公开(公告)号：US20240316129A1

公开(公告)日：2024-09-26

申请号：US18570867

申请日：2022-06-16

申请人： The UAB Research Foundation ,  RESBIOTIC NUTRITION, INC.

发明人： Charitharth Vivek LAL ,  Nancy Wenger

IPC分类号： A61K35/747 ,  A61K9/00 ,  A61K36/19 ,  A61K36/53 ,  A61K36/9066

CPC分类号： A61K35/747 ,  A61K9/0053 ,  A61K36/19 ,  A61K36/53 ,  A61K36/9066

摘要： A combination of herbal extracts and a probiotic supplement and formulated as a dietary supplement helps mitigate symptoms of bronchopulmonary disease in conjunction with the anti-inflammatory mechanisms of the probiotics. Provided are embodiments of a probiotic nutraceutical composition that delivers 3 strains of Lactobacillus spp. to the gut lining of human subjects to reduce neutrophilic inflammation as a result of or causative agent of bronchopulmonary disease. In addition to the three Lactobacillus spp. strains, the compositions can include herbal extracts from holy basil, turmeric, and vasaka for respiratory relief.

公开(公告)号：US11974977B2

公开(公告)日：2024-05-07

申请号：US17338338

申请日：2021-06-03

申请人： LUCOLAS—M.D. LTD

发明人： Alfred Schmidt

IPC分类号： A61K8/63 ,  A61K8/9755 ,  A61K8/9789 ,  A61K8/9794 ,  A61K31/215 ,  A61K31/56 ,  A61K31/5685 ,  A61K36/13 ,  A61K36/185 ,  A61K36/19 ,  A61K36/25 ,  A61K36/31 ,  A61K36/32 ,  A61K36/42 ,  A61K36/48 ,  A61K36/889 ,  A61K45/06 ,  A61Q5/08 ,  A61Q7/00 ,  A61Q7/02

CPC分类号： A61K31/215 ,  A61K8/63 ,  A61K8/9755 ,  A61K8/9789 ,  A61K8/9794 ,  A61K31/56 ,  A61K31/5685 ,  A61K36/13 ,  A61K36/185 ,  A61K36/19 ,  A61K36/25 ,  A61K36/31 ,  A61K36/32 ,  A61K36/42 ,  A61K36/48 ,  A61K36/889 ,  A61K45/06 ,  A61Q5/08 ,  A61Q7/00 ,  A61Q7/02 ,  A61K2800/782 ,  A61K31/5685 ,  A61K2300/00 ,  A61K36/13 ,  A61K2300/00 ,  A61K36/185 ,  A61K2300/00 ,  A61K36/19 ,  A61K2300/00 ,  A61K36/25 ,  A61K2300/00 ,  A61K36/31 ,  A61K2300/00 ,  A61K36/32 ,  A61K2300/00 ,  A61K36/42 ,  A61K2300/00 ,  A61K36/48 ,  A61K2300/00 ,  A61K36/889 ,  A61K2300/00

摘要： The invention describes a combination of at least one aromatase inhibitor selected from the group of chemical-synthetic aromatase inhibitors and aromatase inhibition exhibiting extracts of soya beans and rapeseed, respectively, and at least one plant extract that contains one or more active ingredient substance(s) extracted from the plant, which is(are) selected from the group of 5α reductase type I and/or type II inhibitors and androgen receptor blockers, said combination being contained for example in a composition and having special properties for influencing hair growth. Uses of this combination are also described.

公开(公告)号：US20230293620A1

公开(公告)日：2023-09-21

申请号：US18041467

申请日：2021-08-16

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Kiran Bhupathiraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Venkateswarlu Somepalli ,  Venkata Krishna Raju Alluri ,  Krishanu Senguptha

IPC分类号： A61K36/81 ,  A61K36/59 ,  A61K36/19 ,  A61K33/06 ,  A61K33/30 ,  A61P37/02 ,  A61P29/00

CPC分类号： A61K36/81 ,  A61K36/59 ,  A61K36/19 ,  A61K33/06 ,  A61K33/30 ,  A61P37/02 ,  A61P29/00

摘要： The present invention discloses synergistic herbal compositions comprising a first ingredient Terminalia chebula extract containing metal salt or metal complex or metal chelate of at least one phytochemical in the extract selected from chebulagic acid, chebulinic acid, and gallic acid or mixtures thereof; and a second ingredient selected from extract(s), fraction(s), phytochemical(s) or mixtures thereof derived from Withania somnifera, Tinospora cordifolia and Andrographis paniculata; process for their preparation, methods of treatment and use of such compositions for improving immunity and respiratory health.

