公开(公告)号：US20230092433A1

公开(公告)日：2023-03-23

申请号：US17759770

申请日：2021-01-29

申请人： AMYRIS, INC.

发明人： Christa Lynna MARIANO ,  Ramya VISWANATHAN

IPC分类号： A61K8/27 ,  A61K8/29 ,  A61K8/37 ,  A61K8/31 ,  A61Q17/04

摘要： Provided herein are sunscreen formulations containing a metal oxide sunscreen, squalane, and an antioxidant. The sunscreen formulations provided have increased SPF per unit mass of the metal oxide compared to sunscreen formulations that contain metal oxide without the addition of squalane and antioxidant. Also provided are methods of preventing UV damages to skin involving the application of the sunscreen formulation.

公开(公告)号：US20210338549A1

公开(公告)日：2021-11-04

申请号：US17375512

申请日：2021-07-14

申请人： Amyris, Inc.

发明人： Diva CHAN ,  Ro OTERI ,  Ashlee NUNES

IPC分类号： A61K8/34 ,  A61K8/31 ,  A61Q19/00

摘要： Provided herein are compositions for delivering one or more cannabinoids to the skin of a subject and methods of using the compositions to deliver the one or more cannabinoids to the skin of a subject. The compositions contain a carrier that facilitates the delivery and permeation of cannabinoids to and through the skin. The carriers of the compositions contain squalane or mixtures of squalane and hemisqualane. The compositions described herein may serve as the base for the preparation of various cosmetics or various pharmaceuticals. The cosmetics or pharmaceuticals may be used to reduce inflammation, control pain, or prevent aging of the skin of a subject.

公开(公告)号：US20210230234A1

公开(公告)日：2021-07-29

申请号：US17221371

申请日：2021-04-02

申请人： AMYRIS, INC. ,  TOTAL MARKETING SERVICES

发明人： Penelope R. CHUA ,  Hanxiao JIANG ,  Adam Leon MEADOWS

IPC分类号： C07K14/395 ,  C12P19/62 ,  C12P5/02 ,  C12P7/64 ,  C12P21/00 ,  C12N1/16 ,  C12N15/52 ,  C12N15/63 ,  C12N15/65 ,  C12P21/02

摘要： The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational level. The present disclosure also relates to the use of a maltose dependent degron in combination with a maltose-responsive promoter to control gene expression at the transcriptional level and to control protein stability at the post-translational level. The present disclosure also relates to the use of a stabilization construct that couples expression of a cell-growth-affecting protein with the production of non-catabolic compounds. The present disclosure further relates to the use of a synthetic maltose-responsive promoter. The present disclosure further provides compositions and methods for using a maltose dependent degron, a maltose-responsive promoter, and a stabilization construct, either alone or in various combinations, for the production of non-catabolic compounds in genetically modified host cells.

公开(公告)号：US20210189376A1

公开(公告)日：2021-06-24

申请号：US17271572

申请日：2019-08-28

申请人： AMYRIS, INC.

发明人： Andrew HORWITZ ,  Jessica Mai WALTER ,  Chia-Hong TSAI

IPC分类号： C12N15/10 ,  C12N15/52

摘要： Cells and methods for screening inhibitors against a heterologous target protein are disclosed.

公开(公告)号：US10781298B2

公开(公告)日：2020-09-22

申请号：US15604111

申请日：2017-05-24

申请人： KURARAY CO., LTD. ,  AMYRIS, INC.

发明人： Daisuke Koda ,  Kei Hirata

IPC分类号： C08L9/06 ,  B60C1/00 ,  C08F236/08 ,  C08K3/04 ,  C08K3/36 ,  C08L47/00 ,  C08F236/22 ,  C08L21/00 ,  C08K3/013 ,  C08K3/22 ,  C08L7/00 ,  C08L9/00 ,  C08K3/06 ,  C08K5/548

摘要： The present invention relates to a copolymer including a monomer unit (a) derived from isoprene and a monomer unit (b) derived from farnesene; a process for producing the copolymer including at least the step of copolymerizing isoprene with farnesene; a rubber composition including (A) the copolymer, (B) a rubber component and (C) carbon black; a rubber composition including (A) the copolymer, (B) a rubber component and (D) silica; a rubber composition including (A) the copolymer, (B) a rubber component, (C) carbon black and (D) silica; and a tire using the rubber composition at least as a part thereof.

