Abstract:
Apparatus (70) for assisting a surgeon in procedures involving the heart (31) and methods of employing such apparatus (70) are provided. The apparatus (70) can include a pump (71), and a first fluid conduit (65) having a distal end adapted to be inserted into the superior vena cava (45) of a beating heart (31), a second fluid conduit (67) having a distal end adapted to be inserted into the inferior vena cava (47), and a third fluid conduit (69) having a distal end adapted to be inserted into the pulmonary artery (53) of the beating heart (31), each in liquid fluid communication with the pump (71), which in combination can be operatively positioned to form a closed cardiac pathway extending from the vena cavae (45, 47) and to the pulmonary artery (53) to thereby convey blood collected from the vena cavae (45, 47) into the pulmonary artery (53), operatively bypassing the right side (33) of the heart (31). The pump (71) is positioned to both convey blood flow from each vena cavae (45, 47) and to the third fluid conduit (69), and to provide a blood reservoir (73) which enables the provision of manual assistance to the blood flow to the lungs when blood flow is insufficient.
Abstract:
A transseptal cannula assembly (224) for directing blood from the heart (104) of a patient and a minimally invasive method of implanting the same. The transseptal cannula assembly (224) includes a flexible cannula body (226) having proximal and distal portions with a lumen there between, a tip (228) coupled to the distal portion of the flexible cannula body (226), and first and second anchors (230, 232) coupled to the tip (228). The anchors (230, 232) can be configured to be deployed from a contracted state to an expanded state and are configured to engage opposite sides of the heart tissue (102) when in the expanded state. The anchors (230, 232) resist movement of the cannula assembly (224) along a lengthwise central axis of the flexible cannula body (226).
Abstract:
The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
Abstract:
A method for treating an occlusion in a coronary artery of a patient includes percutaneously advancing an occlusion treatment tool (such as an angioplasty balloon or stent delivery device) through the vasculature of the patient and into a coronary artery to a site of the occlusion. Following the treatment of the occlusion, a therapeutic agent is admitted into the first coronary artery. The therapeutic agent is selected to treat microvasculature obstructions at a target cardiac tissue site distal to the site of the occlusion.
Abstract:
A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.
Abstract:
A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.
Abstract:
A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.
Abstract:
A method of cardioscopy may include creating a primary heart bypass circuit for perfusing an organism, creating a secondary circuit for perfusing the heart of the organism with a non-observation-impairing pumping medium, and observing the heart through the secondary circuit. A cardioscopy apparatus may include a primary heart bypass circuit for perfusing an organism, a secondary circuit for perfusing the heart of the organism with a non-observation-impairing pumping medium, and an observation device for observing the heart through the secondary circuit.
Abstract:
The present invention relates generally to a system and methods for local delivery of drugs directly to the coronary circulation which may be isolated from systemic circulation. More especially it relates to a dialysis system and methods of infusing beneficial drugs, therapeutic agents, and/or other beneficial substances, including high doses of these, such as HDL, therapeutic genes, and/or chelating agents to the coronary system. The multichambered dialysis machine in the present system is capable of removing unwanted/harmful substances from the blood, enriching and/or otherwise processing the blood, and re-circulating the processed blood back to the coronary circulation of patient.It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
Abstract:
An improved cardiopulmonary bypass system (30) which consolidates and miniaturizes the entire CPB circuit on an integrated panel or box-type structure (32) capable of being positioned within (or closely adjacent to) the sterile surgical field (34, 38).