公开(公告)号：WO2014115172A1

公开(公告)日：2014-07-31

申请号：PCT/IN2014/000057

申请日：2014-01-24

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

Inventor： REDDY, Dumbala Srinivasa

IPC: C07C29/147 ,  C07C67/00 ,  C07C67/08 ,  C07C29/92 ,  C07C67/293 ,  C07C41/30 ,  C07C45/51 ,  C07C69/587 ,  C07C33/02 ,  C07C47/21 ,  C07C69/145

CPC classification number: C07C67/293 ,  C07B2200/07 ,  C07B2200/09 ,  C07C29/143 ,  C07C29/147 ,  C07C29/92 ,  C07C41/30 ,  C07C67/00 ,  C07C67/08 ,  C07C2601/10 ,  C07D275/06 ,  C07C43/178 ,  C07C69/587 ,  C07C33/02 ,  C07C69/145

Abstract: The invention disclosed herein relates to an enantioselective process for preparation of biologically active (R) and (S) enantiomers of sex pheromones of the long-tailed Mealybug with high enantiopurity having significant biological activity. Further, the invention provides absolute configuration of synthesized R and S enantiomers.(I)

Abstract translation: 本文公开的本发明涉及用于制备具有显着生物活性的具有高对映体纯度的长尾Mealybug的性信息素的生物活性（R）和（S）对映异构体的对映选择性方法。 此外，本发明提供了合成的R和S对映异构体的绝对构型。（I）

公开(公告)号：WO2014079691A1

公开(公告)日：2014-05-30

申请号：PCT/EP2013/073171

申请日：2013-11-06

Applicant: FIRMENICH SA

Inventor： RIEDHAUSER, Jean-Jacques ,  KNOPFF, Oliver

IPC: C07C51/14 ,  C07C57/03 ,  C07C67/38 ,  C07C69/587

CPC classification number: C07C51/14 ,  C07C67/38 ,  C07C57/03 ,  C07C69/587

Abstract: The present invention concerns a process of carbonylation of poly-unsaturated diene with high selectivity for the preparation of a β,γ - unsaturated carboxylic acid or ester in the presence of water or alcohol and catalyzed by [PdCl 2 P 2 ] complex wherein P 2 is two mono or one bidendate phosphine ligand.

Abstract translation: 本发明涉及一种在水或醇存在下以高选择性制备γ-不饱和羧酸或酯并通过[PdCl 2 P 2]络合物催化的多不饱和二烯的羰基化方法，其中P2是两个单 或一种铋膦配体。

公开(公告)号：WO2013013990A1

公开(公告)日：2013-01-31

申请号：PCT/EP2012/063679

申请日：2012-07-12

Applicant: DSM IP ASSETS B.V. ,  SEREINIG, Natascha ,  JANSSEN, Michèle Catherine Christianne ,  DE VRIES, Johannes Gerardus

Inventor： SEREINIG, Natascha ,  JANSSEN, Michèle Catherine Christianne ,  DE VRIES, Johannes Gerardus

IPC: C07C69/58 ,  C07C69/587 ,  C07C69/716 ,  C07C67/333

CPC classification number: C07C67/333 ,  B01J31/24 ,  C07C69/58 ,  C07C69/587 ,  C07C69/716 ,  C07C69/732

Abstract: The invention relates to a process for the isomerization of unsaturated fatty acids or esters or amides thereof, said process comprising reacting: (a) an unsaturated fatty acid or ester or amide thereof; (b) a source of Pd; (c) a bidentate diphosphine of formula I, R1R2 > P1-R-P2

Abstract translation: 本发明涉及不饱和脂肪酸或其酯或酰胺异构化的方法，所述方法包括使（a）不饱和脂肪酸或其酯或酰胺反应; （b）Pd源; （c）式I的二齿二膦，R1R2> P1-R-P2

