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    RAPID DELIVERY AND/OR RECEIVING OF FLUIDS
    2.
    发明申请
    RAPID DELIVERY AND/OR RECEIVING OF FLUIDS 审中-公开
    快速输送和/或接收流体

    公开(公告)号：WO2012018486A3

    公开(公告)日：2012-04-12

    申请号：PCT/US2011043698

    申请日：2011-07-12

    申请人： SEVENTH SENSE BIOSYSTEMS INC ,  DAVIS SHAWN ,  CHICKERING DONALD E ,  HAGHGOOIE RAMIN

    发明人： DAVIS SHAWN ,  CHICKERING DONALD E ,  HAGHGOOIE RAMIN

    IPC分类号： A61B5/15 ,  A61B5/153 ,  A61M5/158

    CPC分类号： A61M37/0015 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150282 ,  A61B5/150427 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150511 ,  A61B5/150526 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15144 ,  A61B5/157 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  Y10T29/4998

    摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. In another aspect, the present invention is generally directed to arrangements of skin insertion objects such as microneedles and methods of forming and arranging skin insertion objects. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

    摘要翻译： 本发明一般涉及用于从受试者例如皮肤和/或从皮肤下方递送和/或接收物质或物质例如血液的系统和方法。 一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面接受或提取血液的装置和方法 ）和在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是独立的，并且在某些情况下，可将该装置应用于皮肤并被激活以从受试者接收血液。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液中的分析物。 例如，可以从装置接收血液，和/或该装置可以包含能够确定血液和/或怀疑含在血液中的分析物的传感器或试剂。 另一方面，本发明一般涉及皮肤插入物体如微针的布置以及形成和布置皮肤插入物体的方法。 本发明的其它方面涉及用于接收血液（或其它体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

    RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS
    3.
    发明申请
    RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS 审中-公开
    快速交付和/或取消流体

    公开(公告)号：WO2011088214A2

    公开(公告)日：2011-07-21

    申请号：PCT/US2011/021134

    申请日：2011-01-13

    申请人： SEVENTH SENSE BIOSYSTEMS, INC. ,  CHICKERING, Donald, E. ,III ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin ,  BERNSTEIN, Howard ,  LEVINSON, Douglas, A. ,  MICHELMAN, Mark

    发明人： CHICKERING, Donald, E. ,III ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin ,  BERNSTEIN, Howard ,  LEVINSON, Douglas, A. ,  MICHELMAN, Mark

    IPC分类号： A61M5/178 ,  A61B5/151 ,  A61B5/145

    CPC分类号： A61B5/6849 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685

    摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

    摘要翻译： 本发明总体上涉及用于递送和/或从皮肤和/或皮肤下面的受试者递送和/或取出物质或诸如血液或间质液的物质的方法。 在一个方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从皮肤和/或从皮肤下方抽取或提取血液的装置和方法 ）和在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液中的分析物。 例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。 本发明的其它方面涉及用于抽出血液（或其它体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

    SAMPLING DEVICE INTERFACES
    4.
    发明申请
    SAMPLING DEVICE INTERFACES 审中-公开
    采样设备接口

    公开(公告)号：WO2011088211A2

    公开(公告)日：2011-07-21

    申请号：PCT/US2011/021131

    申请日：2011-01-13

    申请人： SEVENTH SENSE BIOSYSTEMS, INC. ,  CHICKERING, Donald, E. ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin ,  BERNSTEIN, Howard ,  LEVINSON, Douglas, A.

    发明人： CHICKERING, Donald, E. ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin ,  BERNSTEIN, Howard ,  LEVINSON, Douglas, A.

    IPC分类号： A61B5/151

    CPC分类号： A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685

    摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self- contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

    摘要翻译： 本发明总体上涉及用于从受试者（例如从皮肤和/或从皮肤下方）输送和/或排出一种或多种物质（例如血液或间质液）的系统和方法。 在一个方面，本发明总体上涉及用于使用含有液体转运体的装置（例如，一个或多个微针）从受试者（例如从皮肤和/或皮肤下面）抽取或抽取血液的装置和方法 ）以及在接收血液之前具有小于大气压的内部压力的储存室。 在某些情况下，该装置可以是自包含的，并且在某些情况下，该装置可以被施加到皮肤上，并且被激活以从受试者中抽取血液。 该装置在某些情况下可以与外部设备连接以确定装置内包含的或被装置收集的流体内包含的分析物。 例如，该装置可以被安装或接合在外部保持器上，该装置可以包括用于将流体输送出装置的端口，该装置可以包括用于询问容纳在装置内的流体的窗口等。 然后可以处理装置或其一部分，以单独地或利用外部装置来确定血液和/或血液内的分析物。 例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。 本发明的其它方面涉及用于抽取血液（或其他体液，例如间质液）的其它装置，涉及这种装置的套件，制造这种装置的方法，使用这种装置的方法等。

