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    Vibratory system for a sorting flow cytometer
    3.
    发明授权
    Vibratory system for a sorting flow cytometer 有权
    用于分选流式细胞仪的振动系统

    公开(公告)号：US06746873B1

    公开(公告)日：2004-06-08

    申请号：US09622621

    申请日：2000-09-18

    申请人： Kristopher S. Buchanan ,  Lisa Herickhoff ,  George Seidel ,  George C. Malachowski ,  Matthias J. G. Ottenberg ,  Douglas H. Ferguson

    发明人： Kristopher S. Buchanan ,  Lisa Herickhoff ,  George Seidel ,  George C. Malachowski ,  Matthias J. G. Ottenberg ,  Douglas H. Ferguson

    IPC分类号： G01N3348

    CPC分类号： G01N15/1404 ,  G01N2015/1418

    摘要： A flow cytometry system is disclosed for oscillating the exterior of a flow cytometer nozzle. Oscillating the exterior of a flow cytometer nozzle at selected oscillations or a sweeping range of oscillations disintegrates particles and gas entrapped within the flow cytometer nozzle. Adherents absorbed to the exterior of the flow cytometer nozzle may also be removed. An energy source (1) serves to generate a selected oscillation or range of oscillations. The energy source (1) is connected to a flexible transfer element (2) which conducts the electrical signals to an oscillation system (3). The oscillation system (3) turns the electrical energy from the energy source (1) into mechanical oscillations and is connected to a portable device (4) which disintegrates particles, dislocates gas within the flow cytometer nozzle and cleans the exterior of the flow cytometer aperture.

    摘要翻译： 公开了流式细胞仪系统，用于振荡流式细胞仪喷嘴的外部。 以选定的振荡或清扫的振荡范围振荡流式细胞仪喷嘴的外部，将颗粒和气体截留在流式细胞仪喷嘴内。 吸附在流式细胞仪喷嘴外部的附着物也可以被去除。 能量源（1）用于产生选定的振荡或振荡范围。 能量源（1）连接到将电信号传导到振荡系统（3）的柔性传递元件（2）。 振荡系统（3）将来自能量源（1）的电能转换成机械振荡，并连接到便携式装置（4），其将颗粒分解，使流式细胞仪喷嘴内的气体脱位并清除流式细胞仪孔的外部 。

    Methods and Apparatus for Real-Time Detection and Clearing of a Clog
    4.
    发明申请
    Methods and Apparatus for Real-Time Detection and Clearing of a Clog 有权
    用于实时检测和清除堵塞的方法和装置

    公开(公告)号：US20160011094A1

    公开(公告)日：2016-01-14

    申请号：US14328755

    申请日：2014-07-11

    申请人： Intellicyt

    发明人： Aaron B. Kennington

    IPC分类号： G01N15/14 ,  G01N15/10

    CPC分类号： G01N15/1404 ,  G01N15/1012 ,  G01N2015/1068 ,  G01N2015/1418

    摘要： A flow cytometer apparatus and methods for detecting and clearing a clog therein are disclosed. An example method for detecting a clog may include (i) detecting, via a fault detection system of a flow cytometer, a first plurality of events associated with a first aliquot from a first sample well, (ii) determining a count of the first plurality of events associated with the first aliquot, (iii) determining whether the count of the first plurality of events is below a minimum count tolerance and (iv) (a) if the count of the first plurality of events is below the minimum count tolerance, then determining that the flow cytometer has a clog, (b) if the count of the first plurality of events is equal to or above the minimum count tolerance, then detecting a second plurality of events associated with a second aliquot from a second sample well.