公开(公告)号：US20230285486A1

公开(公告)日：2023-09-14

申请号：US18079931

申请日：2022-12-13

申请人： Angelica Machado MEY

发明人： Rosa Andrea Nogueira LAISO

IPC分类号： A61K36/19 ,  A61K47/24 ,  A61K47/02 ,  A61P35/00

CPC分类号： A61K36/19 ,  A61K47/24 ,  A61K47/02 ,  A61P35/00

摘要： The present invention refers to a composition for obtaining a natural bioactive for oncologic therapies based on Andrographis paniculata, whose excipient is phosphoryl ethanol amine, and optionally carbonates. The function of the composition is to assist treatments of several types of cancer, and it may be administered as an auxiliary adjuvant in oncologic therapies. Since it consists of diterpenoids, flavonoids and polyphenols as the main bioactive components, it has an anti-inflammatory, antiviral, antibacterial, antioxidant, antiparasitic, antispasmodic, antidiabetic, antipyretic, nematocidal, immunomodulatory and immunostimulatory action. The composition for obtaining a natural bioactive for oncologic therapies comprises: Active principle: Andrographis paniculata, and Excipient: phosphoryl ethanol amine. Optionally, the excipients are comprised of: Phosphoryl ethanol amine-Calcium Carbonate; and Magnesium Carbonate.

公开(公告)号：US20230120111A1

公开(公告)日：2023-04-20

申请号：US17919541

申请日：2019-06-20

申请人： JINGCHU UNIVERSITY OF TECHNOLOGY

发明人： Yang YANG

IPC分类号： A61K36/19 ,  A61K36/489 ,  A61P31/10

摘要： A traditional Chinese medicine composition for treating dermatophytosis and bromhidrosis, which is prepared from radix sophorae flavescentis and peristrophe japonica, has synergistic interaction and anti-fungal effects, and is not easy to produce drug tolerance. After performing compatibility of extracts of matrine and peristrophe japonica, dermatophytosis and bromhidrosis can be treated, and multiple external preparations can be prepared.

公开(公告)号：US20220401500A1

公开(公告)日：2022-12-22

申请号：US17695339

申请日：2022-03-15

申请人： THE UAB RESEARCH FOUNDATION ,  Resbiotic Nutrition, Inc.

发明人： Charitharth Vivek Lal ,  Nancy Wenger

IPC分类号： A61K35/747 ,  A61K36/9066 ,  A61K36/53 ,  A61K36/19 ,  A61K9/00 ,  A23L33/135 ,  A23L33/105

摘要： A combination of herbal extracts and a probiotic supplement and formulated as a dietary supplement helps mitigate symptoms of bronchopulmonary disease in conjunction with the anti-inflammatory mechanisms of the probiotics. Provided are embodiments of a probiotic nutraceutical composition that delivers 3 strains of Lactobacillus spp. to the gut lining of human subjects to reduce neutrophilic inflammation as a result of or causative agent of bronchopulmonary disease. In addition to the three Lactobacillus spp. strains, the compositions can include herbal extracts from holy basil, turmeric, and vasaka for respiratory relief.

