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    Novel salicylanilides and microbiocidal compositions and uses thereof
    2.
    发明授权
    Novel salicylanilides and microbiocidal compositions and uses thereof 失效
    新型水杨酰苯胺和杀微生物组合物及其用途

    公开(公告)号：US4287191A

    公开(公告)日：1981-09-01

    申请号：US140098

    申请日：1980-04-14

    申请人： Robert A. Coburn ,  Richard T. Evans ,  Robert J. Genco ,  Armando Batista

    发明人： Robert A. Coburn ,  Richard T. Evans ,  Robert J. Genco ,  Armando Batista

    IPC分类号： A61K31/60 ,  A01N37/36 ,  A61K8/42 ,  A61K8/69 ,  A61K31/165 ,  A61P1/02 ,  A61P31/04 ,  A61Q11/00 ,  C07C65/40 ,  C07C233/12 ,  C07C101/74 ,  C07C119/02

    CPC分类号： A61Q11/00 ,  A61K8/42 ,  A61K8/69 ,  C07C65/40

    摘要： The composition comprises certain 5-acylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: ##STR1## Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a substituted or unsubstituted alkyl or phenyl group of from 2 to 30 carbon atoms including substituents and M is a radical selected from the group consisting of --C.dbd.N,--F,--NO.sub.2,--H, lower alkyl or lower haloalkyl.The preferred compositions of the invention have a partition coefficient greater than 4 and the substituted moieties in the phenyl ring of the Z group have a combined overall electron withdrawing effect on the phenyl ring of the Z group.The method of the invention comprises contacting the microorganism with a sufficient concentration of the above composition for a sufficient time to inhibit the growth of the microorganism.The above compositions are effective antiseptics against a wide range of microorganisms, especially bacteria, and the compositions surprisingly are especially effective against microorganisms prevalent in dental plaque.

    摘要翻译： 该组合物包含某些5-酰基水杨酰苯胺，更具体地包括由以下通式所包括的化合物：其中Z是包含取代基的6至30个碳原子的取代苯环，R是取代或未取代的烷基或苯基 包括2至30个碳原子，包括取代基，M是选自-C = N，-F，-NO 2，-H，低级烷基或低级卤代烷基的基团。 本发明的优选组合物具有大于4的分配系数，并且Z基团的苯环中的取代部分在Z基团的苯环上具有组合的总吸电子效应。 本发明的方法包括使足够浓度的上述组合物的微生物接触足够的时间以抑制微生物的生长。 上述组合物是针对广泛的微生物，特别是细菌的有效的防腐剂，并且该组合物令人惊奇地对抗牙菌斑中普遍存在的微生物特别有效。

    Diester of 3,5,3',5'-tetrabromo-bisphenol A with halogenated aromatic carboxylic acid
    8.
    发明授权
    Diester of 3,5,3',5'-tetrabromo-bisphenol A with halogenated aromatic carboxylic acid 失效
    3,5,3'，5'-四溴双酚A与卤代芳族羧酸的二酯

    公开(公告)号：US4274998A

    公开(公告)日：1981-06-23

    申请号：US83956

    申请日：1979-10-11

    申请人： Izumi Yamashita ,  Kunio Fukuda ,  Kichiya Tazaki

    发明人： Izumi Yamashita ,  Kunio Fukuda ,  Kichiya Tazaki

    IPC分类号： C08K5/00 ,  C08K5/13 ,  C08K5/17 ,  C08K5/18 ,  C08L7/00 ,  C08L21/00 ,  C08L23/00 ,  C08L33/00 ,  C08L33/02 ,  C08L51/00 ,  C08L51/02 ,  C08L67/00 ,  C08L77/00 ,  C08L101/00 ,  C09K21/08 ,  C07C69/76 ,  C07C69/78 ,  C07C69/84 ,  C07C101/74 ,  C08K5/10

    CPC分类号： C08K5/0066

    摘要： A novel diester compound of the formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2 represents a group of the formula (II): ##STR2## wherein X is bromine atom; Y at least one group selected from the group consisting of alkyl groups having 1 to 4 carbon atoms, alkoxy groups having 1 to 4 carbon atoms, hydroxyl group and primary, secondary or tertiary amino groups; p an integer of 0 to 4; q an integer of 1 to 4; r an integer 1 to 4 and (q+r) is equal to an integer of not more than 5, is found to be capable of imparting excellent flame-retardancy to various inflammable polymeric materials such as polystyrene, polyester, polyamide, polyphenylene oxide, etc. without deleterious effects on other physical properties of such polymeric materials.

    摘要翻译： （I）的新型二酯化合物：其中R 1和R 2各自表示式（II）的基团：其中X是溴原子;（II）其中X是溴原子; Y为选自碳原子数为1〜4的烷基，碳原子数1〜4的烷氧基，羟基，伯，仲或叔氨基的至少1个基团。 p为0〜4的整数; q为1〜4的整数; r为整数1〜4，（q + r）等于5以下的整数，可以赋予各种易燃性聚合物材料如聚苯乙烯，聚酯，聚酰胺，聚苯醚等优异的阻燃性， 等等，对这种聚合物材料的其它物理性能没有有害影响。