公开(公告)号：US4680395A

公开(公告)日：1987-07-14

申请号：US707325

申请日：1985-03-01

申请人： Haukur Kristinsson ,  Werner Topfl

发明人： Haukur Kristinsson ,  Werner Topfl

IPC分类号： C07D251/46 ,  A01N47/36 ,  A01N47/42 ,  C07C67/00 ,  C07C301/00 ,  C07C303/38 ,  C07C303/40 ,  C07C311/63 ,  C07D239/42 ,  C07D239/47 ,  C07D251/16 ,  C07D521/00 ,  C07D239/69

CPC分类号： C07D521/00

摘要： Pyrimidyl-sulfonyl isoureas of the formula ##STR1## in which R.sub.a is the difluoromethoxy group,R.sub.b is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 l-C.sub.5 -haloalkyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.1 -C.sub.5 -haloalkoxy, C.sub.1 -C.sub.5 -alkylthio, C.sub.2 -C.sub.10 -alkoxyalkyl or C.sub.2 -C.sub.10 -alkoxyalkoxy or is an amino group ##STR2## wherein R.sub.c is hydrogen, methyl or ethyl, andR.sub.d is hydrogen, methyl, ethyl or methoxy,A is a radical of the formula ##STR3## Y is oxygen, sulfur or ##STR4## R.sub.1 is hydrogen, halogen, nitro, trifluoromethyl, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -alkoxy, --COR.sub.7, --S(O).sub.m --C.sub.1 -C.sub.5 -alkyl, --SO.sub.2 R.sub.10, XR.sub.11 or --OSO.sub.2 C.sub.1 -C.sub.5 -alkyl,R.sub.2 is hydrogen, fluorine, chlorine, bromine, nitro, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -alkoxy, trifluoromethyl, C.sub.1 -C.sub.5 -haloalkoxy or --COR.sub.7,R.sub.3 is hydrogen, fluorine, chlorine, bromine, nitro, methoxy or trifluoromethyl,R.sub.4 is hydrogen, halogen, nitro, C.sub.1 -C.sub.5 -alkyl, methoxy, --COR.sub.7 or --SO.sub.2 NR.sub.8 R.sub.9,R.sub.5 is hydrogen, fluorine, chlorine, bromine, nitro, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -alkoxy, trifluoromethyl, --S(O).sub.m C.sub.1 -C.sub.5 -alkyl, --COR.sub.7 or --SO.sub.2 NR.sub.8 R.sub.9,R.sub.6 is hydrogen, fluorine, methyl or methoxy,R.sub.7 is hydrogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -haloalkyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.1 -C.sub.5 -haloalkoxy, C.sub.2 l-C.sub.10 -alkoxyalkoxy, C.sub.3 -C.sub.5 -alkenyloxy, C.sub.3 -C.sub.5 -alkynyloxy, phenoxy, benzyloxy, C.sub.1 -C.sub.5 -alkylthio or --NR.sub.8 R.sub.9,R.sub.8 is hydrogen, C.sub.1 -C.sub.5 -alkyl, cyanoalkyl having a maximum of 5 carbon atoms, methoxy, ethoxy or C.sub.3 -C.sub.5 -alkenyl,R.sub.9 is hydrogen, C.sub.1 -C.sub.5 -alkyl or C.sub.3 -C.sub.5 -alkenyl, orR.sub.8 and R.sub.9 together with the nitrogen atom binding them form a 5- or 6-membered, saturated heterocycle which can contain an oxygen or sulfur atom as ring member,R.sub.10 is C.sub.1 -C.sub.5 -haloalkoxy or --NR.sub.8 R.sub.9,R.sub.11 is C.sub.1 -C.sub.5 -alkyl which is substituted by halogen, C.sub.1 -C.sub.5 -alkoxy, --S(O).sub.m C.sub.1 -C.sub.5 -alkyl, --S(O).sub.m C.sub.1 -C.sub.5 -haloalkyl or C.sub.2 l-C.sub.5 -alkenyl which is unsubstituted or substituted by halogen or C.sub.1 -C.sub.5 -alkoxy,R.sub.x is C.sub.1 -C.sub.5 -alkyl,X is oxygen or --X(O).sub.m -- andm is zero, one or twoare intermediates for the preparation of pyrimidyl-sulfonyl ureas having useful herbicidyl and growth regulating properties.