公开(公告)号：US11419912B2

公开(公告)日：2022-08-23

申请号：US15958921

申请日：2018-04-20

申请人： Mars, Incorporated

发明人： Jean Soon Park ,  Ping Hu ,  Yakang Lin ,  Lori Ann Reinsalu

IPC分类号： A61K36/9066 ,  A61K36/484 ,  A61K36/889 ,  A61K45/06 ,  A61K36/752 ,  A61K36/77 ,  A61K36/81 ,  A61K36/82 ,  A61K36/835 ,  A61K36/87 ,  A61K36/88 ,  A61K36/9068 ,  A61K36/00 ,  A61K36/15 ,  A61K36/16 ,  A61K36/185 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/324 ,  A61K36/41 ,  A61K36/45 ,  A61K36/47 ,  A61K36/48 ,  A61K36/53 ,  A61K36/54 ,  A61K36/55 ,  A61K36/61 ,  A61K36/634 ,  A61K36/67 ,  A61K36/708 ,  A61K36/718 ,  A61K36/736

摘要： The present invention relates to compositions containing plant materials or extracts with inhibitory effect on a 5-HT3a and/or NK-1 receptor for preventing or treating idiopathic vomiting.

公开(公告)号：US20210299197A1

公开(公告)日：2021-09-30

申请号：US16834351

申请日：2020-03-30

申请人： Script Essentials, LLC

发明人： Suzy Cohen

IPC分类号： A61K36/06 ,  A61K36/63 ,  A61K36/19 ,  A61K31/145 ,  A61K36/539 ,  A61K31/05 ,  A61K9/48 ,  A61K9/20

摘要： The present disclosure relates to methods of administering a composition to a patient, particularly in the form of a dietary supplement, which addresses immune system deficiencies and promotes healthy immune system functioning. The present disclosure also related to compositions and methods for improving or boosting immune system functioning. The present disclosure further provides novel compositions for balancing immune response in human subjects.

公开(公告)号：US10881700B1

公开(公告)日：2021-01-05

申请号：US15725888

申请日：2017-10-05

申请人： KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Dina Ahmed Hajjar ,  Stephan Kremb ,  Christian Voolstra ,  Timothy Ravasi

IPC分类号： A61K36/00 ,  A61K36/19 ,  A61K45/06

摘要： Human Immunodeficiency Virus (HIV) causes AIDS, a life-threatening disease characterized by immunosuppressive, opportunistic infections and malignancies. Although many drugs have been approved over the past decade as suitable for use in the treatment of individuals with HIV, the need for antiviral drugs of greater efficiency is still pressing. One valuable source for antiviral bioactivity has been proven to be the natural products of a wide range of plants. In this study, we investigated the anti-reverse transcriptase (RT)-HIV-1 potential activity of Avicennia marina (gray mangrove) collected from the Red Sea shore, Saudi Arabia. Metabolites from A. marina were extracted using organic solvents followed by solid phase extraction (SPE) and high-performance liquid chromatography (HPLC). Gas chromatography mass spectrometry (GC-MS) was applied to assess the active HPLC fractions and to establish a correlation between the fractions' chemical composition and biological activity. The chemical analyses revealed the existence of many polyphenol compounds. Polyphenol compounds have been proven to act as multi-target anti-HIV agents. Furthermore, imaging-based High-Content Screening (HCS) with a set of cellular staining was established to characterize mechanisms of activity and potential side-effects, such as toxicity and cell cycle arrest. In summary, we discovered and assessed for the first time anti-RT-HIV-1 activity for A. marina collected from Red Sea shore, Saudi Arabia. Our results suggest this plant is a promising candidate for the development of potential novel HIV-1 inhibitors.

公开(公告)号：US20200254043A1

公开(公告)日：2020-08-13

申请号：US16649583

申请日：2018-09-28

申请人： NEILOS S.R.L.

发明人： Umberto DI MAIO

IPC分类号： A61K36/19 ,  A61K36/185 ,  A61K31/198 ,  A61K9/00 ,  A61P11/10 ,  A61P11/14

摘要： The present invention relates to a composition comprising or, alternatively, consisting of an effective amount of a mixture which comprises at least, or consists of: a) an extract of Pelargonium sidoides; b) an extract of Adhatoda vasica; and c) N-acetyl cysteine for use in a method for the preventive or therapeutic treatment of at least one respiratory tract disorder in a subject, wherein said treatment method comprises the administration of said composition to the subject.