    摘要翻译： 公开了一种用于检测和清除其中堵塞的流式细胞仪装置和方法。 用于检测堵塞的示例性方法可以包括（i）经由流式细胞仪的故障检测系统检测与第一样品池相关联的第一等分试样的第一多个事件，（ii）确定第一多个样品的计数 （iii）确定所述第一多个事件的计数是否低于最小计数容限，以及（iv）（a）如果所述第一多个事件的计数低于所述最小计数容限， 然后确定流式细胞计数器具有堵塞，（b）如果第一多个事件的计数等于或高于最小计数容限，则从第二样本阱检测与第二等分试样相关联的第二多个事件。

    Particle injector for a cell sorter
    8.
    发明申请
    Particle injector for a cell sorter 失效

    公开(公告)号：US20060115890A1

    公开(公告)日：2006-06-01

    申请号：US10556017

    申请日：2004-05-10

    申请人： Torsten Muller ,  Stefan Hummel ,  Annette Pfennig

    发明人： Torsten Muller ,  Stefan Hummel ,  Annette Pfennig

    IPC分类号： C12M1/34

    CPC分类号： G01N15/1404 ,  G01N2015/1409 ,  G01N2015/1413 ,  G01N2015/1418

    摘要： The invention relates to a particle injector for introducing particles into a carrier flow of a microfluidic system, especially for injecting biological cells into the carrier flow of a cell sorter. The particle injector includes an inlet for receiving the carrier flow, an outlet for discharging the carrier flow including the introduced particles, a carrier flow channel which connects the inlet to the outlet, and an injection channel flowing into the carrier flow channel for introducing the particles into the carrier flow. The inventive particle injector is characterized in that the carrier flow channel has substantially no dead volume.

    Methods and Apparatus for Real-Time Detection and Clearing of a Clog
    9.
    发明申请
    Methods and Apparatus for Real-Time Detection and Clearing of a Clog 审中-公开

    公开(公告)号：US20180364144A1

    公开(公告)日：2018-12-20

    申请号：US16049899

    申请日：2018-07-31

    申请人： Intellicyt

    发明人： Aaron B. Kennington

    IPC分类号： G01N15/14 ,  G01N15/10

    CPC分类号： G01N15/1404 ,  G01N15/1012 ,  G01N2015/1068 ,  G01N2015/1418

    摘要： A flow cytometer apparatus and methods for detecting and clearing a clog therein are disclosed. An example method for detecting a clog may include (i) detecting, via a fault detection system of a flow cytometer, a first plurality of events associated with a first aliquot from a first sample well, (ii) determining a count of the first plurality of events associated with the first aliquot, (iii) determining whether the count of the first plurality of events is below a minimum count tolerance and (iv) (a) if the count of the first plurality of events is below the minimum count tolerance, then determining that the flow cytometer has a clog, (b) if the count of the first plurality of events is equal to or above the minimum count tolerance, then detecting a second plurality of events associated with a second aliquot from a second sample well.

    Methods and Apparatus for Real-Time Detection and Clearing of a Clog
    10.
    发明申请
    Methods and Apparatus for Real-Time Detection and Clearing of a Clog 审中-公开

    公开(公告)号：US20170138836A1

    公开(公告)日：2017-05-18

    申请号：US15411366

    申请日：2017-01-20

    申请人： Intellicyt

    发明人： Aaron B. Kennington

    IPC分类号： G01N15/14

    CPC分类号： G01N15/1404 ,  G01N15/1012 ,  G01N2015/1068 ,  G01N2015/1418

    摘要： A flow cytometer apparatus and methods for detecting and clearing a clog therein are disclosed. An example method for detecting a clog may include (i) detecting, via a fault detection system of a flow cytometer, a first plurality of events associated with a first aliquot from a first sample well, (ii) determining a count of the first plurality of events associated with the first aliquot, (iii) determining whether the count of the first plurality of events is below a minimum count tolerance and (iv) (a) if the count of the first plurality of events is below the minimum count tolerance, then determining that the flow cytometer has a clog, (b) if the count of the first plurality of events is equal to or above the minimum count tolerance, then detecting a second plurality of events associated with a second aliquot from a second sample well.