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18 条记录 (耗时 0.017 秒)

    Thioglycoside analogs of gangliosides
    1.
    发明授权
    Thioglycoside analogs of gangliosides 失效
    神经节苷脂的硫糖苷类似物

    公开(公告)号：US5380829A

    公开(公告)日：1995-01-10

    申请号：US842532

    申请日：1992-02-27

    申请人： Akira Hasegawa ,  Makoto Kiso

    发明人： Akira Hasegawa ,  Makoto Kiso

    IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61P31/12 ,  A61P31/16 ,  C07H15/10 ,  C07H15/14 ,  C12N9/99 ,  C07H5/08

    CPC分类号： C07H15/10 ,  C07H15/14 ,  Y02P20/55

    摘要： Disclosed are thioglycoside analogs of gangliosides represented by the formula ##STR1## in which Y represents a radical of the following formula ##STR2## and X represents a radical of the formula ##STR3## wherein m is an integer of 15 to 25, l is an integer of 0 to 3 and n is an integer of 11 to 15. The thioglycoside analogs are expected to exert specific enzyme-inhibitory effects.

    摘要翻译： 公开了由式“IMAGE”表示的神经节苷脂的硫代糖苷类似物，其中Y表示下式的基团，其中X表示下式的基团：其中m是 15〜25的整数，l为0〜3的整数，n为11〜15的整数。预期硫代糖苷类似物具有特异性的酶抑制作用。

    Combinatorial library of moenomycin analogs and methods of producing same
    6.
    发明授权
    Combinatorial library of moenomycin analogs and methods of producing same 失效
    霉酚霉素类似物组合库及其生产方法

    公开(公告)号：US06114309A

    公开(公告)日：2000-09-05

    申请号：US975229

    申请日：1997-11-21

    申请人： Nigel Mark Allanson ,  Tin Yau Chan ,  Nicole T. Hatzenbuhler ,  Rakesh K. Jain ,  Ramesh Kakarla ,  Rui Liang ,  Dashan Liu ,  Domingos J. Silva ,  Michael J. Sofia

    发明人： Nigel Mark Allanson ,  Tin Yau Chan ,  Nicole T. Hatzenbuhler ,  Rakesh K. Jain ,  Ramesh Kakarla ,  Rui Liang ,  Dashan Liu ,  Domingos J. Silva ,  Michael J. Sofia

    IPC分类号： C12Q1/02 ,  A61K31/7016 ,  A61K31/702 ,  A61P31/04 ,  C07B61/00 ,  C07H1/02 ,  C07H5/08 ,  C07H11/04 ,  C07H15/04 ,  C07H15/203 ,  A61K31/70 ,  C07H13/00

    CPC分类号： C07H15/04 ,  C07H15/203 ,  C40B40/00

    摘要： A combinatorial chemical library of compounds structurally related to the moenomycin class of antibiotics has the formula ##STR1## wherein D is a donor mono- or disaccharide, A is an acceptor monosaccharide, and P-R is a lipophosphoglycerate mimetic group. Members of the library have a glycosidic linkage between the anomeric carbon of D and the C2 carbon of A, and the D-A moiety is in turn covalently linked through the anomeric carbon of A to the P-R group. Members of the library exhibit their greatest structural diversity in terms of substitutions occurring at the C3 position of the A residue, substitutions at the C2 position of the D residue, and different P-R groups used in assembling the compounds. Members of the library are preferably synthesized by solid phase techniques involving stepwise coupling of the respective units to a support, functionalizing the A and/or D saccharides either before or after immobilizing them on the support, and cleaving the assembled compounds from the support. Preferred functionalities attached to the sugar residues are amides, carbamates, ureas, sulfonamides, substituted amines, esters, carbonates, and sulfates. Exemplary P-R groups are derivatives of homoserine, glyceric acid, salicylates and mandelic acid. Members of the library can be screened for anti-microbial activity by contacting them with a culture of microbes and monitoring the growth rate of the microbes.

