公开(公告)号：US20240344069A1

公开(公告)日：2024-10-17

申请号：US18753979

申请日：2024-06-25

申请人： Emerald Therapeutics, Inc.

发明人： Daniel J. Kleinbaum ,  Brian M. Frezza ,  Brad Bond ,  Jonathan Leung ,  George W. Fraser

IPC分类号： C12N15/113 ,  B82Y10/00 ,  C07H21/04 ,  C12N15/11 ,  C12Q1/68 ,  G06N3/00 ,  G06N3/123

CPC分类号： C12N15/113 ,  B82Y10/00 ,  C07H21/04 ,  C12N15/11 ,  C12Q1/68 ,  G06N3/002 ,  G06N3/123 ,  C12N2310/322 ,  C12N2310/334

摘要： Provided are nucleic acid translators capable of carrying out logic operations with improved efficiency, maximized output and reduced off-target effects, in particular in a biological system. Methods of using these translators to transduce signal are also provided.

公开(公告)号：US12014256B2

公开(公告)日：2024-06-18

申请号：US17647783

申请日：2022-01-12

申请人： Dell Products L.P.

发明人： Ofir Ezrielev ,  Avitan Gefen ,  Jehuda Shemer

IPC分类号： G11C13/00 ,  G06N3/00

CPC分类号： G06N3/002 ,  G11C13/0016

摘要： One example method includes encoding data as a polysaccharide structure, synthesizing the polysaccharide structure to create polysaccharide storage media that comprises the data, and storing the polysaccharide storage media. The example method may also include receiving a read request directed to the polysaccharide storage media, mapping the polysaccharide structure to create a map in response to the read request, traversing the map of the polysaccharide structure to determine an X-base number, and obtaining the data by converting the X-base number to a binary form.

公开(公告)号：US20240169179A2

公开(公告)日：2024-05-23

申请号：US17607970

申请日：2020-09-10

申请人： Science Solutions LLC ,  Consejo Nacional De investigaciones Cientificas Y Tecnicas (Conicet)

发明人： Carla Alejandra GIMENEZ ,  Guillermo Daniel REPIZO ,  Federico Alberto PEREYRA BONNET ,  Lucia Ana CURTI ,  Franco GOYTIA ,  Maria Eugenia FARIAS

IPC分类号： G06N3/00 ,  G06N10/40

CPC分类号： G06N3/002 ,  G06N10/40

摘要： Provided herein are novel Class 2 Type II and Type V CRISPR-Cas RNA-guided endonucleases and systems comprising the same. Provided also are methods of making, and methods of use thereof. Exemplary methods of use include modifying target DNAs and detecting targeting DNAs, useful for therapeutic and diagnostic applications.

公开(公告)号：US11854668B2

公开(公告)日：2023-12-26

申请号：US17261271

申请日：2019-05-29

申请人： EVONETIX LTD

发明人： Matthew James Hayes ,  Raquel Maria Sanches-Kuiper

IPC分类号： G11C25/00 ,  G16B50/00 ,  B01L7/00 ,  C12Q1/6844 ,  G06N3/00 ,  G11C11/54 ,  G11C13/00

CPC分类号： G16B50/00 ,  B01L7/52 ,  C12Q1/6844 ,  G06N3/002 ,  G11C11/54 ,  G11C13/0019 ,  G11C25/00

摘要： Data storage is provided using double-stranded nucleic acid molecules provided on a thermal control device comprising a plurality of sites and temperature control circuitry to independently control a temperature of each of the plurality of sites. The temperature control circuitry, controls the site temperatures to provide a different temperature at a target site compared to other sites of the plurality of sites. The different temperatures at the target site and the other sites provide a greater probability of a read or write operation acting on the target site compared to the other sites. The temperature-based addressing helps to increase physical storage density.

公开(公告)号：US20230359858A1

公开(公告)日：2023-11-09

申请号：US18296936

申请日：2023-04-06

申请人： CCLabs Pty Ltd

发明人： Hon Weng Chong

IPC分类号： G06N3/00 ,  G06N3/063 ,  G06T7/00 ,  G06N20/10 ,  G06N3/08

CPC分类号： G06N3/002 ,  G06N3/063 ,  G06T7/0002 ,  G06N20/10 ,  G06N3/08

摘要： A biological computing platform may include a multielectrode array (MEA) connected to a computing device. The MEA may include a 2D grid of excitation sites, biological neurons disposed on the MEA, a processing device to apply a plurality of impulses at excitation sites having coordinates on the 2D grid, and one or more sensors to measure electrical signals output by one or more of the biological neurons at coordinates of the 2D grid, wherein the processing device is to receive the electrical signals from the one or more sensors and generate a representation of the electrical signals. The computing device may be programmed to receive a digital input signal, convert the digital input signal into instructions for the plurality of impulses, send the instructions to the MEA, receive the representation of the electrical signals from the MEA, and process the representation of the electrical signals.