公开(公告)号：US4629802A

公开(公告)日：1986-12-16

申请号：US707358

申请日：1985-03-01

申请人： Haukur Kristinsson ,  Werner Topfl

发明人： Haukur Kristinsson ,  Werner Topfl

IPC分类号： C07D251/46 ,  A01N47/36 ,  A01N47/42 ,  C07C67/00 ,  C07C301/00 ,  C07C303/38 ,  C07C303/40 ,  C07C311/63 ,  C07D239/42 ,  C07D239/47 ,  C07D251/16 ,  C07D521/00 ,  C07C119/20

CPC分类号： C07D521/00

摘要： A novel process for producing sulfonylureas of the formula I having a herbicidal action and an action regulating plant growth ##STR1## wherein A is an unsubstituted or substituted phenyl, naphthyl, furan, thiophene or pyridine group, E is a nitrogen atom or the methine group, R.sub.a is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -haloalkyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.1 -C.sub.5 -haloalkoxy, C.sub.1 -C.sub.5 -alkylthio or C.sub.2 -C.sub.10 -alkoxyalkoxy, and R.sub.b is the same as R.sub.a or is an unsubstituted or substituted amino group, and salts thereof, which process comprises firstly condensing an imidocarbonic acid ester with a sulfonyl chloride of the formula II to the sulfonylimidocarbonic acid diester of the formula IV ##STR2## wherein R is an alkyl group, and reacting this in an ethereal solvent in the presence of sodium hydride or potassium tertbutylate with a 2-aminopyrimidine or 2-amino-1,3,5-triazine of the formula V, and finally reacting the formed sulfonylisourea of the formula VI in an organic solvent with hydrochloric acid to obtain the sulfonylurea of the formula I, and isolating this as such or as a salt; ##STR3## The sulfonylimidocarbonic acid diesters of the formula IV and certain sulfonylisoureas of the formula VI, required as intermediates, are novel compounds. The process has the advantage that no sulfonamides are needed as intermediates.

摘要翻译： 一种制备具有除草作用和调节植物生长作用的式I的磺酰脲的新方法，其中A是未取代或取代的苯基，萘基，呋喃，噻吩或吡啶基，E是氮原子或 次甲基，R a为氢，卤素，C 1 -C 5 - 烷基，C 1 -C 5 - 卤代烷基，C 1 -C 5 - 烷氧基，C 1 -C 5 - 卤代烷氧基，C 1 -C 5 - 烷硫基或C 2 -C 10 - 烷氧基烷氧基，Rb为 与R a相同或为未取代或取代的氨基及其盐，该方法包括首先将亚氨基碳酸酯与式II的磺酰氯缩合成式IV的磺酰亚胺基碳酸二酯其中R是烷基 并将其在惰性溶剂中，在氢化钠或叔丁醇钾存在下与式V的2-氨基嘧啶或2-氨基-1,3,5-三嗪反应，最后使形成的式VI的磺酰基异脲 在有盐酸的有机溶剂中 在式I的磺酰脲中，并将其分离为盐或盐; 作为中间体，式IV的磺酰亚胺基碳酸二酯和式VI的某些磺酰基异脲是新化合物。 该方法的优点是不需要磺酰胺作为中间体。

