公开(公告)号：US20100119550A1

公开(公告)日：2010-05-13

申请号：US12094757

申请日：2005-11-24

申请人： Yasuyuki Gomi ,  Michiaki Takahashi ,  Koichi Yamanishi

发明人： Yasuyuki Gomi ,  Michiaki Takahashi ,  Koichi Yamanishi

IPC分类号： A61K39/00 ,  C12N7/01 ,  A61K45/00 ,  C12N15/74 ,  C12N1/21 ,  C12N5/071 ,  C12N15/64 ,  A61P31/04 ,  A61P37/04

CPC分类号： A61K39/25 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2710/16762 ,  C12N2760/18734 ,  C12N2800/204 ,  C12N2800/50 ,  C12N2820/55 ,  Y02A50/39 ,  Y02A50/394

摘要： The problems to be solved by the present invention are to provide: a recombinant varicella-zoster virus; a process for producing the same; a pharmacological composition containing a recombinant varicella-zoster virus; a vector containing a BAC vector sequence in the specific gene of a genomic gene of varicella-zoster virus; cells containing such a vector; a fragment capable of homologous recombination with a genome of varicella-zoster virus; a nucleic acid cassette containing the BAC vector sequence; and a multivalent vaccine. The above problems were solved by developing a process for producing a recombinant varicella-zoster virus, wherein the BAC vector sequence is inserted into a specific virus gene.

摘要翻译： 本发明要解决的问题是提供：重组水痘带状疱疹病毒; 其制造方法; 含有重组水痘带状疱疹病毒的药物组合物; 在水痘带状疱疹病毒基因组基因的特定基因中含有BAC载体序列的载体; 含有这种载体的细胞; 能够与水痘带状疱疹病毒基因组同源重组的片段; 含有BAC载体序列的核酸盒; 和多价疫苗。 通过开发生产重组水痘带状疱疹病毒的方法解决了上述问题，其中将BAC载体序列插入到特定病毒基因中。

公开(公告)号：US07659114B2

公开(公告)日：2010-02-09

申请号：US11869896

申请日：2007-10-10

申请人： Kazuo Kawakami ,  Masahiko Kishi ,  Masami Mochizuki

发明人： Kazuo Kawakami ,  Masahiko Kishi ,  Masami Mochizuki

IPC分类号： A61A48/00 ,  C12N15/63

CPC分类号： C12N7/00 ,  A61K48/00 ,  A61K2039/525 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/16622 ,  C12N2710/16722 ,  C12N2710/16743 ,  C12N2710/16761

摘要： An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication of FHV-1 and has least two types of foreign nucleic acid sequences inserted thereinto, usable as a vector virus or a vaccine. In this attenuated recombinant FHV-1, at least two types of foreign genes are inserted in such a manner as allowing the expression into two different gene regions exerting no lethal effect on the proliferation of the virus in the feline herpesvirus 1 genome.

摘要翻译： 一种减毒的猫重组疱疹病毒1（FHV-1），其通过鉴定基因组中的基因区域而制备，其中可以表达插入的外来基因而不影响FHV-1的复制，并且其中插入有至少两种类型的外来核酸序列， 可用作载体病毒或疫苗。 在这种减毒的重组FHV-1中，插入至少两种类型的外来基因，使得能够表达两个不同的基因区域，对猫疱疹病毒1基因组中病毒的增殖没有致死作用。

公开(公告)号：US20060160202A1

公开(公告)日：2006-07-20

申请号：US10772806

申请日：2004-02-05

申请人： Nikolaus Osterrieder ,  Jens Rudolph

发明人： Nikolaus Osterrieder ,  Jens Rudolph

IPC分类号： C12N15/869 ,  C12N7/00 ,  C07H21/04

CPC分类号： C12N15/86 ,  A61K2039/5256 ,  C12N7/00 ,  C12N2710/16661 ,  C12N2710/16743 ,  C12N2710/16761 ,  C12N2800/204

摘要： The invention belongs to the field of animal health, in particular equine diseases caused by equine herpesvirus (EHV). The invention relates to artificial chromosomes comprising the genome of equine herpesviruses, methods of producing attenuated or virulent EHV with or without the insertion of foreign genes, EHV obtainable with said methods and pharmaceutical compositions comprising said viruses.

