公开(公告)号：US20240241094A1

公开(公告)日：2024-07-18

申请号：US18387271

申请日：2023-11-06

申请人： Thermo Finnigan LLC

发明人： Philip M. Remes ,  Scott T. Quarmby

IPC分类号： G01N30/86 ,  B01D15/08 ,  G01N30/14 ,  G01N30/72 ,  G06N20/00

CPC分类号： G01N30/8693 ,  B01D15/08 ,  G01N30/14 ,  G01N30/7233 ,  G06N20/00 ,  G01N2030/027

摘要： A method of performing mass spectrometry includes obtaining, based on a series of mass spectra acquired over time with a first sampling rate as analytes elute from a separation system during an experiment, a first mass chromatogram dataset. The first mass chromatogram dataset represents a detected intensity of ions derived from the analytes and having a selected m/z as a function of time over a time period. The method further includes generating, based on the first mass chromatogram dataset and an upsampling model trained to upsample mass chromatogram data, a second mass chromatogram dataset representing an estimated intensity of the ions as a function of time over the time period. The second mass chromatogram dataset has a second sampling rate that is greater than the first sampling rate.

公开(公告)号：US20240230602A9

公开(公告)日：2024-07-11

申请号：US17969779

申请日：2022-10-20

申请人： Dionex Corporation

发明人： Mrinal K. Sengupta ,  George Tang ,  Husam Al-Esawi

IPC分类号： G01N30/14 ,  B01D15/24 ,  B01D15/36 ,  B01D15/42 ,  B01D61/46 ,  G01N30/32 ,  G01N30/64

CPC分类号： G01N30/14 ,  B01D15/24 ,  B01D15/361 ,  B01D15/424 ,  B01D61/46 ,  G01N30/32 ,  G01N30/64 ,  G01N2030/027

摘要： Systems and methods are described for ion chromatography systems and electrolytic suppressors. By varying the operating frequency of an electrolytic suppressor, the generation of bubbles and noise can be minimized. This leads to more accurate results in e.g., a conductivity detector downstream of an electrolytic suppressor within an ion chromatography system. In certain embodiments, it has been found that frequencies of around 700-750 Hz, 100-150 Hz and 925-975 Hz have achieved the best results.

公开(公告)号：US11946912B2

公开(公告)日：2024-04-02

申请号：US17364517

申请日：2021-06-30

申请人： Entech Instruments Inc.

发明人： Daniel B. Cardin

IPC分类号： G01N30/14 ,  G01N30/12 ,  G01N30/02

CPC分类号： G01N30/12 ,  G01N30/14 ,  G01N2030/025 ,  G01N2030/128 ,  G01N2030/143

摘要： Techniques disclosed herein can be used to perform a rapid, splitless injection of a sample including SVOCs and VOCs. In some embodiments, a system includes two focusing traps combined in series, one inside of a GC oven and one in a separate oven to concentrate the SVOCs inside of the GC oven and concentrate the VOCs outside of the GC oven. Heating the VOC focusing trap and reversing the flow through both focusers allows splitless injection of compounds boiling from as low as −100° C. to as high as 600° C. in a single analysis, with a narrow injection bandwidth to optimize both sensitivity and the resolving power of the analyzer.

公开(公告)号：US20240077461A1

公开(公告)日：2024-03-07

申请号：US18241090

申请日：2023-08-31

申请人： SHIMADZU CORPORATION

发明人： Takuya YONEKURA

IPC分类号： G01N30/32 ,  B01D15/14 ,  B01D15/36 ,  G01N30/14 ,  G01N30/16 ,  G01N30/64

CPC分类号： G01N30/32 ,  B01D15/14 ,  B01D15/367 ,  G01N30/14 ,  G01N30/16 ,  G01N30/64 ,  G01N2030/027

摘要： An ion chromatography analysis system includes a system monitoring part being configured to detect an abnormality, to determine, based on a fluctuation rate in a certain time of the predetermined state of a most recent of the monitor value, whether the fluctuation is a short-term fluctuation that occurs in a short term or a long-term fluctuation that occurs in a long term, and to identify a cause of the abnormality by using whether the fluctuation is the short-term fluctuation or the long-term fluctuation.

公开(公告)号：US20230393106A1

公开(公告)日：2023-12-07

申请号：US18192444

申请日：2023-03-29

申请人： HONGYUNHONGHE TOBACCO (GROUP) CO.,LTD

发明人： Yueming XU ,  Bin CHEN ,  Jilai ZHOU ,  Haiying FANG ,  Renjie XU ,  Wenjing YANG ,  Zheng MO ,  Peng ZHOU

IPC分类号： G01N30/72 ,  G01N30/86 ,  G01N30/14

CPC分类号： G01N30/7206 ,  G01N30/86 ,  G01N30/14 ,  G01N2333/415 ,  G01N2333/37

摘要： A metabonomics-based tobacco leaf mildewing identification method, which comprises: obtaining tobacco leaf samples of the same variety, and carrying out artificial mildewing on a certain amount of tobacco leaf samples to obtain mildewed tobacco leaves; measuring volatile and semi-volatile components in the tobacco leaves before and after the tobacco leaf samples are mildewed by adopting a solid phase microextraction-gas chromatography-mass spectrometry method; performing data processing on the collected mass spectrum data to obtain the proportion content of different types of compounds in the mildewed sample and the normal sample, and further obtaining the change difference of the content of volatile compounds in the tobacco leaf sample before and after mildewing; and establishing a tobacco leaf mildewing identification model according to the discrimination variables. The accuracy and efficiency of tobacco mildew identification can be improved, the quality of tobacco shreds is improved.