公开(公告)号：WO2012099855A3

公开(公告)日：2012-10-04

申请号：PCT/US2012021512

申请日：2012-01-17

Applicant: MARELLE LLC ,  FARRELL MARK ,  GUARAGNO MICHELLE

Inventor： FARRELL MARK ,  GUARAGNO MICHELLE

IPC: C01B31/02 ,  B01D17/00 ,  B01J8/20

CPC classification number: C01B31/0206 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/15 ,  C07C29/12 ,  C07C29/62 ,  C07C35/44 ,  C07C45/70 ,  C07C46/00 ,  C07C49/84 ,  C07C50/26 ,  C07C67/08 ,  C07C69/013 ,  C07C69/52 ,  C07C69/587 ,  C07C231/12 ,  C07C303/02 ,  C07C2601/16 ,  C07C2604/00 ,  C07D495/04 ,  C07J5/0053 ,  C07C35/52 ,  C07C309/25 ,  C07C233/25

Abstract: Provided herein are water-soluble, functionalized fullerenes, and processes for producing water-soluble, functionalized fullerenes. The process includes sulfonating a fullerene in an acidic solution comprising sulfuric acid to produce a sulfonated fuUerene, isolating the sulfonated fullerene from the acidic solution without neutralizing the acidic solution, reacting the sulfonated fullerene with hydrogen peroxide to form a reaction product, and isolating a polyhydroxylated fullerene from the reaction product produced from reacting the sulfonated fullerene with the hydrogen peroxide. The process of producing water-soluble fullerenes further includes functionalizing a polyhydroxylated fullerene with one or more pendant functional groups by reacting the polyhydroxylated fullerene with one or more functional group precursors.

Abstract translation: 本文提供水溶性官能化富勒烯，以及生产水溶性官能化富勒烯的方法。 该方法包括在包含硫酸的酸性溶液中磺化富勒烯以产生磺化的富勒烯，从酸性溶液中分离磺化富勒烯而不中和酸性溶液，使磺化富勒烯与过氧化氢反应形成反应产物，并分离出多羟基化 来自由磺化富勒烯与过氧化氢反应产生的反应产物的富勒烯。 制备水溶性富勒烯的方法还包括通过使多羟基化富勒烯与一种或多种官能团前体反应来使具有一个或多个侧链官能团的多羟基化富勒烯官能化。

公开(公告)号：WO2012126088A1

公开(公告)日：2012-09-27

申请号：PCT/CA2012/000239

申请日：2012-03-16

Applicant: PHENOMENOME DISCOVERIES INC. ,  KHAN, Mohamed Amin ,  WOOD, Paul L.

Inventor： KHAN, Mohamed Amin ,  WOOD, Paul L.

IPC: C07C309/73 ,  C07C303/14 ,  C07C51/353 ,  C07C51/36 ,  C07C67/333 ,  C07C69/606 ,  C07C57/03

CPC classification number: C07C51/09 ,  C07C29/103 ,  C07C67/30 ,  C07C67/303 ,  C07C67/317 ,  C07C69/606 ,  C07C303/28 ,  C07C309/73 ,  C07C69/608 ,  C07C69/587 ,  C07C57/03 ,  C07C33/04

Abstract: A method for preparing docosahexaenoic acid (DHA). The method comprises coupling a compound represented by Formula I with a compound represented by Formula II followed by partial hydrogenation to obtain a compound represented by Formula III. The compound represented by Formula III acts as a DHA precursor and thus can be hydrolysed to obtain DHA. Novel starting materials represented by Formula I and Formula II, and synthetic routes for preparing the same are also provided.

Abstract translation: 二十二碳六烯酸（DHA）的制备方法。 该方法包括将由式I表示的化合物与由式II表示的化合物偶联，然后进行部分氢化，得到式III表示的化合物。 由式III表示的化合物用作DHA前体，因此可以水解以获得DHA。 还提供了由式I和式II表示的新型起始物质及其制备方法。

公开(公告)号：WO2012099855A2

公开(公告)日：2012-07-26

申请号：PCT/US2012/021512

申请日：2012-01-17

Applicant: MARELLE, LLC ,  FARRELL, Mark ,  GUARAGNO, Michelle

Inventor： FARRELL, Mark ,  GUARAGNO, Michelle

IPC: C01B31/02 ,  B01J8/20 ,  B01D17/00

CPC classification number: C01B31/0206 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/15 ,  C07C29/12 ,  C07C29/62 ,  C07C35/44 ,  C07C45/70 ,  C07C46/00 ,  C07C49/84 ,  C07C50/26 ,  C07C67/08 ,  C07C69/013 ,  C07C69/52 ,  C07C69/587 ,  C07C231/12 ,  C07C303/02 ,  C07C2601/16 ,  C07C2604/00 ,  C07D495/04 ,  C07J5/0053 ,  C07C35/52 ,  C07C309/25 ,  C07C233/25

