公开(公告)号：WO2009022191A3

公开(公告)日：2009-04-16

申请号：PCT/HU2008000095

申请日：2008-08-01

Applicant: PECSI TUDOMANYEGYETEM ,  BARDOS TAMAS ,  BELLYEI ARPAD ,  ILLES TAMAS ,  NEMETH PETER

Inventor： BARDOS TAMAS ,  BELLYEI ARPAD ,  ILLES TAMAS ,  NEMETH PETER

IPC: A61F2/30 ,  A61B17/16 ,  A61B17/32

CPC classification number: A61F2/30756 ,  A61B17/00491 ,  A61B17/06166 ,  A61B17/32 ,  A61B17/322 ,  A61B17/68 ,  A61B2017/00969 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/4202 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/3096

Abstract: The articular cartilage according to the invention is made of pure cartilage and is provided with incisions (12) on the surface facing the bone. The cartilage cells are preferably seeded on the surface provided with incisions (12). The method for producing the articular cartilage comprises the step of collecting cartilage from joints, wherein pure cartilage is collected without bone, and incisions are made on the surface of the cartilage intended to face the bone. It is preferably fresh frozen until use. The device for harvesting articular cartilage, comprises handle and cutting blade, wherein the cutting blade (4) is curvilinear and is pro-vided with spacer elements (5), meanwhile the device for producing incisions in articular cartilages comprises handle (2) and a bridge (3) connected to said handle (2) and being provided with one or more cutting blade(s) (4). During the method for applying the articular cartilage the articular cartilage is fixed by thin surgical yarn stitches, by fibrin glue or by small anchors (Fig.8).

Abstract translation: 根据本发明的关节软骨由纯软骨制成并且在面向骨的表面上设有切口（12）。 软骨细胞优选接种在设有切口（12）的表面上。 用于制造关节软骨的方法包括从关节收集软骨的步骤，其中收集无骨的纯软骨，并且在旨在面向骨的软骨表面上形成切口。 它最好是新鲜冷冻直到使用。 用于收获关节软骨的装置包括手柄和切割刀片，其中切割刀片（4）为曲线形并且具有间隔元件（5），同时用于在关节软骨中产生切口的装置包括手柄（2）和 连接到所述手柄（2）并且设有一个或多个切割刀片（4）的桥（3）。 在施用关节软骨的方法中，关节软骨通过薄手术纱线缝合，纤维蛋白胶或小锚固定（图8）。

公开(公告)号：WO2009011849A2

公开(公告)日：2009-01-22

申请号：PCT/US2008008643

申请日：2008-07-16

Applicant: LIFENET HEALTH ,  CHEN SILVIA S ,  WOLFINBARGER LLOYD ,  QIN XIAOFEI ,  CHEN JINGSONG ,  THOMAS RONY ,  MOORE MARK ,  JONES ALYCE LINTHURST

Inventor： CHEN SILVIA S ,  WOLFINBARGER LLOYD ,  QIN XIAOFEI ,  CHEN JINGSONG ,  THOMAS RONY ,  MOORE MARK ,  JONES ALYCE LINTHURST

IPC: A61F2/28

CPC classification number: A61F2/30756 ,  A61B17/1604 ,  A61B17/1635 ,  A61B17/1675 ,  A61F2/28 ,  A61F2/30749 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30751 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/4646 ,  A61F2002/4648 ,  A61F2002/4649 ,  A61F2230/0069 ,  A61F2250/0014 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3804 ,  A61L2430/06

Abstract: The present invention is directed to crafting of cartilage to facilitate disinfection, cleaning, devitalization, recellularization, and integration after implantation. The present invention also is directed to cleaning and devitalization of cartilage. Moreover, the present invention provides processes for recellularization of cartilage and implantation of cartilage

Abstract translation: 本发明涉及软骨的制作，以便于植入后的消毒，清洁，失活，收缩和整合。 本发明还涉及软骨的清洁和失活。 此外，本发明提供软骨的再结晶化和软骨植入的方法

公开(公告)号：WO2008106254A2

公开(公告)日：2008-09-04

申请号：PCT/US2008/051796

申请日：2008-01-23

Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION ,  SEMLER, Eric, J. ,  TRUNCALE, Katherine, G. ,  CALLAHAN, Alex, B. ,  YANNARIELLO-BROWN, Judith, I.