公开(公告)号：US11674965B2

公开(公告)日：2023-06-13

申请号：US16192113

申请日：2018-11-15

申请人： MediBeacon, Inc.

发明人： Jeng J. Shieh

IPC分类号： G01N30/06 ,  G01N1/38 ,  G01N33/58 ,  G01N30/14 ,  G01N30/22 ,  C07D229/00

CPC分类号： G01N33/582 ,  G01N30/14 ,  C07D229/00 ,  G01N1/38 ,  G01N30/22 ,  G01N2800/347 ,  Y10T436/147777

摘要： Disclosed herein is a method for analyzing the concentration of a fluorescent compound in the plasma of a patient. The method includes collecting a sample of plasma from a patient, diluting the sample with a solvent and analyzing the diluted sample by HPLC. The sample does not need to be dried down during sample preparation nor is an internal standard required.

公开(公告)号：US20220291177A1

公开(公告)日：2022-09-15

申请号：US17629728

申请日：2020-07-23

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Glenn Martin SAMMIS ,  Daniel L. BIZZOTTO ,  Pouya REZAZADEH-AZAR

IPC分类号： G01N30/14 ,  G01N1/40 ,  G01N30/64 ,  G01N27/48

摘要： Methods and apparatuses for rapid detection and quantification of analytes are disclosed. The analytes may be opioids such as fentanyl. The method includes the use of an internal standard. The internal standard is introduced into the unknown sample. The method may involve a separation step prior to an electrochemical detection step. In some embodiments, the separation step is omitted. The analyte may be selectively adsorbed onto a surface of an electrode by maintaining a potential on the electrode during which a solution containing the dissolved analyte flows through the electrode. Performing electroanalysis on the analyte-adsorbed electrode detects and quantifies only the adsorbed analyte. In some embodiments, the internal standard is methyl vanillate.

公开(公告)号：US20220276263A1

公开(公告)日：2022-09-01

申请号：US17673876

申请日：2022-02-17

申请人： IDEXX LABORATORIES, INC.

发明人： E.A. Prabodha Ekanayaka ,  Jordan Haddock ,  Murthy V.S.N. Yerramilli

IPC分类号： G01N33/68 ,  G01N30/14 ,  G01N30/72 ,  G01N30/88 ,  G01N33/62 ,  G01N33/70

摘要： The present invention relates to methods for detecting and/or measuring alanine transaminase (ALT) activity, aspartate transaminase (AST) activity, alkaline phosphatase (ALP) activity, glucose levels, creatinine levels, urea levels, asymmetric dimethylarginine (ADMA) levels, and/or symmetrical dimethylarginine (SDMA) levels in a sample. The method allows all of the activities and analytes, or any combination of activities and analytes, to be measured in a single assay.

公开(公告)号：US20220252559A1

公开(公告)日：2022-08-11

申请号：US17615291

申请日：2020-05-29

申请人： Genzyme Corporation

发明人： Wei-Lien Chuang ,  Felipe Gazos Lopes ,  Joshua Pacheco ,  Gerard Sanderink

IPC分类号： G01N30/46 ,  G01N30/72 ,  G01N30/14 ,  B01D15/18 ,  B01D15/32

摘要： The present invention relates to a novel analytical method for detecting one or more analytes in a source sample by continuous flow 2D LC-MS/MS using a single LC system.

公开(公告)号：US11365214B2

公开(公告)日：2022-06-21

申请号：US16462464

申请日：2017-07-12

申请人： DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES

发明人： Lihua Zhang ,  Huiming Yuan ,  Zhigang Sui ,  Kaiguang Yang ,  Yukui Zhang

IPC分类号： C07K1/14 ,  C12Q1/37 ,  G01N1/40 ,  G01N30/14 ,  G01N30/72 ,  G01N30/06

摘要： The invention relates to a method for the treatment of body fluid proteins, by which proteins from body fluids such as blood or urine are extracted by adding a certain proportion of high molecular polymer solution under low temperature condition followed by denaturation and reduction by adding a certain concentration of surfactant and tris(2-carboxyethyl) phosphine (TCEP) under a high temperature condition. Subsequently, the iodoacetic acid brushes grafted on silica microspheres called as solid-phase alkylation reagents are added into protein solution, which can react rapidly with the protein sulfhydryl group. After centrifugation, the microspheres are obtained and repeatedly washed with methanol and buffer to remove interferences such as sugars, salts, surfactants, lipids to obtain high-purity proteins, and finally protease is added to digest proteins into peptides. After centrifugation, the peptide products are obtained, and directly analyzed by liquid chromatography-mass spectrometry (LC-MS) system. Compared with the traditional protein pretreatment method, the method has many advantages such as good anti-interference capability, easy operation and short pretreatment time.