公开(公告)号：WO2017160930A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022438

申请日：2017-03-15

Applicant: KALYRA PHARMACEUTICALS, INC.

Inventor： BUNKER, Kevin, Duane ,  SLEE, Deborah, Helen ,  HOPKINS, Chad, Daniel ,  PINCHMAN, Joseph, Robert ,  KAHRAMAN, Mehmet ,  HUANG, Peter, Qinhua

IPC: A61K31/136 ,  A61K31/137 ,  A61K31/165 ,  A61K31/167 ,  A61P25/06 ,  A61P29/00 ,  A61K31/428 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/4045 ,  C07D209/30 ,  C07D231/56 ,  C07D235/06 ,  C07D235/14 ,  C07D277/64 ,  C07D277/68 ,  C07D471/04

CPC classification number: A61K31/428 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/135 ,  A61K31/137 ,  A61K31/165 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/485 ,  A61K45/06 ,  A61P29/00 ,  C07D209/30 ,  C07D231/56 ,  C07D235/06 ,  C07D235/14 ,  C07D277/64 ,  C07D277/68 ,  C07D471/04 ,  A61K2300/00

Abstract: Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.

公开(公告)号：WO2016161160A1

公开(公告)日：2016-10-06

申请号：PCT/US2016/025345

申请日：2016-03-31

Applicant: KALYRA PHARMACEUTICALS, INC.

Inventor： HUANG, Peter Qinhua ,  KAHRAMAN, Mehmet ,  SLEE, Deborah, Helen ,  BUNKER, Kevin, Duane ,  HOPKINS, Chad, Daniel ,  PINCHMAN, Joseph, Robert ,  ABRAHAM, Sunny ,  SIT, Rakesh, Kumar ,  SEVERANCE, Daniel, Lee

IPC: C07D487/10 ,  C07D211/18 ,  A61K31/33 ,  A61P35/00

CPC classification number: C07D487/10 ,  A61P35/00 ,  C07D471/10

Abstract: Disclosed herein are spirocyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

Abstract translation: 本文公开了螺环化合物，以及用本文所述的一种或多种化合物改善和/或治疗本文所述的癌症的药物组合物和方法。

公开(公告)号：WO2017205459A1

公开(公告)日：2017-11-30

申请号：PCT/US2017/034163

申请日：2017-05-24

Applicant: KALYRA PHARMACEUTICALS, INC.

Inventor： BUNKER, Kevin, Duane ,  HUANG, Peter, Qinhua ,  ABRAHAM, Sunny ,  PINCHMAN, Joseph, Robert ,  HOPKINS, Chad, Daniel ,  SLEE, Deborah, Helen

IPC: C07D403/14 ,  C07D209/04 ,  A61K31/404 ,  A61P35/00

Abstract: Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

Abstract translation: 本文公开了含氮双环化合物以及药物组合物以及用本文所述的一种或多种化合物改善和/或治疗本文所述癌症的方法。

公开(公告)号：WO2017160922A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022430

申请日：2017-03-15

Applicant: KALYRA PHARMACEUTICALS, INC.

Inventor： BUNKER, Kevin, Duane ,  SLEE, Deborah, Helen ,  HOPKINS, Chad, Daniel ,  PINCHMAN, Joseph, Robert ,  KAHRAMAN, Mehmet ,  HUANG, Peter, Qinhua

IPC: A61K31/136 ,  A61K31/137 ,  A61K31/165 ,  A61K31/167 ,  A61P25/06 ,  A61P29/00 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/415 ,  A61K31/44 ,  A61K31/505 ,  C07D277/28 ,  C07D285/135 ,  C07D285/12 ,  C07D271/113 ,  C07D277/40 ,  C07D239/42 ,  C07D213/73 ,  C07D263/48 ,  C07D231/12 ,  C07D213/38 ,  C07D285/08 ,  C07D277/32 ,  C07C211/52 ,  C07C211/29 ,  C07C233/13 ,  C07C233/15 ,  C07C233/07 ,  C07C233/25

Abstract: Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.

公开(公告)号：WO2018106571A1

公开(公告)日：2018-06-14

申请号：PCT/US2017/064435

申请日：2017-12-04

Applicant: KALYRA PHARMACEUTICALS, INC.

Inventor： BUNKER, Kevin, Duane ,  PINCHMAN, Joseph, Robert

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/10

CPC classification number: C07H17/08 ,  A61P31/10

Abstract: Compounds of the Formulae (I) and (II) as described herein, or pharmaceutically acceptable salts thereof, are described, along with pharmaceutical compositions comprising such compounds, salts or combinations thereof, as well as methods for using them to make compounds of the Formula (Illa) and/or (Illb), and/or other compounds of the Formulae (I) and (II). Such compounds, salts and compositions are useful for inhibiting fungal growth. For example, in an embodiment, fungal infections can be treated by administering effective amounts of such compounds, salts and/or compositions to a subject in need thereof.

公开(公告)号：WO2017160925A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022433

申请日：2017-03-15

Applicant: KALYRA PHARMACEUTICALS, INC.

