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    IMAGE-GUIDED LUMBAR PUNCTURE ASPIRATION AND INJECTOR SYSTEM AND METHOD
    1.
    发明申请
    IMAGE-GUIDED LUMBAR PUNCTURE ASPIRATION AND INJECTOR SYSTEM AND METHOD 审中-公开

    公开(公告)号：WO2021011731A1

    公开(公告)日：2021-01-21

    申请号：PCT/US2020/042257

    申请日：2020-07-16

    Applicant: ALCYONE LIFESCIENCES, INC.

    Inventor： SINGH, Deep, Arjun ,  ANAND, Pj

    IPC: A61B8/00 ,  A61B8/08 ,  A61B17/00 ,  A61B19/00

    Abstract: An image-guided lumbar puncture aspiration and injector system. The system includes an auto-injection device having a housing, at least one syringe having a fluid, a controller, a processor, a memory, and a display. An imaging device is communicatively coupled to the auto-injection device and captures images of a lumbar puncture area of a patient to be displayed on the display of the auto-injection device, helping identify a location for a lumbar puncture procedure. A needle assembly is coupled to the at least one syringe of the auto¬ injection device. An outer needle is adapted to be inserted into a location of the lumbar puncture area identified by the imaging device, and an inner needle is adapted to be inserted into the dura of the patient. The outer sheath needle protects the inner needle from contaminants. The controller operates the auto- injection device based on a programmed infusion and aspiration profile.

    MICROFLUIDIC DRUG DELIVERY DEVICES
    3.
    发明申请
    MICROFLUIDIC DRUG DELIVERY DEVICES 审中-公开
    微流感药物递送装置

    公开(公告)号：WO2013019830A2

    公开(公告)日：2013-02-07

    申请号：PCT/US2012/049100

    申请日：2012-08-01

    Applicant: ALCYONE LIFESCIENCES, INC. ,  ANAND, Pj ,  SINGH, Deep, Arjun

    Inventor： ANAND, Pj ,  SINGH, Deep, Arjun

    IPC: A61M37/00 ,  A61M25/01 ,  A61M25/06 ,  A61M31/00

    CPC classification number: A61M5/16804 ,  A61B5/036 ,  A61B5/14503 ,  A61B5/4839 ,  A61M5/172 ,  A61M25/0023 ,  A61M25/0026 ,  A61M2025/0042 ,  A61M2205/50

    Abstract: The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.

    Abstract translation: 本文公开的方法，系统和装置通常涉及药物对流增强的递送到患者内的目标区域。 公开了微流体导管装置，其特别适用于通过对流靶向递送药物，包括能够多方向药物递送的装置，使用文丘里效应控制流体压力和速度的装置，以及包括适形气囊的装置。 还公开了使用这种装置治疗各种疾病的方法，包括治疗脑和脊柱海绵体畸形，海绵体瘤和血管瘤的方法，治疗神经疾病的方法，使用多个微流体递送装置的治疗方法，治疗听力障碍的方法， 使用微流体装置的脊髓药物递送，以及在胎儿手术期间递送干细胞和治疗剂的方法。 还公开了制造这种装置的方法。

    THERAPY SPECIFIC, PRE-PROGRAMMED AUTO INJECTION DEVICE
    5.
    发明申请
    THERAPY SPECIFIC, PRE-PROGRAMMED AUTO INJECTION DEVICE 审中-公开

    公开(公告)号：WO2019099583A1

    公开(公告)日：2019-05-23

    申请号：PCT/US2018/061142

    申请日：2018-11-14

    Applicant: ALCYONE LIFESCIENCES, INC.

    Inventor： ANAND, Pj ,  SINGH, Deep, Arjun ,  FREUND, Jonathan ,  PERKINS-NEATON, Katelyn ,  WASHBURN, Thomas, T.

    IPC: A61M5/19 ,  A61M5/20

    Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient and a method of using the hand-held auto-injection device. The auto-injection device includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol to expel a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location and/or draw a fluid from the infusion and aspiration location into a respective barrel of the plurality of syringes.

    DRUG DELIVERY SYSTEMS AND METHODS
    6.
    发明申请
    DRUG DELIVERY SYSTEMS AND METHODS 审中-公开

    公开(公告)号：WO2018119179A1

    公开(公告)日：2018-06-28

    申请号：PCT/US2017/067796

    申请日：2017-12-21

    Applicant: ALCYONE LIFESCIENCES, INC.

    Inventor： ANAND, Pj ,  BROPHY, Morgan ,  SINGH, Deep, Arjun ,  EBERL, Gregory ,  ARZUMAND, Ayesha ,  MOURA, Stela

    IPC: A61M5/168 ,  A61M5/14 ,  A61M25/14

    Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.

    SYSTEMS AND METHODS FOR SHUNTING FLUID
    8.
    发明申请
    SYSTEMS AND METHODS FOR SHUNTING FLUID 审中-公开
    用于流体流动的系统和方法

    公开(公告)号：WO2014116640A1

    公开(公告)日：2014-07-31

    申请号：PCT/US2014/012449

    申请日：2014-01-22

    Applicant: ALCYONE LIFESCIENCES, INC.

    Inventor： ANAND, Pj ,  SINGH, Deep, Arjun ,  BROPHY, Morgan ,  FALLON, Timothy ,  DEGON, Robert ,  ATTAR, Matthew ,  WONG, Anthony ,  WALLER, Allison ,  EAST, Andrew ,  MCINTYRE, Jon, T.

    IPC: A61M25/14 ,  A61B17/22 ,  A61B18/24

    CPC classification number: A61M27/006 ,  A61M39/225 ,  A61M2025/0019 ,  A61M2039/0018 ,  A61M2205/0205 ,  A61M2205/32 ,  A61M2205/3344 ,  A61M2230/20

    Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRl)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRl, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system and for opening auxiliary fluid pathways through a shunt system are also disclosed herein.

    Abstract translation: 本文提供的系统和方法通常涉及分流流体，例如在治疗脑积水时分流脑脊液。 提供了自清洁导管，其包括分开的尖端，其被配置为使得在其中插入导管的空腔中的脉动流动可导致尖端彼此撞击，从而清除障碍物。 还提供了内置流量指示器的导管。 示例性流量指示器包括从导管的内表面径向向内延伸并且包括可成像部分（例如在磁共振成像（MR1）下可见的部分））的突起。 可以使用MR1检测由流体流过导管引起的流动指示器的运动，从而提供关于导管是部分地还是完全阻塞的可靠指示。 本文还公开了用于冲洗分流系统和用于打开通过分流系统的辅助流体路径的系统和方法。

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