公开(公告)号：US4343648A

公开(公告)日：1982-08-10

申请号：US251921

申请日：1981-04-07

申请人： Gerhard Hamprecht ,  Rolf-Dieter Acker ,  Bruno Wuerzer

发明人： Gerhard Hamprecht ,  Rolf-Dieter Acker ,  Bruno Wuerzer

IPC分类号： A01N47/18 ,  A01N43/72 ,  A01N47/20 ,  A01N47/30 ,  A01N47/34 ,  C07C311/63 ,  C07D285/00 ,  C07D285/15

CPC分类号： C07D285/15 ,  A01N43/72 ,  A01N47/20 ,  A01N47/30 ,  C07C311/63

摘要： 6H-1,2,4,6-Thiatriazine-1,1-dioxides of the formula ##STR1## where R.sup.1 and R.sup.2 are an aliphatic radical, a cycloaliphatic radical or a substituted aliphatic radical, R.sup.1 may also be unsubstituted or substituted phenyl, unsubstituted or substituted benzyl, or tetrahydrofurylmethyl and R.sup.2 may also be lower alkoxycarbo-lower alkoxy, lower alkylmercapto-carbo-lower alkoxy, lower alkoxy-carbo-lower alkylmercapto, lower alkylmercapto-carbo-lower alkylmercapto, unsubstituted or substituted aryl or unsubstituted or substituted benzyl,R.sup.3 is hydrogen, an aliphatic radical, a cycloaliphatic radical or substituted aliphatic radical,R.sup.4 and R.sup.5 are lower alkyl and R.sup.5 may also be hydrogen,X and Y are oxygen, sulfur, sulfinyl or sulfonyl andX.sup.1 is oxygen or sulfur, and herbicides containing these compounds.

摘要翻译： 具有下式的其中R 1和R 2是脂族基团，脂环族基团或取代的脂肪族基团的式I-1,2,4,6-三噻嗪-1,1-二氧化物，R 1也可以是未取代的或取代的苯基 ，未取代或取代的苄基或四氢呋喃基甲基，R 2还可以是低级烷氧基羧基 - 低级烷氧基，低级烷基巯基 - 低碳烷基，低级烷氧基 - 低碳烷基巯基，低级烷基巯基 - 低碳烷基巯基，未取代或取代的芳基或未取代的 取代的苄基，R 3是氢，脂族基团，脂环族基团或取代的脂族基团，R 4和R 5是低级烷基，R 5也可以是氢，X和Y是氧，硫，亚磺酰基或磺酰基，X 1是氧或硫， 和含有这些化合物的除草剂。

公开(公告)号：US20130029325A1

公开(公告)日：2013-01-31

申请号：US13637025

申请日：2011-03-22

申请人： Nobuyuki Kurosawa ,  Masaharu Isobe

发明人： Nobuyuki Kurosawa ,  Masaharu Isobe

IPC分类号： G01N21/64 ,  C07D313/00 ,  C07C311/63 ,  C12N5/071 ,  C07K14/00

CPC分类号： G01N33/582 ,  G01N33/56966

摘要： A method which can isolate plasma cells and plasmablasts efficiently and with high purity, from mammals and birds, without using a cell surface marker is provided.Further disclosed is a fluorescent probe wherein the staining selectivity for the endoplasmic reticulum of cells is higher than the staining selectivity for cell organelles other than the endoplasmic reticulum. Also disclosed is a method for identifying plasma cells and plasmablasts which includes staining cells derived from lymph node tissue or similar by using this probe, and identifying plasma cells and plasmablasts on the basis of the fluorescence intensity from the stained cells. Also disclosed is a fluorescent probe wherein the staining selectivity for cell nuclei is higher than the staining selectivity for cell organelles other than the cell nuclei. Also disclosed is a method for identifying plasma cells and plasmablasts in lymph node tissue or similar which includes staining cells derived from lymph node tissue or similar by using this probe, and identifying plasma cells and plasmablasts on the basis of the fluorescence intensity from the stained cells.

摘要翻译： 提供了一种可以不使用细胞表面标记物从哺乳动物和鸟类中高效分离血浆细胞和浆细胞而获得高纯度的方法。 进一步公开了一种荧光探针，其中细胞的内质网的染色选择性高于除内质网以外的细胞器的染色选择性。 还公开了一种用于鉴定浆细胞和浆细胞的方法，其包括通过使用该探针染色衍生自淋巴结组织或类似物的细胞，并且基于来自染色细胞的荧光强度鉴定浆细胞和浆细胞。 还公开了一种荧光探针，其中细胞核的染色选择性高于细胞核以外的细胞器的染色选择性。 还公开了一种用于鉴定淋巴结组织或类似物中的浆细胞和浆细胞的方法，其包括通过使用该探针来染色来自淋巴结组织或类似物的细胞，并且基于来自染色细胞的荧光强度鉴定浆细胞和浆细胞 。