    COMPOSITIONS AND METHODS FOR RAPID ONE-STEP DIAGNOSIS
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR RAPID ONE-STEP DIAGNOSIS 审中-公开
    用于快速一步诊断的组合物和方法

    公开(公告)号：WO2009149308A2

    公开(公告)日：2009-12-10

    申请号：PCT/US2009/046333

    申请日：2009-06-04

    申请人： SEVENTH SENSE BIOSYSTEMS, INC. ,  LEVINSON, Douglas, Adam

    发明人： LEVINSON, Douglas, Adam

    IPC分类号： C12Q1/28 ,  B01L3/00 ,  G01N33/483 ,  G08B7/00 ,  A61B5/00

    CPC分类号： G01N33/54386 ,  A61B5/14532 ,  A61B5/411 ,  G01N33/543

    摘要： Devices for fast easy monitoring of analyte levels, disease, or other physiological changes are provided. In some cases, the devices may include particles or the like that can be placed and read at the site of detection, typically on or in the skin or mucosa. In one embodiment, the particles may include anisotropic particles. Typically the devices will typically provide a visual colorimetic signal, but other signals are possible, such as smell, taste (e.g., release of food acceptable flavor), or tactile (e.g., shape change). The devices are preferably single use, disposable devices, although some may be able to provide multiple readings over a period of time. These devices may be used with any patient and are particularly useful for pediatric and elderly patients, as well as for the military, and people without health insurance. The devices can be used to assess when intervention may be required without expensive testing at a physician's office, or simply for routine maintenance of those who are concerned about their health.

    摘要翻译： 提供了用于快速容易地监测分析物水平，疾病或其他生理变化的装置。 在一些情况下，装置可以包括可以在检测位置（通常在皮肤或粘膜上或皮肤或粘膜中）放置和读取的颗粒等。 在一个实施方案中，颗粒可以包括各向异性颗粒。 通常，装置通常将提供视觉拟像信号，但是其他信号也是可能的，例如气味，味道（例如食物可接受风味的释放）或触觉（例如，形状变化）。 这些装置优选是单次使用的一次性装置，尽管一些装置可能能够在一段时间内提供多个读数。 这些装置可以与任何患者一起使用，对于儿科和老年患者以及军人以及没有健康保险的人特别有用。 该设备可用于评估何时可能需要进行干预，而不需要在医生办公室进行昂贵的测试，或者简单地对那些关心健康的人进行日常维护。

    SYSTEMS AND METHODS FOR COLLECTING FLUID FROM A SUBJECT
    8.
    发明申请
    SYSTEMS AND METHODS FOR COLLECTING FLUID FROM A SUBJECT 审中-公开
    从主体收集流体的系统和方法

    公开(公告)号：WO2012149155A9

    公开(公告)日：2013-03-14

    申请号：PCT/US2012035207

    申请日：2012-04-26

    申请人： SEVENTH SENSE BIOSYSTEMS INC ,  HAGHGOOIE RAMIN ,  CHICKERING DONALD E III ,  DAVIS SHAWN ,  MICHELMAN MARK ,  CHU LU YANG

    发明人： HAGHGOOIE RAMIN ,  CHICKERING DONALD E III ,  DAVIS SHAWN ,  MICHELMAN MARK ,  CHU LU YANG

    IPC分类号： A61B5/15 ,  A61B5/151

    CPC分类号： A61B5/150099 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B10/0045 ,  A61B2010/008 ,  A61M37/0015 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061

    摘要： Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the "pooling" of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device and have a volume that is larger than a recess of the fluid transporter that receives fluid from a surface.

