公开(公告)号：US06749857B1

公开(公告)日：2004-06-15

申请号：US09376463

申请日：1999-08-18

申请人： Iain D. Peters ,  Beth-Ann G. Coller ,  Michael McDonell ,  John M. Ivy ,  Kent Harada

发明人： Iain D. Peters ,  Beth-Ann G. Coller ,  Michael McDonell ,  John M. Ivy ,  Kent Harada

IPC分类号： A01J2100

CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N2770/24122 ,  Y02A50/386

摘要： The present invention discloses and claims vaccines containing, as an active ingredient, a secreted recombinantly produced dimeric form of truncated flaviviral envelope protein. The vaccines are capable of eliciting the production of neutralizing antibodies against flaviviruses. The dimeric forms of truncated flaviviral envelope protein are formed 1) by directly linking two tandem copies of 80% E in a head to tail fashion via a flexible tether; 2) via the formation of a leucine zipper domain through the homodimeric association of two leucine zipper helices each fused to the carboxy terminus of an 80% E molecule; or 3) via the formation of a non-covalently associated four-helix bundle domain formed upon association of two helix-turn-helix moieties each attached to the carboxy terminus of an 80% E molecule. All products are expressed as a polyprotein including prM and the modified 80% E products are secreted from Drosophila melanogaster Schneider 2 cells using the human tissue plasminogen activator secretion signal sequence (tPAL). Secreted products are generally more easily purified than those expressed intracellularly, facilitating vaccine production. One embodiment of the present invention is directed to a vaccine for protection of a subject against infection by dengue virus. The vaccine contains, as active ingredient, the dimeric form of truncated envelope protein of a dengue virus serotype. The dimeric truncated E is secreted as a recombinantly produced protein from eucaryotic cells. The vaccine may further contain portions of additional dengue virus serotype dimeric E proteins similarly produced. Another embodiment of the present invention is directed to methods to utilize the dimeric form of truncated dengue envelope protein for diagnosis of infection in individuals at risk for the disease. The diagnostic contains, as active ingredient, the dimeric form of truncated envelope protein of a dengue virus serotype. The dimeric truncated E is secreted as a recombinantly produced protein from eucaryotic cells. The diagnostic may further contain portions of additional dengue virus serotype dimeric E proteins similarly produced.

公开(公告)号：US06257866B1

公开(公告)日：2001-07-10

申请号：US09286046

申请日：1999-04-05

申请人： Alton L. Fritz ,  Michael L. Fritz ,  Kenneth A. Fritz ,  Edward J. Gasiorek ,  Wayne L. Case

发明人： Alton L. Fritz ,  Michael L. Fritz ,  Kenneth A. Fritz ,  Edward J. Gasiorek ,  Wayne L. Case

IPC分类号： A01J2100

CPC分类号： B29C51/06 ,  B29C51/10 ,  B29C51/42 ,  B29C51/422 ,  B29C51/426 ,  B29C2791/006 ,  B29C2791/007 ,  B29C2795/002

摘要： A sheet of thermoformable plastic material is positioned by air pressure adjacent a planar surface of a heating plate to heat and at least soften the sheet. The softened sheet is draped over a mold by the force of air pressure to form a molded part upon cooling. Registration pins engaging the sheet maintain the sheet in registration with the mold to insure correct positioning of any indicia on the sheet with corresponding elements of the mold. A plurality of sheets may be fused to one another during heating of the sheets.

摘要翻译： 一片可热成形的塑料材料通过与加热板的平坦表面相邻的空气压力定位，以加热并且至少软化片材。 通过空气压力将软化的片材覆盖在模具上，以在冷却时形成模制部件。 与纸张接合的定位销保持纸张与模具对准，以确保在模具上具有相应元件的任何标记上的任何标记的正确定位。 在片材的加热期间，多个片材可以彼此熔合。

公开(公告)号：US06773255B2

公开(公告)日：2004-08-10

申请号：US09854604

申请日：2001-05-15

申请人： Volker Benz ,  Hans Lorenz ,  Michael Meier-Kaiser ,  Michael Müller ,  Klaus-Ernst Pöhlmann

