公开(公告)号：WO2015164626A3

公开(公告)日：2015-10-29

申请号：PCT/US2015/027329

申请日：2015-04-23

Applicant: SEROS MEDICAL, LLC

Inventor： MYUNG, David ,  MANCHE, Edward E. ,  EATON, Donald J. ,  ABBATE, Anthony J.

IPC: A61F9/00 ,  A61M5/142

Abstract: This invention relates to a device for the vacuum-assisted delivery of drugs through an intact surface membrane of an organ.

Abstract translation: 本发明涉及一种用于通过器官的完整表面膜进行真空辅助递送药物的装置。

公开(公告)号：WO2014182696A2

公开(公告)日：2014-11-13

申请号：PCT/US2014/036967

申请日：2014-05-06

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： MAZER, Terry B. ,  PACETTI, Stephen D. ,  LORD, Brenna H.

IPC: A61L31/06

CPC classification number: A61L31/148 ,  A61L31/06 ,  A61L31/146 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0047 ,  A61L2300/254 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/604 ,  C08L67/04

Abstract: Bioresorbable scaffolds and methods of treatment with such scaffolds for neurologic disorders including Parkinson's disease, Huntington's disease, Alzheimer's disease, and brain neoplasms are disclosed. The bioresorbable scaffold includes a bioresorbable body and an active agent or drug associated with the body for treating or ameliorating the neurological disorder. The bioresorbable scaffold is implanted in the neurological vasculature brain or brain tissue to provide localized delivery of the drug or active agent. Embodiments of the invention include scaffolds that are partially bioresorbable or completely bioresorbable.

Abstract translation: 公开了生物可吸收的支架和用这种支架治疗包括帕金森病，亨廷顿舞蹈症，阿尔茨海默病和脑肿瘤的神经障碍的方法。 生物可吸收支架包括生物可吸收体和与身体相关联的用于治疗或改善神经障碍的活性剂或药物。 将生物可吸收的支架植入神经系统的脉管系统脑或脑组织中以提供药物或活性剂的局部递送。 本发明的实施方案包括部分生物可再吸收或完全生物可再吸收的支架。

公开(公告)号：WO2014117075A1

公开(公告)日：2014-07-31

申请号：PCT/US2014/013171

申请日：2014-01-27

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  TROLLSAS, Mikael ,  HOSSAINY, Syed ,  STANKUS, John ,  CONSIGNY, Paul

Inventor： TROLLSAS, Mikael ,  HOSSAINY, Syed ,  STANKUS, John ,  CONSIGNY, Paul

IPC: A61L31/06 ,  A61L31/16

CPC classification number: A61L31/145 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/416 ,  A61L2400/12 ,  A61L2430/36 ,  C08L67/04 ,  C08L71/02

Abstract: It is provided herein methods, devices, and compositions for trans-arterial local delivery of therapeutic agent for the treatment of liver cancers.

Abstract translation: 本文提供用于治疗肝癌的治疗剂的跨动脉局部递送的方法，装置和组合物。

公开(公告)号：WO2014018128A1

公开(公告)日：2014-01-30

申请号：PCT/US2013/034679

申请日：2013-03-29

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： TROLLSAS, Mikael ,  STANKUS, John ,  NGO, Michael H. ,  TSAI, Wen Chung ,  GLAUSER, Thierry

IPC: A61L31/06 ,  A61L31/14

CPC classification number: A61L31/148 ,  A61L31/06 ,  A61L31/08 ,  A61L31/141 ,  A61L2420/02 ,  B05D5/00 ,  C08L67/04

Abstract: Methods of fabricating a bioresorbable polymer scaffold are disclosed including a step of inducing crystallization in a bioresorbable polymer construct through exposure to a liquid penetrant.

Abstract translation: 公开了制备生物可再吸收的聚合物支架的方法，包括通过暴露于液体渗透剂在生物可再吸收的聚合物构造体中诱导结晶的步骤。

公开(公告)号：WO2013052183A1

公开(公告)日：2013-04-11

申请号：PCT/US2012/043357

申请日：2012-06-20

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  STANKUS, John ,  WANG, Yunbing ,  TROLLSAS, Mikael ,  HOSSAINY, Syed Faiyaz Ahmed ,  NGO, Michael H. ,  DAVALIAN, Dariush

Inventor： STANKUS, John ,  WANG, Yunbing ,  TROLLSAS, Mikael ,  HOSSAINY, Syed Faiyaz Ahmed ,  NGO, Michael H. ,  DAVALIAN, Dariush

IPC: A61L31/04 ,  A61L31/12 ,  A61L31/14 ,  A61F2/82

CPC classification number: A61F2/915 ,  A61F2210/0004 ,  A61F2210/0057 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61L31/041 ,  A61L31/129 ,  A61L31/141 ,  A61L31/148

Abstract: Bioabsorbable scaffolds are disclosed with a rigid polymer component and a rubbery polymer component. The rubbery polymer component is miscible, partially miscible, or immiscible with the rigid polymer component.

Abstract translation: 公开了具有刚性聚合物组分和橡胶状聚合物组分的生物可吸收支架。 橡胶状聚合物组分是可混溶的，部分混溶的或与刚性聚合物组分不混溶的。

公开(公告)号：WO2012148452A1

公开(公告)日：2012-11-01

申请号：PCT/US2011/057932

申请日：2011-10-26

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  MA, Xiao ,  TANG, Fuh-Wei ,  DING, Ni

Inventor： WANG, Yunbing ,  MA, Xiao ,  TANG, Fuh-Wei ,  DING, Ni

IPC: B29C71/02 ,  A61F2/82 ,  A61F2/90

CPC classification number: B29C71/02 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2002/91583 ,  A61F2210/0004 ,  A61F2240/001 ,  A61L2/007 ,  A61L2/08 ,  A61L2/087 ,  A61L31/06 ,  A61L31/148 ,  A61L2202/21 ,  A61L2202/24 ,  A61L2400/18 ,  B29C35/02 ,  B29C2035/0877 ,  B29C2071/022 ,  B29L2031/753 ,  C08J7/08 ,  C08J7/123 ,  C08J2367/04 ,  C08L67/04

Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number- average molecular weight of the polymer of the polymeric stent, fall within a narrower range.

Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量在更窄的范围内。

公开(公告)号：WO2012024328A2

公开(公告)日：2012-02-23

申请号：PCT/US2011/047974

申请日：2011-08-16

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  KLEINER, Lothar ,  TANG, Fuh-Wei

Inventor： KLEINER, Lothar ,  TANG, Fuh-Wei

IPC: A61L31/06

CPC classification number: A61L2/08 ,  A61L2/087 ,  A61L31/06 ,  A61L2202/24 ,  A61L2400/18 ,  C08L67/04

Abstract: Methods are disclosed for chemically stabilizing a polymer stent after sterilization. The stent is exposed to a temperature above ambient for a period of time after radiation sterilization. The exposure reduces the concentration of free radicals generated by the radiation.

Abstract translation: 公开了灭菌后化学稳定聚合物支架的方法。 在辐射灭菌后，将支架暴露于高于环境温度的时间内。 暴露降低了由辐射产生的自由基的浓度。

公开(公告)号：WO2011123194A1

公开(公告)日：2011-10-06

申请号：PCT/US2011/025074

申请日：2011-02-16

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  MA, Xiao

Inventor： WANG, Yunbing ,  MA, Xiao

IPC: A61L31/04 ,  A61L31/14 ,  A61L31/06

CPC classification number: A61L31/148 ,  A61F2/82 ,  A61F2/89 ,  A61F2/958 ,  A61F2002/30062 ,  A61F2210/0004 ,  A61K9/1647 ,  A61K9/204 ,  A61L31/06 ,  B29C47/0066 ,  B29K2067/046 ,  B29L2031/7534 ,  C08G63/08 ,  C08G63/90 ,  C08J2367/04 ,  C08L67/04 ,  C09D167/04 ,  C09J167/04

Abstract: Methods of making a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal. Methods include making a poly(L- lactide) material for a stent with uniformly distributed L-lactide monomer through control of polymerization conditions during PLLA synthesis, control of post-processing conditions, or both.

Abstract translation: 公开了由聚（L-丙交酯）和低浓度的L-丙交酯单体制备可生物降解的聚合物支架的方法。 调节L-丙交酯的浓度以提供适合于包括冠状动脉，外周和鼻部在内的不同治疗应用的降解行为。 方法包括通过在PLLA合成期间控制聚合条件，后处理条件的控制或两者来制备具有均匀分布的L-丙交酯单体的支架的聚（L-丙交酯）材料。

公开(公告)号：WO2011011241A2

公开(公告)日：2011-01-27

申请号：PCT/US2010/041996

申请日：2010-07-14

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  OBERHAUSER, James ,  GADA, Manish ,  GLAUSER, Thierry ,  GUERIGUIAN, Vincent ,  STEICHEN, Bethany ,  KLEINER, Lothar ,  MA, Xiao

Inventor： WANG, Yunbing ,  OBERHAUSER, James ,  GADA, Manish ,  GLAUSER, Thierry ,  GUERIGUIAN, Vincent ,  STEICHEN, Bethany ,  KLEINER, Lothar ,  MA, Xiao

IPC: A61L31/06

CPC classification number: A61L31/14 ,  A61L31/06 ,  C08L67/04

Abstract: The present invention relates to implantable medical devices comprising a L-lactide-constitutional unit-containing copolymer having a wt% percent crystallinity of 40% or less.

Abstract translation: 本发明涉及包含具有40％或更低的重量百分比％结晶度的含L-丙交酯结构单元的共聚物的可植入医疗器械。

公开(公告)号：WO2010019478A1

公开(公告)日：2010-02-18

申请号：PCT/US2009/053182

申请日：2009-08-07

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  OBERHAUSER, James

Inventor： WANG, Yunbing ,  OBERHAUSER, James

IPC: A61L31/14 ,  B29C55/24 ,  B29C47/00

CPC classification number: A61L31/148 ,  A61L31/041 ,  B29C47/0004 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/882 ,  B29C47/8895 ,  B29C55/24 ,  B29D23/001 ,  B29K2067/00 ,  B29K2067/046 ,  B29K2995/006 ,  B29L2023/007 ,  B29L2031/7534 ,  C08L67/04

Abstract: Methods of fabricating a polymeric implantable device from a PLLA/PDLA blend such as a stent with improved fracture toughness are disclosed. The blend is melt processed to allow formation of stereocomplex crystallites, which are nucleation sites for crystal growth. A polymer construct is formed from the melt processed blend and device is formed from the polymer construct. The stereocomplex crystallites result in an in increase in nucleation density and reduced crystal size, which increases fracture toughness of the formed device.

Abstract translation: 公开了从具有改进的断裂韧性的支架的PLLA / PDLA共混物制造聚合物可植入装置的方法。 将共混物熔融加工以形成立体复合晶体，其是用于晶体生长的成核位点。 由熔融加工的共混物形成聚合物构件，并且由聚合物构造体形成装置。 立体络合物微晶导致成核密度增加和晶体尺寸减小，这增加了所形成的器件的断裂韧性。