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    SYSTEMS AND TECHNIQUES FOR MONITORING SUBJECTS
    1.
    发明申请
    SYSTEMS AND TECHNIQUES FOR MONITORING SUBJECTS 审中-公开
    用于监测对象的系统和技术

    公开(公告)号：WO2012021801A2

    公开(公告)日：2012-02-16

    申请号：PCT/US2011/047581

    申请日：2011-08-12

    Applicant: SEVENTH SENSE BIOSYSTEMS, INC. ,  LEVINSON, Douglas, A. ,  BERNSTEIN, Howard

    Inventor： LEVINSON, Douglas, A. ,  BERNSTEIN, Howard

    IPC: G06Q50/00 ,  A61M35/00

    CPC classification number: A61B5/4833 ,  A61B5/1112 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150175 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15125 ,  A61B5/15142 ,  A61B5/154 ,  A61B5/157 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6824 ,  A61B10/0045 ,  A61B2010/0009 ,  A61B2010/008 ,  A61M5/1723 ,  A61M37/0015 ,  A61M2037/0023 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G06F19/3468 ,  G06Q20/10 ,  G06Q30/02 ,  G06Q30/0207 ,  G06Q50/22 ,  G16H40/63 ,  Y02A90/22 ,  Y02A90/26

    Abstract: The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.

    Abstract translation: 本发明总体上涉及用于监测和/或提供对象服用的药物或其他药物的反馈的系统和方法。 在一个方面，本发明涉及用于确定受试者皮肤内的物种的装置和方法; 并基于物种的确定向对象产生反馈。 反馈可以是例如视觉，听觉，触觉，温度变化等。在一些情况下，关于种类的确定的信息可以被传输到另一个实体，例如健康护理提供者，计算机， 亲属等等，然后可以以某种方式向对象提供反馈。 在一些情况下，反馈可以直接指示物种，例如物种是否存在，物种的浓度，是否存在涉及物种的反应的副产物，受该物种影响的化合物是否是 存在等。但是，在一些实施例中，反馈也可以是间接的。 例如，可以向受试者呈现外部奖励，例如基于皮肤内物种的确定。 例如，可以基于主体的合规性水平来提供诸如现金，优惠券，歌曲，折扣，个人物品等的奖励。 本发明的其他方面通常涉及涉及这种装置（具有或不具有待监测药物）的试剂盒，促进此类系统的方法等。

    OXYGEN SENSOR
    3.
    发明申请
    OXYGEN SENSOR 审中-公开
    氧传感器

    公开(公告)号：WO2010101625A3

    公开(公告)日：2011-08-11

    申请号：PCT/US2010000630

    申请日：2010-03-02

    Applicant: SEVENTH SENSE BIOSYSTEMS INC ,  LEVINSON DOUGLAS A ,  BERNSTEIN HOWARD

    Inventor： LEVINSON DOUGLAS A ,  BERNSTEIN HOWARD

    IPC: A61B5/15 ,  A61B5/00 ,  G01N33/49 ,  G01N33/72

    CPC classification number: G01N33/84 ,  A61B5/021 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/411 ,  A61B2560/0412 ,  A61M5/14244 ,  G01N33/54366 ,  G01N33/72

    Abstract: The present invention generally relates to systems and methods for determining oxygen in a sample, or in a subject. In one aspect, the present invention is generally directed to an article exhibiting a determinable feature responsive to oxygen, such as oxygen-sensitive particles. The particles may exhibit a determinable change with a change in oxygen concentration, and such particles can accordingly be used to determine oxygen. For example, in one set of embodiments, the particles may be at least partially coated with a protein, such as hemoglobin, that is able to interact with oxygen. In some cases, the protein may aggregate under certain conditions (e.g., under relatively low oxygen concentrations), and such protein aggregation may be used, for example, to cause the particles to become aggregated, which can be determined in some way. In some cases, such aggregation may be irreversible; i.e., the degree of aggregation corresponds to the most extreme oxygen concentrations that the proteins were exposed to. Such articles may be used, for example, to determine oxygen within a sample, or within a subject, such as a human subject. For instance, the article may be formed as a skin patch, or administered to the skin of a subject, e.g., on the surface of the skin, within the dermis or epidermis, etc., to determine oxygen within the subject.

    Abstract translation: 本发明一般涉及用于测定样品或受试者中的氧的系统和方法。 一方面，本发明一般涉及一种表现出对氧敏感的颗粒有氧的可确定特征的物品。 颗粒可以随着氧浓度的变化而呈现可确定的变化，因此可以使用这样的颗粒来确定氧气。 例如，在一组实施方案中，颗粒可以至少部分地涂覆有能够与氧相互作用的蛋白质，例如血红蛋白。 在一些情况下，蛋白质可以在某些条件下（例如，在相对低的氧浓度下）聚集，并且可以使用这种蛋白质聚集，例如使颗粒变得聚集，这可以以某种方式确定。 在某些情况下，这种聚合可能是不可逆的; 即聚集度对应于蛋白质暴露于最极端的氧浓度。 例如，这样的制品可用于测定样品内或受试者（例如人类受试者）内的氧。 例如，制品可以形成为皮肤贴片，或者施用于受试者的皮肤，例如皮肤表面，真皮或表皮等内，以确定受试者内的氧。

    RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF
    4.
    发明申请
    RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF 审中-公开
    适用于皮肤的相对小的装置，模块化系统及其使用方法

    公开(公告)号：WO2011053788A3

    公开(公告)日：2011-07-28

    申请号：PCT/US2010054725

    申请日：2010-10-29

    Applicant: SEVENTH SENSE BIOSYSTEMS INC ,  BERNSTEIN HOWARD ,  CHICKERING DONALD E ,  LEVINSON DOUGLAS A ,  WALT DAVID R ,  DAVIS SHAWN ,  HAGHGOOIE RAMIN

    Inventor： BERNSTEIN HOWARD ,  CHICKERING DONALD E ,  LEVINSON DOUGLAS A ,  WALT DAVID R ,  DAVIS SHAWN ,  HAGHGOOIE RAMIN

    IPC: A61M5/32 ,  A61B5/151 ,  A61B5/157

    CPC classification number: A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61M5/425 ,  A61M35/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/588

    Abstract: The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc.