Inventor： SEMLER, Eric, J. ,  TRUNCALE, Katherine, G. ,  CALLAHAN, Alex, B. ,  YANNARIELLO-BROWN, Judith, I.

CPC classification number: A61F2/30756 ,  A61B17/00491 ,  A61F2/28 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2842 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30225 ,  A61F2002/30227 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30327 ,  A61F2002/30354 ,  A61F2002/30448 ,  A61F2002/30459 ,  A61F2002/30461 ,  A61F2002/30492 ,  A61F2002/30604 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/30932 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0069 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3654 ,  A61L27/38 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/06

Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct (20) with a demineralized cancellous cap (30) and a mineralized cylindrical base member (22) defining a blind bore (23) wrth a through going transverse bore (28) intersecting the blind bore (23). The demineralized cancellous cap (30) has a cylindrical top portion (32) and a smaller diameter cylindrical stem (36) extending away from the top portion (32) which fits into the blind bore (23) of the mineralized base member (22). The cap stem (36) defines a transverse through going bore (37) which is aligned with the through going bore (28) of the base member (22) to receive a cylindrical cortical pin (40) holding the cap (30) within the base member (22). The shaped structure (20) is dimensioned to fit in a drilled bore in a cartilage delect area so that the assembly engages the side wall of the drilled bore in an interference fit.

Abstract translation: 本发明涉及一种软骨修复组件，其包括具有脱矿质松质骨盖（30）的成形同种异体移植两片构件（20）和限定盲孔（23）的矿化圆柱形基底构件（22），所述盲孔（23）绕穿过的横向孔 28）与盲孔（23）相交。 脱矿质松质骨盖（30）具有圆柱形顶部（32）和较小直径的圆柱形杆（36），其远离顶部（32）延伸，该顶部配合入矿化基底构件（22）的盲孔（23） 。 盖杆（36）限定横向通孔（37），其与基部构件（22）的贯穿孔（28）对齐，以容纳将盖（30）保持在内部的圆柱形皮质销（40）内 基座构件（22）。 成形结构（20）的尺寸适于装配在软骨选区中的钻孔中，使得组件以过盈配合接合钻孔的侧壁。

公开(公告)号：WO2006045330A1

公开(公告)日：2006-05-04

申请号：PCT/EP2004/012109

申请日：2004-10-27

Applicant: TETEC-TISSUE ENGINEERING TECHNOLOGIES AKTIENGESELLSCHAFT ,  GAISSMAIER, Christoph ,  FRITZ, Jürgen ,  AICHER, Wilhelm

Inventor： GAISSMAIER, Christoph ,  FRITZ, Jürgen ,  AICHER, Wilhelm

IPC: A61F2/30

CPC classification number: A61F2/30756 ,  A61F2/38 ,  A61F2/44 ,  A61F2002/0086 ,  A61F2002/2817 ,  A61F2002/30004 ,  A61F2002/30011 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30324 ,  A61F2002/30677 ,  A61F2002/30761 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30766 ,  A61F2002/3093 ,  A61F2002/30971 ,  A61F2210/0004 ,  A61F2240/001 ,  A61F2250/0014 ,  A61F2250/0023 ,  A61F2250/003 ,  A61F2250/0036 ,  A61F2310/00365 ,  A61F2310/00383

Abstract: The present invention relates to an implant for repairing a cartilage defect comprising a first layer and a second layer. The first layer comprises a membrane-like structure and the second layer comprises a sponge-like structure with directional and/or interconnected pores. The first layer is facing the synovial space and the second layer is located towards bone.

