公开(公告)号：WO2012036919A3

公开(公告)日：2012-03-22

申请号：PCT/US2011/050302

申请日：2011-09-02

Applicant: GLAXOSMITHKLINE LLC ,  KUMAR, Rakesh

Inventor： KUMAR, Rakesh

IPC: A01N41/06 ,  A61K31/18

Abstract: A novel combination comprising the VEGFR inhibitor 5-[[4-[(2,3-dimethyl-2H- indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, with a B-Raf inhibitor, particularly N-{3-[5- (2-Amino-4-pyrimidinyl)-2-(1,1 -dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6- difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of VEGFR and/or B-Raf is beneficial.

公开(公告)号：WO2011037534A1

公开(公告)日：2011-03-31

申请号：PCT/SG2009/000355

申请日：2009-09-25

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  SEIKO INSTRUMENTS INC. ,  PREMACHANDRAN, Chirayarikathu Veedu Sankarapillai ,  KUMAR, Rakesh ,  RANGANATHAN, Nagarajan ,  CHOI, Won Kyoung ,  LIAO, Ebin ,  MITSUOKA, Yasuyuki ,  TAKAHASHI, Hiroshi ,  MITSUSUE, Ryuta

Inventor： PREMACHANDRAN, Chirayarikathu Veedu Sankarapillai ,  KUMAR, Rakesh ,  RANGANATHAN, Nagarajan ,  CHOI, Won Kyoung ,  LIAO, Ebin ,  MITSUOKA, Yasuyuki ,  TAKAHASHI, Hiroshi ,  MITSUSUE, Ryuta

IPC: B81B7/02 ,  H01L21/44 ,  H01L23/48

CPC classification number: H01L21/6836 ,  B81B2207/092 ,  B81B2207/093 ,  B81B2207/097 ,  B81C2203/019 ,  H01L24/48 ,  H01L24/94 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/48465 ,  H01L2924/00014 ,  H01L2924/01012 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01322 ,  H01L2924/01327 ,  H01L2924/09701 ,  H01L2924/10253 ,  H01L2924/1461 ,  H01L2924/16195 ,  H01L2924/16235 ,  H01L2924/16315 ,  H01L2924/19041 ,  H01L2924/19107 ,  H01L2924/3011 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2224/45015 ,  H01L2924/207

Abstract: In an embodiment, a wafer level package may be provided. The wafer level package may include a device wafer including a MEMS device, a cap wafer disposed over the device wafer, at least one first interconnect disposed between the device wafer and the cap wafer and configured to provide an electrical connection between the device wafer and the cap wafer, and a conformal sealing ring disposed between the device wafer and the cap wafer and configured to surround the at least one first interconnect and the MEMS device so as to provide a conformally sealed environment for the at least one first interconnect and the MEMS device, wherein the conformal sealing ring may be configured to conform to a respective suitable surface of the device wafer and the cap wafer when the device wafer may be bonded to the cap wafer. A method of forming a wafer level package may also be provided.

Abstract translation: 在一个实施例中，可以提供晶片级封装。 晶片级封装可以包括包括MEMS器件的器件晶片，设置在器件晶片上的帽晶片，设置在器件晶片和帽晶片之间的至少一个第一互连，并且被配置为在器件晶片和晶片级封装之间提供电连接 帽状晶片和保形密封环，其设置在器件晶片和盖晶片之间并且被配置为围绕至少一个第一互连和MEMS器件，以便为至少一个第一互连和MEMS器件提供保形密封的环境 ，其中所述保形密封环可以被配置为当所述器件晶片可以结合到所述盖晶片时，使其符合所述器件晶片和所述盖晶片的相应合适的表面。 还可以提供一种形成晶片级封装的方法。

公开(公告)号：WO2010097811A1

公开(公告)日：2010-09-02

申请号：PCT/IN2010/000110

申请日：2010-02-25

Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH ,  SINHA, Arun, Kumar ,  SHARMA, Abhishek ,  KUMAR, Rakesh ,  SHARMA, Naina

Inventor： SINHA, Arun, Kumar ,  SHARMA, Abhishek ,  KUMAR, Rakesh ,  SHARMA, Naina

IPC: C07C45/30 ,  C07C311/49 ,  C07D317/54 ,  C07C47/228 ,  C07C47/23 ,  C07C47/24 ,  C07C47/277

CPC classification number: C07C45/28 ,  C07C45/30 ,  C07C249/16 ,  C07C311/49 ,  C07D317/54 ,  C07C47/228 ,  C07C47/24 ,  C07C47/23 ,  C07C47/277

