公开(公告)号：US07455964B1

公开(公告)日：2008-11-25

申请号：US08785532

申请日：1997-01-17

申请人： Joe W. Gray ,  Colin Conrad Collins ,  Soo-in Hwang ,  Tony Godfrey ,  David Kowbel ,  Johanna Rommens

发明人： Joe W. Gray ,  Colin Conrad Collins ,  Soo-in Hwang ,  Tony Godfrey ,  David Kowbel ,  Johanna Rommens

IPC分类号： C12N1/68

CPC分类号： C12Q1/6886 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/82 ,  C12N9/1205 ,  C12N9/90 ,  C12Q2600/112 ,  C12Q2600/118 ,  G01N33/6893 ,  Y10S436/813

摘要： The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.

公开(公告)号：US07429481B2

公开(公告)日：2008-09-30

申请号：US11227778

申请日：2005-09-14

申请人： Ira Bergman ,  Patricia Whitaker-Dowling

发明人： Ira Bergman ,  Patricia Whitaker-Dowling

IPC分类号： C12N1/68 ,  C12N15/00

CPC分类号： C12N7/00 ,  A61K35/13 ,  A61K48/00 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/33 ,  C12N15/86 ,  C12N2710/16743 ,  C12N2710/16745 ,  C12N2760/20222 ,  C12N2760/20262 ,  C12N2770/36122 ,  C12N2810/60 ,  C12N2810/80

摘要： The present invention relates to viruses that are engineered to contain a surface ligand molecule which targets the virus to a cell of interest. In particular non-limiting embodiments, the cell of interest is desirably ablated and may be a cancer cell, an infected cell, a cell exhibiting a non-malignant proliferative disorder, or a cell of the immune system. Alternatively, the cell of interest is a target for gene therapy.

摘要翻译： 本发明涉及被工程化以含有将病毒靶向感兴趣的细胞的表面配体分子的病毒。 特别是非限制性实施方案，希望消除感兴趣的细胞，并且可以是癌细胞，感染细胞，显示非恶性增殖性病症的细胞或免疫系统的细胞。 或者，感兴趣的细胞是基因治疗的靶标。

公开(公告)号：US07713699B2

公开(公告)日：2010-05-11

申请号：US11897997

申请日：2007-08-31

申请人： John N. Feder ,  Thomas C. Nelson ,  Chandra S. Ramanathan ,  Rolf-Peter Ryseck ,  Michael G. Kornacker

发明人： John N. Feder ,  Thomas C. Nelson ,  Chandra S. Ramanathan ,  Rolf-Peter Ryseck ,  Michael G. Kornacker

IPC分类号： C12N1/68 ,  G01N33/48 ,  C07K14/705

CPC分类号： G01N33/5008 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/28 ,  C07K2319/30 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/6893 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2510/00 ,  G01N2800/347 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法 以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07229766B2

公开(公告)日：2007-06-12

申请号：US10600389

申请日：2003-06-20

申请人： Vepkhia Pilauri ,  James E. Hopper ,  Gang Peng ,  Tamara Vyshkina

发明人： Vepkhia Pilauri ,  James E. Hopper ,  Gang Peng ,  Tamara Vyshkina

IPC分类号： C12N1/68 ,  C12N15/63 ,  C07H21/04 ,  C12N1/00

CPC分类号： C40B30/04

摘要： The invention provides methods for detecting and analyzing protein-protein interactions and agonists and antagonists thereof, detecting and analyzing protein sequences, and regulatable gene expression in multicellular organisms or cells therefrom.

摘要翻译： 本发明提供了用于检测和分析蛋白质 - 蛋白质相互作用及其激动剂及其拮抗剂，检测和分析蛋白质序列以及多细胞生物体或细胞中可调节基因表达的方法。