Abstract translation: 本发明涉及用于修复包括第一层和第二层的软骨缺损的植入物。 第一层包括膜状结构，第二层包括具有定向和/或互连孔的海绵状结构。 第一层面向滑膜空间，第二层位于骨骼。

公开(公告)号：WO2005051242A1

公开(公告)日：2005-06-09

申请号：PCT/GB2004/004536

申请日：2004-10-27

Applicant: XIROS PLC ,  SEEDHOM, Bahaa, Botros ,  LORRISON, Jonathan, Charles

Inventor： SEEDHOM, Bahaa, Botros ,  LORRISON, Jonathan, Charles

IPC: A61F2/30

CPC classification number: A61F2/4618 ,  A61B17/06166 ,  A61F2/30749 ,  A61F2/30756 ,  A61F2002/30113 ,  A61F2002/30131 ,  A61F2002/30143 ,  A61F2002/30144 ,  A61F2002/302 ,  A61F2002/30225 ,  A61F2002/30326 ,  A61F2002/30448 ,  A61F2002/30462 ,  A61F2002/30599 ,  A61F2002/30611 ,  A61F2002/30612 ,  A61F2002/30751 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2220/0008 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0006 ,  A61F2230/0013 ,  A61F2230/0017 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2250/0037 ,  A61F2250/0063

Abstract: A repair kit (10) for use in the repair of damaged cartilage present at or on the surface of a bone site (20) in an animal or human, in which the damaged cartilage is removed from the site and a groove (25) is formed about the site and into the bone (20) prior to implantation of the repair kit (10), and said repair kit comprising: a pad (11) of bio-compatible material shaped and dimensioned to occupy at least part of the site from which the damaged tissue has been removed; elongate connecting portions (14) attached to the periphery of the pad (11) in an array corresponding in shape to the groove (25), said portions being intended to extend away from the general plane of the pad so as to be introduced into the groove and to be anchored therein; and a retaining element (26) slidable depthwise of the groove (25) in order to anchor at least some of the connecting portions (14) in the groove (25) and thereby locate and retain the pad (11) in said part of the bone site. There is also disclosed a method of preparation of the bone site prior to implantation, and also an implant delivery device (46), on which the repair kit can be temporarily stored, and which also serves to deliver the pad, the elongate connecting portions (14) and the retaining element (47) on to the prepared site.

Abstract translation: 用于修复存在于动物或人的骨部位（20）表面上或其表面的受损软骨的修复工具（10），其中从现场移除受损的软骨和凹槽（25）是 在植入修复套件（10）之前围绕该部位形成并进入骨骼（20），并且所述修复套件包括：生物相容性材料的垫（11），其形状和尺寸被设计成占据所述部位的至少一部分， 损坏的组织被去除; 细长的连接部分（14）以与凹槽（25）的形状相对应的阵列附接到焊盘（11）的周边，所述部分旨在远离焊盘的总平面延伸，以便被引入到 凹槽并锚定在其中; 以及保持元件（26），其能够沿所述凹槽（25）的深度方向滑动，以便将所述凹槽（25）中的至少一些所述连接部分（14）锚固，从而将所述垫（11）定位并保持在所述部分 骨骼部位。 还公开了在植入之前制备骨部位的方法，以及植入物递送装置（46），修复工具可以临时存储在该植入物输送装置上，并且还用于输送垫，细长连接部分 14）和保持元件（47）放置在准备的位置上。

公开(公告)号：WO2004071354A1

公开(公告)日：2004-08-26

申请号：PCT/AU2004/000133

申请日：2004-02-05

Applicant: AUSTRALIAN SURGICAL DESIGN AND MANUFACTURE PTY LIMITED ,  ROGER, Gregory, James

Inventor： ROGER, Gregory, James

IPC: A61F2/28

CPC classification number: A61F2/30756 ,  A61F2/30744 ,  A61F2/38 ,  A61F2/4618 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30677 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30787 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2310/00023 ,  A61F2310/00293 ,  A61K9/0004 ,  A61K9/0024 ,  A61L27/225 ,  A61L27/3817 ,  A61L27/3843 ,  A61L27/3847 ,  A61L31/005 ,  A61L31/046

Abstract: A chondrocyte delivery device that has a main body (14) containing chondrocytes. The delivery device is at least partially insertable into a bone (18) of a patient and allowed or caused to elute the chondrocyte from the main body of the delivery device to damaged cartilage (17) in the region.