    Abstract translation: 本发明在某些方面通常涉及应用于皮肤的相对小的装置，模块化系统及其使用方法。 在一些方面，设备被构造和布置成具有多个模块。 例如，该装置可以具有用于递送到和/或从对象皮肤和/或皮肤下方的流体递送的模块和用于传送指示输送到皮肤和/或从皮肤递送的流体的信号的模块，以及 /或受试者皮肤下方的用于分析从皮肤抽出的流体和/或在受试者的皮肤下方的流体的模块等。 在一些实施例中，模块可彼此连接和/或可拆卸，并且在一些情况下，可以在设备与对象接触时执行连接和/或拆卸，例如在固定到对象的同时。 在一些实施例中，该装置可以重复地应用于受试者的皮肤，以递送至/或从对象的皮肤和/或皮肤下方例如在相同位置或不同位置递送流体 受试者的皮肤。 在一些方面，装置可以是独立的和/或具有相对较小的尺寸，并且在一些情况下，该装置的尺寸可被设定为使得其可穿戴和/或能够被受试者携带。 例如，该装置可以具有质量和/或尺寸，其允许受试者携带或穿戴不同时间段，例如至少约一小时，至少约一天，至少约一周 等等，或不超过约一小时，不超过约10分钟等

    DETERMINATION OF TRACERS WITHIN SUBJECTS
    8.
    发明申请
    DETERMINATION OF TRACERS WITHIN SUBJECTS 审中-公开
    确定受试者间的踪迹

    公开(公告)号：WO2010110916A2

    公开(公告)日：2010-09-30

    申请号：PCT/US2010/000919

    申请日：2010-03-26

    Applicant: SEVENTH SENSE BIOSYSTEMS, INC. ,  LEVINSON, Douglas, A.

    Inventor： LEVINSON, Douglas, A.

    IPC: A61K47/48

    CPC classification number: A61K49/006 ,  A61K47/549 ,  A61K47/60 ,  A61K47/62 ,  A61K49/0006

    Abstract: The present invention generally relates to the use of tracers, for example, to track a substance that has been administered to a subject. A tracer may be separate from the substance to be administered, or in some cases, the tracer and the substance are chemically bonded to each other. When administered to a subject (e.g., ingested), the tracer and the substance to be administered may be absorbed and/or metabolized by the subject, and the pharmacokinetic activity of the tracer within the subject may be related to the pharmacokinetic activity of the substance. Thus, by following the pharmacokinetic activity of the tracer, the pharmacokinetic activity of the substance may be determined. The tracer itself may be determined within a subject using any suitable method, depending on the tracer. As an example, the tracer may be determined by administering an indicator able to interact with the tracer. For instance, the indicator may be applied to the skin of the subject, and the indicator may give a different visual appearance based on the concentration of the tracer, or otherwise exhibit a determinable change in a property of the indicator. Other aspects of the invention are generally directed to methods of making or using tracers, methods of promoting the making or use of such tracers, kits involving such tracers, and the like.

    Abstract translation: 本发明一般涉及示踪剂的使用，例如，追踪已经施用于对象的物质。 示踪剂可以与要施用的物质分开，或者在某些情况下，示踪剂和物质彼此化学键合。 当施用于受试者（例如摄入的）时，示踪剂和待施用的物质可以被受试者吸收和/或代谢，受试者内示踪剂的药代动力学活性可以与该物质的药代动力学活性相关 。 因此，通过跟踪示踪剂的药代动力学活性，可以确定该物质的药代动力学活性。 示踪剂本身可以使用任何合适的方法在受试者内确定，取决于示踪剂。 作为例子，示踪剂可以通过施用能够与示踪剂相互作用的指示剂来确定。 例如，指示剂可以施加到受试者的皮肤上，并且指示剂可以基于示踪剂的浓度给出不同的视觉外观，或者以其他方式呈现指示剂性质的可确定的变化。 本发明的其它方面通常涉及制造或使用示踪剂的方法，促进制造或使用这种示踪剂的方法，涉及这种示踪剂的试剂盒等。

    RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS
    10.
    发明申请
    RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS 审中-公开
    快速交付和/或取消流体

    公开(公告)号：WO2011088214A2

    公开(公告)日：2011-07-21

    申请号：PCT/US2011/021134

    申请日：2011-01-13

    Applicant: SEVENTH SENSE BIOSYSTEMS, INC. ,  CHICKERING, Donald, E. ,III ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin ,  BERNSTEIN, Howard ,  LEVINSON, Douglas, A. ,  MICHELMAN, Mark

    Inventor： CHICKERING, Donald, E. ,III ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin ,  BERNSTEIN, Howard ,  LEVINSON, Douglas, A. ,  MICHELMAN, Mark

    IPC: A61M5/178 ,  A61B5/151 ,  A61B5/145

    CPC classification number: A61B5/6849 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685

    Abstract: The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

    Abstract translation: 本发明总体上涉及用于递送和/或从皮肤和/或皮肤下面的受试者递送和/或取出物质或诸如血液或间质液的物质的方法。 在一个方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从皮肤和/或从皮肤下方抽取或提取血液的装置和方法 ）和在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液中的分析物。 例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。 本发明的其它方面涉及用于抽出血液（或其它体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

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