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    Process for reducing acid impurity levels in N-(tertiaryaminoalkyl)acrylamide production
    1.
    发明授权
    Process for reducing acid impurity levels in N-(tertiaryaminoalkyl)acrylamide production 失效
    降低N-（叔氨基烷基）丙烯酰胺生产中酸性杂质含量的方法

    公开(公告)号：US4251461A

    公开(公告)日：1981-02-17

    申请号：US112759

    申请日：1980-01-17

    申请人： David R. Livingston

    发明人： David R. Livingston

    IPC分类号： C07C211/09 ,  C07C67/00 ,  C07C209/00 ,  C07C209/60 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/34 ,  C07C233/38 ,  C07C103/64

    CPC分类号： C07C233/34

    摘要： A non-catalytic process for the preparation of N-(tertiaryaminoalkyl)acrylamides is disclosed which comprises subjecting a corresponding .beta.-aminopropionamide to a pyrolysis temperature of about 180.degree. to 300.degree. C. after storage of the .beta.-aminopropionamide in an atmospheric holding tank at a temperature of about 150.degree. to 220.degree. C. from eight to seventy-two hours prior to pyrolysis. The corresponding .beta.-aminopropionamide compounds can be prepared by mixing and reacting at least two moles of a tertiaryaminoalkyl amine with an acrylic acid or ester compound. The inventive process provides the production of the N-(tertiaryaminoalkyl)acrylamides in high yields with minimal back addition or polymerization and greatly reduced acid impurity levels.

    摘要翻译： 公开了用于制备N-（叔氨基烷基）丙烯酰胺的非催化方法，其包括在将β-氨基丙酰胺储存在大气储存罐中后，使相应的β-氨基丙酰胺经受约180℃至300℃的热解温度 在约150℃至220℃的温度下，在热解之前8至72小时。 相应的β-氨基丙酰胺化合物可以通过混合并使至少两摩尔的叔氨基烷基胺与丙烯酸或酯化合物反应来制备。 本发明方法提供以高产率生产N-（叔氨基烷基）丙烯酰胺，具有最小的反加成或聚合，并大大降低酸杂质水平。

    N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines
    2.
    发明授权
    N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines 失效
    N，N-双{8 2-（3-取代-4-羟基苯基） - 乙基或2-羟乙基{9-聚亚甲基二胺

    公开(公告)号：US4024281A

    公开(公告)日：1977-05-17

    申请号：US623130

    申请日：1975-10-16

    申请人： Donald F. Colella ,  Carl Kaiser

    发明人： Donald F. Colella ,  Carl Kaiser

    IPC分类号： C07C215/50 ,  C07C215/56 ,  C07C233/00 ,  A61K31/165 ,  A61K31/135 ,  C07C91/12 ,  C07C103/64

    CPC分类号： C07C215/56 ,  C07C215/50 ,  C07C233/00

    摘要： N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .beta.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.

    摘要翻译： 具有β-肾上腺素能兴奋剂活性的N，N'-双[2-（3-取代-4-羟基苯基） - 乙基或-2-羟乙基] - 聚亚甲基二胺通常通过N-苄基苯乙胺与 多亚甲基二卤化物或通过β-溴代苯乙酮与N，N'-二苄基 - 聚亚甲基二胺的反应，其进一步的操作取决于3-取代基的性质，然后用​​例如钯 - 碳催化氢化。 关键中间体也是本发明的一部分。

    Preparation of n-(tertiaryaminoalkyl) acrylamides
    3.
    发明授权
    Preparation of n-(tertiaryaminoalkyl) acrylamides 失效
    正 - （叔氨基烷基）丙烯酰胺的制备

    公开(公告)号：US3878247A

    公开(公告)日：1975-04-15

    申请号：US43646774

    申请日：1974-01-25

    申请人： JEFFERSON CHEM CO INC

    发明人： MOSS PHILIP HOTCHKISS ,  GIPSON ROBERT MALONE

    IPC分类号： C07C231/00 ,  B01J39/18 ,  C02F1/54 ,  C07C67/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/38 ,  C07D295/13 ,  C08G59/54 ,  C07C103/64

    CPC分类号： C07D295/13 ,  B01J39/18 ,  C02F1/54 ,  C08G59/54

    摘要： A noncatalytic process for the preparation of N(tertiaryaminoalkyl)acrylamides is disclosed which comprises subjecting a corresponding Beta -aminopropionamide to a temperature of about 180*-300*C. and separating the Ntertiaryaminoalkyl) acrylamide from the reaction product. The corresponding Beta -aminopropionamide compounds can be prepared by mixing and reacting at least 2 moles of a tertiaryaminoalkyl amine with an acrylic acid or ester compound. The inventive process provides the production of the N(tertiaryaminoalkyl)acrylamides in high yields with minimal backaddition or polymerization.

