公开(公告)号：US12129263B2

公开(公告)日：2024-10-29

申请号：US17511193

申请日：2021-10-26

申请人： Denali Therapeutics Inc.

发明人： Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Jianwen A. Feng ,  Brian Fox ,  Cinzia Maria Francini ,  Christopher R. H. Hale ,  Cheng Hu ,  Colin Philip Leslie ,  Maksim Osipov ,  Elena Serra ,  Zachary K. Sweeney ,  Arun Thottumkara

IPC分类号： C07D498/04 ,  A61K31/553 ,  A61P3/10 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P27/02 ,  A61P37/00 ,  A61P43/00 ,  C07D223/16 ,  C07D267/04 ,  C07D267/14 ,  C07D413/14 ,  C07D498/10 ,  C07D519/00

CPC分类号： C07D498/04 ,  C07D223/16 ,  C07D267/04 ,  C07D267/14 ,  C07D413/14 ,  C07D519/00

摘要： The present disclosure relates generally to compounds and compositions, intermediates, processes for their preparation, and their use as kinase inhibitors.

公开(公告)号：US20230041576A1

公开(公告)日：2023-02-09

申请号：US17778492

申请日：2020-11-20

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Beibei Chen ,  Toren Finkel ,  Yuan Liu

IPC分类号： C07D215/36 ,  C07D311/12 ,  C07D213/71 ,  C07D471/04 ,  C07D215/40 ,  C07D217/24 ,  C07D265/36 ,  C07D487/04 ,  C07D267/14 ,  C07D263/46 ,  C07D277/36 ,  C07D241/42 ,  C07D403/04 ,  C07D401/12 ,  C07D403/12

摘要： This document provides compounds that are inhibitors of NF-κB activity, as well as the methods of using such compounds for treating diseases and conditions such as cancer, inflammatory conditions, or autoimmune diseases.

公开(公告)号：US20220363651A1

公开(公告)日：2022-11-17

申请号：US17238321

申请日：2021-04-23

申请人： Valo Early Discovery, Inc.

发明人： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Heather Davis ,  Aleksandra Rudnitskaya ,  David R. Lancia, JR. ,  Kenneth W. Bair ,  David S. Millan ,  Matthew W. Martin

IPC分类号： C07D267/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/04 ,  C07D267/12 ,  C07D243/14 ,  C07D291/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10

摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US11447471B2

公开(公告)日：2022-09-20

申请号：US16625446

申请日：2018-06-22

申请人： KYOWA KIRIN CO., LTD.

发明人： Tomohiro Danjo ,  Hiroki Yamada ,  Takahiro Nakajima

IPC分类号： A61P35/00 ,  C07D263/56 ,  C07D263/57 ,  C07D267/14 ,  C07D277/64 ,  C07D307/83 ,  C07D307/86 ,  C07D313/08 ,  C07D405/12 ,  C07D213/63 ,  C07D213/643 ,  C07D213/75 ,  C07D215/227 ,  C07D215/233 ,  C07D215/26 ,  C07D215/38 ,  C07D215/40 ,  C07D217/02 ,  C07D311/58 ,  C07D311/68 ,  C07D333/66 ,  C07D401/04 ,  C07D401/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/052

摘要： An object of the present invention is to provide an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like. The α,β-unsaturated amide compound represented by the following formula (I) or a pharmaceutically acceptable salt or the like thereof has anticancer activity and the like: [wherein, “A” represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents —O—, —S—, —SO2—, —NRX1— (wherein, RX1 represents hydrogen atom or lower alkyl), —CHRX2— (wherein, RX2 represents hydrogen atom or hydroxy), —CH═CH—, −CO— or —NH—CO—, and n1 and n2 are the same or different, and each represents 0 or 1].

公开(公告)号：US20220227721A1

公开(公告)日：2022-07-21

申请号：US17715935

申请日：2022-04-07

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Huanming CHEN ,  Bo LIANG

IPC分类号： C07D267/14 ,  C07D495/04

摘要： p-phenylenediamine derivatives as potassium channel regulators and preparation methods and medical application thereof. A compound represented by general formula A or a pharmaceutically acceptable salt thereof. A preparation method of the compound and a use of the same as a potassium channel opener.

公开(公告)号：US11365181B2

公开(公告)日：2022-06-21

申请号：US17057457

申请日：2019-05-22

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Huanming Chen ,  Bo Liang

IPC分类号： C07D471/04 ,  C07D265/30 ,  A61K31/165 ,  C07D267/14 ,  C07D495/04

摘要： p-phenylenediamine derivatives as potassium channel regulators and preparation methods and medical applications thereof. A compound represented by general formula A or a pharmaceutically acceptable salt thereof. A preparation method of the compound and a use of the same as a potassium channel opener.

公开(公告)号：US11332451B2

公开(公告)日：2022-05-17

申请号：US17023127

申请日：2020-09-16

申请人： Rigel Pharmaceuticals, Inc.

发明人： Esteban Masuda ,  Simon Shaw ,  Vanessa Taylor ,  Somasekhar Bhamidipati

IPC分类号： A61K31/553 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  C07D413/12 ,  C07D267/14 ,  C07D413/14 ,  C07D487/04

摘要： Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

公开(公告)号：US11274085B2

公开(公告)日：2022-03-15

申请号：US17031815

申请日：2020-09-24

申请人： Valo Health, Inc.

发明人： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  David S. Millan ,  Matthew W. Martin

IPC分类号： A61K31/55 ,  A61K31/554 ,  C07D223/16 ,  C07D281/02 ,  C07D281/10 ,  C07D471/04 ,  C07D513/04 ,  C07D267/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/04 ,  C07D267/12 ,  C07D243/14 ,  C07D291/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10

摘要： The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US20210163429A1

公开(公告)日：2021-06-03

申请号：US17057457

申请日：2019-05-22

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Huanming CHEN ,  Bo LIANG

IPC分类号： C07D267/14 ,  C07D495/04

摘要： p-phenylenediamine derivatives as potassium channel regulators and preparation methods and medical applications thereof. A compound represented by general formula A or a pharmaceutically acceptable salt thereof. A preparation method of the compound and a use of the same as a potassium channel opener.

公开(公告)号：US10988450B2

公开(公告)日：2021-04-27

申请号：US16567007

申请日：2019-09-11

申请人： Valo Early Discovery, Inc.

发明人： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Heather Davis ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  Kenneth W. Bair ,  David S. Millan ,  Matthew W. Martin

IPC分类号： C07D491/08 ,  C07D267/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/04 ,  C07D267/12 ,  C07D243/14 ,  C07D291/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10

摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.