公开(公告)号：US20200263188A1

公开(公告)日：2020-08-20

申请号：US16646013

申请日：2018-09-12

申请人： Amyris, Inc.

发明人： Yoseph TSEGAYE

IPC分类号： C12N15/81 ,  C12N15/113 ,  C12N9/22 ,  C07K16/32 ,  C07K16/28

摘要： The invention provides methods for genetically engineering Kluyveromyces. The methods can be used to genetically engineer Kluyveromyces to produce and secrete full-length antibodies or antibody fragments. The invention also provides methods for production and secretion of antibodies.

公开(公告)号：US20200165651A1

公开(公告)日：2020-05-28

申请号：US16637188

申请日：2018-08-10

申请人： AMYRIS, INC.

发明人： Gale WICHMANN ,  Aditi Khankhoje ,  Tina Mahatdejkul-Meadows

IPC分类号： C12P19/56 ,  C12P7/40 ,  C12N15/81

摘要： Provided herein are compositions and methods for improved production of steviol glycosides in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding a Pisum sativum kaurene oxidase or its variant kaurene oxidase. In some embodiments, the host cell further comprises one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing steviol glycosides in the host cell. The compositions and methods described herein provide an efficient route for the heterologous production of steviol glycosides, including but not limited to, rebaudioside D and rebaudioside M.

公开(公告)号：US10563229B2

公开(公告)日：2020-02-18

申请号：US14910240

申请日：2013-08-07

申请人： AMYRIS, INC. ,  TOTAL MARKETING SERVICES

发明人： Penelope R. Chua ,  Adam Meadows

IPC分类号： C12P7/00 ,  C12N15/00 ,  C12N1/20 ,  C07H21/04 ,  C07H21/02 ,  C12P5/00 ,  C12N15/81 ,  C12N15/63

摘要： The present disclosure relates to the use of a switch for the production of heterologous non-catabolic compounds in microbial host cells. In one aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured under aerobic conditions followed by microaerobic conditions, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions. In another aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured in the presence of maltose followed by the reduction or absence of maltose, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions.

公开(公告)号：US10519475B1

公开(公告)日：2019-12-31

申请号：US16198545

申请日：2018-11-21

申请人： Amyris, Inc.

发明人： Jessica Walter ,  Joshua A. Lerman ,  Michael Leavell ,  Benjamin Yap

IPC分类号： C12P19/12 ,  C12N15/81 ,  C07H13/04 ,  C12N9/10 ,  C12N9/24 ,  C12N9/12 ,  C12N9/88

摘要： Provided herein are genetically modified yeast cells capable of producing one or more human milk oligosaccharides. The yeast cells include one or more heterologous nucleic acids that encode enzymes of a human milk oligosaccharide biosynthetic pathway. The yeast cells do not include a heterologous nucleic acid encoding a fucokinase. Also provided are fermentation compositions including the disclosed genetically modified yeast cells, and related methods of producing and recovering human milk oligosaccharides generated by the yeast cells.

公开(公告)号：US10071034B2

公开(公告)日：2018-09-11

申请号：US14702607

申请日：2015-05-01

申请人： Amyris, Inc.

发明人： Ross Keating Eppler ,  Karl Fisher ,  Roberto Vazquez

IPC分类号： A61K8/31 ,  A61Q19/00 ,  A61Q1/04 ,  A61Q5/00 ,  C11D3/18 ,  A61Q5/06

CPC分类号： A61K8/31 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q5/065 ,  A61Q19/00 ,  C11D3/184

摘要： Provided herein are compositions comprising partially hydrogenated farnesene. In certain embodiments, the compositions are useful as solvents, degreasers, cleaning products, personal care products, and for other uses. Also provided herein are methods of making the compositions and methods of their use.