Inventor： BUNKER, Kevin, Duane ,  SLEE, Deborah, Helen ,  HOPKINS, Chad, Daniel ,  PINCHMAN, Joseph, Robert ,  KAHRAMAN, Mehmet ,  HUANG, Peter, Qinhua

IPC: A61K31/13 ,  A61K31/16 ,  A61K31/33 ,  A61P25/06 ,  A61P29/00 ,  A61K31/337 ,  A61K31/397 ,  A61K31/335 ,  A61K31/341 ,  A61K31/40 ,  A61K31/4468 ,  A61K31/351 ,  C07D205/04 ,  C07D205/12 ,  C07D207/14 ,  C07D211/58 ,  C07D305/14 ,  C07D307/22 ,  C07D309/14 ,  C07D313/04 ,  C07D487/10

CPC classification number: A61K31/397 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/135 ,  A61K31/137 ,  A61K31/337 ,  A61K31/34 ,  A61K31/341 ,  A61K31/35 ,  A61K31/351 ,  A61K31/40 ,  A61K31/439 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/4468 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/485 ,  A61K31/55 ,  A61K45/06 ,  A61P29/00 ,  A61K2300/00

Abstract: Disclosed herein are compounds of Formulae (I), and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.

Abstract translation: （I）和（II）的化合物，合成式（I）和（II）化合物的方法以及使用式（I）和（II）化合物的方法 ）作为镇痛剂。

公开(公告)号：WO2017172957A1

公开(公告)日：2017-10-05

申请号：PCT/US2017/024809

申请日：2017-03-29

Applicant: KALYRA PHARMACEUTICALS, INC.

Inventor： HUANG, Peter, Qinhua ,  SLEE, Deborah, Helen ,  HEGDE, Sayee, Gajanan ,  HOPKINS, Chad, Daniel ,  BUNKER, Kevin, Duane ,  PINCHMAN, Joseph, Robert ,  SIT, Rakesh, Kumar

IPC: C07D471/04 ,  C07D471/14 ,  C07C61/13 ,  C07F7/18 ,  C07C57/04 ,  C07D209/18 ,  C07D209/14 ,  A61K31/437 ,  A61K31/438 ,  A61P35/00 ,  A61P5/30

Abstract: Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as breast cancer.

Abstract translation: 式（I）化合物是雌激素受体α调节剂，其中式（I）中的变量在本公开中描述。 此类化合物及其药学上可接受的盐和组合物可用于治疗雌激素受体α依赖性和/或雌激素受体α介导的疾病或病症，包括以过度细胞增殖为特征的病症，例如乳腺癌。

公开(公告)号：WO2017160926A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022434

申请日：2017-03-15

Applicant: KALYRA PHARMACEUTICALS, INC.

Inventor： BUNKER, Kevin, Duane ,  SLEE, Deborah, Helen ,  HOPKINS, Chad, Daniel ,  PINCHMAN, Joseph, Robert ,  KAHRAMAN, Mehmet ,  HUANG, Peter, Qinhua

IPC: A61K31/13 ,  A61K31/16 ,  A61P25/06 ,  A61P29/00 ,  C07C211/17 ,  C07C211/35 ,  C07C211/37 ,  C07C211/38

CPC classification number: A61K31/16 ,  A61K31/135 ,  A61K31/137 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/485 ,  A61K45/06 ,  A61P25/06 ,  A61P29/00 ,  C07C211/17 ,  C07C211/35 ,  C07C211/37 ,  C07C211/38 ,  C07C215/42 ,  C07C215/44 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/44 ,  C07C2602/50 ,  C07C2603/74 ,  A61K2300/00

Abstract: Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.

Abstract translation: 本文公开了式（I）化合物，合成式（I）化合物的方法和使用式（I）化合物作为止痛剂的方法。

公开(公告)号：WO2016183094A1

公开(公告)日：2016-11-17

申请号：PCT/US2016/031663

申请日：2016-05-10

Applicant: KALYRA PHARMACEUTICALS, INC.

Inventor： BUNKER, Kevin, Duane ,  ABRAHAM, Sunny ,  HOPKINS, Chad, Daniel ,  PINCHMAN, Joseph, Robert ,  HUANG, Peter, Qinhua ,  SLEE, Deborah, Helen

IPC: C07D471/04 ,  C07D473/30 ,  C07D487/04 ,  A61K31/52 ,  A61P1/16 ,  A61P1/18 ,  A61P13/12

CPC classification number: C07D473/30 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04

Abstract: Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

Abstract translation: 本文公开了含氮双环化合物，以及用本文所述的一种或多种化合物改善和/或治疗本文所述的癌症的药物组合物和方法。

公开(公告)号：WO2016044331A1

公开(公告)日：2016-03-24

申请号：PCT/US2015/050275

申请日：2015-09-15

Applicant: KALYRA PHARMACEUTICALS, INC.

Inventor： BUNKER, Kevin, Duane ,  GUO, Chuangxing ,  GRIER, Mark, Charles ,  HOPKINS, Chad, Daniel ,  PINCHMAN, Joseph, Robert ,  SLEE, Deborah, Helen ,  HUANG, Qinhua ,  KAHRAMAN, Mehmet

IPC: A61K31/16 ,  A61K31/10 ,  A61K31/13 ,  A61K31/133 ,  A61P25/04 ,  A61P29/00 ,  C07C233/05 ,  C07C211/19 ,  C07C211/38 ,  C07C233/06 ,  C07C233/12 ,  C07C233/23 ,  C07C317/04 ,  C07C317/12

CPC classification number: C07D213/89 ,  A61K31/13 ,  A61K31/145 ,  A61K31/16 ,  A61K31/164 ,  A61K31/27 ,  A61K31/444 ,  A61K45/06 ,  C07C211/38 ,  C07C215/42 ,  C07C233/05 ,  C07C233/06 ,  C07C233/09 ,  C07C233/13 ,  C07C233/14 ,  C07C233/23 ,  C07C317/30 ,  C07C2601/02 ,  C07C2602/38 ,  C07C2603/62 ,  A61K2300/00

Abstract: Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.

Abstract translation: 本文公开了式（I）和（II）的化合物，合成式（I）和（II）化合物的方法，以及使用式（I）和（II）化合物作为止痛剂的方法。