公开(公告)号：US20220315552A1

公开(公告)日：2022-10-06

申请号：US17714103

申请日：2022-04-05

Applicant: CCT SCIENCES, LLC

Inventor： KYLE OLSON ,  MARIO TREMBLAY

IPC: C07D311/80 ,  A61K9/00 ,  B01D3/10 ,  B01D1/22 ,  B01D5/00 ,  A23L33/105 ,  B01D1/08 ,  C07B37/10 ,  C07B63/02 ,  C07B63/04 ,  C07B37/08 ,  C07B41/06 ,  C07B41/04

Abstract: The present invention describes a process to isomerize industrial hemp derived Cannabidiol (CBD) to a pure Δ8-tetrahydrocannabinol (Δ8-THC) extract. This procedure will produce Δ8-tetrahydrocannabinol that is essentially free from any detectable levels of Δ9-tetrahydrocannabinol (Δ9-THC). Included in this filing are methods and processes to scale the reaction from the lab to process to large scale manufacturing. Additionally, the resulting extract from said methods and processes consists of higher purity than previously reported in the art and greater efficiency compared to prior art.

公开(公告)号：US10081592B2

公开(公告)日：2018-09-25

申请号：US14387028

申请日：2013-03-25

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

Inventor： Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

IPC: C07D401/14 ,  C07C69/757 ,  C07D311/94 ,  C07D313/06 ,  C07D223/14 ,  C07D401/04 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07D303/10 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07B37/06 ,  C07B37/08 ,  C07D307/93 ,  C07D313/08 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07J21/00 ,  C07J69/00 ,  C07J71/00 ,  C07J73/00 ,  C07J75/00

CPC classification number: C07C69/757 ,  C07B37/06 ,  C07B37/08 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07C2601/16 ,  C07C2602/44 ,  C07C2603/86 ,  C07D223/14 ,  C07D303/10 ,  C07D307/93 ,  C07D311/94 ,  C07D313/06 ,  C07D313/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07J21/008 ,  C07J69/00 ,  C07J71/001 ,  C07J71/0031 ,  C07J73/005 ,  C07J73/008 ,  C07J75/005

Abstract: The invention a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

公开(公告)号：US09879040B2

公开(公告)日：2018-01-30

申请号：US15452839

申请日：2017-03-08

Applicant: Dieter Arlt

Inventor： Dieter Arlt

IPC: C07F15/00 ,  C07B37/08 ,  C08F236/12 ,  B01J31/22

CPC classification number: C07F15/0046 ,  B01J31/223 ,  B01J31/2291 ,  B01J31/2295 ,  B01J2231/543 ,  B01J2531/821 ,  C07B37/08 ,  C08F236/12

Abstract: The current invention describes new metathesis catalysts, a method for their preparation and their use in metathesis reactions.

公开(公告)号：US5252191A

公开(公告)日：1993-10-12

申请号：US690684

申请日：1991-04-24

Applicant: Louis F. Pauli ,  Alphons Dufourny ,  Robert B. Koolstra ,  Hans Wynberg ,  Wolter Ten Hoeve

Inventor： Louis F. Pauli ,  Alphons Dufourny ,  Robert B. Koolstra ,  Hans Wynberg ,  Wolter Ten Hoeve

IPC: C07B37/08 ,  C07C401/00 ,  C07D333/18 ,  C07D333/20 ,  C07D333/36 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07J7/00 ,  C07G13/00

CPC classification number: C07D409/04 ,  C07C401/00 ,  C07D333/20 ,  C07D333/36 ,  C07D409/14

Abstract: The invention relates to a method for the photochemical isomerization of organic compounds, in particular for the photochemical conversion of tachysterol compounds into previtamin D compounds and of trans-vitamin D compounds into cis-vitamin D compounds, under the influence of radiation, by exposing a solution of the organic compound to be converted in the presence of a non-polymeric photosensitizer to light with approx. 300-1,000 nm wavelength, and by then isolating the resulting product, wherein a substituted thiophene derivative having a substantial absorption in said wavelength region is used as the photosensitizer. The invention also relates to a new photosensitizer to be used for said isomerization reaction.