    摘要翻译： 结构上与新霉素类抗生素相关的化合物的组合化学文库具有下式：其中D是供体单糖或二糖，A是受体单糖，P-R是脂磷酸甘油酸酯模拟组。 文库成员在D的异头碳和A的C2碳之间具有糖苷键，D-A部分又通过A的端基异碳共价连接到P-R基团。 关于在A残基的C3位置发生的取代，在D残基的C2位置的取代以及用于组装化合物的不同的P-R基团，图书馆的成员表现出最大的结构多样性。 文库的成员优选通过固相技术合成，其包括将各单元逐步偶联到载体上，在将它们固定在载体上之前或之后将A和/或D糖功能化，并将载体化合物从载体上分离。 附着于糖残基的优选功能是酰胺，氨基甲酸酯，脲，磺酰胺，取代的胺，酯，碳酸酯和硫酸酯。 示例性的P-R基团是高丝氨酸，甘油酸，水杨酸盐和扁桃酸的衍生物。 通过与微生物培养物接触并监测微生物的生长速率，可以筛选图书馆成员的抗菌活性。

    SELENO-COMPOUNDS AND THERAPEUTIC USES THEREOF
    8.
    发明申请
    SELENO-COMPOUNDS AND THERAPEUTIC USES THEREOF 审中-公开
    SELENO化合物及其治疗方法

    公开(公告)号：US20140206658A1

    公开(公告)日：2014-07-24

    申请号：US13881594

    申请日：2011-10-28

    申请人： Carl Herbert Schiesser ,  Corin Storkey ,  Michael Jonathan Davies

    发明人： Carl Herbert Schiesser ,  Corin Storkey ,  Michael Jonathan Davies

    IPC分类号： C07H5/08 ,  C07D345/00

    CPC分类号： C07H5/08 ,  A61K31/33 ,  C07D345/00

    摘要： The present invention relates to compounds and compositions useful as antioxidants and in particular to selenium containing compounds of formula (I): wherein n is 1, 2, or 3; m is 2, 3, 4, or 5; and each R] is independently —(optionally substituted C1-C3 alkylene) p-OH, where p is 0 or 1, or a salt thereof. The invention also relates to the use of these seleno-compounds in the treatment of diseases or conditions associated with increased levels of oxidants produced by myeloperoxidase (MPO), such as for instance, atherosclerosis.

    摘要翻译： 本发明涉及可用作抗氧化剂，特别是含有式（I）的含硒化合物的化合物和组合物：其中n为1,2或3; m为2,3,4或5; 并且每个R'独立地为 - （任选取代的C 1 -C 3亚烷基）p -OH，其中p为0或1，或其盐。 本发明还涉及这些硒化合物在治疗与由髓过氧化物酶（MPO）产生的氧化剂水平升高相关的疾病或病症的用途，例如动脉粥样硬化。

    O-.alpha.-D-Multigalactopyranosyl-O-.alpha.-D-multiglucopyranosyl-O-.beta.- D
    10.
    发明授权
    O-.alpha.-D-Multigalactopyranosyl-O-.alpha.-D-multiglucopyranosyl-O-.beta.- D 失效
    O-α-D-多糖吡喃糖基-O-α-D-吡喃葡萄糖基-β-D-多葡萄糖基 - 吡喃葡萄糖苷硫酸盐

    公开(公告)号：US4359459A

    公开(公告)日：1982-11-16

    申请号：US305886

    申请日：1981-09-28

    申请人： Vijay G. Nair ,  Seymour Bernstein

    发明人： Vijay G. Nair ,  Seymour Bernstein

    IPC分类号： C07H3/06 ,  C07H5/08

    CPC分类号： C07H3/06

    摘要： O-.alpha.-D-Galactopyranosyl(1.fwdarw.6)-O-.alpha.-D-galactopyranosyl(1.fwdarw.6)-O-.alpha.-D-glucopyranosyl(1.fwdarw.2)-O-.beta.-D-fructofuranosyl(1.fwdarw.6)-O-.alpha.-D-glucopyranosyl(1.fwdarw.4)-O-.alpha.-D-glucopyranosyl-.alpha.-D-glucopyranoside sulfate salts useful as complement inhibitors and the process of making such compounds.

    摘要翻译： α-D-吡喃半乳糖基（1-> 6）-O-D-吡喃半乳糖基（1-> 6）-O-α-D-吡喃葡萄糖基（1-> 2）-β-D-呋喃果糖基 1-> 6）-O-α-D-吡喃葡萄糖基（1-> 4）-O-α-D-吡喃葡萄糖-α-D-吡喃葡萄糖苷硫酸盐，可用作补体抑制剂及其制备方法。