公开(公告)号：US20230295607A1

公开(公告)日：2023-09-21

申请号：US17989925

申请日：2022-11-18

申请人： CATALOG TECHNOLOGIES, INC.

发明人： Nathaniel Roquet ,  Hyunjun Park ,  Swapnil P. Bhatia ,  Devin Leake

IPC分类号： C12N15/10 ,  G06N3/00 ,  G06N3/123 ,  H04L9/08 ,  H04L9/32

CPC分类号： C12N15/1065 ,  G06N3/002 ,  G06N3/123 ,  H04L9/0869 ,  H04L9/3213

摘要： Methods and systems for security, authentication, tagging, and tracking using nucleic acid (e.g., deoxyribonucleic acid) molecules encoding information. Unique nucleic acid molecules are efficiently produced from pre-fabricated fragments to quickly produce libraries of nucleic acid molecules encoding encrypted or randomized information. Physical objects or artifacts can be tagged with libraries to authenticate the objects, grant access to secured assets or locations, or track the objects or entities. Chemical methods can be applied to verify authenticity, decrypt, or decode information stored in the libraries.

公开(公告)号：US20230161995A1

公开(公告)日：2023-05-25

申请号：US17533720

申请日：2021-11-23

申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION

发明人： Koji Masuda ,  Toshiyuki Yamane

IPC分类号： G06N3/00

CPC分类号： G06N3/002

摘要： A computer-implemented method for storing information into a polynucleotide is provided including using multiple types of nucleotide fragments, wherein each of the nucleotide fragments has an individually different sequence of bases, configuring multiple composite fragments, wherein each of the composite fragments has a set of the nucleotide fragments with different ratios of the nucleotide fragments, and encoding, via an encoder, the information into the composite fragments.

公开(公告)号：US11651188B1

公开(公告)日：2023-05-16

申请号：US16689941

申请日：2019-11-20

申请人： CCLabs Pty Ltd

发明人： Hon Weng Chong

IPC分类号： G06N3/00 ,  G06N3/063 ,  G06T7/00 ,  G06N20/10 ,  G06N3/08

CPC分类号： G06N3/002 ,  G06N3/063 ,  G06N3/08 ,  G06N20/10 ,  G06T7/0002

摘要： A biological computing platform may include a multielectrode array (MEA) connected to a computing device. The MEA may include a 2D grid of excitation sites, biological neurons disposed on the MEA, a processing device to apply a plurality of impulses at excitation sites having coordinates on the 2D grid, and one or more sensors to measure electrical signals output by one or more of the biological neurons at coordinates of the 2D grid, wherein the processing device is to receive the electrical signals from the one or more sensors and generate a representation of the electrical signals. The computing device may be programmed to receive a digital input signal, convert the digital input signal into instructions for the plurality of impulses, send the instructions to the MEA, receive the representation of the electrical signals from the MEA, and process the representation of the electrical signals.

公开(公告)号：US20180181708A1

公开(公告)日：2018-06-28

申请号：US15700018

申请日：2017-09-08

申请人： Edico Genome Corporation

发明人： Pieter van Rooyen ,  Michael Ruehle ,  Rami Mehio

IPC分类号： G06F19/24 ,  G06N3/00 ,  G06F12/0877 ,  G06F19/22 ,  H03K19/177 ,  G06F19/28

CPC分类号： G16B40/00 ,  G06F12/0877 ,  G06F2212/6042 ,  G06N3/002 ,  G06N7/005 ,  G16B30/00 ,  G16B50/00 ,  H03K19/17736

摘要： A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit that may be connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits may be arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the bioinformatics analysis on the reads of genomic data. Each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform the one or more steps in the bioinformatics analysis.

公开(公告)号：US09792405B2

公开(公告)日：2017-10-17

申请号：US15094939

申请日：2016-04-08

申请人： Edico Genome, Corp.

发明人： Pieter van Rooyen ,  Michael Ruehle ,  Rami Mehio

IPC分类号： G06G7/58 ,  G06F19/24 ,  G06F12/0877 ,  G06F19/22 ,  G06F19/28 ,  G06N3/00 ,  H03K19/177

CPC分类号： G06F19/24 ,  G06F12/0877 ,  G06F19/22 ,  G06F19/28 ,  G06F2212/6042 ,  G06N3/002 ,  H03K19/17736

摘要： A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit that may be connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits may be arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the bioinformatics analysis on the reads of genomic data. Each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform the one or more steps in the bioinformatics analysis.