公开(公告)号：US5231218A

公开(公告)日：1993-07-27

申请号：US965307

申请日：1992-10-23

Applicant: Charles E. Sumner, Jr. ,  William E. Choate

Inventor： Charles E. Sumner, Jr. ,  William E. Choate

IPC: B01J27/18 ,  B01J27/188 ,  C07B37/08 ,  C07B61/00 ,  C07C67/293 ,  C07C67/333 ,  C07C69/75

CPC classification number: C07C67/293

Abstract: Provided is a fixed bed heterogeneous catalyst that promotes the isomerization of cis/trans-DMCD to trans-DMCD in economical fashion with short reaction times and in high purity. The catalyst is preferably H.sub.3 PO.sub.4 on a metal oxide, said metal oxide selected from a group consisting of ZrO.sub.2, TiO.sub.2, Al.sub.2 O.sub.3, and HfO.sub.2, or a tungsten-modified ZrO.sub.2.

Abstract translation: 提供了一种固定床多相催化剂，其以经济的方式促进顺式/反式-DMCD异构化为反式DMCD，反应时间短且纯度高。 催化剂优选为金属氧化物上的H 3 PO 4，所述金属氧化物选自ZrO 2，TiO 2，Al 2 O 3和HfO 2，或钨改性的ZrO 2。

公开(公告)号：US11753390B2

公开(公告)日：2023-09-12

申请号：US17714103

申请日：2022-04-05

Applicant: CCT SCIENCES, LLC

Inventor： Kyle Olson ,  Mario Tremblay

IPC: C07D311/80 ,  A61K9/00 ,  B01D3/10 ,  B01D1/22 ,  B01D5/00 ,  A23L33/105 ,  B01D1/08 ,  C07B37/10 ,  C07B63/02 ,  C07B63/04 ,  C07B37/08 ,  C07B41/06 ,  C07B41/04 ,  C07C39/23

CPC classification number: C07D311/80 ,  A23L33/105 ,  A61K9/0014 ,  A61K9/0056 ,  B01D1/08 ,  B01D1/22 ,  B01D3/10 ,  B01D5/0063 ,  C07B37/08 ,  C07B37/10 ,  C07B41/04 ,  C07B41/06 ,  C07B63/02 ,  C07B63/04 ,  A23V2002/00 ,  C07B2200/09 ,  C07C39/23

Abstract: The present invention describes a process to isomerize industrial hemp derived Cannabidiol (CBD) to a pure Δ8-tetrahydrocannabinol (Δ8-THC) extract. This procedure will produce Δ8-tetrahydrocannabinol that is essentially free from any detectable levels of Δ9-tetrahydrocannabinol (Δ9-THC). Included in this filing are methods and processes to scale the reaction from the lab to process to large scale manufacturing. Additionally, the resulting extract from said methods and processes consists of higher purity than previously reported in the art and greater efficiency compared to prior art.

公开(公告)号：US10800730B2

公开(公告)日：2020-10-13

申请号：US16136830

申请日：2018-09-20

Applicant: The Board of Trustees of the University of Illinois

Inventor： Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

IPC: C07C69/757 ,  C07J21/00 ,  C07J69/00 ,  C07J71/00 ,  C07J73/00 ,  C07J75/00 ,  C07D401/14 ,  C07D311/94 ,  C07D313/06 ,  C07D223/14 ,  C07D401/04 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07D303/10 ,  C07B37/06 ,  C07B37/08 ,  C07D307/93 ,  C07D313/08 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06

Abstract: The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

公开(公告)号：US09938253B2

公开(公告)日：2018-04-10

申请号：US14303523

申请日：2014-06-12

Applicant: Trustees of Boston College

Inventor： Amir H. Hoveyda ,  R. Kashif M. Khan ,  Sebastian Torker ,  Ming Joo Koh

