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公开(公告)号：US20220331070A1
公开(公告)日：2022-10-20
申请号：US17857903
申请日：2022-07-05
发明人： Jun Fujinami , Miwa Fujinami , Shinichi Okabe , Yohki Hieda , Yasumichi Kogai , Karl Kazushige Kawabe
摘要： This invention provides a measure that makes it possible to prevent more effectively, in comparison with the prior art, the invasion of germs from the gap between a dental prosthesis and the gingiva when the dental prosthesis is used in an oral cavity as well as the infection and inflammation associated therewith.
There is a dental prosthesis or a component thereof, characterized in that: the dental prosthesis or the component thereof has hydroxyapatite fine particles on a surface of the dental prosthesis or the component thereof; the hydroxyapatite fine particles are sintered bodies; and the hydroxyapatite fine particles have a mean particle size of 10 to 1,000 nm.-
公开(公告)号：US11413580B2
公开(公告)日：2022-08-16
申请号：US17435024
申请日：2020-02-28
申请人： IVIVA Medical, Inc.
摘要： Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.
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公开(公告)号：US11318230B2
公开(公告)日：2022-05-03
申请号：US15211986
申请日：2016-07-15
发明人： Samuel E. Lynch
IPC分类号： A61K38/18 , A61L27/12 , A61L27/24 , A61L27/56 , A61P19/08 , A61P19/04 , A61L27/54 , A61L27/40 , A61L27/58 , A61F2/28 , A61L27/22 , A61K9/00 , A61L27/02 , A61L27/42
摘要： A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.
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公开(公告)号：US20210402059A1
公开(公告)日：2021-12-30
申请号：US17471760
申请日：2021-09-10
发明人： Nir ALTSCHULER
IPC分类号： A61L27/36 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/12 , A61L27/20 , A61L27/40 , C01B25/32 , C01F11/18 , G01N1/00 , A61L27/50 , A61F2/28 , A61F2/30 , A61L27/38
摘要： This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which said substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.
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5.发明授权公开(公告)号：US11109955B2
公开(公告)日：2021-09-07
申请号：US16331226
申请日：2017-03-22
发明人： Ik Soo Kim , Han Gyu Kim , Su Yeon Lee
摘要： The present invention relates to a dermal layer which is for grafting and has an improved graft survival rate, and a method for producing the same, wherein the dermal layer for grafting can be produced by filling a filling solution, including a DNA fragment mixture and chitosan, into an acellular dermal matrix from which cells have been removed. It was observed that the dermal layer for grafting produced in this manner, due to the filling solution filled therein and including a DNA fragment mixture and chitosan, increases the rate at which cells flow in from the tissue surrounding the graft and are fixed, and thereby alleviates an initial inflammatory reaction and promotes blending with the surrounding tissue.
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公开(公告)号：US20210228358A1
公开(公告)日：2021-07-29
申请号：US17231784
申请日：2021-04-15
发明人： Robert G. Matheny
摘要： A prosthetic venous valve having a conical shaped base valve member and a biomaterial delivery construct. The base valve member includes a plurality of fluid flow modulating means that open and allow antegrade blood to be transmitted out of the valve member when the valve member receives antegrade blood therein, and close and prevent retrograde blood from flowing into the valve member. The biomaterial delivery construct is adapted to receive and position the base valve member therein, and be disposed proximate a luminal wall of a venous vessel.
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公开(公告)号：US11013829B2
公开(公告)日：2021-05-25
申请号：US16196272
申请日：2018-11-20
申请人： ACell, Inc.
IPC分类号： A61L27/36 , A61L27/26 , A61L27/28 , A61K35/12 , A61K9/14 , A61K9/16 , A61L27/40 , A61L27/50 , A61L27/54 , A61L27/58
摘要： Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.
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公开(公告)号：US10947236B2
公开(公告)日：2021-03-16
申请号：US16539915
申请日：2019-08-13
申请人： OsteoQC Inc.
发明人： Debra Ellies , F. Scott Kimball , Robert N. Young
IPC分类号： C07D471/14 , A61K31/4375 , A61P19/10 , A61L27/54 , A61L27/36 , A61L27/40 , A61L27/28
摘要： In one aspect, the invention provides compounds of Formula I Formula Ia, Formula Ib, Formula Ic, and Formula Id and salts, hydrates and isomers thereof. In another aspect, the invention provides a method of promoting bone formation in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of Formula I, Formula Ia, Formula Ib, Formula Ic, or Formula Id. The present invention also provides orthopedic and periodontal devices, as well as methods for the treatment of renal disease, diabetes bone loss, and cancer, using a compound of Formula I, Formula Ia, Formula Ib, Formula Ic, or Formula Id.
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公开(公告)号：US10806576B2
公开(公告)日：2020-10-20
申请号：US16024252
申请日：2018-06-29
发明人： William C. Bruchman
摘要： Described embodiments are directed toward centrally-opening leaflet support devices having a frame and one or more support leaflets coupled to the frame forming a hinge where coupled. The described support leaflets have one or more stiffer regions that facilitate the function of a support leaflet to decrease or prevent prolapse of a native valve leaflet. Methods of making and using such valve devices are also described amongst others.
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公开(公告)号：US20200261626A1
公开(公告)日：2020-08-20
申请号：US16280706
申请日：2019-02-20
IPC分类号： A61L27/58 , C07C319/20 , A61L27/40 , A61L27/18 , C08G18/38
摘要： A method of making a hydroxyl-terminated thioketal diol is provided, the method comprising reacting a thioketal ester with a non-pyrophoric reducing agent to form a hydroxyl-terminated thioketal diol. The hydroxyl-terminated thioketal diol can be 2,2-(propane-2,2-diylbis(sulfanediyl)) diethanol. The non-pyrophoric reducing agent can be a sodium aluminum hydride, for example, sodium bis(2-methoxyethoxy)aluminum hydride. The thioketal ester can be dimethyl 2,2-(propane-2,2-diylbis(sulfanediyl)) diacetate. A biodegradable matrix prepared by reacting a hydroxyl-terminated thioketal diol with an isocyanate is provided. A method of making a biodegradable polyurethane composite is also provided.
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