Abstract: Provided herein are water-soluble, functionalized fullerenes, and processes for producing water-soluble, functionalized fullerenes. The process includes sulfonating a fullerene in an acidic solution comprising sulfuric acid to produce a sulfonated fullerene, isolating the sulfonated fullerene from the acidic solution without neutralizing the acidic solution, reacting the sulfonated fullerene with hydrogen peroxide to form a reaction product, and isolating a polyhydroxylated fullerene from the reaction product produced from reacting the sulfonated fullerene with the hydrogen peroxide. The process of producing water-soluble fullerenes further includes functionalizing a polyhydroxylated fullerene with one or more pendant functional groups by reacting the polyhydroxylated fullerene with one or more functional group precursors.

Abstract translation: 本文提供水溶性官能化富勒烯，以及生产水溶性官能化富勒烯的方法。 该方法包括在包含硫酸的酸性溶液中磺化富勒烯以产生磺化富勒烯，从酸性溶液中分离磺化富勒烯而不中和酸性溶液，使磺化富勒烯与过氧化氢反应形成反应产物，并分离出多羟基化 来自由磺化富勒烯与过氧化氢反应产生的反应产物的富勒烯。 制备水溶性富勒烯的方法还包括通过使多羟基化富勒烯与一种或多种官能团前体反应来使具有一个或多个侧链官能团的多羟基化富勒烯官能化。

公开(公告)号：WO2012080033A1

公开(公告)日：2012-06-21

申请号：PCT/EP2011/071878

申请日：2011-12-06

Applicant: PRIME EUROPEAN THERAPEUTICALS S.P.A. in forma abbreviata EUTICALS S.P.A. ,  GUAZZI, Giuseppe ,  VEZZOLI, Lodovico

Inventor： GUAZZI, Giuseppe ,  VEZZOLI, Lodovico

IPC: C07C67/52 ,  C07C67/60 ,  C07C69/587

CPC classification number: C11B7/0083 ,  C07C67/60 ,  C07C69/587

Abstract: The invention relates to a procedure for stabilising polyunsaturated fatty acids with selective reducing agents. In particular, the invention relates to a process of preparation of polyunsaturated acids of the omega-3 series, as such or in the form of esters, which comprises treatment of fish oil or a mixture of acids with urea, and subsequent treatment with a metal hydride, preferably sodium borohydride. The polyunsaturated fatty acids of greatest interest present in fish oil are docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).

Abstract translation: 本发明涉及用选择性还原剂稳定多不饱和脂肪酸的方法。 特别地，本发明涉及制备欧米加-3系列的多不饱和酸的方法，本发明或酯的形式，其包括将鱼油或酸与尿素的混合物处理，随后用金属处理 氢化物，优选硼氢化钠。 鱼油中最感兴趣的多不饱和脂肪酸是二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）。

公开(公告)号：WO2011041639A2

公开(公告)日：2011-04-07

申请号：PCT/US2010/051059

申请日：2010-10-01

Applicant: MILLER, Raymond A.

Inventor： MILLER, Raymond A.

IPC: C07C205/50 ,  A61K31/201 ,  A61P9/00 ,  A61P11/00

CPC classification number: C07C205/50 ,  A61K31/201 ,  C07C57/52 ,  C07C69/587 ,  C07C211/01 ,  C07C317/02 ,  C07C323/52

Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.

