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53 条记录 (耗时 0.018 秒)

    DIFFERENTIAL GENE EXPRESSION IN SPECIFIC REGIONS OF THE BRAIN IN NEURODEGENERATIVE DISEASES
    14.
    发明申请
    DIFFERENTIAL GENE EXPRESSION IN SPECIFIC REGIONS OF THE BRAIN IN NEURODEGENERATIVE DISEASES 审中-公开
    脑中特异性区域差异基因表达在神经损伤疾病中的表达

    公开(公告)号：WO0240996A8

    公开(公告)日：2003-02-13

    申请号：PCT/US0146699

    申请日：2001-11-08

    申请人： MITOKOR ,  HWANG JUNG-JOO ,  BECKER DAVID K ,  DAVIS ROBERT E

    发明人： HWANG JUNG-JOO ,  BECKER DAVID K ,  DAVIS ROBERT E

    IPC分类号： G01N33/50 ,  G01N33/68

    CPC分类号： G01N33/6896 ,  C07K16/18 ,  C07K2317/34 ,  G01N33/5011 ,  G01N33/5014

    摘要： The present invention provides methods and compositions for screening assays for compounds that alter mitochondrial function, and in particular that alter apoptosis, based on the observations that expression of the transcription factor FREAC-2 is up-regulated in Alzheimer's disease and that induction of FREAC-2 expression in a cell results in apoptosis. The invention thus provides methods for identifying agents that alter mitochondrial function by determining the activity of reducing or enhancing apoptosis that follows the induced expression of FREAC-2, useful, for example, in treatment of neurodegenerative diseases ( e.g., Alzheimer's) and/or of diseases of inappropriate cell proliferation or survival ( e.g., cancer). The present invention also includes methods of identifying pharmaceutical/ molecular targets for compounds that alter mitochondrial function ( e.g., by altering apoptosis).

    摘要翻译： 本发明提供了用于筛选针对改变线粒体功能的化合物的测定方法和组合物，特别是基于在阿尔茨海默氏病中上调转录因子FREAC-2的表达和FREAC- 2在细胞中的表达导致细胞凋亡。 因此，本发明提供了通过确定减少或增强FREAC-2诱导表达后的凋亡的活性来鉴定改变线粒体功能的药物的方法，例如可用于治疗神经变性疾病（例如， >阿尔茨海默病）和/或不适当的细胞增殖或存活的疾病（例如，癌症）。 本发明还包括鉴定改变线粒体功能（例如通过改变细胞凋亡）的化合物的药物/分子靶标的方法。

    DISEASES ASSOCIATED WITH ALTERED MITOCHONDRIAL FUNCTION
    15.
    发明申请
    DISEASES ASSOCIATED WITH ALTERED MITOCHONDRIAL FUNCTION 审中-公开
    与改变的麻醉功能相关的疾病

    公开(公告)号：WO0135096A3

    公开(公告)日：2001-11-29

    申请号：PCT/US0031119

    申请日：2000-11-13

    申请人： MITOKOR ,  ANDERSON CHRISTEN M ,  CLEVENGER WILLIAM ,  BECKER DAVID K ,  GRAKO KATHRYN A

    发明人： ANDERSON CHRISTEN M ,  CLEVENGER WILLIAM ,  BECKER DAVID K ,  GRAKO KATHRYN A

    IPC分类号： A61P3/10 ,  C07K14/47 ,  G01N33/50 ,  A61K39/00 ,  A61K48/00 ,  C12N15/11

    CPC分类号： G01N33/5079 ,  C07K14/4705

    摘要： Compositions and methods are provided for the treatment of diseases associated with altered mitochondrial function, and in particular, for type 2 diabetes mellitus. Administration of an agent that increases mitochondrial mass, including promotion of mitochondrial biogenesis by induction of a PGC gene e.g. , PGC-1), a UCP gene and/or a nuclear regulatory factor gene e.g. , NRF-1), is also disclosed. Screening assays for agents that regulate such genes involved in mitochondiral biogenesis, and for genes and gene products that are regulated by such genes involved in mitochondrial biogenesis, are also provided.

    摘要翻译： 提供组合物和方法用于治疗与改变的线粒体功能相关的疾病，特别是用于2型糖尿病。 施用增加线粒体质量的试剂，包括通过诱导PGC基因（例如PGC-1）促进线粒体生物发生，UCP基因和/或核调节因子基因例如< / i>，NRF-1）。 还提供了调节参与线粒体生物发生的这种基因的试剂的筛选测定，以及由参与线粒体生物发生的这些基因调节的基因和基因产物的筛选测定。

    SALIVA SAMPLE COLLECTION SYSTEMS
    16.
    发明申请
    SALIVA SAMPLE COLLECTION SYSTEMS 审中-公开
    SALIVA样品收集系统

    公开(公告)号：WO2013141834A1

    公开(公告)日：2013-09-26

    申请号：PCT/US2012/029584

    申请日：2012-03-18

    申请人： PATHWAY GENOMICS ,  PLANTE, James ,  BECKER, David ,  ELLIOTT, Kathryn ,  MACBEAN, Edgar

    发明人： PLANTE, James ,  BECKER, David ,  ELLIOTT, Kathryn ,  MACBEAN, Edgar

    IPC分类号： A61M1/00

    CPC分类号： A61B10/0051 ,  A61B10/0096

    摘要： Saliva sample collection systems are configured with special attention to ease-of-use for the unskilled user and safe transport and delivery by a conventional delivery services such as Federal Express. A sealed cavity is formed by tight coupling of two primary elements: a receiving vessel element and a sealing cap element. The receiving vessel has integrated therewith: a standing means, a fill-line window, a funnel system, a knife, a threadset, and containment tube among others. A complementary cap element includes a cooperating threadset, label receiving surface, gripping surface, seal means and reservoir with piercable thin-film membrane. These two primary elements may be accommodated in an application-specific shipping container which support two shipping modes whereby the system may be shipped safely to and from a donor user each way in a different shipping mode.