公开(公告)号：US20040185056A1

公开(公告)日：2004-09-23

申请号：US10752482

申请日：2004-01-05

申请人： Board of Regents, University of Nebraska-Lincoln

发明人： Clinton J. Jones

IPC分类号： A61K039/00 ,  A61K039/38

CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/265 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2710/16761

摘要： Vaccines for pathogenic strains of bovine herpesvirus 1 (BHV-1) which are based on attenuated BHV-1 having a mutation in the latency-related gene are provided. Live, attenuated vaccines are also provided which express antigens from other viral or bacterial pathogens and thus form the basis of a variety of vaccines.

摘要翻译： 提供了基于在潜伏期相关基因中具有突变的减毒BHV-1的牛疱疹病毒1（BHV-1）的致病菌株的疫苗。 还提供活的，减毒的疫苗，其表达来自其他病毒或细菌病原体的抗原，因此形成各种疫苗的基础。

公开(公告)号：US06410311B1

公开(公告)日：2002-06-25

申请号：US08854110

申请日：1997-05-09

申请人： Mark D. Cochran ,  Barbara J. Winslow

发明人： Mark D. Cochran ,  Barbara J. Winslow

IPC分类号： A61K3929

CPC分类号： C12N15/86 ,  A61K39/00 ,  C12N2710/16743 ,  Y10S435/948

摘要： This invention provides a recombinant feline herpesvirus comprising a foreign DNA inserted into a feline herpesvirus genome, wherein the foreign DNA is inserted into a region of the genome which corresponds to the 3.0 kb EcoRI-SalI fragment within a SalI A fragment of the feline herpesvirus genome and is capable of being expressed in a host cell into which the virus is introduced. Further this invention provides a recombinant feline herpesvirus comprising a feline herpesvirus genome, wherein the feline herpesvirus genome contains a deletion in a SacII site within the 3.0 kb EcoRI-SalI fragment of the SalI A fragment of the feline herpesvirus genome. Lastly, this invention provides vaccines and methods of immunization of animals infected with feline herpesvirus.

摘要翻译： 本发明提供了一种重组猫疱疹病毒，其包含插入到猫疱疹病毒基因组中的外源DNA，其中将外源DNA插入到与猫疱疹病毒基因组的SalI A片段内的3.0kb EcoRI-SalI片段相对应的基因组区域 并且能够在引入病毒的宿主细胞中表达。 此外，本发明提供了包含猫疱疹病毒基因组的重组猫疱疹病毒，其中猫疱疹病毒基因组在猫疱疹病毒基因组的SalI A片段的3.0kb EcoRI-SalI片段中的SacII位点中含有缺失。 最后，本发明提供疫苗和感染猫疱疹病毒的动物的免疫方法。

公开(公告)号：US06387376B1

公开(公告)日：2002-05-14

申请号：US09531857

申请日：2000-03-21

申请人： Jean-Christophe Francis Audonnet ,  Philippe Guy Nicolas Baudu ,  Michel Albert Emile Riviere

发明人： Jean-Christophe Francis Audonnet ,  Philippe Guy Nicolas Baudu ,  Michel Albert Emile Riviere

IPC分类号： A61K3912

CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N2710/16743 ,  C12N2770/20022

摘要： The recombinant live vaccine comprises, as vector, a feline herpesvirus comprising and expressing at least one nucleotide sequence encoding a polypeptide, this sequence being inserted into the ORF5 and/or ORF2 sites. Polyvalent vaccine formula and feline herpesvirus DNA fragments.

摘要翻译： 重组活疫苗作为载体包含包含并表达至少一个编码多肽的核苷酸序列的猫疱疹病毒，该序列插入ORF5和/或ORF2位点。 多价疫苗配方和猫疱疹病毒DNA片段。

公开(公告)号：US6099843A

公开(公告)日：2000-08-08

申请号：US483474

申请日：1995-06-07

申请人： Robert B. Grieve ,  Glenn R. Frank ,  Nancy Wisnewski

发明人： Robert B. Grieve ,  Glenn R. Frank ,  Nancy Wisnewski

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61P33/02 ,  C07K14/44 ,  C12N15/30

CPC分类号： C12N9/18 ,  A61K39/0003 ,  A61K2039/5256 ,  A61K2039/552 ,  C12N2710/16743 ,  C12N2770/36143

摘要： The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit parasitic helminth phospholipase A.sub.2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.

