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    COMPOSITE ORGANIC-INORGANIC NANOCLUSTERS
    23.
    发明申请
    COMPOSITE ORGANIC-INORGANIC NANOCLUSTERS 审中-公开
    复合有机无机纳米粒子

    公开(公告)号：WO2005090948A2

    公开(公告)日：2005-09-29

    申请号：PCT/US2004/043878

    申请日：2004-12-28

    Applicant: INTEL CORPORATION ,  SU, Xing ,  ZHANG, Jingwu ,  SUN, Lei ,  BERLIN, Andrew

    Inventor： SU, Xing ,  ZHANG, Jingwu ,  SUN, Lei ,  BERLIN, Andrew

    IPC: G01N21/65

    CPC classification number: G01N33/54346 ,  G01N21/658

    Abstract: Composite organic-inorganic nanoclusters (COINs) are provided that produce surface-enhanced Raman signals (SERS) when excited by a laser. The nanoclusters include metal particles and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanocluster and a wide variety of Raman-active organic compounds and combinations thereof can be incorporated into the nanocluster. In addition, polymeric microspheres containing the nanoclusters and methods of making them are also provided. The nanoclusters and microspheres can be used, for example, in assays for multiplex detection of biological molecules.

    Abstract translation: 提供了复合有机 - 无机纳米团簇（COINs），当激光激发时产生表面增强拉曼信号（SERS）。 纳米团簇包括金属颗粒和拉曼活性有机化合物。 实现合适的SERS信号所需的金属在纳米簇中是固有的，并且可以将多种拉曼活性有机化合物及其组合掺入纳米团簇中。 此外，还提供了含有纳米簇的聚合物微球及其制备方法。 纳米团簇和微球可用于例如用于多重检测生物分子的测定中。

    METHODS FOR DETERMINING NUCLEOTIDE SEQUENCE INFORMATION
    24.
    发明申请
    METHODS FOR DETERMINING NUCLEOTIDE SEQUENCE INFORMATION 审中-公开
    确定核苷酸序列信息的方法

    公开(公告)号：WO2005066370A2

    公开(公告)日：2005-07-21

    申请号：PCT/US2004/043730

    申请日：2004-12-24

    Applicant: INTEL CORPORATION ,  SU, Xing

    Inventor： SU, Xing

    IPC: C12Q1/68

    CPC classification number: C12Q1/6818 ,  C12Q1/6874 ,  C12Q2565/632

    Abstract: Provided herein, is a nucleic acid sequencing method based on detection of Raman signatures of oligonucleotide probes. Raman signatures of individually captured nucleic acid probes, optionally labeled by a Raman label or a positively charged enhancer, are detected. The sequences of captured probes are used to identify the nucleotide sequences of captured probes and complementary target nucleic acids, which are then aligned and used to obtain nucleic acid sequence information. In another embodiment, a method is provided for determining a nucleotide occurrence at a target nucleotide position of a target nucleic acid, that utilizes binding of the target nucleic acid to a labeled oligonucleotide probe that binds to the target nucleic acid, wherein the labeled oligonucleotide probe includes a first label and a second label, the first label being capable of affecting an optical property of the second label.

    Abstract translation: 本文提供了基于检测寡核苷酸探针的拉曼特征的核酸测序方法。 检测单独捕获的核酸探针的拉曼特征，任选地标记有拉曼标记或带正电的增强子。 捕获探针的序列用于鉴定捕获的探针和互补靶核酸的核苷酸序列，然后对其进行比对并用于获得核酸序列信息。 在另一个实施方案中，提供了用于确定靶核酸的靶核苷酸位置处的核苷酸发生的方法，该方法利用靶核酸与结合靶核酸的标记的寡核苷酸探针的结合，其中标记的寡核苷酸探针 包括第一标签和第二标签，第一标签能够影响第二标签的光学特性。

    PERIODIC RESET TOTAL RETURN INDEX FUTURES CONTRACTS
    25.
    发明申请
    PERIODIC RESET TOTAL RETURN INDEX FUTURES CONTRACTS 审中-公开
    定期复位总回报指数期货合约

    公开(公告)号：WO2012057985A1

    公开(公告)日：2012-05-03

    申请号：PCT/US2011/055236

    申请日：2011-10-07

    Applicant: CHICAGO MERCANTILE EXCHANGE INC. ,  CO, Richard ,  WANG, Tuen, Tuen ,  SU, Xing ,  LABUSZEWSKI, John

    Inventor： CO, Richard ,  WANG, Tuen, Tuen ,  SU, Xing ,  LABUSZEWSKI, John

    IPC: G06Q40/00

    CPC classification number: G06Q40/04 ,  G06Q40/06

    Abstract: A periodic reset total return index may be based on a standard index, such as an equity index. The value of the periodic reset total return index may be the sum of the standard index plus the income flow generated by the index, such as dividends generated by stocks. The periodic reset total return index valuation may be deployed as the basis for a futures contract. On a periodic basis, the income flow accrued for the preceding period are passed from the short to the long position holder, with a corresponding adjustment of the settlement price of the contract. The expiration of the contract may be settled at the sum of the underlying index quotation plus the income flow accrual for the previous period. A buyer of a futures contract based on a periodic reset total return index receives the performance of the index plus the intervening income flow accrual.