    摘要翻译： 公开了用于制备N-（叔氨基烷基）丙烯酰胺的非催化方法，其包括使相应的β-氨基丙酰胺经受约180-300℃的温度，并从反应产物中分离N-叔氨基烷基）丙烯酰胺。 相应的β-氨基丙酰胺化合物可以通过混合并使至少2摩尔叔氨基烷基胺与丙烯酸或酯化合物反应来制备。 本发明的方法提供以高产率生产N-（叔氨基烷基）丙烯酰胺，具有最小的反加成或聚合。

    Acyl derivatives of substituted bis-arylalkylamino compounds
    4.
    发明授权
    Acyl derivatives of substituted bis-arylalkylamino compounds 失效
    取代的双芳基烷基氨基化合物的酰基衍生物

    公开(公告)号：US4010191A

    公开(公告)日：1977-03-01

    申请号：US424835

    申请日：1973-12-14

    申请人： Kurt Thiele ,  Walter Von Bebenburg ,  Klaus Posselt

    发明人： Kurt Thiele ,  Walter Von Bebenburg ,  Klaus Posselt

    IPC分类号： C07C233/34 ,  C07C103/44 ,  C07C103/64 ,  C07C103/82 ,  C07C125/00

    CPC分类号： C07C233/34

    摘要： Compounds of the formula ##STR1## wherein Ar is phenyl or naphthyl, X is oxygen or the group ##STR2## Y is substituted or unsubstituted alkylene of 1-4 carbon atoms, R.sub.1 is acyloxy, acyloxyalkoxy, acylamino or is --N(Alkyl)(Acyl, R.sub.4 is hydrogen or lower alkyl, R.sub.5 is hydrogen, lower alkyl or acyl, and R.sub.2, R.sub.3, R.sub.6 and R.sub.7 are the same or different and are hydrogen, halogen, hydroxy, lower alkoxy, acyloxy, amino, alkylamino, dialkylamino, acylamino, nitro, lower alkyl, lower halogeno alkyl, or lower alkylthio,Acyl in these radicals being derived from [a] saturated or unsaturated, straight, or branched, substituted or unsubstituted fatty acids of 2-10 carbon atms, [b] substituted or unsubstituted benzoic acids, [c] lower aliphatic mono esters of carbonic acid, or [d] the carbonic acid phenyl mono ester;And pharmaceutically acceptable salts of these compounds; optically active isomers thereof and diastereomers.The compounds have antiphlogistic, analgesic, antipyretic, broncholytic and coronary circulation regulatory action.

    摘要翻译： 其中Ar是苯基或萘基，X是氧或基团Y是具有1-4个碳原子的取代或未取代的亚烷基，R1是酰氧基，酰氧基烷氧基，酰氨基或是-N（烷基） （酰基，R4为氢或低级烷基，R5为氢，低级烷基或酰基，R2，R3，R6和R7相同或不同，为氢，卤素，羟基，低级烷氧基，酰氧基，氨基，烷基氨基，二烷基氨基 ，酰基氨基，硝基，低级烷基，低级卤代烷基或低级烷硫基，在从[A]饱和或不饱和，直链或分支，取代或未被取代的2-10碳原子的脂肪酸衍生的这些辐射中的ACYL，[B] 取代或未取代的苯甲酸，[C]碳酸的低级单体酯，或[D]碳酸苯酯单体;以及这些化合物的药学上可接受的盐;其光学活性异构体及其衍生物。

    Meta-bis anilide derivatives and their utility as herbicides
    6.
    发明授权
    Meta-bis anilide derivatives and their utility as herbicides 失效
    META-BIS苯胺衍生物及其作为除草剂的用途

    公开(公告)号：US3937729A

    公开(公告)日：1976-02-10

    申请号：US342579

    申请日：1973-03-19

    申请人： Eugene G. Teach

    发明人： Eugene G. Teach

    IPC分类号： C07D307/68 ,  C07C103/44 ,  C07C103/64 ,  C07C103/82

    CPC分类号： C07D307/68

    摘要： Compounds corresponding to the formula: ##SPC1##In which R.sub.1 and R.sub.2 are, independently, hydrogen, alkyl, alkoxyalkyl, cycloalkyl, pinonyl, ethylcycloalkyl, lower alkenyl, halogenated lower alkyl, benzyl, ethylphenyl, 2,4-dichlorophenoxy-methylene, styryl, furyl, phenyl or substituted phenyl in which the substituents are nitro, halogen, methyl, or methoxy; R.sub.3 and R.sub.4 are, independently, hydrogen or lower alkyl; X and Y are independently oxygen or sulfur; and Z is halogen, nitro, amino, lower alkyl, lower alkoxy or trifluoromethyl and n is an integer having a value from 0 to 4. The above compounds are effective herbicides, particularly for the control of grasses and broadleaf plants with both pre-emergence and post-emergence activity. Representative compounds are: m-propionamidobutyranilide, m-bis-2,2-dimethylvaleranilide, m-isobutyramido trichloroacetanilide, m-isobutyramido-2-ethylbutyranilide, m-t-butylacetamidopropionanilide, and 3'-N-ethyl propionamido-propionalide.This application is a continuation of application Ser. No. 180,916, filed Sept. 15, 1971, which is a continuation of application Ser. No. 20,104, filed Mar. 16, 1970, which is a continuation-in-part of application Ser. No. 741,267, filed July 1, 1968, which is a continuation-in-part of application Ser. No. 659,865, filed Aug. 11, 1967, all now abandoned.