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    ALTERNATIVE BUTANOL PRODUCTION PROCESS IN A MICROBIAL CELL
    4.
    发明申请
    ALTERNATIVE BUTANOL PRODUCTION PROCESS IN A MICROBIAL CELL 审中-公开
    一种微生物细胞中的替代丁醇生产工艺

    公开(公告)号：WO2010031772A2

    公开(公告)日：2010-03-25

    申请号：PCT/EP2009/061961

    申请日：2009-09-15

    申请人： DSM IP ASSETS B.V. ,  WU, Liang ,  PERKINS, John B. ,  SCHYNS, Ghislain

    发明人： WU, Liang ,  PERKINS, John B. ,  SCHYNS, Ghislain

    IPC分类号： C12N15/53 ,  C12N15/54 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12P7/16

    CPC分类号： C12N9/0006 ,  C12N9/0008 ,  C12N9/0051 ,  C12N9/1022 ,  C12N9/1029 ,  C12P7/16 ,  Y02E50/10

    摘要： The present invention relates to a microbial cell comprising genes encoding enzymes that catalyse the following reactions a) pyruvate to acetolactate, b) acetolactate to 2,3-dihydroxyisovalerate, c) 2,3-dihydroxyisovalerate to 2-ketoisovalerate, d) 2- ketoisovalerate to isobutyryl-CoA, e) isobutyryl-CoA to butyryl-CoA, f) butyryl-CoA to butyraldehyde, and g) butyraldehyde to butanol, wherein the cell produces butanol. The invention further relates to a process for the production of butanol wherein the microbial cell according to the present invention is used.

    摘要翻译： 本发明涉及包含编码酶的基因的微生物细胞，所述酶催化下列反应a）丙酮酸转化为乙酰乳酸，b）乙酰乳酸转化为2,3-二羟基异戊酸，c）2,3-二羟基异戊酸转化成2 d）2-酮异戊酸酯与异丁酰-CoA，e）异丁酰-CoA与丁酰-CoA，f）丁酰-CoA与丁醛，和g）丁醛与丁醇，其中所述细胞产生丁醇。 本发明还涉及生产丁醇的方法，其中使用了根据本发明的微生物细胞。

    NOVEL GENE USEFUL FOR GROWTH CONTROL OF PLANTS
    5.
    发明申请
    NOVEL GENE USEFUL FOR GROWTH CONTROL OF PLANTS 审中-公开
    新基因有用于植物生长控制

    公开(公告)号：WO2008110303A1

    公开(公告)日：2008-09-18

    申请号：PCT/EP2008/001827

    申请日：2008-03-07

    申请人： DSM IP ASSETS B.V. ,  HENRIQUES, Adriano, O. ,  SCHYNS, Ghislain

    发明人： HENRIQUES, Adriano, O. ,  SCHYNS, Ghislain

    IPC分类号： C12N15/31 ,  C07K14/32 ,  C12N1/21 ,  A01N63/02

    CPC分类号： C07K14/32 ,  A01N63/02 ,  A01N63/04

    摘要： The present invention relates to microbial organisms, for example microbial spores, capable for turf management control to replace herbicide against weeds. The invention also relates to polynucleotide sequences comprising genes that encode proteins that are involved in turf management control. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools for growth control of plants. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for turf management control.

    摘要翻译： 本发明涉及微生物生物体，例如微生物孢子，其能够控制草皮去除杂草的除草剂。 本发明还涉及包含编码参与草皮管理控制的蛋白质的基因的多核苷酸序列。 本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。 本发明还涉及所述多核苷酸和多肽作为植物生长控制的生物技术工具的用途。 还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。 本发明还涉及基因工程微生物及其用于草坪管理控制的用途。

    ALTERNATIVE BUTANOL PRODUCTION PROCESS IN A MICROBIAL CELL
    8.
    发明申请
    ALTERNATIVE BUTANOL PRODUCTION PROCESS IN A MICROBIAL CELL 审中-公开
    微生物细胞中的替代丁醇生产过程

    公开(公告)号：WO2010031772A3

    公开(公告)日：2010-06-10

    申请号：PCT/EP2009061961

    申请日：2009-09-15

    申请人： DSM IP ASSETS BV ,  WU LIANG ,  PERKINS JOHN B ,  SCHYNS GHISLAIN

    发明人： WU LIANG ,  PERKINS JOHN B ,  SCHYNS GHISLAIN

    IPC分类号： C12N15/53 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N15/54 ,  C12P7/16

    CPC分类号： C12N9/0006 ,  C12N9/0008 ,  C12N9/0051 ,  C12N9/1022 ,  C12N9/1029 ,  C12P7/16 ,  Y02E50/10

    摘要： The present invention relates to a microbial cell comprising genes encoding enzymes that catalyse the following reactions a) pyruvate to acetolactate, b) acetolactate to 2,3-dihydroxyisovalerate, c) 2,3-dihydroxyisovalerate to 2-ketoisovalerate, d) 2- ketoisovalerate to isobutyryl-CoA, e) isobutyryl-CoA to butyryl-CoA, f) butyryl-CoA to butyraldehyde, and g) butyraldehyde to butanol, wherein the cell produces butanol. The invention further relates to a process for the production of butanol wherein the microbial cell according to the present invention is used.

