利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.006 秒)

    Process for fermentative side chain cleavage of 20-keto pregnanes
    2.
    发明授权
    Process for fermentative side chain cleavage of 20-keto pregnanes 失效
    20-KETO PREGNANES的发酵侧链清洁方法

    公开(公告)号：US3556944A

    公开(公告)日：1971-01-19

    申请号：US3556944D

    申请日：1969-01-10

    申请人： UPJOHN CO

    发明人： MILLER THOMAS L

    IPC分类号： C12P33/00 ,  C07C167/18

    CPC分类号： C12P33/00 ,  Y10S435/911 ,  Y10S435/929 ,  Y10S435/933 ,  Y10S435/934 ,  Y10S435/936

    摘要： A NOVEL METHOD FOR THE INHIBITION OF OVER-OXIDATION DURING THE FERMENTATIVE SIDE CHAIN CLEAVAGE OF 20-KETO COMPOUNDS OF THE PREGNANE SERIES TO OBTAIN THE CORRESPONDING 17-KETOANDROSTANES. THE IMPROVED PROCESS OF THIS INVENTION PROVIDES A METHOD WHEREBY 20-KETOPREGNANES WHICH ARE UNSUBSTITUTED AT THE 1M AND 21-POSITIONS ARE BIOCONVERTED TO THE CORRESPONDING 17-KETO COMPOUNDS OF THE ANDROSTANE SERIES (17-KETOANDROSTANES) IN HIGH YIELD BY EMPLOYING HIGH SUBSTRATE LEVELS TO INHIBIT THE FORMATION OF D-RING LACTONES. THE 17-KETOANDROSTANES PRODUCED BY THE IMPROVED PROCESS OF THIS INVENTION ARE KNOWN USEFUL THERAPEUTIC AGENTS AND THEY ARE ALSO USEFUL AS INTERMEDIATES WHICH CAN BE CONVERTED BY KNOWN METHODS TO KNOWN USEFUL THERAPEUTIC AGENTS.