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1.发明公开公开(公告)号：US20240316177A1
公开(公告)日：2024-09-26
申请号：US18739648
申请日：2024-06-11
申请人： BIOLOGICAL MIMETICS, INC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： Gregory J. Tobin , Michael J. Daly
CPC分类号： A61K39/12 , C12N7/04 , C12N13/00 , A61K2039/5252 , C12N2770/32634 , C12N2770/32661
摘要： Compositions useful as poliovirus immunogens are provided along with methods and compositions for preparing the same. Compositions comprising poliovirus immunogens can enable a host response that includes virus-neutralizing antibodies which can protect the host from infection and/or disease.
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公开(公告)号：US11980662B2
公开(公告)日：2024-05-14
申请号：US17675297
申请日：2022-02-18
申请人： FluGen, Inc.
CPC分类号： A61K39/145 , A61K39/00 , A61K39/0011 , A61K39/12 , C12N7/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/575 , C12N2760/16134 , C12N2760/16143 , C12N2760/16152
摘要： Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
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公开(公告)号：US11918638B2
公开(公告)日：2024-03-05
申请号：US17183227
申请日：2021-02-23
CPC分类号： A61K39/12 , C12N7/00 , C12N7/04 , A61K2039/5254 , A61K2039/55 , C12N2760/18521 , C12N2760/18534 , C12N2760/18551
摘要： Reported herein are novel recombinant respiratory syncytial viruses (RSV) having an attenuated phenotype in which the native positions of the NS1 and/or NS2 genes in the RSV genome are shifted to a higher position, that is at positions that are more distal to the promoter. The changes in the gene positions may be present in combination with mutations at other loci to achieve desired levels of attenuation and immunogenicity. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses.
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公开(公告)号：US20240010686A1
公开(公告)日：2024-01-11
申请号：US18252212
申请日：2021-11-09
IPC分类号： C07K14/005 , C12N9/64 , C12N15/63 , C12N7/04
CPC分类号： C07K14/005 , C12N9/641 , C12N15/63 , C12N7/045 , C12Y304/22028
摘要： Methods and compositions for increasing the production of large amounts of empty capsids of the foot-and-mouth disease virus (FMDV) in a stable manner in mammalian cells by regulating the expression of FMDV 3C protease. The instant methods and compositions are based on the fact that a decreased expression of 3C protease results in a reduced cell toxicity and an increased synthesis of viral capsid proteins, as well as production of recombinant empty capsids. The invention provides recombinant plasmids that direct the expression of P1, 3C, and the use of the plasmids for producing new stable cell lines capable of generating high titers of FMDV empty capsids. The invention provides methods for regulating the expression of the FMDV 3C protease gene at a transcriptional and translational level in order to achieve the required process level of 3C protease for the selection process, as well as the production process.
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5.发明授权公开(公告)号：US11766476B2
公开(公告)日：2023-09-26
申请号：US17130814
申请日：2020-12-22
发明人： Douglas P. Gladue , Manuel V. Borca
CPC分类号： A61K39/12 , C12N7/04 , A61K2039/5254 , C12N2710/12021 , C12N2710/12034
摘要： Provided herein are details on the construction of a recombinant African Swine Fever Virus (ASFV) live attenuated vaccine for prevention of ASF caused by various strains of ASFV, such as the highly virulent Georgia 2007 isolate (“ASFV-G”). An exemplary vaccine comprises a deletion of multiple genes allowing for industrial-scale growth in stable cell lines.
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6.发明公开公开(公告)号：US20230287083A1
公开(公告)日：2023-09-14
申请号：US18014321
申请日：2021-07-06
申请人： IMNATE SARL
CPC分类号： C07K14/70539 , G01N33/6878 , C07K14/005 , C12N7/04 , A61P31/22 , A61P31/16 , A61K2039/5252
摘要： A CD1 peptide-epitope for use in the treatment of a disease caused by an intracellular pathogen, the method for the identification of this CD1 peptide epitope, the pharmaceutical kit comprising this CD1 peptide epitope and the method to treat a patient against a disease caused by an intracellular pathogen or to prevent such infection, based on vaccination with this CD1 peptide-epitope.
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公开(公告)号：US11697817B2
公开(公告)日：2023-07-11
申请号：US17047757
申请日：2018-06-25
发明人： Hideaki Yukawa , Naoto Ohtani , Masaharu Ishii
CPC分类号： C12N15/74 , C12P7/06 , C12P7/16 , C12Y101/01001 , C12Y401/01001
摘要： A transformant obtained by introducing a DNA of (a1), (a2), or (a3) below, and (b) an alcohol dehydrogenase gene, into a bacterium of the genus Hydrogenophilus, can efficiently produce isobutanol utilizing carbon dioxide as a sole carbon source.
(a1) DNA which consists of a base sequence of SEQ ID NO: 1;
(a2) DNA which consists of a base sequence having 90% or more identity with SEQ ID NO: 1, the DNA encoding a polypeptide having 2-keto-acid decarboxylase activity;
(a3) DNA which hybridizes with a DNA consisting of a base sequence complementary to SEQ ID NO: 1 under stringent conditions, and which encodes a polypeptide having 2-keto-acid decarboxylase activity.-
公开(公告)号：US11640851B2
公开(公告)日：2023-05-02
申请号：US17139287
申请日：2020-12-31
摘要： A vaccine candidate is herein described comprised by statistically significant DNA fragments resulting in three types of compositions: 1) a composition of statistically significant DNA fragments, 2) a composition of RNA transcripts corresponding to the statistically significant DNA fragments, and 3) a computational reduction composition wherein the DNA fragments are fully or partially subtracted from a base organism, resulting in a synthetic organism which has a high statistical likelihood of problematic functions being partially or fully removed.
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公开(公告)号：US11369674B2
公开(公告)日：2022-06-28
申请号：US16520113
申请日：2019-07-23
发明人： Gary J. Nabel , Wataru Akahata , Srinivas Rao
摘要： The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases.
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公开(公告)号：US20220160853A1
公开(公告)日：2022-05-26
申请号：US17542100
申请日：2021-12-03
申请人： GeoVax, Inc.
发明人： Farshad Guirakhoo , Arban Domi
摘要： The compositions and methods are described for generating an immune response to a tumor associated antigen (TAA) such as MUC-1, survivin, cyclin B1, HBV, or HPV. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to the tumor associated antigen in the subject to which the vector is administered and optionally, boosting the immune response by administering a tumor associated antigen. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat neoplasms and associated diseases.
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