IPC: C07F15/00 ,  B01J31/12 ,  C07D333/56 ,  C07F7/08 ,  C07C41/30 ,  C07C231/12 ,  C07C29/32 ,  C07D209/12 ,  C07C45/68 ,  C07C51/353 ,  C07B37/08 ,  C07C6/06 ,  C08G61/08 ,  C07F5/02 ,  B01J31/22

CPC classification number: C07D333/56 ,  B01J31/226 ,  B01J31/2273 ,  B01J31/2278 ,  B01J2231/543 ,  B01J2531/821 ,  C07B37/08 ,  C07B2200/09 ,  C07C6/06 ,  C07C29/32 ,  C07C41/30 ,  C07C45/68 ,  C07C51/353 ,  C07C231/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/12 ,  C07F5/025 ,  C07F7/081 ,  C07F15/0046 ,  C08G61/08 ,  C08G2261/3324 ,  C08G2261/418 ,  C07C235/30 ,  C07C33/38 ,  C07C33/50 ,  C07C43/23 ,  C07C43/166 ,  C07C33/30 ,  C07C33/025 ,  C07C47/263 ,  C07C33/02 ,  C07C59/42 ,  C07C43/178 ,  C07C49/835 ,  C07C33/14 ,  C07C33/483 ,  C07C43/176 ,  C07C33/12 ,  C07C43/162 ,  C07C13/28

Abstract: The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, provided compounds promote highly efficient and highly Z-selective metathesis. In some embodiments, provided compounds and methods are particularly useful for producing allyl alcohols. In some embodiments, provided compounds have the structure of formula I. In some embodiments, provided compounds comprise ruthenium, and a ligand bonded to ruthenium through a sulfur atom.

公开(公告)号：US20170283342A1

公开(公告)日：2017-10-05

申请号：US15630060

申请日：2017-06-22

Applicant: Givaudan, S.A. ,  Amyris Inc.

Inventor： Fridtjof SCHRÖDER ,  Fabian RUETHI

IPC: C07B37/02 ,  C07C2/86 ,  C07C45/69 ,  C07B37/08 ,  B01J31/22 ,  C07C67/347 ,  C07C41/30 ,  C07C13/04 ,  C07C69/608 ,  C07C43/21 ,  C07C49/553

CPC classification number: C07B37/02 ,  B01J31/2213 ,  B01J2231/324 ,  B01J2531/824 ,  C07B37/08 ,  C07C2/86 ,  C07C41/30 ,  C07C45/69 ,  C07C49/553 ,  C07C67/347 ,  C07C2531/22 ,  C07C2601/02 ,  C07C2601/16 ,  C07C2602/50 ,  C07C13/04 ,  C07C69/608 ,  C07C43/21

Abstract: A process of converting a carbon-carbon multiple bond to a cyclopropane ring, comprising the addition of a N-alkyl-N-nitroso compound to a mixture of alkene precursor, aqueous base and Pd(II)-catalyst, with the N-alkyl-N-nitroso compound obtained directly from an alkyl amine derivative, NaNO2 and an acid via phase separation of the N-alkyl-N-nitroso compound from the aqueous phase.

公开(公告)号：US20170260220A1

公开(公告)日：2017-09-14

申请号：US15452839

申请日：2017-03-08

Applicant: Dieter Arlt

Inventor： Dieter Arlt

IPC: C07F15/00 ,  C08F236/12 ,  B01J31/22 ,  C07B37/08

CPC classification number: C07F15/0046 ,  B01J31/223 ,  B01J31/2291 ,  B01J31/2295 ,  B01J2231/543 ,  B01J2531/821 ,  C07B37/08 ,  C08F236/12

Abstract: The current invention describes new metathesis catalysts, a method for their preparation and their use in metathesis reactions.