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165 条记录 (耗时 0.025 秒)

    G-protein-conjugated receptor agonist
    2.
    发明授权
    G-protein-conjugated receptor agonist 失效
    G蛋白偶联受体激动剂

    公开(公告)号：US08318781B2

    公开(公告)日：2012-11-27

    申请号：US12597281

    申请日：2008-04-25

    申请人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

    发明人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

    IPC分类号： A01N43/40 ,  A01N43/78 ,  A01N37/12 ,  A01N37/44 ,  A01N43/00 ,  A61K31/445 ,  A61K31/425 ,  A61K31/33 ,  C07D213/72 ,  C07D213/78 ,  C07D277/82 ,  C07C63/00 ,  C07C65/00

    CPC分类号： C07C311/51 ,  C07C217/18 ,  C07D213/74 ,  C07D215/12 ,  C07D257/04

    摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].

    摘要翻译： 公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂， 胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂 垂体激素分泌障碍或脂质调味剂/调味剂。 芳烷基羧酸化合物由通式（I）表示。 （I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

    Tissue Factor Production Inhibitor
    5.
    发明申请
    Tissue Factor Production Inhibitor 审中-公开
    组织因子生产抑制剂

    公开(公告)号：US20080255111A1

    公开(公告)日：2008-10-16

    申请号：US11571367

    申请日：2005-07-01

    申请人： Naoki Terasaka ,  Ayano Hiroshima

    发明人： Naoki Terasaka ,  Ayano Hiroshima

    IPC分类号： A61K31/5377 ,  C07D239/88 ,  A61K31/517 ,  A61K31/404 ,  C07D209/20 ,  A61K31/24 ,  C07C229/52 ,  C07C65/00 ,  A61K31/192 ,  A61P7/02 ,  C07D413/04

    CPC分类号： A61K9/06 ,  A61K9/10 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K9/4875 ,  A61K31/18 ,  A61K31/192 ,  A61K31/381 ,  A61K31/404 ,  A61K31/44 ,  A61K31/517 ,  C07D209/12 ,  C07D239/90 ,  C07D333/24 ,  C07D401/14 ,  C07D409/06 ,  C07D409/12

    摘要： A medicament which has an activity of inhibiting production of tissue factor and comprises an LXR ligand as an active ingredient; and a medicament for treatment and/or prophylaxis of vascular restenosis following angioplasty, endarterectomy, percutaneous transluminal coronary angioplasty (PTCA) or stent implantation, or treatment and/or prophylaxis of blood coagulation diseases, diseases induced by platelet aggregation including stable or unstable angina pectoris, cardiovascular and cerebrovascular diseases including thromboembolism formation diseases accompanying diabetes, rethrombosis following thrombolysis, cerebral ischemic attack, infarction, stroke, ischemia-derived dementia, peripheral artery disease, thromboembolism formation diseases during use of an aorta-coronary artery bypass, glomerulosclerosis, renal embolism, tumor or cancer metastasis, which comprises an LXR ligand as an active ingredient.

    摘要翻译： 具有抑制组织因子产生的活性的药物，其包含LXR配体作为活性成分; 以及用于治疗和/或预防血管成形术，内膜切除术，经皮腔内冠状动脉成形术（PTCA）或支架植入术后的血管再狭窄或治疗和/或预防血液凝固疾病，由血小板聚集引起的疾病的药物，包括稳定或不稳定的心绞痛 ，包括伴随糖尿病的血栓栓塞形成疾病，溶栓后血栓形成，脑缺血发作，梗死，中风，局部缺血性痴呆，外周动脉疾病，主动脉 - 冠状动脉旁路使用期间的血栓栓塞形成疾病，肾小球硬化，肾栓塞的心血管和脑血管疾病 ，肿瘤或癌转移，其包含LXR配体作为活性成分。

    Aromatic polyetherketones
    9.
    发明授权
    Aromatic polyetherketones 失效
    芳香聚醚酮

    公开(公告)号：US06909015B2

    公开(公告)日：2005-06-21

    申请号：US10203479

    申请日：2001-02-09

    申请人： David John Kemmish ,  Brian Wilson

    发明人： David John Kemmish ,  Brian Wilson

    IPC分类号： C08G61/12 ,  C07C65/00

    CPC分类号： C08G61/12

    摘要： The invention relates to polyetherketones and to a process for the preparation of aromatic polyetherketones which process comprises: a) self-condensing a compound of formula (I) wherein n represents 0 or 1 in the presence of an alkyl or optionally substituted aryl sulphonic acid solvent and in the absence of phosphorous pentoxide; or b) condensing a compound of general formula (II) and a compound of general formula (III) wherein p and q independently represent 0 or 1, in the presence of an alkyl or optionally substituted aryl sulphonic acid solvent and in the absence of phosphorous pentoxide; or c) a combination of a) and b)

    摘要翻译： 本发明涉及聚醚酮和制备芳族聚醚酮的方法，该方法包括：a）在烷基或任选取代的芳基磺酸溶剂存在下，将式（I）化合物自缩合，其中n表示0或1 并且在不存在五氧化二磷的情况下; 或b）在烷基或任选取代的芳基磺酸溶剂的存在下，在不存在磷的情况下，将通式（II）的化合物和通式（III）的化合物（其中p和q独立地表示0或1） 五氧化二 或c）a）和b）

    Process for the manufacture of isobutyric anhydride
    10.
    发明申请
    Process for the manufacture of isobutyric anhydride 失效
    制造异丁酸酐的方法

    公开(公告)号：US20050014974A1

    公开(公告)日：2005-01-20

    申请号：US10824618

    申请日：2004-04-15

    申请人： Jean-Michel Paul ,  Patrick Busca

    发明人： Jean-Michel Paul ,  Patrick Busca

    IPC分类号： C07C51/083 ,  C07C51/56 ,  C07C53/124 ,  C07C65/00

    CPC分类号： C07C51/083 ,  C07C51/56 ,  C07C53/08 ,  C07C53/124

    摘要： This process for the manufacture of isobutyric anhydride by reacting acetic anhydride with isobutyric acid, distilling the acetic acid generated as it is formed, is characterized in that the reactor is initially loaded with at least a portion of one of the reagents and a portion of the other such that the reagents are in an excess molar ratio relative to the stoichiometry of one of the reagents, and the reaction is carried out while adding the remainder of the reagents as the reaction progresses and according to the place left free in the reactor by the distillation of the acetic acid produced by the reaction, until the desired overall molar ratio of the reagents is reached.

    摘要翻译： 用于通过使乙酸酐与异丁酸反应制备异丁酸酐的方法，蒸馏生成的乙酸，其特征在于反应器最初装载有至少一部分试剂和一部分试剂 其它使得试剂相对于一种试剂的化学计量为过量的摩尔比，并且当反应进行时加入其余试剂并根据反应器中剩余的位置由反应器中的位置进行反应 蒸馏通过反应产生的乙酸，直到达到所需试剂的总摩尔比。