公开(公告)号：US3736122A

公开(公告)日：1973-05-29

申请号：US3736122D

申请日：1969-04-10

申请人： TUNG C ,  HAMM P C

发明人： TUNG C ,  HAMM P C

IPC分类号： C07C311/63 ,  A01N9/16

CPC分类号： C07C311/63

摘要： HERBICIDAL USE OF COMPOUNDS OF THE FORMULA

(RN-C6H4-SO2-N-CO-N(-R2)-R'')(-) HN(+)(-R6)(-R7)-R8

WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF CHLORO, CARBON ATOMS, ALKOXY HAVING A MAXIMUM OF FOUR CARBROMO, IODO, CYANO, ALKYL HAVING A MIXIMUM OF FOUR BON ATOMS, NITRO, AMINO AND THE GROUP

-NH-CO-R3

WHEREIN R3 IS HYDROGEN OR ALKYL HAVING A MAXIMUM OF FOUR CARBON ATOMS, N IS THE INTEGER ONE TO THREE, PROVIDED THAT WHEN N IS ONE, R IS SUBSTITUTED IN THE 4''-POSITION OF THE PHENYL RING, R'' AND R2 ARE EACH INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKYL HAVING A MAXIMUM OF TWELVE CARBON ATOMS, ALKOXY HAVING A MAXIMUM OF FIVE CARBON ATOMS, ALKYNYL HAVING AT LEAST THREE AND A MAXIMUM OF FIVE CARBON ATOMS, CYCLOALKENYL HAVING AT LEAST FIVE AND A MAXIMUM OF SEVEN CARBON ATOMS, CYCLOALKYL HAVING AT LEAST FIVE AND A MAXIMUM OF SEVEN CARBON ATOMS, MONO SUBSTITUTED CYCLOALKYL SAID SUBSTITUENT BEING ALKYL HAVING A MAXIMUM OF FOUR CARBON ATOMS, PHENYL, SUBSTITUTED PHENYL HAVING A MAXIMUM OF THREE SUBSTITUENTS SAID SUBSTITUENTS BEING SELECTED FROM THE GROUP CONSISTING OF ALKYL HAVING A MAXIMUM OF FOUR CARBON ATOMS, BROBROMINE AND THE ROUP FOUR CARBON ATOMS, TRIFLUOROMETHYL, PHENOXY, MONO AND DIHALOGENATED PHENOXY SAID HALOGEN BEING CHLORINE OR BROME AND THE GROUP

-OOC-N(-R4)-R5

SAID GROUP BEING IN THE 3-POSITION WHEREIN R4 AND R5 ARE EACH INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ALKYL HAVING A MAXIMUM OF FOUR CARBON ATMS, R6 R7 AND R8 ARE EACH INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKYL HAVING A MAXIMUM OF TWELVE CARBON ATOMS, ALKENYL HAVING A MAXIMUM OF SIX CARBON ATOMS PROVIDED THAT THE ACETYLENIC LINKAGE IS NOT ON THE CARBON ATTACHED TO THE NITROGEN, HYDROXYALKYL HAVING A MAXIMUM OF SIX CARBON ATOMS, TWO OF THE GROUPS R5, R6 AND R7 CAN BE JOINED TOGETHER TO FORM AN ALKYLENE HAVING FOUR TO SEVEN CARBON ATOMS, PROVIDED THAT WHEN TWO OF THE GROUPS R5, R6 AND R7 ARE JOINED TOGETHER THE REMAINING GROUP IS HYDROGEN, AND FURTHER PROVIDED THAT THE GROUPS R5, R6 AND R7 ARE NOT ALL HYDROGEN.

公开(公告)号：US4521597A

公开(公告)日：1985-06-04

申请号：US542312

申请日：1983-10-14

申请人： Haukur Kristinsson ,  Werner Topfl

发明人： Haukur Kristinsson ,  Werner Topfl

IPC分类号： C07D251/46 ,  A01N47/36 ,  A01N47/42 ,  C07C67/00 ,  C07C301/00 ,  C07C303/38 ,  C07C303/40 ,  C07C311/63 ,  C07D239/42 ,  C07D239/47 ,  C07D251/16 ,  C07D521/00 ,  C07D251/18 ,  C07D239/69 ,  C07D251/52

