公开(公告)号：WO2011139589A9

公开(公告)日：2011-12-29

申请号：PCT/US2011033491

申请日：2011-04-21

Applicant: MEDTRONIC ARDIAN LLC ,  LEUNG MARK S ,  CLARK BENJAMIN J ,  MICHLITSCH KENNETH ,  THAI ERIK ,  WU ANDREW ,  ZARINS DENISE

Inventor： LEUNG MARK S ,  CLARK BENJAMIN J ,  MICHLITSCH KENNETH ,  THAI ERIK ,  WU ANDREW ,  ZARINS DENISE

IPC: A61B18/14

CPC classification number: A61B18/082 ,  A61B17/320068 ,  A61B18/02 ,  A61B18/0206 ,  A61B18/10 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00714 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1861 ,  H04L29/12066 ,  H04L61/1511

Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract translation: 本文公开了通过血管内通路实现肾脏神经调节的导管装置，系统和方法。 本申请的一个方面，例如，涉及包括细长轴的导管治疗装置的装置，系统和方法。 细长轴的尺寸和构造被设计成经由血管内路径将能量递送元件递送到肾动脉。 热或电性肾神经调节可以通过直接和/或通过间接施加热和/或电能来加热或冷却或以其他方式电调制有助于肾功能的神经纤维或者供给或灌注 神经纤维。

公开(公告)号：WO2011091069A1

公开(公告)日：2011-07-28

申请号：PCT/US2011/021757

申请日：2011-01-19

Applicant: ARDIAN, INC. ,  BEETEL, Robert, J. ,  BARMAN, Neil, C. ,  CLARK, Benjamin, J. ,  FRIEDRICHS, Paul ,  MICHLITSCH, Kenneth, J. ,  NAGA, Karun, D. ,  WU, Andrew ,  ZARINS, Denise

Inventor： BEETEL, Robert, J. ,  BARMAN, Neil, C. ,  CLARK, Benjamin, J. ,  FRIEDRICHS, Paul ,  MICHLITSCH, Kenneth, J. ,  NAGA, Karun, D. ,  WU, Andrew ,  ZARINS, Denise

IPC: A61B6/00

CPC classification number: A61N5/1042 ,  A61B6/506 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61N5/1067 ,  A61N7/02 ,  A61N2005/1061

Abstract: The present disclosure describes methods and apparatus for renal neuromodulation via stereotactic radiotherapy for the treatment of hypertension, heart failure, chronic kidney disease, diabetes, insulin resistance, metabolic disorder or other ailments. Renal neuromodulation may be achieved by locating renal nerves and then utilizing stereotactic radiotherapy to expose the renal nerves to a radiation dose sufficient to reduce neural activity. A neural location element may be provided for locating target renal nerves, and a stereotactic radiotherapy system may be provided for exposing the located renal nerves to a radiation dose sufficient to reduce the neural activity, with reduced or minimized radiation exposure in adjacent tissue. Renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as at pre-ganglionic positions.

Abstract translation: 本公开描述了通过立体定向放射治疗高血压，心力衰竭，慢性肾脏疾病，糖尿病，胰岛素抵抗，代谢紊乱或其它疾病的肾神经调节的方法和装置。 肾神经调节可以通过定位肾神经，然后利用立体定向放射治疗来将肾神经暴露于足以减少神经活动的辐射剂量来实现。 可以提供用于定位目标肾神经的神经位置元件，并且可以提供立体定向放射治疗系统，用于将所定位的肾神经暴露于足以减少或最小化相邻组织中的辐射暴露的神经活动的辐射剂量。 肾神经可能位于神经节水平和/或神经节后位置以及神经节前位置。

公开(公告)号：WO2006039199A3

公开(公告)日：2006-04-13

申请号：PCT/US2005/034117

申请日：2005-09-22

Applicant: USGI MEDICAL INC. ,  ROTHE, Chris ,  EWERS, Richard, C. ,  LAM, Cang, C. ,  SAADAT, Vahid ,  MICHLITSCH, Kenneth, J.

Inventor： ROTHE, Chris ,  EWERS, Richard, C. ,  LAM, Cang, C. ,  SAADAT, Vahid ,  MICHLITSCH, Kenneth, J.

IPC: A61B17/04

Abstract: Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.

公开(公告)号：WO2006039199A2

公开(公告)日：2006-04-13

申请号：PCT/US2005034117

申请日：2005-09-22

Applicant: USGI MEDICAL INC ,  ROTHE CHRIS ,  EWERS RICHARD C ,  LAM CANG C ,  SAADAT VAHID ,  MICHLITSCH KENNETH J

Inventor： ROTHE CHRIS ,  EWERS RICHARD C ,  LAM CANG C ,  SAADAT VAHID ,  MICHLITSCH KENNETH J

IPC: A61B17/08

CPC classification number: A61B17/0469 ,  A61B17/00234 ,  A61B17/0482 ,  A61B17/29 ,  A61B2017/003 ,  A61B2017/00349 ,  A61B2017/00371 ,  A61B2017/00827 ,  A61B2017/00867 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0441 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06028 ,  A61B2017/06052 ,  A61B2017/06076 ,  A61B2017/2927

Abstract: Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.

