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    Solid Substrates for Promoting Cell and Tissue Growth
    1.
    发明申请
    Solid Substrates for Promoting Cell and Tissue Growth 有权

    公开(公告)号：US20210402059A1

    公开(公告)日：2021-12-30

    申请号：US17471760

    申请日：2021-09-10

    申请人： CARTIHEAL (2009) LTD.

    发明人： Nir ALTSCHULER

    IPC分类号： A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/12 ,  A61L27/20 ,  A61L27/40 ,  C01B25/32 ,  C01F11/18 ,  G01N1/00 ,  A61L27/50 ,  A61F2/28 ,  A61F2/30 ,  A61L27/38

    摘要： This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which said substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.

    Solid Substrates for Mitigating or Preventing Cell and Tissue Adhesion and Vascularization
    6.
    发明申请
    Solid Substrates for Mitigating or Preventing Cell and Tissue Adhesion and Vascularization 有权
    用于缓解或预防细胞和组织粘附和血管形成的固体基质

    公开(公告)号：US20150374880A1

    公开(公告)日：2015-12-31

    申请号：US14767432

    申请日：2014-02-10

    申请人： CARTIHEAL (2009) LTD

    发明人： Nir ALTSCHULER

    IPC分类号： A61L27/12 ,  A61L27/40 ,  G01N1/00 ,  A61L27/56 ,  C01B25/32 ,  C01F11/18 ,  A61L27/20 ,  A61L27/54

    CPC分类号： A61L27/3608 ,  A61F2/28 ,  A61F2/30 ,  A61F2/30756 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0086 ,  A61L27/12 ,  A61L27/20 ,  A61L27/3604 ,  A61L27/3637 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3834 ,  A61L27/40 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/112 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2430/02 ,  A61L2430/06 ,  C01B25/32 ,  C01F11/18 ,  C01P2006/90 ,  G01N1/00

    摘要： This invention provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrate comprises a marine organism skeletal derivative and is characterized by a specific fluid uptake capacity value of less than 40%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value and processes for selection of an optimized marine organism skeletal derivative-based solid substrate for mitigating or preventing cell or tissue adherence and/or vascularization and applications of the same. This invention also provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrate is characterized by having a contact angle value of more than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrate is characterized by a minimal surface roughness (Ra) or substantial surface smoothness, as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for mitigating or preventing cell or tissue adherence and/or vascularization and applications of the same.

    摘要翻译： 本发明提供了用于减轻或预防细胞或组织粘附和/或血管形成的固体底物，该固体底物包含海洋生物骨架衍生物，其特征在于小于40％的特定流体吸收容量值，其特定的流体吸收容量值为 通过建立自发流体吸收值除以总流体吸收值和选择用于减轻或预防细胞或组织粘附和/或血管形成及其应用的优化的海洋生物骨骼衍生物固体底物的方法来确定。 本发明还提供了用于减轻或预防细胞或组织粘附和/或血管化的固体底物，该固体底物的特征在于当与流体接触时具有大于60度的接触角值。 本发明还提供了用于减轻或预防细胞或组织粘附和/或血管化的固体底物，该固体底物的特征在于通过扫描电子显微镜或原子力显微镜测量的最小表面粗糙度（Ra）或实质表面平滑度。 本发明还提供了用于选择优化的基于珊瑚的固体底物以减轻或预防细胞或组织粘附和/或血管化及其应用的方法。

    Implantation Tool and Protocol for Optimized Solid Substrates Promoting Cell and Tissue Growth
    7.
    发明申请
    Implantation Tool and Protocol for Optimized Solid Substrates Promoting Cell and Tissue Growth 审中-公开

    公开(公告)号：US20200368027A1

    公开(公告)日：2020-11-26

    申请号：US16959447

    申请日：2018-12-30

    申请人： Cartiheal (2009) Ltd.

    发明人： Nir ALTSCHULER

    IPC分类号： A61F2/30 ,  A61F2/46

    摘要： This invention provides methods for optimal implantation of a solid substrate for promoting cell or tissue growth or restored function in an osteochondral, bone or cartilage tissue in a subject in need thereof. The methods include selecting and preparing a solid substrate for promoting cell or tissue growth or restored function for implantation, which solid substrate has a length and width or that promotes a tight fit within the boundaries of the implantation site and is further characterized by a height sufficient such that when a first terminus of said solid substrate is implanted within a bone in a site for implantation, a second terminus of said solid substrate is at a height at least 2 mm less than an articular cartilage layer surface or is proximal to a tide mark region in said implantation site and optionally applying a biocompatible polymer layer to an apical surface of said implant, which layer does not exceed the articular cartilage layer surface in height. Tools for implementation of optimal positioning are described including a unique tool (5-120) for trimming cartilage at the implantation site.

    Solid Substrates for Promoting Cell and Tissue Growth
    10.
    发明申请
    Solid Substrates for Promoting Cell and Tissue Growth 审中-公开
    用于促进细胞和组织生长的固体基质

    公开(公告)号：US20160000969A1

    公开(公告)日：2016-01-07

    申请号：US14767428

    申请日：2014-02-10

    申请人： CARTIHEAL (2009) LTD

    发明人： Nir ALTSCHULER

    IPC分类号： A61L27/36 ,  A61L27/54 ,  A61L27/20 ,  A61L27/50 ,  A61L27/52

    摘要： This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.

    摘要翻译： 本发明提供用于促进细胞或组织生长或恢复功能的固体底物，该固体底物的特征在于至少75％的特定流体摄取能力值，该特定的流体吸收容量值通过建立自发流体吸收值除以 总液体吸收值。 本发明还提供用于促进细胞或组织生长或恢复功能的固体基质，该固体基质的特征在于当与流体接触时具有小于60度的接触角值。 本发明还提供用于促进细胞或组织生长或恢复功能的固体基质，该固体基质的特征在于通过扫描电子显微镜或原子力显微镜测量的显着表面粗糙度（Ra）。 本发明还提供用于选择优化的基于珊瑚的固体底物以促进细胞或组织生长或恢复其功能和应用的方法。