CPC分类号： C07D521/00

摘要： A novel process for producing sulfonylureas of the formula I having a herbicidal action and an action regulating plant growth ##STR1## wherein A is an unsubstituted or substituted phenyl, naphthyl, furan, thiophene or pyridine group, E is a nitrogen atom or the methine group, R.sub.a is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -haloalkyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.1 -C.sub.5 -haloalkoxy, C.sub.1 -C.sub.5 -alkylthio or C.sub.2 -C.sub.10 -alkoxyalkoxy, and R.sub.b is the same as R.sub.a or is an unsubstituted or substituted amino group, and salts thereof, which process comprises firstly condensing an imidocarbonic acid ester with a sulfonyl chloride of the formula II to the sulfonylimidocarbonic acid diester of the formula IV ##STR2## wherein R is an alkyl group, and reacting this in an ethereal solvent in the presence of sodium hydride or potassium tertbutylate with a 2-aminopyrimidine or 2-amino-1,3,5-triazine of the formula V, and finally reacting the formed sulfonylisourea of the formula VI in an organic solvent with hydrochloric acid to obtain the sulfonylurea of the formula I, and isolating this as such or as a salt; ##STR3## The sulfonylimidocarbonic acid diesters of the formula IV and certain sulfonylisoureas of the formula VI, required as intermediates, are novel compounds. The process has the advantage that no sulfonamides are needed as intermediates.

摘要翻译： 一种制备具有除草作用和调节植物生长作用的式I的磺酰脲的新方法，其中A是未取代或取代的苯基，萘基，呋喃，噻吩或吡啶基，E是氮原子或 次甲基，R a为氢，卤素，C 1 -C 5 - 烷基，C 1 -C 5 - 卤代烷基，C 1 -C 5 - 烷氧基，C 1 -C 5 - 卤代烷氧基，C 1 -C 5 - 烷硫基或C 2 -C 10 - 烷氧基烷氧基，Rb为 与R a相同或为未取代或取代的氨基及其盐，该方法包括首先将亚氨基碳酸酯与式II的磺酰氯缩合成式IV的磺酰亚胺基碳酸二酯其中R是烷基 并将其在惰性溶剂中，在氢化钠或叔丁醇钾存在下与式V的2-氨基嘧啶或2-氨基-1,3,5-三嗪反应，最后使形成的式VI的磺酰基异脲 在有盐酸的有机溶剂中 在式I的磺酰脲中，并将其分离为盐或盐; 作为中间体，式IV的磺酰亚胺基碳酸二酯和式VI的某些磺酰基异脲是新化合物。 该方法的优点是不需要磺酰胺作为中间体。

公开(公告)号：US4316015A

公开(公告)日：1982-02-16

申请号：US199820

申请日：1980-10-23

申请人： Gerhard Hamprecht ,  Rolf-Dieter Acker ,  Bruno Wuerzer

发明人： Gerhard Hamprecht ,  Rolf-Dieter Acker ,  Bruno Wuerzer

IPC分类号： A01N43/72 ,  A01P13/00 ,  C07C311/63 ,  C07D251/38 ,  C07D285/00 ,  C07D285/15

CPC分类号： C07D285/15 ,  A01N43/72 ,  C07C311/63

摘要： 6H-1,2,4,6-Thiatriazine-1,1-dioxides of the formula I ##STR1## where R.sup.1 is an aliphatic radical, a cycloaliphatic radical, a substituted aliphatic radical, a cycloalkoxy-substituted aliphatic radical, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl, R.sup.2 is hydrogen, an aliphatic radical, a cycloaliphatic radical or substituted alkyl, X is oxygen, sulfur, sulfinyl or sulfonyl and Hal is halogen, herbicides containing these compounds, processes for their preparation, and methods for using the products as herbicides.

摘要翻译： 式I的6H-1,2,4,6-三噻嗪-1,1-二氧化物其中R 1是脂族基团，脂环族基团，取代的脂族基团，环烷氧基取代的脂族基团，未取代的或未取代的 取代的苯基或未取代或取代的苄基，R 2是氢，脂族基团，脂环族基团或取代的烷基，X是氧，硫，亚磺酰基或磺酰基，Hal是卤素，含有这些化合物的除草剂，其制备方法和方法 用作除草剂的产品。