    Abstract translation: 定期复位总回报指数可以基于标准指数，如权益指数。 定期复位总回报指数的价值可能是标准指数加上指数产生的收益流动的总和，如股票产生的股息。 周期性复位总回报指数估值可以部署为期货合约的基础。 定期对上期所得的收益流入短仓转为长期持有人，并对合同结算价格进行相应调整。 合同到期可以按照相关指数报价加上一个期间的应计利润总额结算。 基于定期复位总回报指数的期货合约的买方收到指数的表现加上累计收入流动应计利润。

    EXTERNAL MODIFICATION OF COMPOSITE ORGANIC INORGANIC NANOCLUSTERS
    27.
    发明申请
    EXTERNAL MODIFICATION OF COMPOSITE ORGANIC INORGANIC NANOCLUSTERS 审中-公开
    复合有机无机纳米粒子的外部修饰

    公开(公告)号：WO2007018551A2

    公开(公告)日：2007-02-15

    申请号：PCT/US2005/031582

    申请日：2005-09-02

    Applicant: INTEL CORPORATION ,  ZHANG, Jingwu ,  SU, Xing ,  LEI, Sun

    Inventor： ZHANG, Jingwu ,  SU, Xing ,  LEI, Sun

    IPC: G01N33/58 ,  G01N33/543 ,  G01N21/65

    CPC classification number: G01N21/658 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/783 ,  Y10T428/12049 ,  Y10T428/2991 ,  Y10T428/2998

    Abstract: Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    Abstract translation: 提供了能够从其中结合的有机拉曼活性分子提供增强拉曼信号的改性和官能化的金属纳米团簇。 例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告者进行分析物检测。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    NUCLEIC ACID SEQUENCING BY RAMAN MONITORING OF UPTAKE OF NUCLEOTIDES DURING MOLECULAR REPLICATION
    29.
    发明申请
    NUCLEIC ACID SEQUENCING BY RAMAN MONITORING OF UPTAKE OF NUCLEOTIDES DURING MOLECULAR REPLICATION 审中-公开
    在分子复制期间通过拉曼监测核酸摄取的核酸序列

    公开(公告)号：WO2005066369A3

    公开(公告)日：2006-02-02

    申请号：PCT/US2004043633

    申请日：2004-12-28

    Applicant: INTEL CORP ,  BERLIN ANDREW ,  SU XING ,  CHAN SELENA ,  KOO TAE-WOONG ,  SUN LEI ,  SUNDARARAJAN NARAYAN

    Inventor： BERLIN ANDREW ,  SU XING ,  CHAN SELENA ,  KOO TAE-WOONG ,  SUN LEI ,  SUNDARARAJAN NARAYAN

    IPC: C12Q1/68 ,  G01N21/65

    CPC classification number: G01N21/658 ,  C12Q1/6869 ,  C12Q2565/632 ,  C12Q2533/101

    Abstract: The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS) or surface enhanced coherent anti-Stokes Raman spectroscopy (SECARS). The detection can be part of a nucleic acid sequencing reaction to detect uptake of a deoxynucleotide triphosphate during a nucleic acid polymerization reaction, such as a nucleic acid sequencing reaction. The nucleic acid sequence of a synthesized nascent strand, and the complementary sequence of the template strand, can be determined by tracking the order of incorporation of nucleotides during the polymerization reaction. Methods for enhancing the SERS signal of a nucleotide or nucleoside by cleaving the base from a sugar moiety are provided. Furthermore, methods for detecting single base repeats are provided.

    Abstract translation: 本文公开的方法和装置可用于检测核苷酸，核苷和碱基并用于核酸序列测定。 该方法涉及使用表面增强拉曼光谱（SERS）或表面增强相干抗斯托克斯拉曼光谱（SECARS）检测核苷酸，核苷或碱基。 检测可以是在核酸聚合反应（例如核酸测序反应）期间检测脱氧核苷酸三磷酸的摄取的核酸测序反应的一部分。 合成的新生链的核酸序列和模板链的互补序列可以通过跟踪聚合反应期间核苷酸掺入的顺序来确定。 提供了通过从糖部分切割碱来增强核苷酸或核苷的SERS信号的方法。 此外，提供了用于检测单碱基重复的方法。

    METHODS FOR DETERMINING NUCLEOTIDE SEQUENCE INFORMATION
    30.
    发明申请
    METHODS FOR DETERMINING NUCLEOTIDE SEQUENCE INFORMATION 审中-公开
    确定核酸序列信息的方法

    公开(公告)号：WO2005066370A3

    公开(公告)日：2005-11-03

    申请号：PCT/US2004043730

    申请日：2004-12-24

    Applicant: INTEL CORP ,  SU XING

    Inventor： SU XING

    IPC: C12Q1/68

    CPC classification number: C12Q1/6818 ,  C12Q1/6874 ,  C12Q2565/632

    Abstract: Provided herein, is a nucleic acid sequencing method based on detection of Raman signatures of oligonucleotide probes. Raman signatures of individually captured nucleic acid probes, optionally labeled by a Raman label or a positively charged enhancer, are detected. The sequences of captured probes are used to identify the nucleotide sequences of captured probes and complementary target nucleic acids, which are then aligned and used to obtain nucleic acid sequence information. In another embodiment, a method is provided for determining a nucleotide occurrence at a target nucleotide position of a target nucleic acid, that utilizes binding of the target nucleic acid to a labeled oligonucleotide probe that binds to the target nucleic acid, wherein the labeled oligonucleotide probe includes a first label and a second label, the first label being capable of affecting an optical property of the second label.

    Abstract translation: 本文提供了基于检测寡核苷酸探针的拉曼特征的核酸测序方法。 检测单独捕获的核酸探针的拉曼特征，任选由拉曼标记或带正电荷的增强子标记。 捕获的探针的序列用于鉴定捕获的探针和互补靶核酸的核苷酸序列，然后将其对准并用于获得核酸序列信息。 在另一个实施方案中，提供了用于确定靶核酸的靶核苷酸位置上的核苷酸发生的方法，其利用靶核酸与结合靶核酸的标记的寡核苷酸探针的结合，其中标记的寡核苷酸探针 包括第一标签和第二标签，第一标签能够影响第二标签的光学性质。

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