Abstract translation: 这里描述了用于操纵和固定组织的装置和方法。 在创建患者体内的组织折叠时，组织折叠操作组件通常可以具有细长管状构件，可滑动地设置穿过管状构件的接合构件和适于经由螺旋构件接合组织的远端，组织稳定构件， 适于稳定其间的组织的管状构件远端和可围绕组织稳定器枢转的输送管。 稳定构件可适于相对于细长管状构件的纵向轴线成角度。 而且，一个或所有的关节运动控制和功能可以被集成到可通过刚性或柔性管状主体连接到组织操纵组件的单个手柄组件中。

公开(公告)号：WO2004012602A3

公开(公告)日：2004-02-12

申请号：PCT/EP2003/008246

申请日：2003-07-25

Applicant: ABBOTT LABORATORIES VASCULAR ENTERPRISES, LIMITED ,  MICHLITSCH, Kenneth, J.

Inventor： MICHLITSCH, Kenneth, J.

IPC: A61B17/00

Abstract: Apparatus (10) is provided for sealing a vascular puncture tract by forming the autologous plug within the puncture tract, and extruding that plug into the puncture tract. The apparatus of the present invention forms an autologous blood plug by drawing blood into the apparatus from a vessel, mixing a blood congealing agent with the drawn blood, and ejecting a plug formed from the clotted blood within the puncture tract. Also provided are various closure elements (22) to isolate the drawn blood from the vessel during mixture with the blood congealing agent, and to facilitate placement of the apparatus relative to the vessel.

公开(公告)号：WO2011139589A3

公开(公告)日：2012-03-15

申请号：PCT/US2011033491

申请日：2011-04-21

Applicant: MEDTRONIC ARDIAN LLC ,  LEUNG MARK S ,  CLARK BENJAMIN J ,  MICHLITSCH KENNETH ,  THAI ERIK ,  WU ANDREW ,  ZARINS DENISE

Inventor： LEUNG MARK S ,  CLARK BENJAMIN J ,  MICHLITSCH KENNETH ,  THAI ERIK ,  WU ANDREW ,  ZARINS DENISE

IPC: A61B18/14

CPC classification number: A61B18/082 ,  A61B17/320068 ,  A61B18/02 ,  A61B18/0206 ,  A61B18/10 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00714 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1861 ,  H04L29/12066 ,  H04L61/1511

Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract translation: 本文公开了用于通过血管内通路实现肾神经调节的导管设备，系统和方法。 例如，本申请的一个方面涉及结合包括细长轴的导管治疗装置的装置，系统和方法。 细长轴的尺寸和构造被设定为经由血管内路径将能量输送元件输送到肾动脉。 可以通过直接和/或通过间接应用热和/或电能来加热或冷却或以其他方式电调节有助于肾功能的神经纤维，或者通过给予或灌注 神经纤维。

公开(公告)号：WO2011130005A2

公开(公告)日：2011-10-20

申请号：PCT/US2011/030496

申请日：2011-03-30

Applicant: MEDTRONIC ARDIAN LLC ,  CLARK, Benjamin, C. ,  GEORGE, William, R. ,  MICHLITSCH, Kenneth, J. ,  SAM, John, Paul ,  THAI, Erik ,  WU, Andrew

Inventor： CLARK, Benjamin, C. ,  GEORGE, William, R. ,  MICHLITSCH, Kenneth, J. ,  SAM, John, Paul ,  THAI, Erik ,  WU, Andrew

IPC: A61B18/14 ,  A61B19/00 ,  A61B17/00

CPC classification number: A61B18/08 ,  A61B34/74 ,  A61B2017/003 ,  A61B2018/00916

Abstract: The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.

Abstract translation: 本公开包括用于血管内治疗装置的手柄组件。 在一个实施例中，手柄组件包括用于偏转血管内治疗装置的远侧区域的致动器。 在一个实施例中，手柄组件包括用于独立于手柄组件旋转血管内治疗装置的旋转器。 在一个实施例中，手柄组件包括旋转限制元件，用于限制血管内治疗装置相对于手柄组件的独立旋转。 还提供了通过本发明的手柄组件进行血管内递送，偏转和放置血管内治疗装置的方法和系统。

公开(公告)号：WO2005122914A2

公开(公告)日：2005-12-29

申请号：PCT/US2005/020349

申请日：2005-06-08

Applicant: USGI MEDICAL INC. ,  SAADAT, Vahid ,  EWERS, Richard, C. ,  MAAHS, Tracy, D. ,  KHAIRKHAHAN, Alex ,  MICHLITSCH, Kenneth, J.

