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公开(公告)号：US11739051B2
公开(公告)日：2023-08-29
申请号：US16968854
申请日：2019-02-06
发明人： Lars Olsson , Viveca T. Oltner
IPC分类号： A61K9/14 , C07C215/40 , A61K9/28 , A61K9/48
CPC分类号： C07C215/40 , A61K9/14 , A61K9/28 , A61K9/4808 , C07B2200/13
摘要： Novel crystalline particles, methods for manufacture of crystalline particles, and solid unit dosage forms, particularly tablets or capsules, of bis-choline tetrathiomolybdate are provided. In particular, provided herein are crystalline particles that allow for a more stable solid unit dosage form of bis-choline tetrathiomolybdate.
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公开(公告)号：US11434405B2
公开(公告)日：2022-09-06
申请号：US17010683
申请日：2020-09-02
IPC分类号： C09K8/06 , C07C213/04 , C07C215/40 , C09K8/34 , C09K8/54 , C09K8/82 , C09K8/86 , E21B41/02
摘要： A quaternary amine composition selected from the group consisting of Formula I, Formula II, Formula III, and combinations of the same. A method of synthesizing a quaternary amine composition comprising the steps of reacting an alkoxylated dimer diamine with a methyl halogen, where the methyl halogen is selected from the group consisting of methyl chloride, methyl iodine, and combinations of the same; and allowing the reaction to proceed to produce the quaternary amine composition, the quaternary amine composition selected from the group consisting of Formula I, Formula II, Formula III, and combinations of the same. A method of treating a well comprising the steps of introducing an additive-containing well fluid to a well, where the additive-containing well fluid comprises a quaternary amine composition and a well fluid, allowing the additive-containing well fluid to interact with the well, and treating the well with the additive-containing fluid.
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公开(公告)号：US11407927B2
公开(公告)日：2022-08-09
申请号：US17010604
申请日：2020-09-02
IPC分类号： C09K8/06 , C07C213/04 , C07C215/40 , C09K8/34 , C09K8/54 , C09K8/82 , C09K8/86 , E21B41/02
摘要： A quaternary amine composition selected from the group consisting of Formula I, Formula II, Formula III, and combinations of the same. A method of synthesizing a quaternary amine composition comprising the steps of reacting an alkoxylated dimer diamine with a methyl halogen, where the methyl halogen is selected from the group consisting of methyl chloride, methyl iodine, and combinations of the same; and allowing the reaction to proceed to produce the quaternary amine composition, the quaternary amine composition selected from the group consisting of Formula I, Formula II, Formula III, and combinations of the same. A method of treating a well comprising the steps of introducing an additive-containing well fluid to a well, where the additive-containing well fluid comprises a quaternary amine composition and a well fluid, allowing the additive-containing well fluid to interact with the well, and treating the well with the additive-containing fluid.
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公开(公告)号：US20210309629A1
公开(公告)日：2021-10-07
申请号：US17285443
申请日：2020-06-12
发明人： Tony Durst , Jay Van Der Vlugt , Amanda Saikaley
IPC分类号： C07D311/80 , C07C215/40 , C07C211/63 , C07D487/08 , C07D487/04 , C07D453/04
摘要： Disclosed are methods for separating, recovering, and purifying tetrahydrocannabinolic acid (THCA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in a selected C5-C7 hydrocarbon solvent, adding thereto a selected amine to thereby precipitate a THCA-amine salt therefrom, dissolving the recovered THCA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallize a purified THCA-amine salt therefrom. The recrystallized THCA-amine salt may be decarboxylated to form a mixture of Δ9-tetrahydrocannabinol (Δ9-THC) and amine. The Δ9-THC amine mixture may be acidified to separate the amine from Δ9-THC. The recovered Δ9-THC may be concentrated to produce a highly purified Δ9-THC. Also disclosed are THCA-amine salts produced with amines selected from groups of diamines, amino alcohols, and tertiary amines.
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公开(公告)号：US20210139499A1
公开(公告)日：2021-05-13
申请号：US17075148
申请日：2020-10-20
发明人： Anuj K. Kumar , Raymond E. Forslund
IPC分类号： C07D495/04 , C07C215/40
摘要： Disclosed herein are thienopyrimidine meglumine salts according to Formula (I) used for treating or preventing heart failure:
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公开(公告)号：US10995220B2
公开(公告)日：2021-05-04
申请号：US15558738
申请日：2016-03-16
发明人： Parthiban Anbanandam
IPC分类号： C09D5/16 , A01N33/12 , C08G18/75 , C08G18/32 , C09D175/04 , C08G18/08 , A01N47/12 , C07C215/40 , C08G18/24 , C09D175/12 , C08G73/02
摘要： Provision of hydroxyl group functionalized quaternary ammonium halides, photocurable or hydrolytically curable urethane based polymers thereof and their use as antifouling agents.
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公开(公告)号：US10689326B2
公开(公告)日：2020-06-23
申请号：US16197076
申请日：2018-11-20
申请人： BASF SE
发明人： Markus Hansch , Harald Boehnke , Wolfgang Grabarse , Hannah Maria Koenig , Arno Lange , Ludwig Voelkel
IPC分类号： C07C215/08 , C07D209/12 , C10M133/44 , C10M133/54 , C10M133/58 , C10M141/06 , C10M161/00 , C10L1/14 , C10L1/232 , C10L1/2383 , C10L10/04 , C10L10/06 , C10M133/08 , C10L1/222 , C07C215/40 , C07C213/04 , C07D207/04 , C10L1/22 , C10L1/188 , C10L1/189
摘要： The present invention relates to novel quaternized ammonium salts of hydrocarbyl epoxides, to the preparation thereof and to the use thereof as a fuel additive and lubricant additive, such as, more particularly, as a detergent additive; for reducing or preventing deposits in the injection systems of direct injection diesel engines, especially in common rail injection systems, for reducing the fuel consumption of direct injection diesel engines, especially of diesel engines with common rail injection systems, and for minimizing power loss in direct injection diesel engines, especially in diesel engines with common rail injection systems; and as an additive for gasoline fuels, especially for operation of DISI engines.
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公开(公告)号：US10683281B2
公开(公告)日：2020-06-16
申请号：US16535553
申请日：2019-08-08
申请人： Pfizer Inc.
发明人： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , David James Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Yajing Lian , Chris Limberakis , Allyn T. Londregan , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC分类号： C07D405/12 , C07D405/14 , C07C53/06 , C07C53/10 , C07C215/40 , C07D413/14 , C07D471/04
摘要： Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US10577334B2
公开(公告)日：2020-03-03
申请号：US16098586
申请日：2017-05-05
发明人： Minhua Chen , Yanfeng Zhang , Jiaoyang Li , Xiaoyu Zhang
IPC分类号： C07D263/57 , C07C215/40 , A61K31/423 , A61P25/28
摘要： The present disclosure relates to a novel crystalline form E of Tafamidis meglumine, process for preparation and use thereof. When compared with prior crystalline forms, the novel crystalline form of the present disclosure has the advantages of simple process and low hygroscopicity, which provides a new and better choice for the development of Tafamidis meglumine drug product and is of great significance.
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公开(公告)号：US20190382384A1
公开(公告)日：2019-12-19
申请号：US16436311
申请日：2019-06-10
申请人： Pfizer Inc.
发明人： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , David James Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Yajing Lian , Chris Limberakis , Allyn T. Londregan , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC分类号： C07D405/12 , C07D471/04 , C07D405/14 , C07D413/14 , C07C53/06 , C07C53/10 , C07C215/40
摘要： Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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