Abstract translation: 一种具有含有软骨细胞的主体（14）的软骨细胞递送装置。 递送装置至少部分地可插入到患者的骨骼（18）中，并允许或使软骨细胞从输送装置的主体洗脱到该区域中的软骨（17）。

公开(公告)号：WO2004010907A1

公开(公告)日：2004-02-05

申请号：PCT/US2003/023442

申请日：2003-07-28

Applicant: THERICS, INC.

Inventor： SHERWOOD, Jill, K. ,  MONKHOUSE, Donald ,  GAYLO, Christopher, M.

IPC: A61F2/30

CPC classification number: A61F2/30942 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/468 ,  A61F2002/0086 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30004 ,  A61F2002/30011 ,  A61F2002/30062 ,  A61F2002/30199 ,  A61F2002/30301 ,  A61F2002/30678 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2002/3093 ,  A61F2002/30952 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2002/30971 ,  A61F2002/4648 ,  A61F2210/0004 ,  A61F2230/0063 ,  A61F2230/0095 ,  A61F2240/001 ,  A61F2250/0014 ,  A61F2250/0023 ,  A61F2310/00179 ,  A61F2310/00203 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61L27/46 ,  A61L27/56 ,  B29C64/165 ,  B29L2031/7532

Abstract: The devices dsclosed herein are composite implantable devices having a gradient of one or more of the following: materials, macroarchitecture, microarchitecture, or mechanical properties, which can be used to select or promote attachment of specific cell types on and in the devices prior to and/or after implantation. In preferred embodiments, the implants include complex three-dimensional structure, including curved regions and saddle-shaped areas. In various embodiements, the gradient forms a transition zone in the device from a region composed of materials or having properties best suited for one type of tissue to a region composed of materials or having properties suited for a different type of tissue. Methods to improve these devices for use in repair or replacement of cartilage and/or bone have been developed, which specifically address 1) the selection of the appropriate polymeric material for the cartilage region, 2) mechanical testing of the bone region including the effect of porosity and polymer/calcium phosphate r

Abstract translation: 本文中关闭的装置是具有以下一种或多种的梯度的复合植入式装置：材料，宏观结构，微结构或机械性质，其可用于选择或促进特定细胞类型附着在装置之前和之中 /或植入后。 在优选实施例中，植入物包括复杂的三维结构，包括弯曲区域和鞍形区域。 在各种实施方案中，梯度在由材料构成的区域或具有最适合于一种类型的组织的特性的区域中形成过渡区域到由材料构成的区域或具有适于不同类型的组织的性质的区域。 已经开发了改进用于软骨和/或骨的修复或替换的这些装置的方法，其具体涉及1）用于软骨区域的合适的聚合物材料的选择，2）骨区域的机械测试，包括 孔隙度和聚合物/磷酸钙r

公开(公告)号：WO2003094703A2

公开(公告)日：2003-11-20

申请号：PCT/US2003/014996

申请日：2003-05-13

Applicant: ARTICULAR ENGINEERING, LLC ,  MASUDA, Koichi ,  HEJNA, Michael, J. ,  PFISTER, Brian, E.

Inventor： MASUDA, Koichi ,  HEJNA, Michael, J. ,  PFISTER, Brian, E.

IPC: A61B

CPC classification number: G09B23/30 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30766 ,  A61F2310/00293 ,  A61F2310/00359 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3852 ,  A61L27/56 ,  Y10S623/901

Abstract: Compositions, methods of production and use, and kits for an osteochondral graft involving both articular cartilage and underlying bone are provided.