    摘要翻译： 本发明涉及一种微生物细胞，其包含编码酶的基因，其催化以下反应：a）丙酮酸至乙酰乳酸，b）乙酰乳酸至2,3-二羟基异戊酸酯，c）2,3-二羟基异戊酸酯为2-酮异戊酸酯，d）2-酮异戊酸 异丁酰辅酶A，异丁酰辅酶A，丁酰辅酶A，f）丁酰辅酶A，丁醛，和g）丁醛至丁醇，其中该细胞产生丁醇。 本发明还涉及生产丁醇的方法，其中使用本发明的微生物细胞。

    SPORE SURFACE DISPLAYS OF BIOACTIVE MOLECULES
    10.
    发明申请
    SPORE SURFACE DISPLAYS OF BIOACTIVE MOLECULES 审中-公开
    生物活性分子的孢子表面展示

    公开(公告)号：WO2008017483A3

    公开(公告)日：2008-04-10

    申请号：PCT/EP2007007052

    申请日：2007-08-09

    申请人： DSM IP ASSETS BV ,  HENRIQUES ADRIANO ,  SCHYNS GHISLAIN ,  WENZEL THIBAUT JOSE ,  POTOT SEBASTIAN

    发明人： HENRIQUES ADRIANO ,  SCHYNS GHISLAIN ,  WENZEL THIBAUT JOSE ,  POTOT SEBASTIAN

    IPC分类号： C12N15/75 ,  C07K14/32 ,  C07K17/02 ,  C12N11/16

    CPC分类号： C12N15/75 ,  A23K10/16 ,  A23K10/18 ,  A23K20/189 ,  A61K38/00 ,  C07K14/32 ,  C07K14/33 ,  C07K14/38 ,  C12N9/16 ,  C12Y301/03001 ,  C12Y301/03008 ,  C12Y301/03026 ,  C12Y302/01031

    摘要： This invention discloses novel bacterial spore systems. It has now been found surprisingly that under certain conditions bacterial spore systems can be used in the food and feed industry, preferably in animal feeding and as biohybrid material. More precisely applicant has found the following: Genetically modified or genetically engineered viable spore systems expressing bioactive polypeptides, for example bacteriocins and/or enzymatically active feed enzymes, at the spore surface, have a great potential use in animal feeding. Further, it has been found that genetically modified or "genetically engineered inert spore systems expressing affinity ligands or immobilized enzymes at the surface have a great potential use in biocatalysis and in the construction of biocatalytic films. Especially the resistance to harsh chemicals, desiccation, strong pressure, or high temperatures allows the spores to be a potentially valuable tool for the display of bioactive molecules, like biocatalytic enzymes or bioactive feed enzymes that must survive harsh conditions to deliver their full potential. Finally, applicant has found that instead of translational fusions to spore structural genes as it is known from the prior art described above, passenger bioactive polypeptides, as for example enzymes, bacteriocins, affinity ligands, can also be fused to spore-specific surface enzymes, for example to spore specific enzymes as mentioned herein above.

    摘要翻译： 本发明公开了新的细菌孢子系统。 现在令人惊讶地发现，在某些条件下，细菌孢子系统可以用于食品和饲料工业，优选用于动物饲养和作为生物混杂材料。 更确切地说，申请人已经发现：在孢子表面表达生物活性多肽，例如细菌素和/或酶活性饲料酶的基因修饰或基因工程活的孢子系统在动物饲养中具有很大的潜在用途。 此外，已经发现基因修饰或“基因工程惰性孢子系统在表面表达亲和配体或固定化酶在生物催化和生物催化膜的构建中具有很大的潜在用途，特别是耐受苛刻的化学品，干燥，强 压力或高温使得孢子成为展示生物活性分子的潜在有价值的工具，如生物催化酶或生物活性饲料酶，其必须在苛刻的条件下存活以充分发挥其潜力。最后，申请人发现，代替平移融合 孢子结构基因，如从上述现有技术中已知的那样，乘客生物活性多肽（例如酶，细菌素，亲和配体）也可以与孢子特异性表面酶融合，例如芽孢如上所述的特异性酶。