    摘要翻译： 用于从受试者例如皮肤递送和/或接收流体或其它材料（例如血液或间质液）的系统和方法。 珠粒破坏剂和/或毛细管可用于促进流体从受试者输送到装置中。 珠粒破坏者可能会破坏皮肤表面上的体液（如血液）的“汇集”，并有助于以期望的方式影响流动。 毛细管可以将装置中的流体的流动例如传导到通向储存室的通道或其它流动路径的入口。 可以使用真空（相对于环境的减压）来将流体接收到装置中，例如通过使用相对低的压力将流体引入通向存储室的通道的入口。 真空源可以是装置的一部分，并且具有大于从表面接收流体的流体输送器的凹部的体积。

    SYSTEMS AND TECHNIQUES FOR MONITORING SUBJECTS
    9.
    发明申请
    SYSTEMS AND TECHNIQUES FOR MONITORING SUBJECTS 审中-公开
    监控项目的系统和技术

    公开(公告)号：WO2012021801A3

    公开(公告)日：2012-05-24

    申请号：PCT/US2011047581

    申请日：2011-08-12

    申请人： SEVENTH SENSE BIOSYSTEMS INC ,  LEVINSON DOUGLAS A ,  BERNSTEIN HOWARD

    发明人： LEVINSON DOUGLAS A ,  BERNSTEIN HOWARD

    IPC分类号： G06Q50/00 ,  A61M35/00

    CPC分类号： A61B5/4833 ,  A61B5/1112 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150175 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15125 ,  A61B5/15142 ,  A61B5/154 ,  A61B5/157 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6824 ,  A61B10/0045 ,  A61B2010/0009 ,  A61B2010/008 ,  A61M5/1723 ,  A61M37/0015 ,  A61M2037/0023 ,  G06F19/3418 ,  G06F19/3456 ,  G06F19/3468 ,  G06Q20/10 ,  G06Q30/02 ,  G06Q30/0207 ,  G06Q50/22 ,  G16H40/63 ,  Y02A90/22 ,  Y02A90/26

    摘要： The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.

    摘要翻译： 本发明一般涉及用于监测和/或提供受试者所采取的药物或其他药物的反馈的系统和方法。 一方面，本发明涉及用于确定受试者皮肤内物种的装置和方法; 并根据物种的确定向对象产生反馈。 反馈可以是例如视觉，听觉，触觉，温度变化等。在一些情况下，关于物种的确定的信息可以被传输到另一个实体，例如医疗保健提供者，计算机， 相对等，其然后可以以某种方式向受试者提供反馈。 在一些情况下，反馈可以直接指示物种，例如物种是否存在，物种的浓度，是否存在涉及物种的反应的副产物，受物种影响的化合物是否为 存在等。然而，在一些实施例中，反馈也可以是间接的。 例如，受试者可以例如基于皮肤内物种的确定来呈现外部奖励。 例如，可以基于主体的合规级别来提供诸如现金，优惠券，歌曲，折扣，个人物品等的奖励。 本发明的其它方面通常涉及涉及这种装置的试剂盒（有或没有待监测的药物），促进这种系统的方法等。

    SAMPLING DEVICE INTERFACES
    10.
    发明申请
    SAMPLING DEVICE INTERFACES 审中-公开
    采样设备接口

    公开(公告)号：WO2011088211A3

    公开(公告)日：2011-12-01

    申请号：PCT/US2011021131

    申请日：2011-01-13

    申请人： SEVENTH SENSE BIOSYSTEMS INC ,  CHICKERING DONALD E ,  DAVIS SHAWN ,  HAGHGOOIE RAMIN ,  BERNSTEIN HOWARD ,  LEVINSON DOUGLAS A

    发明人： CHICKERING DONALD E ,  DAVIS SHAWN ,  HAGHGOOIE RAMIN ,  BERNSTEIN HOWARD ,  LEVINSON DOUGLAS A

    IPC分类号： A61B5/151

    CPC分类号： A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685

    摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self- contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

    摘要翻译： 本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。 一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽出或提取血液的装置和方法 ）和在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是自包含的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。 在一些情况下，该装置可以与外部设备接口以确定包含在装置内或由装置收集的流体中的分析物。 例如，该装置可以安装或接合在外部支架上，该装置可以包括用于将流体输送出装置的端口，该装置可包括询问包含在装置内的流体等的窗口。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液中的分析物。 例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。 本发明的其它方面涉及用于抽出血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。