公开(公告)号：US20220315552A1

公开(公告)日：2022-10-06

申请号：US17714103

申请日：2022-04-05

申请人： CCT SCIENCES, LLC

发明人： KYLE OLSON ,  MARIO TREMBLAY

IPC分类号： C07D311/80 ,  A61K9/00 ,  B01D3/10 ,  B01D1/22 ,  B01D5/00 ,  A23L33/105 ,  B01D1/08 ,  C07B37/10 ,  C07B63/02 ,  C07B63/04 ,  C07B37/08 ,  C07B41/06 ,  C07B41/04

摘要： The present invention describes a process to isomerize industrial hemp derived Cannabidiol (CBD) to a pure Δ8-tetrahydrocannabinol (Δ8-THC) extract. This procedure will produce Δ8-tetrahydrocannabinol that is essentially free from any detectable levels of Δ9-tetrahydrocannabinol (Δ9-THC). Included in this filing are methods and processes to scale the reaction from the lab to process to large scale manufacturing. Additionally, the resulting extract from said methods and processes consists of higher purity than previously reported in the art and greater efficiency compared to prior art.

公开(公告)号：US10081592B2

公开(公告)日：2018-09-25

申请号：US14387028

申请日：2013-03-25

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

发明人： Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

IPC分类号： C07D401/14 ,  C07C69/757 ,  C07D311/94 ,  C07D313/06 ,  C07D223/14 ,  C07D401/04 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07D303/10 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07B37/06 ,  C07B37/08 ,  C07D307/93 ,  C07D313/08 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07J21/00 ,  C07J69/00 ,  C07J71/00 ,  C07J73/00 ,  C07J75/00

CPC分类号： C07C69/757 ,  C07B37/06 ,  C07B37/08 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07C2601/16 ,  C07C2602/44 ,  C07C2603/86 ,  C07D223/14 ,  C07D303/10 ,  C07D307/93 ,  C07D311/94 ,  C07D313/06 ,  C07D313/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07J21/008 ,  C07J69/00 ,  C07J71/001 ,  C07J71/0031 ,  C07J73/005 ,  C07J73/008 ,  C07J75/005

摘要： The invention a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

公开(公告)号：US09879040B2

公开(公告)日：2018-01-30

申请号：US15452839

申请日：2017-03-08

申请人： Dieter Arlt

发明人： Dieter Arlt

IPC分类号： C07F15/00 ,  C07B37/08 ,  C08F236/12 ,  B01J31/22

CPC分类号： C07F15/0046 ,  B01J31/223 ,  B01J31/2291 ,  B01J31/2295 ,  B01J2231/543 ,  B01J2531/821 ,  C07B37/08 ,  C08F236/12

摘要： The current invention describes new metathesis catalysts, a method for their preparation and their use in metathesis reactions.

公开(公告)号：US5252191A

公开(公告)日：1993-10-12

申请号：US690684

申请日：1991-04-24

申请人： Louis F. Pauli ,  Alphons Dufourny ,  Robert B. Koolstra ,  Hans Wynberg ,  Wolter Ten Hoeve

发明人： Louis F. Pauli ,  Alphons Dufourny ,  Robert B. Koolstra ,  Hans Wynberg ,  Wolter Ten Hoeve

IPC分类号： C07B37/08 ,  C07C401/00 ,  C07D333/18 ,  C07D333/20 ,  C07D333/36 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07J7/00 ,  C07G13/00

CPC分类号： C07D409/04 ,  C07C401/00 ,  C07D333/20 ,  C07D333/36 ,  C07D409/14

摘要： The invention relates to a method for the photochemical isomerization of organic compounds, in particular for the photochemical conversion of tachysterol compounds into previtamin D compounds and of trans-vitamin D compounds into cis-vitamin D compounds, under the influence of radiation, by exposing a solution of the organic compound to be converted in the presence of a non-polymeric photosensitizer to light with approx. 300-1,000 nm wavelength, and by then isolating the resulting product, wherein a substituted thiophene derivative having a substantial absorption in said wavelength region is used as the photosensitizer. The invention also relates to a new photosensitizer to be used for said isomerization reaction.

公开(公告)号：US5231218A

公开(公告)日：1993-07-27

申请号：US965307

申请日：1992-10-23

申请人： Charles E. Sumner, Jr. ,  William E. Choate

发明人： Charles E. Sumner, Jr. ,  William E. Choate

IPC分类号： B01J27/18 ,  B01J27/188 ,  C07B37/08 ,  C07B61/00 ,  C07C67/293 ,  C07C67/333 ,  C07C69/75

CPC分类号： C07C67/293

摘要： Provided is a fixed bed heterogeneous catalyst that promotes the isomerization of cis/trans-DMCD to trans-DMCD in economical fashion with short reaction times and in high purity. The catalyst is preferably H.sub.3 PO.sub.4 on a metal oxide, said metal oxide selected from a group consisting of ZrO.sub.2, TiO.sub.2, Al.sub.2 O.sub.3, and HfO.sub.2, or a tungsten-modified ZrO.sub.2.