Abstract: The present invention provides a process for the preparation of some novel 2-aryl and 2,2-diaryl aldehydes and analogues which are privileged intermediates for commercially important nonsteroidal anti-inflammatory drugs including naproxen, flurbiprofen and potent anticancer drug candidates, including phenstatin through a unique single step synthetic methodology utilizing easily available substrates in the form of aryl alkenes as well as environmentally benign aqueous reaction conditions in the form of solvents such as mixtures of water and DMSO or Dioxane and reagents N-bromosuccinimide, N- iodosuccinimide, N-cholorosuccinimide and phase transfer catalyst such as cetyltrimethyl ammonium bromide, N-hexyl ammonium chloride for a reaction time varying from 1min- 30min, depending upon microwave or conventional heating, without using expensive transition metal catalysts or lewis acids/bases with yield varying from 35-55 %, depending upon the solvent and substrate used. The developed method provides a clean and convenient alternative to access a diverse range of medicinally important 2-aryl and 2,2- diaryl aldehyde based scaffolds in lieu of the conventional multistep protocols employing expensive and hazardous transition metal catalysts and lewis acids/bases.

Abstract translation: 本发明提供了制备一些新的2-芳基和2,2-二芳基醛和类似物的方法，它们是商业上重要的非甾体抗炎药物的特权中间体，包括萘普生，氟比洛芬和有效的抗癌药物候选物，包括通过 利用芳基烯烃形式的容易获得的底物以及以水和DMSO或二恶烷的混合物和二恶烷的溶剂形式的环境友好的水性反应条件的独特的单步合成方法和试剂N-溴代琥珀酰亚胺，N-碘代琥珀酰亚胺，N-氯代琥珀酰亚胺 和相转移催化剂如十六烷基三甲基溴化铵，N-己基氯化铵，反应时间根据微波或常规加热反应时间为1min-30min，而不使用昂贵的过渡金属催化剂或路易斯酸/碱，产率从35-55 取决于所用的溶剂和底物。 开发的方法提供了一种干净和方便的替代方案，用于获得各种各样的药物重要的2-芳基和2,2-二芳基醛基支架，代替采用昂贵且危险的过渡金属催化剂和路易斯酸/碱的常规多步骤方案。

公开(公告)号：WO2008106286A2

公开(公告)日：2008-09-04

申请号：PCT/US2008/053150

申请日：2008-02-06

Applicant: SPECIALTY COATING SYSTEMS, INC. ,  DOLBIER, William, R., Jr. ,  XIE, Puhui ,  KUMAR, Rakesh

Inventor： DOLBIER, William, R., Jr. ,  XIE, Puhui ,  KUMAR, Rakesh

CPC classification number: C07C17/392 ,  C07C17/269 ,  C08F14/18 ,  C07C25/22 ,  C08F2/04

Abstract: A composition comprising perfluoro-[2,2]-paracyclophane dimer compound is disclosed. The synthesis reaction of the paracyclophane dimer from 1,4-bis(chlorodifluoromethane)-2,3,5,6-tetrafluorobenzene involves heating in the presence of a metal catalyst and a solvent. A perfluorinated paraxylylene coating formed from the perfluorinated paracyclophane dimer is also disclosed.

Abstract translation: 公开了包含全氟 - [2,2] - 对环芳烷二聚物化合物的组合物。 从1,4-双（氯二氟甲烷）-2,3,5,6-四氟苯的对二甲苯基环二聚物的合成反应包括在金属催化剂和溶剂存在下加热。 还公开了由全氟化对二甲苯基二聚体形成的全氟化对二甲苯涂层。

公开(公告)号：WO2007081554A3

公开(公告)日：2007-07-19

申请号：PCT/US2006/049333

申请日：2006-12-27

Applicant: SPECIALTY COATING SYSTEMS, INC. ,  KUMAR, Rakesh

Inventor： KUMAR, Rakesh

IPC: G02B1/10 ,  G02B26/08

Abstract: Conformal coatings are disclosed. A fluorinated thin film, for example, is formed by vapor phase polymerization on a variety of sensitive surfaces that may include electronic and automotive sensors, biochips, implantable sensors and biomedical devices.

公开(公告)号：WO2006002299A3

公开(公告)日：2006-01-05

申请号：PCT/US2005/022213

申请日：2005-06-22

Applicant: SARNOFF CORPORATION ,  SHAN, Ying ,  MATEI, Bogdan , C. M. ,  SAWHNEY, Harpreet Singh ,  KUMAR, Rakesh

Inventor： SHAN, Ying ,  MATEI, Bogdan , C. M. ,  SAWHNEY, Harpreet Singh ,  KUMAR, Rakesh

IPC: G06K9/62

Abstract: A method and apparatus for recognizing an object, comprising providing a set of scene features from a scene, pruning a set of model features, generating a set of hypotheses associated with the pruned set of model features for the set of scene features, pruning the set of hypotheses, and verifying the set of pruned hypotheses is provided.