Abstract translation: 本文提供了活化的脂肪酸，包括活化的脂肪酸的药物组合物，使用活化的脂肪酸治疗各种疾病的方法以及制备活化的脂肪酸的方法。

公开(公告)号：WO2008132552A3

公开(公告)日：2009-01-15

申请号：PCT/IB2007004588

申请日：2007-11-01

Applicant: PRONOVA BIOPHARMA NORGE AS ,  HOLMEIDE ANNE KRISTIN ,  ROSMAN JENNY

Inventor： HOLMEIDE ANNE KRISTIN ,  ROSMAN JENNY

IPC: C07C33/02 ,  A61K31/045 ,  A61K31/047 ,  A61K31/075 ,  A61K31/10 ,  A61K31/22 ,  C07C43/178 ,  C07C69/007 ,  C07C69/24 ,  C07C69/40 ,  C07C69/587 ,  C07C69/96 ,  C07C309/67 ,  C07C323/14 ,  C07F9/113

CPC classification number: C07H15/04 ,  A23D9/00 ,  A61K31/045 ,  A61K31/047 ,  A61K31/075 ,  A61K31/10 ,  A61K31/22 ,  A61K31/225 ,  A61K31/232 ,  A61K31/255 ,  A61K31/265 ,  A61K31/661 ,  A61K45/06 ,  A61K49/0004 ,  C07C57/03 ,  C07C57/12 ,  C07C69/007 ,  C07C69/24 ,  C07C69/40 ,  C07C69/587 ,  C07C69/96 ,  C07C211/20 ,  C07C229/30 ,  C07C305/14 ,  C07C323/14 ,  C07C323/54 ,  C07F9/091 ,  C07F9/106 ,  C07F9/113 ,  A61K2300/00

Abstract: Omega-3 lipid compounds of the general formula (1): wherein P represents a hydrogen atom, Formulas (a), (b), (c) or (d) and (e), Y is a C14-C22 alkenyl group with at least one double bond, having E and/or Z, configuration;., or any pharmaceutically acceptable complex, solvate, salt or pro-drug thereof, with the proviso that R1 and R2 are not simultaneously a hydrogen atom. Also disclosed are pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments, in particular for the treatment of cardiovascular and metabolic diseases.

Abstract translation: 通式（1）的ω-3脂质化合物：其中P表示氢原子，式（a），（b），（c）或（d）和（e）中，Y为C 14 -C 22烯基， 具有E和/或Z构型的至少一个双键，或其任何药学上可接受的复合物，溶剂合物，盐或前药，条件是R 1和R 2不同时为氢原子。 还公开了包含这些化合物的药物组合物和脂质组合物，以及用作药物的这种化合物，特别是用于治疗心血管和代谢疾病。

公开(公告)号：WO2008008440A3

公开(公告)日：2008-06-26

申请号：PCT/US2007015905

申请日：2007-07-12

Applicant: MATERIA INC ,  LEE CHOON WOO

Inventor： LEE CHOON WOO

IPC: C07C67/475 ,  C07C69/58 ,  C07C69/608

CPC classification number: C07C67/343 ,  C07C29/32 ,  C07C67/475 ,  C07C2601/08 ,  C08G61/08 ,  C11C3/00 ,  C11C3/003 ,  C07C33/02 ,  C07C69/753 ,  C07C69/587 ,  C07C69/732 ,  C07C69/602

Abstract: This invention relates generally to olefin metathesis, and more particularly relates to the ring-opening, ring insertion cross-metathesis of cyclic olefins with internal olefins such as seed oils and the like. In one embodiment, a method is provided for carrying out a catalytic ring-opening cross-metathesis reaction, comprising contacting at least one olefinic substrate with at least one cyclic olefin as a cross metathesis partner, in the presence of a ruthenium alkylidene olefin metathesis catalyst under conditions effective to allow ring insertion cross metathesis whereby the cyclic olefin is simultaneously opened and inserted into the olefinic substrate. The invention has utility in the fields of catalysis, organic synthesis, and industrial chemistry.

Abstract translation: 本发明总体上涉及烯烃复分解，更具体地涉及环烯烃与内烯烃如种子油等的开环，环插入交叉复分解。 在一个实施方案中，提供了用于进行催化开环交叉复分解反应的方法，其包括使至少一种烯烃底物与至少一种环烯烃作为交叉复分解配偶体在钌亚烷基烯烃复分解催化剂 在有效地允许环插入交叉复分解的条件下，由此环烯烃同时开放并插入到烯烃底物中。 本发明在催化，有机合成和工业化学领域具有实用性。