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公开(公告)号：US11406945B2
公开(公告)日：2022-08-09
申请号：US15457802
申请日：2017-03-13
发明人： Yves A. Delmotte
IPC分类号： A61L26/00 , B01F23/20 , B01F25/45 , B01F25/421 , B01F25/452 , B01F31/65 , B01F33/501 , B01F35/52 , A61K9/12 , A61K38/36 , B01F101/22 , B01F101/00
摘要： A device or system includes a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough. The mixer is in communication with sources or streams of at least two separate components which, when mixed, form a combined fluid stream. The sources or streams may be, at least initially, on opposite sides of the mixer, or the sources or streams may be on the upstream side of the mixer with an outlet disposed downstream of the mixer. A related method may include providing a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough, and selecting a material for the mixer based on physical characteristics of said material, said characteristics including a selected one or more of mean flow pore size, thickness and porosity volume.
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公开(公告)号：US20220410088A1
公开(公告)日：2022-12-29
申请号：US17879953
申请日：2022-08-03
发明人： Yves A. Delmotte
IPC分类号： B01F23/20 , B01F25/45 , B01F25/421 , B01F25/452 , B01F31/65 , B01F33/501 , B01F35/52 , A61K9/12 , A61K38/36
摘要： A device or system includes a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough. The mixer is in communication with sources or streams of at least two separate components which, when mixed, form a combined fluid stream. The sources or streams may be, at least initially, on opposite sides of the mixer, or the sources or streams may be on the upstream side of the mixer with an outlet disposed downstream of the mixer. A related method may include providing a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough, and selecting a material for the mixer based on physical characteristics of said material, said characteristics including a selected one or more of mean flow pore size, thickness and porosity volume.
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公开(公告)号：US11628412B2
公开(公告)日：2023-04-18
申请号：US17255646
申请日：2019-04-15
发明人： Masakazu Enomura
IPC分类号： B22C5/00 , B01F25/45 , B01F25/452 , B01F27/91 , B01F27/92 , B01F27/81 , B01F27/921
摘要： A stirrer is provided that can more efficiently achieve shearing applied, by an action of an intermittent jet flow, to a fluid to be processed. The stirrer concentrically includes a rotor including a blade, a partition wall, and a screen, wherein: the screen includes a plurality of slits in a circumferential direction thereof and screen members located between the adjacent slit; by rotating at least the rotor of the two components, the fluid to be processed is discharged from the inside to the outside of the screen as the intermittent jet flow through the slit of the screen; the screen has a cylindrical shape having a circular cross section; an opening of the slit provided on the inner wall surface of the screen is used as an inflow opening; openings of the plurality of slits provided on the outer wall surface of the screen are used as outflow openings; and the width of the outflow openings in the circumferential direction is set to be smaller than the width of the inflow opening in the circumferential direction.
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公开(公告)号：US11383234B2
公开(公告)日：2022-07-12
申请号：US16813106
申请日：2020-03-09
IPC分类号： B01L3/00 , B01J19/00 , G01N15/14 , B01F33/30 , B01F33/302 , B01F33/3031 , G01N15/10 , B01F25/45 , B01F25/433 , B01F25/452 , B01F25/23 , B01L3/02
摘要： Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid, etc. In some cases, the droplets may each have a substantially uniform number of entities therein. For example, 95% or more of the droplets may each contain the same number of entities of a particular species. In another aspect, the invention relates to systems and methods for dividing a fluidic droplet into two droplets, for example, through charge and/or dipole interactions with an electric field. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In a related aspect of the invention, systems and methods for allowing fluid mixing within droplets to occur are also provided. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles, etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets. In some cases, the fluidic droplets can be sorted at relatively high rates, e.g., at about 10 droplets per second or more. Another aspect of the invention provides the ability to determine droplets, or a component thereof, for example, using fluorescence and/or other optical techniques (e.g., microscopy), or electric sensing techniques such as dielectric sensing.
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