公开(公告)号：WO2005003792A3

公开(公告)日：2005-01-13

申请号：PCT/US2004/021303

申请日：2004-07-01

Applicant: SARNOFF CORPORATION ,  ARPA, Aydin ,  HANNA, Keith ,  SAMARASEKERA, Supun ,  KUMAR, Rakesh ,  SAWHNEY, Harpreet

Inventor： ARPA, Aydin ,  HANNA, Keith ,  SAMARASEKERA, Supun ,  KUMAR, Rakesh ,  SAWHNEY, Harpreet

IPC: H04N7/18

Abstract: Method and apparatus for dynamically placing sensors in a 3D model (101) is provided. Specifically, in one embodiment, the method selects a 3D model (101) and a sensor for placement into the 3D model (101). The method renders the sensor and the 3D model (101) in accordance with sensor parameters associated with the sensor and parameters desired by a user. In addition, the method determines whether an occlusion to the sensor is present.

公开(公告)号：WO2004114648A3

公开(公告)日：2004-12-29

申请号：PCT/US2004/019722

申请日：2004-06-21

Applicant: SARNOFF CORPORATION ,  SAMARASEKERA, Supun ,  KUMAR, Rakesh ,  HANNA, Keith ,  SAWHNEY, Harpreet ,  ARPA, Aydin ,  AGGARWAL, Manoj ,  PARAGANO, Vincent

Inventor： SAMARASEKERA, Supun ,  KUMAR, Rakesh ,  HANNA, Keith ,  SAWHNEY, Harpreet ,  ARPA, Aydin ,  AGGARWAL, Manoj ,  PARAGANO, Vincent

IPC: H04N7/18

Abstract: A scalable architecture for providing real-time multi-camera distributed video processing and visualization. An exemplary system comprises at least one video capture and storage system (140) for capturing and storing a plurality of alarm situations or events, and at least one video rendering system for displaying an alarm situation in a context that speeds up comprehension and response. One advantage of the present architecture is that these systems are scalable, such that additional sensors (e.g. cameras, motion sensors, infrared sensors, chemical sensors, biological sensors, temperature sensors and the like) can be added in large numbers without overhelming the ability of security forces to comprehend the alarm situation.

公开(公告)号：WO2012123902A1

公开(公告)日：2012-09-20

申请号：PCT/IB2012/051201

申请日：2012-03-14

Applicant: CSIR ,  KUMAR, Rakesh ,  ANANDJIWALA, Rajesh

Inventor： KUMAR, Rakesh ,  ANANDJIWALA, Rajesh

IPC: C08G65/00

CPC classification number: C08L71/14

Abstract: A process for producing a polyfurfuryl alcohol product includes mixing furfuryl alcohol (FA) and a catalyst component capable of catalyzing a condensation reaction of FA to polyfurfuryl alcohol (PFA). The mixing is effected at a temperature T mix , where T mix 1 , where T 1 > T mix and 50°C 1 for a period of time t 1 , where t 1 is sufficiently long for polymerization to take place and for the polymerized product that is formed to set. The polymerized product is heated to T 2 , where 90°C 2 2 for a period of time t 2 , where 0.5h 2 3 , where 150°C 3 3 for a period of time t 3 , where 0.5h 3

Abstract translation: 制备聚糠醇产物的方法包括混合糠醇（FA）和能够催化FA与聚糠醇（PFA）的缩合反应的催化剂组分。 混合在温度Tmix，Tmix1，其中T1> Tmix和50℃C1的时间t1进行，其中t1足够长以进行聚合，并且对于形成的聚合产物进行设定。 将聚合的产物加热至T2，其中在90℃下加热一段时间t2，其中0.5h23，其中150℃33一段时间t3，其中0.5h 3 <2h，用于进一步固化聚合产物。

公开(公告)号：WO2011146710A1

公开(公告)日：2011-11-24

申请号：PCT/US2011/037141

申请日：2011-05-19

Applicant: GLAXOSMITHKLINE LLC ,  GILMER, Tona, M. ,  KUMAR, Rakesh

Inventor： GILMER, Tona, M. ,  KUMAR, Rakesh

IPC: G01N33/574

CPC classification number: A61K31/517 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K31/4155 ,  A61K31/4375 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-Chloro-4-[(3- fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4- quinazolinamine, or a pharmaceutically acceptable hydrate and/or salt thereof, and N-{(1 S)-2-amino-1 -[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1 H - pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3-氯-4 - [（3-氟苄基）氧基]苯基} -6- [5 - （{[2-（甲磺酰基）乙基]氨基 }甲基）-2-呋喃基] -4-喹唑啉胺或其药学上可接受的水合物和/或盐和N - {（1S）-2-氨基-1 - [（3-氟苯基）甲基]乙基} 5-氯-4-（4-氯-1-甲基-1H-吡唑-5-基）-2-噻吩甲酰胺或其药学上可接受的盐。