摘要翻译： 本发明涉及寄生蠕虫PLA2蛋白; 包括寄生虫的PLA2核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制寄生蠕虫磷脂酶A2活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

公开(公告)号：US6083511A

公开(公告)日：2000-07-04

申请号：US920562

申请日：1997-08-29

申请人： David Edward Onions ,  Lesley Nicolson

发明人： David Edward Onions ,  Lesley Nicolson

IPC分类号： A61K39/245 ,  A61K39/00 ,  A61P31/12 ,  A61P31/22 ,  C07K14/00 ,  C07K14/03 ,  C07K16/00 ,  C07K16/08 ,  C12N1/21 ,  C12N15/09 ,  C12N15/38 ,  C12P21/02 ,  C12R1/19 ,  C12R1/92 ,  A61K39/255 ,  A61K39/27 ,  C07K1/00

CPC分类号： C07K14/005 ,  C07K16/08 ,  A61K39/00 ,  C12N2710/16722 ,  C12N2710/16734 ,  C12N2710/16743

摘要： The present invention involves isolated equine herpesvirus-4 (EHV-4) or gH or gC polypeptides and antigenic fragments. Methods of using the polypeptides and the fragments thereof are also presented.

摘要翻译： 本发明涉及分离的马疱疹病毒-4（EHV-4）或gH或gC多肽和抗原片段。 还提出了使用多肽及其片段的方法。

公开(公告)号：US5874280A

公开(公告)日：1999-02-23

申请号：US344833

申请日：1994-11-23

申请人： Gunther Keil

发明人： Gunther Keil

IPC分类号： C07K14/06 ,  C12N7/00 ,  C12N7/01 ,  C12N15/869 ,  A61K39/245 ,  C07H21/04

CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16722 ,  C12N2710/16743

摘要： The present invention is concerned with a Bovine Herpesvirus I (BHV-I) mutant comprising a heterologous gene introduced into a section of the BHV-I genome. The invention also relates to a vector vaccine comprising such a BHV-I mutant which expresses a heterologous polypeptide derived from a bovine pathogen and induces an adequate immune response in an inoculated host against both FHV an the bovine pathogen. Furthermore, the invention relates to a method for obtaining a BHV-I mutant by self-selection.

摘要翻译： 本发明涉及包含引入到BHV-1基因组的一部分中的异源基因的牛疱疹病毒I（BHV-1）突变体。 本发明还涉及包含这样的BHV-1突变体的载体疫苗，其表达来自牛病原体的异源多肽，并在接种的宿主中诱导针对牛病原体的FHV的足够的免疫应答。 此外，本发明涉及通过自我选择获得BHV-1突变体的方法。

公开(公告)号：US5804197A

公开(公告)日：1998-09-08

申请号：US680726

申请日：1996-07-12

申请人： Elizabeth J. Haanes ,  Rexann S. Frank

发明人： Elizabeth J. Haanes ,  Rexann S. Frank

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K31/70 ,  A61K39/245 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/22 ,  A61P33/00 ,  A61P37/00 ,  C07K14/03 ,  C12N5/10 ,  C12N7/01 ,  C12N7/04 ,  C12N15/869 ,  A61K39/00 ,  C12N15/00

CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  C12N9/1211 ,  C12N2710/16721 ,  C12N2710/16722 ,  C12N2710/16743

摘要： The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid molecules. The present invention also relates to the use of such genomes and viruses in a variety of applications, including as therapeutic compositions to protect animals from disease. The present invention also relates to novel isolated CHV nucleic acid molecules, to CHV proteins encoded by such nucleic acid molecules, and to antibodies raised against such CHV proteins as well as to the use of such CHV nucleic acid molecules, proteins and antibodies as therapeutic compositions to protect an animal from CHV. The present invention also includes constructs comprising CHV nucleic acid molecules that include heterologous nucleic acid molecules, to recombinant vectors including such constructs, and to the use of such constructs and vectors in the production of recombinant CHV and recombinant CHV genomes.