发明人： Volker Benz ,  Hans Lorenz ,  Michael Meier-Kaiser ,  Michael Müller ,  Klaus-Ernst Pöhlmann

IPC分类号： A01J2100

CPC分类号： B29C47/065 ,  B29C47/0019 ,  B29C47/0021 ,  B29C47/062 ,  B29C47/064 ,  B29C47/067 ,  B29C70/20 ,  B29K2995/0039 ,  B29K2995/0041 ,  E01F8/0017 ,  Y10T428/24942

摘要： Multilayer plastic composites containing at least two incompatible plastics, A and B, in which the layering sequence alternates between A and B, the layers of plastic B are discontinued at regular intervals, and the resulting gaps in the layers are filled in with plastic A, exhibit good adhesion between the layers. In preferred embodiments of the invention, the amorphous, crystalline, or semi-crystalline plastic B has a higher coefficient of thermal expansion than the amorphous plastic A. The plastic composite is preferably produced via coextrusion.

摘要翻译： 包含至少两种不相容的塑料A和B的多层塑料复合材料，其中层叠顺序在A和B之间交替，塑料B的层以规则的间隔中断，并且所得层中的间隙用塑料A填充， 在层之间表现出良好的附着力。 在本发明的优选实施方案中，无定形，结晶或半晶体塑料B具有比无定形塑料A更高的热膨胀系数。塑料复合材料优选通过共挤出生产。

公开(公告)号：US06254375B1

公开(公告)日：2001-07-03

申请号：US09317470

申请日：1999-05-24

申请人： Ulrich Thomas ,  Rolf Blöcher ,  Celestino Inverardi

发明人： Ulrich Thomas ,  Rolf Blöcher ,  Celestino Inverardi

IPC分类号： A01J2100

CPC分类号： B65B9/04 ,  B29C51/20 ,  B65B47/00

摘要： The present invention relates to a matrix for the production of a package trough having at least one undercut, consisting of a bottom part, side parts oriented transversely and side parts oriented parallel to the direction of package trough feed, wherein at least one side part oriented parallel to the direction of feed serves as a mold for the undercut, and wherein said side part is fixed in its spatial position in relation to the machine frame whereas the other parts of the matrix can be displaced vertically downwards.

摘要翻译： 本发明涉及一种用于生产具有至少一个底切的包装槽的基体，该底切由底部组成，侧向部分横向取向并且与侧向包装槽方向平行取向，其中至少一个侧面部分定向 平行于进给方向的模具用作底切的模具，并且其中所述侧部部分相对于机架固定在其空间位置，而矩阵的其它部分可以垂直向下移位。

公开(公告)号：US06203307B1

公开(公告)日：2001-03-20

申请号：US09382734

申请日：1999-08-25

申请人： Thomas M. Neider ,  Robert J. Rudt

发明人： Thomas M. Neider ,  Robert J. Rudt

IPC分类号： A01J2100

CPC分类号： D21G1/006 ,  D21G1/0066

摘要： A hot soft nip calender apparatus is provided for a paper mill. The apparatus includes at least one heated calender roller and a finishing belt which is moved in proximity to the heated calender roller by a plurality of drive rollers and at least one pressure roller. Thus, a heated calender nip is defined between the heated calender roller and the finishing belt. A web of paper is passed through the nip, such that one surface of the web of paper is contacted by the heated calender roller, while the opposed surface of the web is contacted by the finishing belt. The finishing belt has an extremely smooth surface for contacting the web of paper so as to impart appropriate smoothness and gloss characteristics to that surface. The finishing belt can readily be changed when worn or damaged or to alter the characteristics being imparted to a web of paper.

摘要翻译： 为造纸厂提供了一种热软压区压延机。 该设备包括至少一个加热的压光辊和精加工带，其通过多个驱动辊和至少一个压力辊在靠近加热的压延辊附近移动。 因此，在加热的压延辊和精加工带之间限定加热的压延辊隙。 纸幅通过辊隙，使得纸幅的一个表面被加热的压光辊接触，同时幅材的相对表面与精整带接触。 精加工带具有非常光滑的表面，用于接触纸幅，以赋予该表面适当的平滑度和光泽特性。 修整带可以在磨损或损坏时容易地改变，或者改变赋予纸幅的特性。