利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

899 条记录 (耗时 0.027 秒)

    EXPANDING THE T CELL REPERTOIRE TO INCLUDE SUBDOMINANT EPITOPES BY VACCINATION WITH ANTIGENS DELIVERED AS PROTEIN FRAGMENTS OR PEPTIDE COCKTAILS
    93.
    发明申请
    EXPANDING THE T CELL REPERTOIRE TO INCLUDE SUBDOMINANT EPITOPES BY VACCINATION WITH ANTIGENS DELIVERED AS PROTEIN FRAGMENTS OR PEPTIDE COCKTAILS 审中-公开
    通过用作为蛋白质片段或肽蛋白质递送的抗原进行疫苗扩增细胞代谢物来包含亚群体外周血单核细胞

    公开(公告)号：WO2008000261A2

    公开(公告)日：2008-01-03

    申请号：PCT/DK2007/000312

    申请日：2007-06-26

    申请人： STATENS SERUM INSTITUT ,  AAGAARD, Claus ,  DIETRICH, Jes ,  ANDERSEN, Peter

    发明人： AAGAARD, Claus ,  DIETRICH, Jes ,  ANDERSEN, Peter

    IPC分类号： A61K39/00 ,  A61K39/02

    CPC分类号： A61K39/00 ,  A61K39/04 ,  A61K2039/55511 ,  A61K2039/5555 ,  Y02A50/412

    摘要： The present invention teaches a convenient way of inducing a broad recognition of dominant and subdominant responses to epitopes of any given antigen of importance for prophylaxis or treatment of a chronic disease by immunizing with pools of overlapping fragments (synthetic peptides e.g. 10-30 mers with 2-20 aa overlap) of the desired antigen in appropriate adjuvants. The T cell repertoire is primed to include not only the immunodominant epitope recognized when the intact molecule is used for immunization and induced by the chronic infection itself, but induce a much broader and balanced response to a number of the subdominant epitopes as well. The resulting T-cell response to subdominant epitopes is important for protection against chronic diseases that on their own induces a response focused only towards immunodominant epitopes. The major advantage of the present invention is that it requires no prior knowledge of the precise localisation and identity of the subdominant epitopes and their recognition in a human population, but expands the T-cell repertoire and thereby the total number of epitopes recognized by specific T cells primed by vaccination from a few immunodominant epitopes to multiple of epitopes of vaccine relevance. For chronic disease controlled by humoral immunity the T helper cell response primed by the peptide mix may conveniently be boosted by the full size protein for maximum induction of an antibody response as well.

    摘要翻译： 本发明教导了一种方便的方法，通过用重叠片段的集合（例如10-30个细胞与2个（例如10-30个细胞）免疫）来诱导对预防或治疗慢性疾病具有重要意义的任何给定抗原的表位的显性和亚显性反应的广泛认识 -20 aa重叠）所需抗原在适当的佐剂中。 引导T细胞谱不仅包括当完整分子用于免疫并由慢性感染本身诱导时识别的免疫显性表位，而且还诱导对多个亚显性表位的更广泛和平衡的响应。 所产生的对亚显性抗原决定簇的T细胞应答对于防止慢性疾病是重要的，所述慢性疾病本身诱导仅针对免疫显性表位的反应。 本发明的主要优点在于，它不需要在人群中亚显性表位的精确定位和鉴定的先验知识，而且扩展了T细胞谱，从而扩展了特定T识别的表位总数 通过从少数免疫显性表位接种到多种疫苗相关表位的疫苗引发的细胞。 对于通过体液免疫控制的慢性疾病，通过肽混合物引发的T辅助细胞应答可以方便地由全尺寸蛋白质加强以最大限度地诱导抗体应答。

    COMBINATION THERAPY METHOD AND FORMULATION
    94.
    发明申请
    COMBINATION THERAPY METHOD AND FORMULATION 审中-公开
    组合治疗方法与配方

    公开(公告)号：WO2007143174A2

    公开(公告)日：2007-12-13

    申请号：PCT/US2007/013076

    申请日：2007-06-01

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  ALBANI, Salvatore

    发明人： ALBANI, Salvatore

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0008 ,  A61K38/164 ,  A61K38/1709 ,  A61K2039/55511

    摘要： This invention concerns a pharmaceutical formulation and method for treating autoimmune disorders. The formulation and method provide for a combination therapy regimen wherein two separate substances are administered to a patient having or predisposed to having the disorder. The two components comprise at least one immunomodulatory peptide and a chloroquine derivative. The combination of the two components can be administered together or separately.

    摘要翻译： 本发明涉及用于治疗自身免疫性疾病的药物制剂和方法。 制剂和方法提供了组合治疗方案，其中将两种分开的物质施用于具有或易患有该病症的患者。 两种组分包含至少一种免疫调节肽和氯喹衍生物。 两种组分的组合可以一起施用或分开施用。

    METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER
    96.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER 审中-公开
    治疗癌症的方法和组合

    公开(公告)号：WO2007078615A2

    公开(公告)日：2007-07-12

    申请号：PCT/US2006/046977

    申请日：2006-12-11

    申请人： CAVIT SCIENCES, INC

    发明人： KING, Colm

    IPC分类号： A61K38/17

    CPC分类号： A61K39/39 ,  A61K35/74 ,  A61K45/06 ,  A61K2039/555 ,  A61K2039/55511 ,  A61K2300/00

    摘要： A novel method of treating and preventing cancer diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of cancer and the diseases associated with such cancers. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made compositions comprising a substance exhibiting Tubercin and/or SSM activity and/or Z-IOO or a functional derivative thereof.

    摘要翻译： 提供了一种治疗和预防癌症疾病的新方法。 特别地，本发明涉及用于抑制癌症和与这种癌症相关的疾病的组合物和方法。 更具体地说，本发明涉及包含天然和人造组合物的抑制化合物，其包含显示Tubercin和/或SSM活性的物质和/或Z-100或其功能性衍生物。