    摘要翻译： 唾液样本收集系统被配置为特别注意非熟练用户的易用性，并通过常规传送服务（如联邦快递）进行安全的传输和传送。 通过紧密耦合两个主要元件形成密封空腔：接收容器元件和密封帽元件。 接收容器与其结合：立式装置，填充线窗，漏斗系统，刀，螺纹组和容纳管等。 互补盖元件包括配合螺纹组件，标签接收表面，抓握表面，密封装置和具有可撕裂薄膜膜的储存器。 这两个主要元件可以容纳在特定于应用的运输容器中，其支持两种运送模式，由此系统可以以不同的运送模式每次以方式运送给和来自捐赠者的用户。

    PROCESS FOR SELECTIVELY REMOVING NITRIDE FROM SUBSTRATES
    17.
    发明申请
    PROCESS FOR SELECTIVELY REMOVING NITRIDE FROM SUBSTRATES 审中-公开
    从基材中选择性地除去氮化物的方法

    公开(公告)号：WO2012078580A1

    公开(公告)日：2012-06-14

    申请号：PCT/US2011/063441

    申请日：2011-12-06

    申请人： FSI INTERNATIONAL, INC. ,  RATKOVICH, Anthony S. ,  BUTTERBAUGH, Jeffery W. ,  BECKER, David S.

    发明人： RATKOVICH, Anthony S. ,  BUTTERBAUGH, Jeffery W. ,  BECKER, David S.

    IPC分类号： H01L21/302

    CPC分类号： H01L21/31111 ,  H01L21/67051 ,  H01L21/6708

    摘要： A method of selectively removing silicon nitride from a substrate comprises providing a substrate having silicon nitride on a surface thereof; and dispensing phosphoric acid and sulfuric acid onto the surface of the substrate as a mixed acid liquid stream at a temperature greater than about 150°C. In this method, water is added to a liquid solution of the mixed acid liquid stream as or after the liquid solution of the mixed acid liquid stream passes through a nozzle.

    摘要翻译： 从衬底选择性地去除氮化硅的方法包括在其表面上提供具有氮化硅的衬底; 并在高于约150℃的温度下将磷酸和硫酸作为混合酸液体流分配到基材的表面上。 在该方法中，在混合酸液体液体的液体溶液通过喷嘴之后或之后，将水加入到混合酸液体液体的液体溶液中。

    ULTRASONIC PROBE VOLUME COMPENSATION SYSTEM
    19.
    发明申请
    ULTRASONIC PROBE VOLUME COMPENSATION SYSTEM 审中-公开
    超声探头体积补偿系统

    公开(公告)号：WO2005094690A1

    公开(公告)日：2005-10-13

    申请号：PCT/IB2005/050985

    申请日：2005-03-22

    申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. ,  WICKLINE, Kevin ,  HART, Jeffrey ,  HORNBERGER, Alan ,  HARPSTER, Mark ,  CRUIKSHANK, Charles ,  BECKER, David

    发明人： WICKLINE, Kevin ,  HART, Jeffrey ,  HORNBERGER, Alan ,  HARPSTER, Mark ,  CRUIKSHANK, Charles ,  BECKER, David

    IPC分类号： A61B8/12

    CPC分类号： A61B8/4461 ,  A61B8/12 ,  A61B8/4281 ,  A61B8/445 ,  A61B8/483

    摘要： An ultrasound probe includes a transducer which is pivotally mounted inside a fluid chamber for scanning a region outside the probe as the transducer is oscillated. A volume compensation balloon is attached to the fluid chamber and is partially filled with acoustic fluid at nominal (room) temperatures. The balloon is made of a high performance thermoplastic which enables the balloon to have a very thin wall. The thin wall is highly compliant as the volume of the fluid inside the balloon changes, and remains so at low temperatures of transport and use. The thin wall exhibits a low permeability to the acoustic fluid. The balloon is formed of a non elastic material and exhibits good thermal stability and high burst strength.

    摘要翻译： 超声波探头包括一个换能器，该换能器枢转地安装在流体腔内，用于当换能器振荡时扫描探针外部的区域。 体积补偿球囊连接到流体室，并在标称（室内）温度下部分地填充声学流体。 气球由高性能热塑性塑料制成，使得气球具有非常薄的壁。 当气囊内的体积变化时，薄壁是高度柔顺的，并且在运输和使用的低温下保持如此。 薄壁对声学流体表现出低渗透性。 气球由非弹性材料形成，表现出良好的热稳定性和较高的破裂强度。