can generate a voltage and apply the voltage between the cutting edge and a section receiver such as a semiconductor chip grid. Through electrostatic force caused by the voltage, another end of the section can anchor to the section receiver. The section is then spread on the receiver. The system is automatable, highly efficient, and does not need liquid to float sample sections, and can therefore maintain the integration of the sample sections.

公开(公告)号：US20170205317A1

公开(公告)日：2017-07-20

申请号：US15476983

申请日：2017-04-01

Applicant: Clarapath, Inc.

Inventor： CONG ZHANG ,  Mark Fasciano ,  Partha P. Mitra

IPC: G01N1/06 ,  G01N1/31

CPC classification number: G01N1/06 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00009 ,  G01N2001/061 ,  G01N2035/00019

Abstract: An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.

公开(公告)号：US09324129B2

公开(公告)日：2016-04-26

申请号：US12993525

申请日：2009-05-15

Applicant: Craig D. Crump ,  Brad Kahler ,  Dan Braegelman

Inventor： Craig D. Crump ,  Brad Kahler ,  Dan Braegelman

IPC: G01N1/28 ,  G06T3/00 ,  G06T17/10 ,  G01N1/06 ,  G01N1/36

CPC classification number: G06T3/00 ,  G01N1/286 ,  G01N2001/061 ,  G01N2001/366 ,  G06T17/10

Abstract: Improved methods and apparatus for cross-sectional scanning of parts employ a scanning station in which the focal plane of the scanning apparatus never moves in the vertical direction, i.e., the direction in which the stage of the part/potting combination moves. Distinct steps of material removal and scanning alternate with an intermediate step of moving the part/potting combination in the vertical direction after a surface layer has been removed, thus placing the newly-created surface back into the non-moving focal plane for the next scanning step. A removal station (not the stage carrying the part/potting combination) repeatedly moves into and out of the field of view of the scanning station between scanning steps. The material removal station is specially configured to remove the desired surface layer of the part/potting combination and the created debris, without requiring the separate environment characteristic of previous commercial applications.

Abstract translation: 用于部件的横截面扫描的改进的方法和装置采用扫描站，其中扫描装置的焦平面从不在垂直方向上移动，即部件/灌封组合的台移动的方向。 材料去除和扫描的不同步骤与在去除表面层之后在垂直方向上移动部件/灌封组合的中间步骤交替，从而将新生成的表面放回到不可移动的焦平面中进行下一次扫描 步。 在扫描步骤之间，移动台（不是承载部件/灌封组合的台架）在扫描台的视场内重复移动和移出。 材料去除站被特别地构造成去除部分/灌封组合的所需表面层和所产生的碎屑，而不需要先前商业应用的独立的环境特性。

公开(公告)号：US20150168276A1

公开(公告)日：2015-06-18

申请号：US14574217

申请日：2014-12-17

Applicant: ALESSI TECHNOLOGIES, LLC

Inventor： Nolan Orfield ,  Collin Rich ,  Vincent Alessi

IPC: G01N1/28

CPC classification number: G01N1/36 ,  G01N1/06 ,  G01N1/2813 ,  G01N1/312 ,  G01N1/44 ,  G01N35/00029 ,  G01N35/00732 ,  G01N35/00871 ,  G01N2001/061 ,  G01N2035/00039 ,  G01N2035/00138 ,  G01N2035/00831

Abstract: A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby transmitting fluid flow that drives delivery of the section from the fluid channel inlet toward the section-mounting region.

Abstract translation: 一种用于将截面安装在基底上的系统和方法，所述系统包括：流体通道，其包括：流体通道入口，其接收通过位于流体通道入口附近的样品分段模块从大块嵌入样品处理的部分， 在流体通道入口下游的安装区域和在区段安装区域下游的流体通道出口; 与流体通道出口流体连通的储存器; 以及歧管，其流体地联接到储存器，其将流体从储存器输送到流体通道入口，从而传输流体流动，其驱动区段从流体通道入口向区段安装区域的输送。

公开(公告)号：US20110069300A1

公开(公告)日：2011-03-24

申请号：US12993525

申请日：2009-05-15

Applicant: Craig D. Crump ,  Brad Kahler ,  Dan Braegelman

Inventor： Craig D. Crump ,  Brad Kahler ,  Dan Braegelman

IPC: G01N1/28

CPC classification number: G06T3/00 ,  G01N1/286 ,  G01N2001/061 ,  G01N2001/366 ,  G06T17/10

Abstract: Improved methods and apparatus for cross-sectional scanning of parts employ a scanning station in which the focal plane of the scanning apparatus never moves in the vertical direction, i.e., the direction in which the stage of the part/potting combination moves. Distinct steps of material removal and scanning alternate with an intermediate step of moving the part/potting combination in the vertical direction after a surface layer has been removed, thus placing the newly-created surface back into the non-moving focal plane for the next scanning step. A removal station (not the stage carrying the part/potting combination) repeatedly moves into and out of the field of view of the scanning station between scanning steps. The material removal station is specially configured to remove the desired surface layer of the part/potting combination and the created debris, without requiring the separate environment characteristic of previous commercial applications.

Abstract translation: 用于部件的横截面扫描的改进的方法和装置采用扫描站，其中扫描装置的焦平面从不在垂直方向上移动，即部件/灌封组合的台移动的方向。 材料去除和扫描的不同步骤与在去除表面层之后在垂直方向上移动部件/灌封组合的中间步骤交替，从而将新生成的表面放回到不可移动的焦平面中进行下一次扫描 步。 在扫描步骤之间，移动台（不是承载部件/灌封组合的台架）在扫描台的视场内重复移动和移出。 材料去除站被特别地构造成去除部分/灌封组合的所需表面层和所产生的碎屑，而不需要先前商业应用的独立的环境特性。

公开(公告)号：US07703368B2

公开(公告)日：2010-04-27

申请号：US11552549

申请日：2006-10-25

Applicant: Anton Lang ,  Michael Zimmermann

Inventor： Anton Lang ,  Michael Zimmermann

IPC: B26D7/26

CPC classification number: G01N1/06 ,  G01N2001/061 ,  Y10T83/929 ,  Y10T83/9457 ,  Y10T83/9469 ,  Y10T83/9471 ,  Y10T83/9488 ,  Y10T83/949

Abstract: A knife holder for a microtome having a vibrating knife comprises a support element and a clamping element movable relative to the support element. The support element is embodied with a support surface for the knife, and the clamping element is embodied with a clamping surface. For clamping the knife, the support surface and clamping surface are settable at a distance of 0.1 to 1.5 from one another.

Abstract translation: 具有振动刀的切片机的刀架包括支撑元件和相对于支撑元件可移动的夹紧元件。 支撑元件具有用于刀的支撑表面，并且夹紧元件具有夹紧表面。 为了夹紧刀，支撑表面和夹紧表面可彼此相距0.1至1.5的距离。