摘要翻译： 提供了一种固定床多相催化剂，其以经济的方式促进顺式/反式-DMCD异构化为反式DMCD，反应时间短且纯度高。 催化剂优选为金属氧化物上的H 3 PO 4，所述金属氧化物选自ZrO 2，TiO 2，Al 2 O 3和HfO 2，或钨改性的ZrO 2。

公开(公告)号：US10800730B2

公开(公告)日：2020-10-13

申请号：US16136830

申请日：2018-09-20

申请人： The Board of Trustees of the University of Illinois

发明人： Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

IPC分类号： C07C69/757 ,  C07J21/00 ,  C07J69/00 ,  C07J71/00 ,  C07J73/00 ,  C07J75/00 ,  C07D401/14 ,  C07D311/94 ,  C07D313/06 ,  C07D223/14 ,  C07D401/04 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07D303/10 ,  C07B37/06 ,  C07B37/08 ,  C07D307/93 ,  C07D313/08 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06

摘要： The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

公开(公告)号：US09938253B2

公开(公告)日：2018-04-10

申请号：US14303523

申请日：2014-06-12

申请人： Trustees of Boston College

发明人： Amir H. Hoveyda ,  R. Kashif M. Khan ,  Sebastian Torker ,  Ming Joo Koh

IPC分类号： C07F15/00 ,  B01J31/12 ,  C07D333/56 ,  C07F7/08 ,  C07C41/30 ,  C07C231/12 ,  C07C29/32 ,  C07D209/12 ,  C07C45/68 ,  C07C51/353 ,  C07B37/08 ,  C07C6/06 ,  C08G61/08 ,  C07F5/02 ,  B01J31/22

CPC分类号： C07D333/56 ,  B01J31/226 ,  B01J31/2273 ,  B01J31/2278 ,  B01J2231/543 ,  B01J2531/821 ,  C07B37/08 ,  C07B2200/09 ,  C07C6/06 ,  C07C29/32 ,  C07C41/30 ,  C07C45/68 ,  C07C51/353 ,  C07C231/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/12 ,  C07F5/025 ,  C07F7/081 ,  C07F15/0046 ,  C08G61/08 ,  C08G2261/3324 ,  C08G2261/418 ,  C07C235/30 ,  C07C33/38 ,  C07C33/50 ,  C07C43/23 ,  C07C43/166 ,  C07C33/30 ,  C07C33/025 ,  C07C47/263 ,  C07C33/02 ,  C07C59/42 ,  C07C43/178 ,  C07C49/835 ,  C07C33/14 ,  C07C33/483 ,  C07C43/176 ,  C07C33/12 ,  C07C43/162 ,  C07C13/28

摘要： The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, provided compounds promote highly efficient and highly Z-selective metathesis. In some embodiments, provided compounds and methods are particularly useful for producing allyl alcohols. In some embodiments, provided compounds have the structure of formula I. In some embodiments, provided compounds comprise ruthenium, and a ligand bonded to ruthenium through a sulfur atom.

公开(公告)号：US20170283342A1

公开(公告)日：2017-10-05

申请号：US15630060

申请日：2017-06-22

申请人： Givaudan, S.A. ,  Amyris Inc.

发明人： Fridtjof SCHRÖDER ,  Fabian RUETHI

IPC分类号： C07B37/02 ,  C07C2/86 ,  C07C45/69 ,  C07B37/08 ,  B01J31/22 ,  C07C67/347 ,  C07C41/30 ,  C07C13/04 ,  C07C69/608 ,  C07C43/21 ,  C07C49/553

CPC分类号： C07B37/02 ,  B01J31/2213 ,  B01J2231/324 ,  B01J2531/824 ,  C07B37/08 ,  C07C2/86 ,  C07C41/30 ,  C07C45/69 ,  C07C49/553 ,  C07C67/347 ,  C07C2531/22 ,  C07C2601/02 ,  C07C2601/16 ,  C07C2602/50 ,  C07C13/04 ,  C07C69/608 ,  C07C43/21

摘要： A process of converting a carbon-carbon multiple bond to a cyclopropane ring, comprising the addition of a N-alkyl-N-nitroso compound to a mixture of alkene precursor, aqueous base and Pd(II)-catalyst, with the N-alkyl-N-nitroso compound obtained directly from an alkyl amine derivative, NaNO2 and an acid via phase separation of the N-alkyl-N-nitroso compound from the aqueous phase.

公开(公告)号：US20170260220A1

公开(公告)日：2017-09-14

申请号：US15452839

申请日：2017-03-08

申请人： Dieter Arlt

发明人： Dieter Arlt

IPC分类号： C07F15/00 ,  C08F236/12 ,  B01J31/22 ,  C07B37/08

CPC分类号： C07F15/0046 ,  B01J31/223 ,  B01J31/2291 ,  B01J31/2295 ,  B01J2231/543 ,  B01J2531/821 ,  C07B37/08 ,  C08F236/12

摘要： The current invention describes new metathesis catalysts, a method for their preparation and their use in metathesis reactions.

公开(公告)号：US08841440B2

公开(公告)日：2014-09-23

申请号：US12935660

申请日：2009-04-01

申请人： Chih-Chang Chu ,  Chao Zhong

发明人： Chih-Chang Chu ,  Chao Zhong

IPC分类号： C07B37/08 ,  C08B37/08

CPC分类号： C08B37/003 ,  A01N43/16 ,  A61L26/0023 ,  A61L27/20 ,  A61L27/60 ,  C08L5/08 ,  A01N59/16 ,  A01N2300/00

摘要： Organo-soluble chitosan salts, method for preparing organo-soluble salts, chitosan-derived materials prepared with organo-soluble chitosan salts, and methods for preparing chitosan-derived materials are disclosed.

摘要翻译： 公开了有机溶解性壳聚糖盐，有机可溶性盐的制备方法，由有机可溶性壳聚糖盐制备的壳聚糖衍生物质，以及制备壳聚糖衍生物质的方法。