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公开(公告)号：US20230139045A1
公开(公告)日：2023-05-04
申请号：US17903190
申请日：2022-09-06
发明人： Wook KIM , Seonyeong GWAK , Jaehoon KIM , Hyung Sun KIM , Mijin LEE , Yoonman LEE , Hanill LEE , Suheon IM , Sung-Hyun JUNG
IPC分类号： C07D403/10 , C07D405/14 , C07D409/14 , C07F7/08 , C07D403/04 , C07D491/048 , C07D495/04 , C07D487/04 , H01L51/00 , H01L51/50
摘要： Provided a compound for an organic optoelectronic device represented by Chemical Formula 1, a composition for an organic optoelectronic device including the same, an organic optoelectronic device, and a display device. Details of Chemical Formula 1 are as defined in the specification.
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公开(公告)号：US20230131832A1
公开(公告)日：2023-04-27
申请号：US17843378
申请日：2022-06-17
申请人： LG DISPLAY CO., LTD.
发明人： Tae-Ryang HONG , Dong-Young KIM
IPC分类号： C07D495/04 , H01L51/50 , C07D491/048 , C07D487/04 , C07C15/38 , C07D209/82 , C07D405/10 , C07D409/10 , C07D405/14 , C07D409/14 , H01L51/00
摘要： An organic light emitting diode (OLED) includes at least one emitting material layer (EML) disposed between two electrodes and including a first compound of a pyrimidine-based organic compound substituted with at least one electron-withdrawing group and a second compound of an organic compound having a tetracene-based core. The OLED can be included in an organic light emitting device. The first compound and the second compound can be the same emitting material layer or adjacently disposed emitting material layers. The OLED can lower its driving voltage and improve its luminous efficiency utilizing the advantages of the first and second compounds by adjusting energy levels between the first and second compounds.
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公开(公告)号：US11634414B2
公开(公告)日：2023-04-25
申请号：US16633538
申请日：2018-08-02
申请人： LG CHEM, LTD.
发明人： Seongmi Cho , Wanpyo Hong , Dong Hoon Lee , Jungoh Huh , Min Woo Jung , Jungha Lee
IPC分类号： C07D311/96 , C07D335/04 , C07D407/14 , C07D409/14 , H01L51/00 , C07D491/048 , C07D487/04 , C07D495/04 , H01L51/50
摘要： Provided is a hetero-cyclic compound of Chemical Formula 1: and an organic light emitting device comprising the same.
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公开(公告)号：US20230115580A1
公开(公告)日：2023-04-13
申请号：US17720079
申请日：2022-04-13
发明人： Adam Szymaniak , Jianming Yu , Kevin McGrath , Xiben Li , Tyler J. Mann , Robert Leon , In Jong Kim , Yat Sun Or , Long Nguyen
IPC分类号： C07D491/048 , C07D519/00 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20230112499A1
公开(公告)日：2023-04-13
申请号：US17786268
申请日：2020-12-14
发明人： Olaf PANKNIN , Frank SACHER , Nicole SCHMIDT , Gernot LANGER , Katrin NOWAK-REPPEL , Reinhard NUBBEMEYER , Sabine PILARI , Antje ROTTMANN , Hideki MIYATAKE ONDOZABAL , Holger SIEBENEICHER , Antonius TER LAAK , Hana CERNECKA
IPC分类号： C07D491/048 , C07D519/00
摘要： The present invention covers furoindazole compounds of general formula (I): in which (I) are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of autoimmune diseases such as multiple sclerosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, primary and secondary autoimmune uveitis, inflammatory disorders like endometriosis, inflammatory eye diseases, inflammatory kidney diseases, inflammatory liver diseases like non-alcoholic, alcoholic- and toxic fatty liver diseases, lung diseases like asthma, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and metabolic and metabolic-endocrine disorders like metabolic syndrome, insulin resistance, diabetes mellitus type I and type II, and polycystic ovary syndrome (PCOS) disorders, neuropathic and inflammatory pain disorders in humans and animals.
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公开(公告)号：US11622968B2
公开(公告)日：2023-04-11
申请号：US16838753
申请日：2020-04-02
IPC分类号： A61K31/55 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/437 , A61K31/4525 , C07D491/048 , C07D401/14 , C07D491/10 , C07D413/10 , C07D401/06 , C07D405/04 , C07D487/04 , C07D413/14 , C07D491/107 , C07D401/04 , C07D405/14 , C07D405/10 , C07D405/12 , C07D471/04 , C07D401/12 , C07D491/052 , C07D401/10 , C07D513/04 , A61K31/453 , A61K31/451
摘要： Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
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公开(公告)号：US11613531B2
公开(公告)日：2023-03-28
申请号：US16641465
申请日：2018-06-13
发明人： Eduardas Skucas , Kevin G. Liu , Ji-In Kim , Masha V. Poyurovsky , Rigen Mo
IPC分类号： C07D403/14 , C07D401/14 , C07D413/14 , C07D471/10 , C07D487/08 , C07D487/10 , C07D491/048 , C07D491/052 , C07D495/04 , C07D498/10 , C07D519/00 , A61P11/00
摘要： The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of inhibiting ROCK1 and/or ROCK2 that are useful for the treatment of disease.
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公开(公告)号：US20230065143A1
公开(公告)日：2023-03-02
申请号：US17824175
申请日：2022-05-25
发明人： Mijin LEE , Ho Kuk JUNG , Youngkyoung JO , Jonghoon KIM , Jinhyun LUI , Jongwoo WON , Youngmook LIM , Hyungyu LEE , Sung-Hyun JUNG
IPC分类号： C07D209/82 , C07D405/14 , C07D405/04 , C07D493/04 , C07D409/14 , C07D409/10 , C07D405/10 , C07D495/04 , C07D491/048 , C07D403/10 , C07D403/14 , C07D403/04 , C07D487/04 , C07D307/91 , C07D333/76 , C07F15/00 , C07C211/54 , H01L51/00
摘要： A compound for an organic optoelectronic device, a composition for an organic optoelectronic device including the same, an organic optoelectronic device, and a display device, the compound being represented by Chemical Formula 1:
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公开(公告)号：US20230030115A1
公开(公告)日：2023-02-02
申请号：US17367726
申请日：2021-07-06
发明人： Yanping ZHAO , Hongjun WANG , Gong LI , Yuanyuan JIANG , Xiang LI , Bin LIU , Weiting ZHONG , Kai LIU , Fajie LI , Liying ZHOU , Yanan LIU
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/6558 , A61P37/00 , A61K31/416 , A61K31/506 , A61P29/00
摘要： The present invention relates to a Rho-associated protein kinase inhibitor of formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and a use of the same in preventing or treating a disease mediated by Rho-associated protein kinase (ROCK).
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公开(公告)号：US20230021834A1
公开(公告)日：2023-01-26
申请号：US17320574
申请日：2021-05-14
发明人： Zacharia Cheruvallath , Jason Green , Ben Johnson , Kristin Schleicher , Huikai Sun , Mingnam Tang
IPC分类号： A61K31/4439 , A61K31/40 , A61K31/4355 , A61K31/438 , A61K31/4468 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K31/506 , C07D207/14 , C07D211/58 , C07D401/12 , C07D401/14 , C07D403/12 , C07D491/048
摘要： Disclosed are compounds of Formula 1, stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein L, r, s, R5, R6, R7, R9, R10, R11, R12, X1, X2, X3, X4, X13, and X14 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.
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