公开(公告)号：US4316014A

公开(公告)日：1982-02-16

申请号：US166856

申请日：1980-07-08

申请人： Gerhard Hamprecht ,  Rolf-Dieter Acker ,  Bruno Wuerzer

发明人： Gerhard Hamprecht ,  Rolf-Dieter Acker ,  Bruno Wuerzer

IPC分类号： A01N43/72 ,  A01P13/00 ,  C07C275/70 ,  C07C311/63 ,  C07C335/32 ,  C07C335/36 ,  C07D285/00 ,  C07D285/15

CPC分类号： C07D285/15 ,  A01N43/72 ,  C07C275/70 ,  C07C311/63 ,  C07C335/32 ,  C07C335/36

摘要： 5,6-Dihydro-1,2,4,6-thiatriazin-5-one-1,1-dioxides of the formula ##STR1## where R.sup.1 is hydrogen, a metal atom or an unsubstituted or substituted ammonium radical,R.sup.2 is a saturated or unsaturated straight-chain aliphatic radical of up to 10 carbon atoms, a cycloaliphatic radical or 3 to 7 carbon atoms, a branched saturated or unsaturated aliphatic radical of 3 to 10 carbon atoms, a halogen-, alkoxy- or alkylmercapto-substituted aliphatic radical of 2 to 10 carbon atoms tetrahydrofuryl substituted methyl, a cycloalkoxy-substituted aliphatic radical of 4 to 10 carbon atoms, unsubstituted or halogen-substituted benzyl or phenyl, halophenyl, or alkylphenyl of a total of up to 10 carbon atoms,R.sup.3 is hydrogen, a straight-chain aliphatic radical of up to 10 carbon atoms, a cycloaliphatic radical of 3 to 7 carbon atoms, a branched aliphatic radical of 3 to 10 carbon atoms, haloalkyl, or alkoxyalkyl of 2 to 10 carbon atoms andX is oxygen and may also be sulfur if R.sup.2 is unsubstituted or halogen-substituted benzyl, processes for their preparation, and herbicides containing the above compounds.

摘要翻译： 其中R 1是氢，金属原子或未取代的或取代的铵基的式Ⅰa的5,6-二氢-1,2,4,6-三噻嗪-5-酮-1,1-二氧化物，R2是 具有至多10个碳原子的饱和或不饱和直链脂族基团，脂环族基团或3至7个碳原子，3至10个碳原子的支链饱和或不饱和脂族基团，卤素，烷氧基或烷基巯基取代的 2至10个碳原子的脂族基团，四氢呋喃基取代的甲基，4-10个碳原子的环烷氧基取代的脂肪族基团，未取代的或卤素取代的苄基或苯基，卤代苯基或总共多至10个碳原子的烷基苯基，R3是 氢，至多10个碳原子的直链脂族基团，3至7个碳原子的脂环族基团，3至10个碳原子的支链脂族基团，卤代烷基或2至10个碳原子的烷氧基烷基，X是氧 如果R 2是未取代的或卤代的，也可以是硫 正取代的苄基，其制备方法和含有上述化合物的除草剂。

公开(公告)号：US20240254120A1

公开(公告)日：2024-08-01

申请号：US18538687

申请日：2023-12-13

申请人： Arrys Therapeutics, Inc. ,  Askat Inc.

发明人： Mark MANFREDI ,  Jeffrey Ecsedy ,  Alfredo C. Castro ,  Yoshiyuki Okumura

IPC分类号： C07D471/04 ,  C07C311/16 ,  C07C311/63 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07C311/16 ,  C07C311/63 ,  C07D519/00

摘要： The present invention provides N-((4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethyl)carbamoyl)-4-methylbenzenesulfonamide compositions, and the use thereof for treating a proliferative disorder.

公开(公告)号：US20210300921A1

公开(公告)日：2021-09-30

申请号：US17258527

申请日：2019-07-11

申请人： Arrys Therapeutics, Inc. ,  AskAt Inc.

发明人： Mark MANFREDI ,  Jeffrey ECSEDY ,  Alfredo C. CASTRO ,  Yoshiyuki OKUMURA

IPC分类号： C07D471/04 ,  C07D519/00 ,  C07C311/63 ,  C07C311/16

摘要： The present invention provides N-((4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethyl)carbamoyl)-4-methylbenzenesulfonamide compositions, and the use thereof for treating a proliferative disorder.