Abstract translation: 提供了组合物，生产和使用方法，以及涉及关节软骨和下面的骨的骨软骨移植试剂盒。

公开(公告)号：WO01030276A1

公开(公告)日：2001-05-03

申请号：PCT/EP2000/010062

申请日：2000-10-12

IPC: A61B17/00 ,  A61B17/16 ,  A61B17/68 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/30 ,  A61F2/46 ,  A61L27/58 ,  A61L27/00

CPC classification number: A61L27/58 ,  A61B17/1604 ,  A61B17/68 ,  A61B2017/00004 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30756 ,  A61F2/4618 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61F2002/30171 ,  A61F2002/30225 ,  A61F2002/30326 ,  A61F2002/30448 ,  A61F2002/30761 ,  A61F2002/30762 ,  A61F2002/30785 ,  A61F2002/30808 ,  A61F2002/30841 ,  A61F2002/30848 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2002/30901 ,  A61F2002/3092 ,  A61F2002/30948 ,  A61F2002/30952 ,  A61F2002/4681 ,  A61F2210/0004 ,  A61F2220/005 ,  A61F2230/005 ,  A61F2230/0069 ,  A61F2250/0037 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61L2430/06

Abstract: The invention relates to a cartilage substitute structure (1) which uses anchor elements (2) that penetrate into the bone and are fixed therein by means of friction, clamping or a positive-fit, in order to ensure that said cartilage substitute structure (1) is fixed in a mechanically secure manner. This type of anchoring process allows the connection between the bone and the cartilage substitute structure (1) to optionally remain open, thus making it suitable for the transfer of cells from the bone marrow into the cartilage substitute structure (1).

Abstract translation: 本发明提供一种软骨替换结构（1），具有延伸到由摩擦来固定骨锚固元件（2），在骨夹紧或强制联锁的帮助下，可确保软骨替换结构的机械上可靠的固定（1）。 通过这种类型的锚定的，骨和软骨替换结构（1）之间的连接可以，如果必要的话，开式设计，并且因此也以从骨髓成软骨替换结构单元的通道（1）可以是合适的。

公开(公告)号：WO0102030A2

公开(公告)日：2001-01-11

申请号：PCT/IL0000386

申请日：2000-07-04

Applicant: UNIV RAMOT ,  NEVO ZVI ,  ROBINSON DROR

Inventor： NEVO ZVI ,  ROBINSON DROR

IPC: A61L27/00 ,  A61F2/30 ,  A61K35/12 ,  A61L27/36 ,  C12M3/02 ,  C12N5/00 ,  C12N5/077

CPC classification number: A61L27/3691 ,  A61F2/3094 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61K35/12 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3629 ,  A61L27/3687 ,  C12M21/08 ,  C12M25/14 ,  C12N5/0062 ,  C12N5/0655 ,  C12N2533/90 ,  C12N2533/92

Abstract: The invention concerns a device with a constant perfusion system for maintenance of viable cells, tissues and composite implants, which involves a pressure generator for producing rhythmic pulses of pressure on the biological specimen. All the operative parameters of the system are controllable, easily manipulated. The invention further concerns a scaffold which is used as a growth supportive base for various cells and tissue explants from three-dimensional tissue comprising naturally derived connective or skeletal tissue cross-linked with one of the following: hyaluronic acid, proteoglycans, glycosaminolycans, chondroitin sulfates, heparan sulfates, heparins and dextran sulfates.

Abstract translation: 本发明涉及一种具有用于维持活细胞，组织和复合植入物的恒定灌注系统的装置，其包括用于在生物样本上产生节奏脉冲压力的压力发生器。 系统的所有操作参数都是可控的，易于操作。 本发明还涉及一种支架，其用作来自三维组织的各种细胞和组织移植物的生长支持基质，其包含与以下之一交联的天然衍生的结缔组织或骨骼组织：透明质酸，蛋白聚糖，糖胺聚糖，硫酸软骨素 ，硫酸乙酰肝素，肝素和硫酸葡聚糖。