Inventor： SAADAT, Vahid ,  EWERS, Richard, C. ,  MAAHS, Tracy, D. ,  KHAIRKHAHAN, Alex ,  MICHLITSCH, Kenneth, J.

IPC: A61B17/08

CPC classification number: A61B17/0644 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B2017/00867 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2090/037

Abstract: Systems for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.

Abstract translation: 这里描述了用于优化锚固力的系统。 在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。 当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。 可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。 此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

公开(公告)号：WO2005058239A3

公开(公告)日：2005-12-08

申请号：PCT/US2004041570

申请日：2004-12-10

Applicant: USGI MEDICAL INC ,  SAADAT VAHID C ,  MICHLITSCH KENNETH J ,  EWERS RICHARD C ,  ROTHE CHRIS ,  BRENNEMAN RODNEY ,  LAM CANG C ,  CHEN EUGENE C

Inventor： SAADAT VAHID C ,  MICHLITSCH KENNETH J ,  EWERS RICHARD C ,  ROTHE CHRIS ,  BRENNEMAN RODNEY ,  LAM CANG C ,  CHEN EUGENE C

IPC: A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61B17/08 ,  A61B17/12 ,  A61B17/28 ,  A61B17/34 ,  A61K20060101

CPC classification number: A61B17/29 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/12099 ,  A61B17/3478 ,  A61B2017/003 ,  A61B2017/0406 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0458 ,  A61B2017/0459 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/06176 ,  A61B2017/2905

Abstract: Apparatus and methods are provided for forming a gastrointestinal tissue fold by engaging tissue at a first tissue contact point and moving the first tissue contact point from a position initially distal to, or in line with, a second tissue contact point to a position proximal of the second contact point, thereby forming the tissue fold, and extending an anchor assembly (36) through the tissue fold from a vicinity of the second tissue contact point. Adjustable anchor assemblies (36); as well as anchor delivery systems (34), shape-lockable guides (1000) and methods for endoluminally performing medical procedures, such as gastric reduction, treatment of gastroesophageal reflux disease, resection of lesions, and treatment of bleeding sites; are also provided.

Abstract translation: 提供了设备和方法，用于通过在第一组织接触点处接合组织并使第一组织接触点从最初远端或与第二组织接触点一致的位置移动到第二组织接触点的近端位置来形成胃肠组织折叠 从而形成组织折叠，并且使锚固组件（36）从第二组织接触点的附近穿过组织折叠部延伸。 可调锚固组件（36）; 以及锚定递送系统（34），可锁定形状的引导件（1000）以及用于治疗胃溃疡，治疗胃食管反流疾病，切除病变以及出血部位治疗等内科手术的方法。 也提供。

公开(公告)号：WO2005086945A2

公开(公告)日：2005-09-22

申请号：PCT/US2005/008125

申请日：2005-03-09

Applicant: USGI MEDICAL INC. ,  SAADAT, Vahid ,  ROTHE, Chris, A. ,  EWERS, Richard, C. ,  MAAHS, Tracy, D. ,  MICHLITSCH, Kenneth, J.

Inventor： SAADAT, Vahid ,  ROTHE, Chris, A. ,  EWERS, Richard, C. ,  MAAHS, Tracy, D. ,  MICHLITSCH, Kenneth, J.

IPC: A61B1/005 ,  A61B1/018 ,  A61B1/273 ,  A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61B17/28 ,  A61B17/30

CPC classification number: A61B1/0055 ,  A61B1/018 ,  A61B1/2736 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/29 ,  A61B2017/00296 ,  A61B2017/003 ,  A61B2017/00323 ,  A61B2017/00827 ,  A61B2017/0406 ,  A61B2017/0417 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/06052 ,  A61B2017/2905 ,  A61B2017/2906 ,  A61B2017/306

Abstract: Systems, devices and methods for endoscopic procedures are provided involving accessing and manipulating tissues beyond the capabilities of traditional endoscopic instruments. Embodiments of the systems include an elongated main body which has one or more independently shape-lockable sections and a variety of instruments which are either built in to the main body or advanceable through lumens which extend through the main body. Such instruments may include scopes, suction instruments, aspiration instruments, tool arms, plicators, needles, graspers, and cutters, to name a few. The ability to steer and shape-lock specific sections of the main body enables access to target locations which are typically challenging to reach and provides a stabilized platform to perform a desired procedure at the target location.

Abstract translation: 提供用于内窥镜手术的系统，装置和方法，其涉及访问和操纵超出传统内窥镜仪器能力的组织。 该系统的实施例包括具有一个或多个独立形状可锁定部分的细长主体以及内置于主体中或通过延伸穿过主体的内腔前进的各种器具。 这样的仪器可以包括示波器，抽吸仪器，抽吸仪器，工具臂，矫正器，针，抓取器和切割器等等。 转向和形状锁定主体的特定部分的能力使得能够访问通常具有挑战性的目标位置，并且提供稳定的平台以在目标位置执行期望的过程。