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37 条记录 (耗时 0.022 秒)

    Axial CI source—off-axis electron beam
    1.
    发明授权
    Axial CI source—off-axis electron beam 有权

    公开(公告)号：US12014916B2

    公开(公告)日：2024-06-18

    申请号：US18182176

    申请日：2023-03-10

    申请人： Thermo Finnigan LLC

    发明人： Scott T. Quarmby ,  Edward B. McCauley ,  George B. Guckenberger

    IPC分类号： H01J49/14 ,  H01J49/06 ,  H01J49/26

    CPC分类号： H01J49/147 ,  H01J49/067 ,  H01J49/26

    摘要： An ion source includes an electron generator, an ionization chamber, and a magnetic field. The electron generator is configured to produce electrons. The ionization chamber has an electron entrance aperture through a first wall, an ion exit aperture through a second wall, and an axis. The ionization chamber is configured to produce ions. The magnetic field is arranged to confine electrons in a beam directed through the electron entrance aperture, in a direction within 45 degrees of parallel to the axis, and towards a location displaced from the ion exit aperture.

    Preventing Dry Syringes
    2.
    发明公开
    Preventing Dry Syringes 审中-公开

    公开(公告)号：US20240139750A1

    公开(公告)日：2024-05-02

    申请号：US18050583

    申请日：2022-10-28

    申请人： Thermo Finnigan LLC

    发明人： Scott T. Quarmby ,  Xin Zheng ,  Charles Vogt

    IPC分类号： B01L3/02

    CPC分类号： B01L13/02

    摘要： Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus, includes timing logic to determine a maximum time without wetting for a syringe; and rinsing logic to control an autosampler to rinse the syringe when the maximum time without wetting is reached.

    Long life electron multiplier
    6.
    发明授权
    Long life electron multiplier 有权

    公开(公告)号：US11410838B2

    公开(公告)日：2022-08-09

    申请号：US17011359

    申请日：2020-09-03

    申请人： Thermo Finnigan LLC

    发明人： Michael W. Senko ,  Joshua T. Maze ,  Scott T. Quarmby

    IPC分类号： H01J43/22 ,  H01J49/02

    摘要： An electron multiplier includes a series of discrete electron emissive surfaces or a continuous electron emissive resistive surface configured to provide an electron amplification chain; and a housing surrounding the series of electron emissive surfaces or the continuous electron emissive resistive surface and separating the environment inside the housing from the environment outside the housing. The housing includes an electron-transparent, gas-impermeable barrier configured to allow electrons to pass through into the housing to reach a first discrete electron emissive surface of the series of discrete electron emissive surfaces or a first portion of the continuous electron emissive resistive surface.

    AMPLIFIER AMPLITUDE DIGITAL CONTROL FOR A MASS SPECTROMETER
    7.
    发明申请
    AMPLIFIER AMPLITUDE DIGITAL CONTROL FOR A MASS SPECTROMETER 有权

    公开(公告)号：US20210305991A1

    公开(公告)日：2021-09-30

    申请号：US16833731

    申请日：2020-03-30

    申请人： Thermo Finnigan LLC

    发明人： Johnathan W. Smith ,  Scott T. Quarmby ,  Dustin J. Kreft ,  Michael W. Senko

    IPC分类号： H03M1/06 ,  G01J3/433

    摘要： Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole based on an amplifier RF input signal. An analog-to-digital converter (ADC) can generate a digital representation of the RF signal. A controller circuit can receive the digital representation and adjust an amplitude of the amplifier RF input signal based on differences between an amplitude of a fundamental frequency of the RF signal being different than an expected amplitude.

    Multidimensional dynode detector
    8.
    发明授权
    Multidimensional dynode detector 有权

    公开(公告)号：US10784095B2

    公开(公告)日：2020-09-22

    申请号：US16224593

    申请日：2018-12-18

    申请人： Thermo Finnigan LLC

    发明人： Johnathan W. Smith ,  Scott T. Quarmby

    IPC分类号： H01J49/00 ,  H01J49/02 ,  H01J49/42

    摘要： A mass spectrometer is described that includes a multipole configured to pass an ion stream, the ion stream comprising an abundance of one or more ion species within stability boundaries defined by (a, q) values. A detector formed by a plurality of dynodes is configured to detect the spatial and temporal properties of the abundance of ions, where each dynode arranged such that it is struck by ions in a known spatial relationship with the ion stream. The detector also includes a plurality of charged particle detectors, each associated with one or more of the plurality of dynodes. A processing system is configured to record and store a pattern of detection of ions in the abundance of ions by the dynodes in the detector.

    Methods for determining instrument linearity and quantification
    9.
    发明授权
    Methods for determining instrument linearity and quantification 有权

    公开(公告)号：US10598641B2

    公开(公告)日：2020-03-24

    申请号：US16222089

    申请日：2018-12-17

    申请人： Thermo Finnigan LLC

    发明人： Edward B. McCauley ,  Scott T. Quarmby

    IPC分类号： G01N30/86 ,  H01J49/00 ,  G01N30/72

    摘要： A method of assessing the linearity and dynamic range of a mass spectrometer is described comprising analyzing two or more test standards containing positional isomers, for example, using a series of N isomeric analytes with or without an internal standard where N is an integer from 2 to 6 inclusive. The concentrations of the N isomeric analytes may or may not be interleaved between two or more standards. The method allows for repeated instrument characterization without having many of the problems associated with using only a single standard such as octafluoronaphthalene (OFN), for example, persistence, and it may lessen sample carryover issues between adjacent samples. Methods are described using positional isomers of dibromodifluorobenzene in various configurations that show an improved means for qualitative and quantitative analysis of one or more analytes by GC-MS.