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    SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF PRODUCING THEM
    5.
    发明申请
    SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF PRODUCING THEM 审中-公开
    可持续发布APO A-I型胶原蛋白及其生产方法

    公开(公告)号：WO2009070209A3

    公开(公告)日：2009-07-16

    申请号：PCT/US2008012767

    申请日：2008-11-14

    Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  MURASE KATSUYUKI ,  HOSSAINY SYED F A ,  ASTAFIEVA IRINA ,  ZHAO LI ,  MA HONG

    Inventor： MURASE KATSUYUKI ,  HOSSAINY SYED F A ,  ASTAFIEVA IRINA ,  ZHAO LI ,  MA HONG

    IPC: A61K9/14 ,  A61K9/16 ,  A61K38/17

    CPC classification number: C07K7/08 ,  A61F2/95 ,  A61K9/1075 ,  A61K9/127 ,  A61K38/00 ,  A61L29/16 ,  A61L2300/25 ,  A61L2300/802 ,  A61M25/1011 ,  A61M2025/0086 ,  A61M2025/105 ,  A61M2025/1075 ,  C07K7/06 ,  C07K14/775

    Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

    Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质 胆固醇运输。 包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

    METHODS & COMPOSITIONS FOR TREATING TISSUE USING SILK PROTEINS
    10.
    发明申请
    METHODS & COMPOSITIONS FOR TREATING TISSUE USING SILK PROTEINS 审中-公开
    用丝素蛋白处理组织的方法和组合物

    公开(公告)号：WO2008069919A2

    公开(公告)日：2008-06-12

    申请号：PCT/US2007024158

    申请日：2007-11-16

    Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  HOSSAINY SYED ,  NGO MICHAEL ,  TROLLSAS MIKAEL ,  STANKUS JOHN ,  MICHAL GENE

    Inventor： HOSSAINY SYED ,  NGO MICHAEL ,  TROLLSAS MIKAEL ,  STANKUS JOHN ,  MICHAL GENE

    IPC: A61L27/48

    CPC classification number: A61K47/42 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/52 ,  Y10S530/812 ,  Y10S530/815 ,  C08L89/00 ,  C08L71/02

    Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

    Abstract translation: 本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。 还公开了包括适合递送组合物的递送装置的试剂盒。 在一些实施方案中，组合物可以包括至少三种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。 在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。

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